Výsledky vyhľadávania - "Nowak, Gabriel"

Interaction between zinc, the GPR39 zinc receptor and the serotonergic system in depression Autor Siodłak, Dominika, Nowak, Gabriel, Mlyniec, Katarzyna

“…•Mild and severe zinc deficiency is a risk factor in developing depressive symptoms.•Zn2+ modulates the activity of the 5-HT1A receptor.•Monoamine-based…”
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Epigenetic marks and their relationship with BDNF in the brain of suicide victims Autor Misztak, Paulina, Pańczyszyn-Trzewik, Patrycja, Nowak, Gabriel, Sowa-Kućma, Magdalena

“…Background Suicide is a common phenomenon affecting people of all ages. There is a strong relationship between suicidal ideation and depressive disorders…”
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The role of zinc in neurodegenerative inflammatory pathways in depression Autor Szewczyk, Bernadeta, Kubera, Marta, Nowak, Gabriel

“…According to new hypothesis, depression is characterized by decreased neurogenesis and enhanced neurodegeneration which, in part, may be caused by inflammatory…”
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GPR39 (Zinc Receptor) Knockout Mice Exhibit Depression-Like Behavior and CREB/BDNF Down-Regulation in the Hippocampus Autor Młyniec, Katarzyna, Budziszewska, Bogusława, Holst, Birgitte, Ostachowicz, Beata, Nowak, Gabriel

“…Background:Zinc may act as a neurotransmitter in the central nervous system by activation of the GPR39 metabotropic receptors.Methods:In the present study, we…”
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Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase Autor Misztak, Paulina, Sowa-Kućma, Magdalena, Pańczyszyn-Trzewik, Patrycja, Szewczyk, Bernadeta, Nowak, Gabriel

“…Chronic stress is the key factor contributing to the development of depressive symptoms. Chronic restraint stress (CRS) is well validated and is one of the…”
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Phospholipid-protein balance in affective disorders: Analysis of human blood serum using Raman and FTIR spectroscopy. A pilot study Autor Depciuch, Joanna, Sowa-Kućma, Magdalena, Nowak, Gabriel, Dudek, Dominika, Siwek, Marcin, Styczeń, Krzysztof, Parlińska-Wojtan, Magdalena

“…[Display omitted] •The Raman and FTIR spectra of blood serum from depressed subjects show a decrease in the amount of phospholipids and proteins.•The…”
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Relationship between Zinc (Zn2+) and Glutamate Receptors in the Processes Underlying Neurodegeneration Autor Pochwat, Bartłomiej, Szewczyk, Bernadeta, Nowak, Gabriel

“…The results from numerous studies have shown that an imbalance between particular neurotransmitters may lead to brain circuit dysfunction and development of…”
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Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity Autor Cui, R., Radziwoń-Zaleska, Maria, Nowak, Gabriel, Wlaź, Piotr, Doboszewska, Urszula, Młyniec, Katarzyna

“…Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that…”
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Mood disorders: Regulation by metabotropic glutamate receptors Autor Pilc, Andrzej, Chaki, Shigeyuki, Nowak, Gabriel, Witkin, Jeffrey M.

“…Medicinal therapies for mood disorders neither fully serve the efficacy needs of patients nor are they free of side-effect issues. Although monoamine-based…”
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Repeated Sulforaphane Treatment Reverses Depressive-like Behavior and Exerts Antioxidant Effects in the Olfactory Bulbectomy Model in Mice Autor Pańczyszyn-Trzewik, Patrycja, Stachowicz, Katarzyna, Misztak, Paulina, Nowak, Gabriel, Sowa-Kućma, Magdalena

“…Growing evidence suggests that activators of nuclear factor erythroid-derived 2-like 2 (Nrf2), such as sulforaphane, may represent promising novel…”
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Zinc supplementation augments efficacy of imipramine in treatment resistant patients: A double blind, placebo-controlled study Autor Siwek, Marcin, Dudek, Dominika, Paul, Ian A., Sowa-Kućma, Magdalena, Zięba, Andrzej, Popik, Piotr, Pilc, Andrzej, Nowak, Gabriel

“…One of the main problems in the therapy of depression is the limited efficacy of antidepressants and the limited utility of augmentation strategies. Zinc, a…”
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The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims Autor Młyniec, Katarzyna, Doboszewska, Urszula, Szewczyk, Bernadeta, Sowa-Kućma, Magdalena, Misztak, Paulina, Piekoszewski, Wojciech, Trela, Franciszek, Ostachowicz, Beata, Nowak, Gabriel

“…Zinc is one of the most important trace elements in our body. Patients suffering from depression show lower serum zinc levels compared to healthy controls…”
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The role of the GPR39 receptor in zinc deficient-animal model of depression Autor Młyniec, Katarzyna, Budziszewska, Bogusława, Reczyński, Witold, Sowa-Kućma, Magdalena, Nowak, Gabriel

