Výsledky vyhľadávania - "Nobis, Max"

MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth Autor Kalafatovic, Daniela, Nobis, Max, Son, Jiye, Anderson, Kurt I., Ulijn, Rein V.

“…A central challenge in cancer care is to ensure that therapeutic compounds reach their targets. One approach is to use enzyme-responsive biomaterials, which…”
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Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress Autor Lamm, Noa, Read, Mark N, Nobis, Max, Van Ly, David, Page, Scott G, Masamsetti, V Pragathi, Timpson, Paul, Biro, Maté, Cesare, Anthony J

“…Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility of intracellular structures. Although F-actin is traditionally…”
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Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis Autor Papanicolaou, Michael, Parker, Amelia L., Yam, Michelle, Filipe, Elysse C., Wu, Sunny Z., Chitty, Jessica L., Wyllie, Kaitlin, Tran, Emmi, Mok, Ellie, Nadalini, Audrey, Skhinas, Joanna N., Lucas, Morghan C., Herrmann, David, Nobis, Max, Pereira, Brooke A., Law, Andrew M. K., Castillo, Lesley, Murphy, Kendelle J., Zaratzian, Anaiis, Hastings, Jordan F., Croucher, David R., Lim, Elgene, Oliver, Brian G., Mora, Fatima Valdes, Parker, Benjamin L., Gallego-Ortega, David, Swarbrick, Alexander, O’Toole, Sandra, Timpson, Paul, Cox, Thomas R.

“…The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in shaping their…”
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MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer Autor Cipponi, Arcadi, Goode, David L, Bedo, Justin, McCabe, Mark J, Pajic, Marina, Croucher, David R, Rajal, Alvaro Gonzalez, Junankar, Simon R, Saunders, Darren N, Lobachevsky, Pavel, Papenfuss, Anthony T, Nessem, Danielle, Nobis, Max, Warren, Sean C, Timpson, Paul, Cowley, Mark, Vargas, Ana C, Qiu, Min R, Generali, Daniele G, Keerthikumar, Shivakumar, Nguyen, Uyen, Corcoran, Niall M, Long, Georgina V, Blay, Jean-Yves, Thomas, David M

“…In microorganisms, evolutionarily conserved mechanisms facilitate adaptation to harsh conditions through stress-induced mutagenesis (SIM). Analogous processes…”
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Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis Autor von Karstedt, Silvia, Conti, Annalisa, Nobis, Max, Montinaro, Antonella, Hartwig, Torsten, Lemke, Johannes, Legler, Karen, Annewanter, Franka, Campbell, Andrew D, Taraborrelli, Lucia, Grosse-Wilde, Anne, Coy, Johannes F, El-Bahrawy, Mona A, Bergmann, Frank, Koschny, Ronald, Werner, Jens, Ganten, Tom M, Schweiger, Thomas, Hoetzenecker, Konrad, Kenessey, Istvan, Hegedüs, Balazs, Bergmann, Michael, Hauser, Charlotte, Egberts, Jan-Hendrik, Becker, Thomas, Röcken, Christoph, Kalthoff, Holger, Trauzold, Anna, Anderson, Kurt I, Sansom, Owen J, Walczak, Henning

“…Many cancers harbor oncogenic mutations of KRAS. Effectors mediating cancer progression, invasion, and metastasis in KRAS-mutated cancers are only incompletely…”
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Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity Autor Yan, Chenxu, Zeng, Tianshu, Lee, Kailun, Nobis, Max, Loh, Kim, Gou, Luoning, Xia, Zefeng, Gao, Zhongmin, Bensellam, Mohammed, Hughes, Will, Lau, Jackie, Zhang, Lei, Ip, Chi Kin, Enriquez, Ronaldo, Gao, Hanyu, Wang, Qiao-Ping, Wu, Qi, Haigh, Jody J., Laybutt, D. Ross, Timpson, Paul, Herzog, Herbert, Shi, Yan-Chuan

“…Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here we identify a conserved pathway that links signalling through…”
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Molecular mobility and activity in an intravital imaging setting - implications for cancer progression and targeting Autor Nobis, Max, Warren, Sean C, Lucas, Morghan C, Murphy, Kendelle J, Herrmann, David, Timpson, Paul

