Výsledky vyhľadávania - "Nunneley, Jerritt"

Protease inhibitors targeting coronavirus and filovirus entry Autor Zhou, Yanchen, Vedantham, Punitha, Lu, Kai, Agudelo, Juliet, Carrion, Ricardo, Nunneley, Jerritt W., Barnard, Dale, Pöhlmann, Stefan, McKerrow, James H., Renslo, Adam R., Simmons, Graham

“…•We identify vinylsulfones as lead candidate inhibitors of Ebola virus and SARS-CoV.•K11777 inhibited Ebola virus and SARS-CoV entry in the sub-nanomolar…”
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Particle-to-PFU ratio of Ebola virus influences disease course and survival in cynomolgus macaques Autor Alfson, Kendra J, Avena, Laura E, Beadles, Michael W, Staples, Hilary, Nunneley, Jerritt W, Ticer, Anysha, Dick, Jr, Edward J, Owston, Michael A, Reed, Christopher, Patterson, Jean L, Carrion, Jr, Ricardo, Griffiths, Anthony

“…This study addresses the role of Ebola virus (EBOV) specific infectivity in virulence. Filoviruses are highly lethal, enveloped, single-stranded negative-sense…”
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Filoviruses utilize glycosaminoglycans for their attachment to target cells Autor Salvador, Beatriz, Sexton, Nicole R, Carrion, Jr, Ricardo, Nunneley, Jerritt, Patterson, Jean L, Steffen, Imke, Lu, Kai, Muench, Marcus O, Lembo, David, Simmons, Graham

“…Filoviruses are the cause of severe hemorrhagic fever in human and nonhuman primates. The envelope glycoprotein (GP), responsible for both receptor binding and…”
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Characterization of Immune Responses Induced by Ebola Virus Glycoprotein (GP) and Truncated GP Isoform DNA Vaccines and Protection Against Lethal Ebola Virus Challenge in Mice Autor Li, Wenfang, Ye, Ling, Carrion, Jr, Ricardo, Mohan, Gopi S, Nunneley, Jerritt, Staples, Hilary, Ticer, Anysha, Patterson, Jean L, Compans, Richard W, Yang, Chinglai

“…In addition to its surface glycoprotein (GP), Ebola virus directs the production of large quantities of a truncated glycoprotein isoform (sGP) that is secreted…”
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Intradermal Immunization of EBOV VLPs in Guinea Pigs Induces Broader Antibody Responses Against GP Than Intramuscular Injection Autor Liu, Ying, Wen, Zhiyuan, Carrion, Ricardo, Nunneley, Jerritt, Staples, Hilary, Ticer, Anysha, Patterson, Jean L., Compans, Richard W., Ye, Ling, Yang, Chinglai

“…Ebolavirus (EBOV) infection in humans causes severe hemorrhagic fevers with high mortality rates that range from 30 to 80% as shown in different outbreaks…”
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Pathogenic Old World arenaviruses inhibit TLR2/Mal-dependent proinflammatory cytokines in vitro Autor Hayes, Melissa W, Carrion, Jr, Ricardo, Nunneley, Jerritt, Medvedev, Andrei E, Salvato, Maria S, Lukashevich, Igor S

“…Lymphocytic choriomeningitis virus (LCMV), the prototype arenavirus, and Lassa virus (LASV), the causative agent of Lassa fever (LF), have extensive strain…”
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