Suchergebnisse - "O'Donnell, Max R"

Latent Class Analysis Reveals COVID-19-related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids von Sinha, Pratik, Furfaro, David, Cummings, Matthew J, Abrams, Darryl, Delucchi, Kevin, Maddali, Manoj V, He, June, Thompson, Alison, Murn, Michael, Fountain, John, Rosen, Amanda, Robbins-Juarez, Shelief Y, Adan, Matthew A, Satish, Tejus, Madhavan, Mahesh, Gupta, Aakriti, Lyashchenko, Alexander K, Agerstrand, Cara, Yip, Natalie H, Burkart, Kristin M, Beitler, Jeremy R, Baldwin, Matthew R, Calfee, Carolyn S, Brodie, Daniel, O'Donnell, Max R

“… Two distinct subphenotypes have been identified in acute respiratory distress syndrome (ARDS), but the presence of subgroups in ARDS associated with …”
Weitere Angaben

Reply to Al-Ward et al. : HIV, Sepsis, and Postdischarge Mortality in Sub-Saharan Africa von Cummings, Matthew J, Bakamutumaho, Barnabas, O'Donnell, Max R

Weitere Angaben

Racial and ethnic disparities post-hospitalization for COVID-19: barriers to access to care for survivors of COVID-19 acute respiratory distress syndrome von Cañas, Alicia, Wolf, Allison, Mak, Angela, Ruddy, Jacob, El-Sadek, Sal, Gomez, Laura, Furfaro, David, Fullilove, Robert, Burkart, Kristin M., Zelnick, Jennifer, O’Donnell, Max R.

“… Racial and ethnic health disparities in the incidence and severity of Coronavirus Disease 2019 (COVID-19) have been observed globally and in the United States …”
Volltext

Adherence Measured Using Electronic Dose Monitoring is Associated with Emergent Antiretroviral Resistance and Poor Outcomes in People with Human Immunodeficiency Virus/AIDS and Multidrug-Resistant Tuberculosis von Bateman, Mark, Wolf, Allison, Chimukangara, Benjamin, Brust, James C M, Lessells, Richard, Amico, Rivet, Boodhram, Resha, Singh, Nalini, Orrell, Catherine, Friedland, Gerald, Naidoo, Kogieleum, Padayatchi, Nesri, O'Donnell, Max R

“… Medication adherence is known to challenge treatment of human immunodeficiency virus (HIV)/AIDS and multidrug-resistant tuberculosis (MDR-TB). We hypothesized …”
Weitere Angaben

Molecular phenotypes of critical illness confer prognostic and biological enrichment in sub-Saharan Africa: a prospective cohort study from Uganda von Cummings, Matthew J, Lutwama, Julius J, Tomoiaga, Alin S, Owor, Nicholas, Lu, Xuan, Ross, Jesse E, Muwanga, Moses, Nsereko, Christopher, Nayiga, Irene, Nie, Kai, Kayiwa, John, Che, Xiaoyu, Wayengera, Misaki, Kim-Schulze, Seunghee, Lipkin, W Ian, O’Donnell, Max R, Bakamutumaho, Barnabas

“… The generalisability of critical illness molecular phenotypes to low- and middle-income countries (LMICs) is unknown. We show that molecular phenotypes derived …”
Volltext

Three hospitalized non-critical COVID-19 subphenotypes and change in intubation or death over time: A latent class analysis with external and longitudinal validation von Stringer, William S., Labar, Amy S., Geleris, Joshua D., Sholle, Evan V., Berlin, David A., McGroder, Claire M., Cummings, Matthew J., O’Donnell, Max R., Yi, Haoyang, Yang, Xuehan, Wei, Ying, Schenck, Edward J., Baldwin, Matthew R.

“… There are two subphenotypes of COVID-19 acute respiratory distress syndrome with differential responses to corticosteroids, but whether similar subphenotypes …”
Volltext

Adherence in the treatment of patients with extensively drug-resistant tuberculosis and HIV in South Africa: a prospective cohort study von OʼDonnell, Max R, Wolf, Allison, Werner, Lise, Horsburgh, C Robert, Padayatchi, Nesri

“… Extensively drug-resistant tuberculosis (XDR-TB)/HIV coinfection is difficult to treat with frequent adverse drug reactions and associated with high mortality …”
Weitere Angaben

Evaluation of screening strategies for pulmonary tuberculosis among hospitalized patients in a low-burden setting: cost-effectiveness of GeneXpert MTB/RIF compared to smear microscopy von Hickey, Andrew J., Cummings, Matthew J., Zafari, Zafar, Louh, Irene K., Li, Jianhua, O’Donnell, Max R.