“…Molecular mobility, localisation and spatiotemporal activity are at the core of cell biological processes and deregulation of these dynamic events can underpin…”
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Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer Autor Nobis, Max, McGhee, Ewan J, Morton, Jennifer P, Schwarz, Juliane P, Karim, Saadia A, Quinn, Jean, Edward, Mike, Campbell, Andrew D, McGarry, Lynn C, Evans, T R Jeffry, Brunton, Valerie G, Frame, Margaret C, Carragher, Neil O, Wang, Yingxiao, Sansom, Owen J, Timpson, Paul, Anderson, Kurt I

“…Cancer invasion and metastasis occur in a complex three-dimensional (3D) environment, with reciprocal feedback from the surrounding host tissue and…”
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An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade Autor Houbaert, Diede, Nikolakopoulos, Apostolos Panagiotis, Jacobs, Kathryn A., Meçe, Odeta, Roels, Jana, Shankar, Gautam, Agrawal, Madhur, More, Sanket, Ganne, Maarten, Rillaerts, Kristine, Boon, Louis, Swoboda, Magdalena, Nobis, Max, Mourao, Larissa, Bosisio, Francesca, Vandamme, Niels, Bergers, Gabriele, Scheele, Colinda L.G.J., Agostinis, Patrizia

“…Lymphatic endothelial cells (LECs) of the lymph node (LN) parenchyma orchestrate leukocyte trafficking and peripheral T cell dynamics. T cell responses to…”
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Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer Autor Conway, James R.W., Warren, Sean C., Herrmann, David, Murphy, Kendelle J., Cazet, Aurélie S., Vennin, Claire, Shearer, Robert F., Killen, Monica J., Magenau, Astrid, Mélénec, Pauline, Pinese, Mark, Nobis, Max, Zaratzian, Anaiis, Boulghourjian, Alice, Da Silva, Andrew M., del Monte-Nieto, Gonzalo, Adam, Arne S.A., Harvey, Richard P., Haigh, Jody J., Wang, Yingxiao, Croucher, David R., Sansom, Owen J., Pajic, Marina, Caldon, C. Elizabeth, Morton, Jennifer P., Timpson, Paul

“…Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to…”
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Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer Autor Kennedy, Sean P., Han, Jeremy Z. R., Portman, Neil, Nobis, Max, Hastings, Jordan F., Murphy, Kendelle J., Latham, Sharissa L., Cadell, Antonia L., Miladinovic, Dushan, Marriott, Gabriella R., O’Donnell, Yolande E. I., Shearer, Robert F., Williams, James T., Munoz, Amaya Garcia, Cox, Thomas R., Watkins, D. Neil, Saunders, Darren N., Timpson, Paul, Lim, Elgene, Kolch, Walter, Croucher, David R.

“…Background The oncogenic receptor tyrosine kinase (RTK) ERBB2 is known to dimerize with other EGFR family members, particularly ERBB3, through which it…”
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A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma Autor Gonzalez Rajal, Alvaro, Marzec, Kamila A, McCloy, Rachael A, Nobis, Max, Chin, Venessa, Hastings, Jordan F, Lai, Kaitao, Kennerson, Marina, Hughes, William E, Vaghjiani, Vijesh, Timpson, Paul, Cain, Jason E, Watkins, D Neil, Croucher, David R, Burgess, Andrew

“…We previously used a pulse-based in vitro assay to unveil targetable signalling pathways associated with innate cisplatin resistance in lung adenocarcinoma…”
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Removing physiological motion from intravital and clinical functional imaging data Autor Warren, Sean C, Nobis, Max, Magenau, Astrid, Mohammed, Yousuf H, Herrmann, David, Moran, Imogen, Vennin, Claire, Conway, James RW, Mélénec, Pauline, Cox, Thomas R, Wang, Yingxiao, Morton, Jennifer P, Welch, Heidi CE, Strathdee, Douglas, Anderson, Kurt I, Phan, Tri Giang, Roberts, Michael S, Timpson, Paul

“…Intravital microscopy can provide unique insights into the function of biological processes in a native context. However, physiological motion caused by…”
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The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues Autor Johnsson, Anna-Karin E., Dai, Yanfeng, Nobis, Max, Baker, Martin J., McGhee, Ewan J., Walker, Simon, Schwarz, Juliane P., Kadir, Shereen, Morton, Jennifer P., Myant, Kevin B., Huels, David J., Segonds-Pichon, Anne, Sansom, Owen J., Anderson, Kurt I., Timpson, Paul, Welch, Heidi C.E.

