Search Results - "Nithianantham, Stanley"

Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs by Min, Jaeki, Mayasundari, Anand, Keramatnia, Fatemeh, Jonchere, Barbara, Yang, Seung Wook, Jarusiewicz, Jamie, Actis, Marisa, Das, Sourav, Young, Brandon, Slavish, Jake, Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H., Yun, Mi‐Kyung, Li, Zhenmei, Nithianantham, Stanley, Chai, Sergio, Chen, Taosheng, Shelat, Anang, Lee, Richard E., Nishiguchi, Gisele, White, Stephen W., Roussel, Martine F., Potts, Patrick Ryan, Fischer, Marcus, Rankovic, Zoran

“…Targeting cereblon (CRBN) is currently one of the most frequently reported proteolysis‐targeting chimera (PROTAC) approaches, owing to favorable drug‐like…”
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Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR by Garcia-Maldonado, Efren, Huber, Andrew D., Chai, Sergio C., Nithianantham, Stanley, Li, Yongtao, Wu, Jing, Poudel, Shyaron, Miller, Darcie J., Seetharaman, Jayaraman, Chen, Taosheng

“…Nuclear receptors are ligand-activated transcription factors that can often be useful drug targets. Unfortunately, ligand promiscuity leads to two-thirds of…”
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Discovery of antivirulence agents against methicillin-resistant Staphylococcus aureus by Khodaverdian, Varandt, Pesho, Michelle, Truitt, Barbara, Bollinger, Lucy, Patel, Parita, Nithianantham, Stanley, Yu, Guanping, Delaney, Elizabeth, Jankowsky, Eckhard, Shoham, Menachem

“…Antivirulence agents inhibit the production of disease-causing virulence factors but are neither bacteriostatic nor bactericidal. Antivirulence agents against…”
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Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays by Nithianantham, Stanley, Cook, Brian D, Beans, Madeleine, Guo, Fei, Chang, Fred, Al-Bassam, Jawdat

“…XMAP215/Stu2/Alp14 proteins accelerate microtubule plus-end polymerization by recruiting tubulins via arrays of tumor overexpressed gene (TOG) domains, yet…”
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Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia by Chang, Yunchao, Min, Jaeki, Jarusiewicz, Jamie A, Actis, Marisa, Yu-Chen Bradford, Shanshan, Mayasundari, Anand, Yang, Lei, Chepyala, Divyabharathi, Alcock, Lisa J, Roberts, Kathryn G, Nithianantham, Stanley, Maxwell, Dylan, Rowland, Lauren, Larsen, Randolph, Seth, Aman, Goto, Hiroaki, Imamura, Toshihiko, Akahane, Koshi, Hansen, Baranda S, Pruett-Miller, Shondra M, Paietta, Elisabeth M, Litzow, Mark R, Qu, Chunxu, Yang, Jun J, Fischer, Marcus, Rankovic, Zoran, Mullighan, Charles G

“…CRLF2-rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) accounts for more than half of Philadelphia chromosome-like (Ph-like) ALL and is associated with a…”
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Decoding the selective chemical modulation of CYP3A4 by Wang, Jingheng, Nithianantham, Stanley, Chai, Sergio C., Jung, Young-Hwan, Yang, Lei, Ong, Han Wee, Li, Yong, Zhang, Yifan, Miller, Darcie J., Chen, Taosheng

“…Drug-drug interactions associate with concurrent uses of multiple medications. Cytochrome P450 (CYP) 3A4 metabolizes a large portion of marketed drugs. To…”
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Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers by Scholey, Jessica E, Nithianantham, Stanley, Scholey, Jonathan M, Al-Bassam, Jawdat

“…Chromosome segregation during mitosis depends upon Kinesin-5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor…”
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The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding by Bodrug, Tatyana, Wilson-Kubalek, Elizabeth M, Nithianantham, Stanley, Thompson, Alex F, Alfieri, April, Gaska, Ignas, Major, Jennifer, Debs, Garrett, Inagaki, Sayaka, Gutierrez, Pedro, Gheber, Larisa, McKenney, Richard J, Sindelar, Charles Vaughn, Milligan, Ronald, Stumpff, Jason, Rosenfeld, Steven S, Forth, Scott T, Al-Bassam, Jawdat

“…Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar…”
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Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication by Yu, Xiaolan, Shahir, Abdel-Malek, Sha, Jingfeng, Feng, Zhimin, Eapen, Betty, Nithianantham, Stanley, Das, Biswajit, Karn, Jonathan, Weinberg, Aaron, Bissada, Nabil F, Ye, Fengchun