“…► Zinc deficiency causes depressive-like behaviour. ► Zinc deficiency induces a decrease in expression of the BDNF protein. ► Zinc deficiency induces a…”
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Antidepressant-like activity of magnesium in the chronic mild stress model in rats: alterations in the NMDA receptor subunits Autor Pochwat, Bartłomiej, Szewczyk, Bernadeta, Sowa-Kucma, Magdalena, Siwek, Agata, Doboszewska, Urszula, Piekoszewski, Wojciech, Gruca, Piotr, Papp, Mariusz, Nowak, Gabriel

“…Recent data suggests that the glutamatergic system is involved in the pathophysiology and treatment of major depressive disorder (MDD) and that the…”
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Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice Autor Pochwat, Bartłomiej, Szewczyk, Bernadeta, Kotarska, Katarzyna, Rafało-Ulińska, Anna, Siwiec, Marcin, Sowa, Joanna E., Tokarski, Krzysztof, Siwek, Agata, Bouron, Alexandre, Friedland, Kristina, Nowak, Gabriel

“…N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained antidepressant like-activity in rodents through a molecular mechanism of action…”
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Technical design report for the CODEX-β demonstrator Autor Aielli, Giulio, Alimena, Juliette, Balcarcel-Salazar, Saul, Beacham, James, Haim, Eli Ben, Burucs, András Barnabás, Cardarelli, Roberto, Charles, Matthew J., Vidal, Xabier Cid, Roeck, Albert De, Dey, Biplab, Dobrescu, Silviu, Durmus, Ozgur, Elashri, Mohamed, Gligorov, Vladimir V., Suarez, Rebeca Gonzalez, Gorordo, Thomas, Gray, Zarria, Henderson, Conor, Henry, Louis, Ilten, Philip, Johnson, Daniel, Kautz, Jacob, Knapen, Simon, Liu, Bingxuan, Liu, Yang, Soliño, Saul López, Pérez, Pablo Eduardo Menéndez-Valdés, Mombächer, Titus, Nachman, Benjamin, Northacker, David T., Nowak, Gabriel M., Papucci, Michele, Pásztor, Gabriella, Rial, Eloi Pazos, Martínez, María Pereira, Peters, Michael, Pfaller, Jake, Pizzimento, Luca, Casasús, Máximo Pló, Rassati, Gian Andrea, Robinson, Dean J., Fernández, Emilio Xosé Rodríguez, Sahoo, Debashis, Simsek, Sinem, Sokoloff, Michael D., Subash, Joeal, Suresh, Aditya, Swallow, Paul, Swanson, James, Upadhyay, Abhinaba, Vari, Riccardo, Sierra, Carlos Vázquez, Veres, Gábor, Watson, Nigel, Wilkinson, Michael K., Williams, Michael, Winkler, Eleanor

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Studies on the Anticonvulsant Activity and Influence on GABA-ergic Neurotransmission of 1,2,4-Triazole-3-thione- Based Compounds Autor Plech, Tomasz, Kaproń, Barbara, Łuszczki, Jarogniew, Wujec, Monika, Paneth, Agata, Siwek, Agata, Kołaczkowski, Marcin, Żołnierek, Maria, Nowak, Gabriel

“…The anticonvulsant activity of several 1,2,4-triazole-3-thione derivatives on mouse maximal electroshock-induced seizures was tested in this study…”
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Combined hyperforin and lanicemine treatment instead of ketamine or imipramine restores behavioral deficits induced by chronic restraint stress and dietary zinc restriction in mice Autor Pochwat, Bartłomiej, Misztak, Paulina, Masternak, Julia, Bączyńska, Ewa, Bijata, Krystian, Roszkowska, Matylda, Bijata, Monika, Włodarczyk, Jakub, Szafarz, Małgorzata, Wyska, Elżbieta, Muszyńska, Bożena, Krakowska, Agata, Opoka, Włodzimierz, Nowak, Gabriel, Szewczyk, Bernadeta

“…Clinical and preclinical studies show evidence that chronic stress or nutritional deficits in dietary zinc (Zn) intake may be risk factors for developing major…”
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(Neuro)inflammation and neuroprogression as new pathways and drug targets in depression: From antioxidants to kinase inhibitors Autor Maes, Michael, Leonard, Brian, Fernandez, Alberto, Kubera, Marta, Nowak, Gabriel, Veerhuis, Rob, Gardner, Ann, Ruckoanich, Piaynuj, Geffard, Michel, Altamura, Carlo, Galecki, Piotr, Berk, Michael

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Alterations of Serum Magnesium Concentration in Animal Models of Seizures and Epilepsy—The Effects of Treatment with a GPR39 Agonist and Knockout of the Gpr39 Gene Autor Doboszewska, Urszula, Sawicki, Jan, Sajnóg, Adam, Szopa, Aleksandra, Serefko, Anna, Socała, Katarzyna, Pieróg, Mateusz, Nieoczym, Dorota, Mlyniec, Katarzyna, Nowak, Gabriel, Barałkiewicz, Danuta, Sowa, Ireneusz, Wlaź, Piotr

“…Several ligands have been proposed for the GPR39 receptor, including the element zinc. The relationship between GPR39 and magnesium homeostasis has not yet…”
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