Suchergebnisse - "Netea, Mihai G"

Considering BCG vaccination to reduce the impact of COVID-19 von Curtis, Nigel, Sparrow, Annie, Ghebreyesus, Tedros A, Netea, Mihai G

“… In addition to its specific effect against tuberculosis, the BCG vaccine has beneficial nonspecific (off-target) effects on the immune system that protect …”
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Trained immunity-related vaccines: innate immune memory and heterologous protection against infections von Ziogas, Athanasios, Netea, Mihai G.

“… The innate immune system is able to build memory-like features in response to certain infections or vaccines, resulting in enhanced responsiveness upon …”
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The immunopathology of sepsis and potential therapeutic targets von van der Poll, Tom, van de Veerdonk, Frank L., Scicluna, Brendon P., Netea, Mihai G.

“… Key Points Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. The sepsis-associated host response is …”
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Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens von Netea, Mihai G, Schlitzer, Andreas, Placek, Katarzyna, Joosten, Leo A B, Schultze, Joachim L

“… Immunological memory is an important evolutionary trait that improves host survival upon reinfection. Memory is a characteristic recognized within both the …”
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Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection von Netea, Mihai G, Giamarellos-Bourboulis, Evangelos J, Domínguez-Andrés, Jorge, Curtis, Nigel, van Crevel, Reinout, van de Veerdonk, Frank L, Bonten, Marc

“… SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe pneumonia in a small proportion of patients. The increased …”
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Beneficial non-specific effects of live vaccines against COVID-19 and other unrelated infections von Aaby, Peter, Netea, Mihai G, Benn, Christine S

“… Live attenuated vaccines could have beneficial, non-specific effects of protecting against vaccine-unrelated infections, such as BCG protecting against …”
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Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities von Li, Xiaofei, Wang, Hui, Yu, Xiang, Saha, Gundappa, Kalafati, Lydia, Ioannidis, Charalampos, Mitroulis, Ioannis, Netea, Mihai G, Chavakis, Triantafyllos, Hajishengallis, George

“… Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune responsiveness of hematopoietic stem and progenitor cells (HSPC) and …”
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The Intersection of Epigenetics and Metabolism in Trained Immunity von Fanucchi, Stephanie, Domínguez-Andrés, Jorge, Joosten, Leo A B, Netea, Mihai G, Mhlanga, Musa M

“… The last few years have witnessed an increasing body of evidence that challenges the traditional view that immunological memory is an exclusive trait of the …”
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Trained immunity - basic concepts and contributions to immunopathology von Ochando, Jordi, Mulder, Willem J M, Madsen, Joren C, Netea, Mihai G, Duivenvoorden, Raphaël

“… Trained immunity is a functional state of the innate immune response and is characterized by long-term epigenetic reprogramming of innate immune cells. This …”
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Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship von Netea-Maier, Romana T., Smit, Johannes W.A., Netea, Mihai G.

“… In order to adapt to the reduced availability of nutrients and oxygen in the tumor microenvironment and the increased requirements of energy and building …”
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Trained immunity: General and emerging concepts von Vuscan, Patricia, Kischkel, Brenda, Joosten, Leo A. B., Netea, Mihai G.

“… Summary Over the past decade, compelling evidence has unveiled previously overlooked adaptive characteristics of innate immune cells. Beyond their traditional …”
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Trained Immunity: Reprogramming Innate Immunity in Health and Disease von Bekkering, Siroon, Domínguez-Andrés, Jorge, Joosten, Leo A B, Riksen, Niels P, Netea, Mihai G

“… Traditionally, the innate and adaptive immune systems are differentiated by their specificity and memory capacity. In recent years, however, this paradigm has …”
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Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses von Boutens, Lily, Hooiveld, Guido J., Dhingra, Sourabh, Cramer, Robert A., Netea, Mihai G., Stienstra, Rinke

“… Aims/hypothesis Recent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory …”
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IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections von Slaats, Jeroen, ten Oever, Jaap, van de Veerdonk, Frank L., Netea, Mihai G.

“… The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate …”
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Blocking IL-1 to prevent respiratory failure in COVID-19 von van de Veerdonk, Frank L., Netea, Mihai G.

“… COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it …”
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Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome von Chen, Lianmin, Zhernakova, Daria V., Kurilshikov, Alexander, Andreu-Sánchez, Sergio, Wang, Daoming, Augustijn, Hannah E., Vich Vila, Arnau, Weersma, Rinse K., Medema, Marnix H., Netea, Mihai G., Kuipers, Folkert, Wijmenga, Cisca, Zhernakova, Alexandra, Fu, Jingyuan

“… The levels of the thousands of metabolites in the human plasma metabolome are strongly influenced by an individual’s genetics and the composition of their diet …”
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Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly von Giamarellos-Bourboulis, Evangelos J, Tsilika, Maria, Moorlag, Simone, Antonakos, Nikolaos, Kotsaki, Antigone, Domínguez-Andrés, Jorge, Kyriazopoulou, Evdoxia, Gkavogianni, Theologia, Adami, Maria-Evangelia, Damoraki, Georgia, Koufargyris, Panagiotis, Karageorgos, Athanassios, Bolanou, Amalia, Koenen, Hans, van Crevel, Reinout, Droggiti, Dionyssia-Irene, Renieris, George, Papadopoulos, Antonios, Netea, Mihai G

“… BCG vaccination in children protects against heterologous infections and improves survival independently of tuberculosis prevention. The phase III ACTIVATE …”
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β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1 von Moorlag, Simone J.C.F.M., Khan, Nargis, Novakovic, Boris, Kaufmann, Eva, Jansen, Trees, van Crevel, Reinout, Divangahi, Maziar, Netea, Mihai G.

“… β-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called “trained immunity,” resulting in an enhanced …”
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Impact of Historic Migrations and Evolutionary Processes on Human Immunity von Domínguez-Andrés, Jorge, Netea, Mihai G.

“… The evolution of mankind has constantly been influenced by the pathogens encountered. The various populations of modern humans that ventured out of Africa …”
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Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases von Sanna, Serena, van Zuydam, Natalie R., Mahajan, Anubha, Kurilshikov, Alexander, Vich Vila, Arnau, Võsa, Urmo, Mujagic, Zlatan, Masclee, Ad A. M., Jonkers, Daisy M. A. E., Oosting, Marije, Joosten, Leo A. B., Netea, Mihai G., Franke, Lude, Zhernakova, Alexandra, Fu, Jingyuan, Wijmenga, Cisca, McCarthy, Mark I.

“… Microbiome-wide association studies on large population cohorts have highlighted associations between the gut microbiome and complex traits, including type 2 …”
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