Suchergebnisse - "Oligonucleotide Array Sequence Analysis - methods"

ENmix: a novel background correction method for Illumina HumanMethylation450 BeadChip von Xu, Zongli, Niu, Liang, Li, Leping, Taylor, Jack A.

“… The Illumina HumanMethylation450 BeadChip is increasingly utilized in epigenome-wide association studies, however, this array-based measurement of DNA methylation is subject to measurement variation …”
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Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway von Higgs, Brandon W, Liu, Zheng, White, Barbara, Zhu, Wei, White, Wendy I, Morehouse, Chris, Brohawn, Philip, Kiener, Peter A, Richman, Laura, Fiorentino, David, Greenberg, Steven A, Jallal, Bahija, Yao, Yihong

“… Methods Overexpressed transcripts were identified in the whole blood (WB) of 262 patients with SLE, 44 with DM, 33 with PM, 28 with SSc and 89 with RA and compared with 24 healthy subjects using Affymetrix microarray …”
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Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations von Planell, Núria, Lozano, Juan J, Mora-Buch, Rut, Masamunt, M Carme, Jimeno, Mireya, Ordás, Ingrid, Esteller, Miriam, Ricart, Elena, Piqué, Josep M, Panés, Julián, Salas, Azucena

“… Objective Ulcerative colitis (UC) is a chronic condition characterised by the relapsing inflammation despite previous endoscopic and histological healing. Our …”
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Diversity of Staphylococcus aureus Isolates in European Wildlife von Monecke, Stefan, Gavier-Widén, Dolores, Hotzel, Helmut, Peters, Martin, Guenther, Sebastian, Lazaris, Alexandros, Loncaric, Igor, Müller, Elke, Reissig, Annett, Ruppelt-Lorz, Antje, Shore, Anna C., Walter, Birgit, Coleman, David C., Ehricht, Ralf

“… The aim of the present study was to investigate the molecular epidemiology of S. aureus in a convenience sample of European wildlife and to review what previously has been observed in the subject field. 124 …”
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Gene expression networks in COPD: microRNA and mRNA regulation von Ezzie, Michael E, Crawford, Melissa, Cho, Ji-Hoon, Orellana, Robert, Zhang, Shile, Gelinas, Richard, Batte, Kara, Yu, Lianbo, Nuovo, Gerard, Galas, David, Diaz, Philip, Wang, Kai, Nana-Sinkam, S Patrick

“… BackgroundThe mechanisms underlying chronic obstructive pulmonary disease (COPD) remain unclear. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules …”
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Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes von Ntoumou, E., Tzetis, M., Braoudaki, M., Lambrou, G., Poulou, M., Malizos, K., Stefanou, N., Anastasopoulou, L., Tsezou, A.

“… Background MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for …”
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Immune transcriptome alterations in the temporal cortex of subjects with autism von Garbett, Krassimira, Ebert, Philip J., Mitchell, Amanda, Lintas, Carla, Manzi, Barbara, Mirnics, Károly, Persico, Antonio M.

“… Expression profiling of the superior temporal gyrus of six autistic subjects and matched controls revealed increased transcript levels of many immune system-related genes …”
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Air toxics and epigenetic effects: ozone altered microRNAs in the sputum of human subjects von Fry, Rebecca C, Rager, Julia E, Bauer, Rebecca, Sebastian, Elizabeth, Peden, David B, Jaspers, Ilona, Alexis, Neil E

“… Twenty healthy adult human volunteers were exposed to 0.4 ppm O3 for 2 h. Induced sputum samples were collected from each subject 48 h preexposure and 6 h postexposure for evaluation of miRNA expression and markers of inflammation in the airways …”
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Application of DNA microarray technology for the simultaneous identification of agricultural Frankliniella thrips (Thysanoptera: Thripidae) von Boonmee, Watchalawalee, Pham, Thai-Hong, Yahaya, Zary Shariman, Chiu, Chun-I, Yeh, Wen-Bin

“… Among them, species within the genus Frankliniella are particularly notorious pests and are subject to quarantine regulations globally …”
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Cross-sectional survey on immunoglobulin E reactivity in 23 077 subjects using an allergenic molecule-based microarray detection system von Scala, E., Alessandri, C., Bernardi, M. L., Ferrara, R., Palazzo, P., Pomponi, D., Quaratino, D., Rasi, C., Zaffiro, A., Zennaro, D., Mari, A.