“…The small G protein family Rac has numerous regulators that integrate extracellular signals into tight spatiotemporal maps of its activity to promote specific…”
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Live microscopy of multicellular spheroids with multi-modal near-infrared nanoparticles reveals differences in oxygenation gradients Autor Debruyne, Angela C., Okkelman, Irina A., Heymans, Nina, Pinheiro, Cláudio, Hendrix, An, Nobis, Max, Borisov, Sergey M., Dmitriev, Ruslan I.

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Live Microscopy of Multicellular Spheroids with the Multimodal Near-Infrared Nanoparticles Reveals Differences in Oxygenation Gradients Autor Debruyne, Angela C., Okkelman, Irina A., Heymans, Nina, Pinheiro, Cláudio, Hendrix, An, Nobis, Max, Borisov, Sergey M., Dmitriev, Ruslan I.

“…Assessment of hypoxia, nutrients, metabolite gradients, and other hallmarks of the tumor microenvironment within 3D multicellular spheroid and organoid models…”
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CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan Autor Vennin, Claire, Mélénec, Pauline, Rouet, Romain, Nobis, Max, Cazet, Aurélie S., Murphy, Kendelle J., Herrmann, David, Reed, Daniel A., Lucas, Morghan C., Warren, Sean C., Elgundi, Zehra, Pinese, Mark, Kalna, Gabriella, Roden, Daniel, Samuel, Monisha, Zaratzian, Anaiis, Grey, Shane T., Da Silva, Andrew, Leung, Wilfred, Mathivanan, Suresh, Wang, Yingxiao, Braithwaite, Anthony W., Christ, Daniel, Benda, Ales, Parkin, Ashleigh, Phillips, Phoebe A., Whitelock, John M., Gill, Anthony J., Sansom, Owen J., Croucher, David R., Parker, Benjamin L., Pajic, Marina, Morton, Jennifer P., Cox, Thomas R., Timpson, Paul

“…Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic cancer tissues and can both promote and restrain disease progression…”
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Acute compressive stress activates RHO/ROCK-mediated cellular processes Autor Boyle, Sarah T., Kular, Jasreen, Nobis, Max, Ruszkiewicz, Andrew, Timpson, Paul, Samuel, Michael S.

“…The ability to rapidly respond to applied force underpins cell/tissue homeostasis. This response is mediated by mechanotransduction pathways that regulate…”
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Pharmacologic Inhibition of Glutamate Dehydrogenase 1 Improves Functional Recovery of Neuromuscular Junctions and Muscle Function in Duchenne Muscular Dystrophy Autor Pereira-Nunes, Andreia, Ammarah, Ummi, Shang, Min, Charatsidou, Iris, Sharma, Himal, Pereira Sorroche, Bruna, Nobis, Max, Burg, Thibaut, Verschoren, Stijn, Relaix, Frédéric, Rotini, Alessio, Van Den Bosch, Ludo, Delfini, Marcello, Berardi, Emanuele, Mazzone, Massimiliano

“…Presynaptic terminals of neuromuscular junctions (NMJs) are sensitive to glutamate, which contributes to NMJ plasticity and synaptic neurotransmission…”
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Compression-dependent microtubule reinforcement enables cells to navigate confined environments Autor Ju, Robert J., Falconer, Alistair D., Schmidt, Christanny J., Enriquez Martinez, Marco A., Dean, Kevin M., Fiolka, Reto P., Sester, David P., Nobis, Max, Timpson, Paul, Lomakin, Alexis J., Danuser, Gaudenz, White, Melanie D., Haass, Nikolas K., Oelz, Dietmar B., Stehbens, Samantha J.

“…Cells migrating through complex three-dimensional environments experience considerable physical challenges, including tensile stress and compression. To move,…”
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