“… Objective:Hospitalized patients undergoing evaluation for pulmonary tuberculosis (TB) require airborne isolation while testing for Mycobacterium tuberculosis …”
Volltext

Engineered Mycobacteriophage TM4::GeNL Rapidly Determines Bedaquiline, Pretomanid, Linezolid, Rifampicin, and Clofazimine Sensitivity in Mycobacterium tuberculosis Clinical Isolates von Rajagopalan, Saranathan, Rourke, Amy K, Asare, Emmanuel, Kohlerschmidt, Donna J, Das, Lahari, Ngema, Senamile L, Mulholland, Claire V, Vilchèze, Catherine, Mahalingam, Vaishnavi, Moodley, Sashen, Truebody, Barry, Mackenzie, Jared, Steyn, Adrie J C, Perumal, Rubeshan, Berney, Michael, Larsen, Michelle H, O'Donnell, Max R, Escuyer, Vincent E, Jacobs, Jr, William R

“… Drug-resistant tuberculosis is a growing public health threat, and early characterization of the resistance phenotype is essential for guiding treatment and …”
Weitere Angaben

Luciferase reporter mycobacteriophage (TM4:: GeNL ) enables rapid assessment of drug susceptibilities and inducible macrolide resistance in Mycobacterium abscessus complex von Rajagopalan, Saranathan, Das, Lahari, Kohlerschmidt, Donna J., Rourke, Amy K., Shakir, Salika M., Larsen, Michelle H., O’Donnell, Max R., Szymczak, Wendy A., Escuyer, Vincent E., Thwe, Phyu M., Jacobs, William R.

“… Mycobacterium abscessus (MAB) is a notorious human pathogen causing severe infections in individuals with cystic fibrosis and immunocompromised patients …”
Volltext

COVID-19 immune signatures in Uganda persist in HIV co-infection and diverge by pandemic phase von Cummings, Matthew J., Bakamutumaho, Barnabas, Lutwama, Julius J., Owor, Nicholas, Che, Xiaoyu, Astorkia, Maider, Postler, Thomas S., Kayiwa, John, Kiconco, Jocelyn, Muwanga, Moses, Nsereko, Christopher, Rwamutwe, Emmanuel, Nayiga, Irene, Kyebambe, Stephen, Haumba, Mercy, Bosa, Henry Kyobe, Ocom, Felix, Watyaba, Benjamin, Kikaire, Bernard, Tomoiaga, Alin S., Kisaka, Stevens, Kiwanuka, Noah, Lipkin, W. Ian, O’Donnell, Max R.

“… Little is known about the pathobiology of SARS-CoV-2 infection in sub-Saharan Africa, where severe COVID-19 fatality rates are among the highest in the world …”
Volltext

Identification of transcriptomic sepsis endotypes in sub-Saharan Africa: derivation, validation, and global alignment in two Ugandan cohorts von Cummings, Matthew J., Lutwama, Julius J., Tomoiaga, Alin S., Zhao, Meng, Owor, Nicholas, Lu, Xuan, Eliku, Peter James, Ross, Jesse E., Nsereko, Christopher, Nayiga, Irene, Kyebambe, Stephen, Nsubuga, John Bosco, Shinyale, Joseph, Asasira, Ignatius, Kiyingi, Tonny, Ochar, Thomas, Kiwubeyi, Moses, Nankwanga, Rittah, Reynolds, Steven J., Nakibuuka, Martina Cathy, Kayiwa, John, Haumba, Mercy, Nakaseegu, Joweria, Che, Xiaoyu, Nie, Kai, Kim-Schulze, Seunghee, Ghosh, Sankar, Lipkin, W. Ian, O’Donnell, Max R., Bakamutumaho, Barnabas

“… Purpose Sub-Saharan Africa carries the highest global burden of critical illness, yet transcriptomic sepsis endotypes have not been defined in the region …”
Volltext

Multidimensional analysis of the host response reveals prognostic and pathogen-driven immune subtypes among adults with sepsis in Uganda von Cummings, Matthew J., Bakamutumaho, Barnabas, Price, Adam, Owor, Nicholas, Kayiwa, John, Namulondo, Joyce, Byaruhanga, Timothy, Muwanga, Moses, Nsereko, Christopher, Sameroff, Stephen, Tokarz, Rafal, Wong, Wai, Shah, Shivang S., Larsen, Michelle H., Lipkin, W. Ian, Lutwama, Julius J., O’Donnell, Max R.