“… Summary Background The availability of allergenic molecules and high‐throughput microtechnologies allow the collection of a large number of IgE results at the …”
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A single-sample microarray normalization method to facilitate personalized-medicine workflows von Piccolo, Stephen R., Sun, Ying, Campbell, Joshua D., Lenburg, Marc E., Bild, Andrea H., Johnson, W. Evan

“… Gene-expression microarrays allow researchers to characterize biological phenomena in a high-throughput fashion but are subject to technological biases and inevitable variabilities that arise …”
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Analytical challenges and technical limitations in assessing circulating miRNAs von Zampetaki, Anna, Mayr, Manuel

“… MiRNAs are emerging as promising biomarkers in cardiovascular diseases and may constitute a novel mechanism of intercellular communication. Accurate …”
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One-sample missing DNA-methylation value imputation von Kemda Ngueda, Christelle, Palm, Julia, Remo, Flavia, Scherag, André, Leistritz, Lutz

“… Results The proposed method in single-subject cases yielded an average imputation accuracy of RMSE = 0.2713 (95%-CI from 0.2696 to 0.2730) in β-value units (range: 0–1) based on real 450 …”
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Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model von Selvamani, Amutha, Williams, Madison H, Miranda, Rajesh C, Sohrabji, Farida

“… ) female and male rats were subject to MCAo (middle cerebral artery occlusion) using ET-1 (endothelin-1). Circulating miRNAs were analysed in blood samples at 2 and 5 …”
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Meta-Analysis Derived (MAD) Transcriptome of Psoriasis Defines the “Core” Pathogenesis of Disease von Tian, Suyan, Krueger, James G., Li, Katherine, Jabbari, Ali, Brodmerkel, Carrie, Lowes, Michelle A., Suárez-Fariñas, Mayte

“… The cause of psoriasis, a common chronic inflammatory skin disease, is not fully understood. Microarray experiments have been widely used in recent years to …”
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Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies von Teschendorff, Andrew E., Zhuang, Joanna, Widschwendter, Martin

“… Motivation: A common difficulty in large-scale microarray studies is the presence of confounding factors, which may significantly skew estimates of statistical …”
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A novel approach for correction of crosstalk effects in pathway analysis and its application in osteoporosis research von Zhou, Yu, Gao, Yunlong, Xu, Chao, Shen, Hui, Tian, Qing, Deng, Hong-Wen

“… To identify the key dysfunctional pathways in osteoporosis, we performed pathway analyses on microarray data of monocytes from subjects with extremely high/low hip bone mineral density …”
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Class prediction for high-dimensional class-imbalanced data von Blagus, Rok, Lusa, Lara

“… The rules are derived using the values of the variables available for each subject: the main characteristic of high-dimensional data is that the number of variables greatly exceeds the number of samples …”
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Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex von Bakulski, Kelly M, Dolinoy, Dana C, Sartor, Maureen A, Paulson, Henry L, Konen, John R, Lieberman, Andrew P, Albin, Roger L, Hu, Howard, Rozek, Laura S

“… This study investigates human postmortem frontal cortex genome-wide DNA methylation profiles between 12 LOAD and 12 cognitively normal age- and gender-matched subjects …”
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Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression von Bernard, R, Kerman, I A, Thompson, R C, Jones, E G, Bunney, W E, Barchas, J D, Schatzberg, A F, Myers, R M, Akil, H, Watson, S J

“… Several studies have proposed that brain glutamate signaling abnormalities and glial pathology have a role in the etiology of major depressive disorder (MDD) …”
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