“…Periodontal pathogens such as Porphyromonas gingivalis and Fusobacterium nucleatum produce five different short-chain fatty acids (SCFAs) as metabolic…”
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Kaposi's sarcoma-associated herpesvirus induces rapid release of angiopoietin-2 from endothelial cells by Ye, Feng-Chun, Zhou, Fu-Chun, Nithianantham, Stanley, Chandran, Bala, Yu, Xiao-Lan, Weinberg, Aaron, Gao, Shou-Jiang

“…Kaposi sarcoma-associated herpesvirus (KSHV) stimulates proliferation, angiogenesis, and inflammation to promote Kaposi sarcoma (KS) tumor growth, which…”
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Crystal structure of N ′-hydroxypyrimidine-2-carboximidamide by Jasmine, Nithianantham Jeeva, Muthiah, Packianathan Thomas, Stanley, Nithianantham

“…The title compound, C 5 H 6 N 4 O, is approximately planar, with an angle of 11.04 (15)° between the planes of the pyrimidine ring and the non-H atoms of the…”
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Crystal structure of FadA adhesin from Fusobacterium nucleatum reveals a novel oligomerization motif, the leucine chain by Nithianantham, Stanley, Xu, Minghua, Yamada, Mitsunori, Ikegami, Akihiko, Shoham, Menachem, Han, Yiping W

“…Many bacterial appendages have filamentous structures, often composed of repeating monomers assembled in a head-to-tail manner. The mechanisms of such linkages…”
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Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics by Nithianantham, Stanley, Le, Sinh, Seto, Elbert, Jia, Weitao, Leary, Julie, Corbett, Kevin D, Moore, Jeffrey K, Al-Bassam, Jawdat

“…Microtubule dynamics and polarity stem from the polymerization of αβ-tubulin heterodimers. Five conserved tubulin cofactors/chaperones and the Arl2 GTPase…”
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Malleable folding of coiled-coils regulates kinesin-3 dimerization by Al-Bassam, Jawdat, Nithianantham, Stanley

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Soluble mimics of the cytoplasmic face of the human V1-vascular vasopressin receptor bind arrestin2 and calmodulin by Wu, Nan, Macion-Dazard, Rosemarie, Nithianantham, Stanley, Xu, Zhen, Hanson, Susan M, Vishnivetskiy, Sergey A, Gurevich, Vsevolod V, Thibonnier, Marc, Shoham, Menachem

“…Signal transduction by G protein-coupled receptors (GPCRs) is mediated by interactions between intracellular proteins and exposed motifs on the cytoplasmic…”
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Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity by Fardini, Yann, Wang, Xiaowei, Témoin, Stéphanie, Nithianantham, Stanley, Lee, David, Shoham, Menachem, Han, Yiping W.

“…Summary Fusobacterium nucleatum is a Gram‐negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed‐species,…”
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Pan‐HSP90 ligand binding reveals isoform‐specific differences in plasticity and water networks by Stachowski, Timothy R., Nithianantham, Stanley, Vanarotti, Murugendra, Lopez, Karlo, Fischer, Marcus

“…Isoforms of heat shock protein 90 (HSP90) fold oncoproteins that facilitate all 10 hallmarks of cancer. However, its promise as a therapeutic target remains…”
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Structural basis for disassembly of katanin heterododecamers by Nithianantham, Stanley, McNally, Francis J, Al-Bassam, Jawdat

“…The reorganization of microtubules in mitosis, meiosis, and development requires the microtubule-severing activity of katanin. Katanin is a heterodimer…”
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The big thaw: waters freed from cryo-cooling yield dynamic protein–ligand interactions by Stachowski, Timothy, Vanarotti, Murugendra, Nithianantham, Stanley, Jayaraman, Seetharaman, Lopez, Karlo, Fischer, Marcus

“…Abstract only…”
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New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition by Zahid, Huda, Buchholz, Caroline R., Singh, Manjulata, Ciccone, Michael F., Chan, Alice, Nithianantham, Stanley, Shi, Ke, Aihara, Hideki, Fischer, Marcus, Schonbrunn, Ernst, dos Santos, Camila O., Landry, Joseph W., Pomerantz, William C. K.

“…The nucleosome remodeling factor (NURF) alters chromatin accessibility through interactions with its largest subunit,the bromodomain PHD finger transcription…”
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