“… Background The global burden of sepsis is concentrated in sub-Saharan Africa, where severe infections disproportionately affect young, HIV-infected adults and …”
Volltext

Treatment Outcomes for Extensively Drug-Resistant Tuberculosis and HIV Co-infection von O’Donnell, Max R., Padayatchi, Nesri, Kvasnovsky, Charlotte, Werner, Lise, Master, Iqbal, Horsburgh, C. Robert

“… High mortality rates have been reported for patients co-infected with extensively drug-resistant tuberculosis (XDR-TB) and HIV, but treatment outcomes have not …”
Volltext

Spatiotemporal Clustering of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis Is Associated With Human Immunodeficiency Virus Status and Drug-Susceptibility Patterns in KwaZulu-Natal, South Africa von Wolf, Allison, Padayatchi, Nesri, Naidoo, Kogieleum, Master, Iqbal, Mathema, Barun, O'Donnell, Max R

“… Using an open-access spatiotemporal analytics program, we mapped spatiotemporal heterogeneity loci in tuberculosis (TB) cases (clusters) and dynamic changes, …”
Weitere Angaben

A Transcriptomic Classifier Model Identifies High-Risk Endotypes in a Prospective Study of Sepsis in Uganda von Cummings, Matthew J, Bakamutumaho, Barnabas, Tomoiaga, Alin S, Owor, Nicholas, Jain, Komal, Price, Adam, Kayiwa, John, Namulondo, Joyce, Byaruhanga, Timothy, Muwanga, Moses, Nsereko, Christopher, Nayiga, Irene, Kyebambe, Stephen, Sameroff, Stephen, Che, Xiaoyu, Lutwama, Julius J, Lipkin, W Ian, O'Donnell, Max R

“… In high-income countries (HICs), sepsis endotypes defined by distinct pathobiological mechanisms, mortality risks, and responses to corticosteroid treatment …”
Weitere Angaben

Precision Surveillance for Viral Respiratory Pathogens: Virome Capture Sequencing for the Detection and Genomic Characterization of Severe Acute Respiratory Infection in Uganda von Cummings, Matthew J, Tokarz, Rafal, Bakamutumaho, Barnabas, Kayiwa, John, Byaruhanga, Timothy, Owor, Nicholas, Namagambo, Barbara, Wolf, Allison, Mathema, Barun, Lutwama, Julius J, Schluger, Neil W, Lipkin, W Ian, O'Donnell, Max R

“… Precision public health is a novel set of methods to target disease prevention and mitigation interventions to high-risk subpopulations. We applied a precision …”
Weitere Angaben

Linezolid vs glycopeptide antibiotics for the treatment of suspected methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a meta-analysis of randomized controlled trials von Walkey, Allan J, O'Donnell, Max R, Wiener, Renda Soylemez

“… Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of nosocomial pneumonia. Societal guidelines suggest linezolid may be the preferred …”
Weitere Angaben

Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing von O'Donnell, Max R, Larsen, Michelle H, Brown, Tyler S, Jain, Paras, Munsamy, Vanisha, Wolf, Allison, Uccellini, Lorenzo, Karim, Farina, de Oliveira, Tulio, Mathema, Barun, Jacobs, William R, Pym, Alexander

“… A critical gap in tuberculosis (TB) treatment is detection of emergent drug resistance. We hypothesized that advanced phenotyping with whole-genome sequencing …”
Weitere Angaben

Associations between Organ Dysfunction Scoring Systems and Dysregulated Host Responses in Adults with Severe Infection in Uganda: A Prospective Cohort Study von Tiao, Jonathan, Bakamutumaho, Barnabas, Owor, Nicholas, Kayiwa, John, Namulondo, Joyce, Byaruhanga, Timothy, Muwanga, Moses, Nsereko, Christopher, Nayiga, Irene, Che, Xiaoyu, Lipkin, W Ian, Lutwama, Julius J, O'Donnell, Max R, Cummings, Matthew J

“… Scoring systems for organ dysfunction (e.g., the quick Sepsis-related Organ Failure Assessment [qSOFA], Modified Early Warning Score [MEWS], and Universal …”
Weitere Angaben