Suchergebnisse - "Neoplasm Proteins - biosynthesis"

Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer von Mereiter, Stefan, Magalhães, Ana, Adamczyk, Barbara, Jin, Chunsheng, Almeida, Andreia, Drici, Lylia, Ibáñez-Vea, Maria, Gomes, Catarina, Ferreira, José A., Afonso, Luis P., Santos, Lúcio L., Larsen, Martin R., Kolarich, Daniel, Karlsson, Niclas G., Reis, Celso A.

“… Terminal α2-3 and α2-6 sialylation of glycans precludes further chain elongation, leading to the biosynthesis of cancer relevant epitopes such as sialyl-Lewis …”
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Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion von Stylianou, Andreas, Gkretsi, Vasiliki, Stylianopoulos, Triantafyllos

“… Tumor microenvironment consists of the extracellular matrix (ECM), stromal cells, such as fibroblasts (FBs) and cancer associated fibroblasts (CAFs), and a …”
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Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma von Dawkins, Joshua B N, Wang, Jun, Maniati, Eleni, Heward, James A, Koniali, Lola, Kocher, Hemant M, Martin, Sarah A, Chelala, Claude, Balkwill, Frances R, Fitzgibbon, Jude, Grose, Richard P

“… Genes encoding the histone H3 lysine 4 methyltransferases KMT2C and KMT2D are subject to deletion and mutation in pancreatic ductal adenocarcinoma (PDAC …”
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Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells von Purwar, Rahul, Schlapbach, Christoph, Xiao, Sheng, Kang, Hong Soon, Elyaman, Wassim, Jiang, Xiaodong, Jetten, Anton M, Khoury, Samia J, Fuhlbrigge, Robert C, Kuchroo, Vijay K, Clark, Rachael A, Kupper, Thomas S

“… In this issue, Thomas Kupper and colleagues report that mice deficient for ROR-γ or interleukin-23 (IL-23) receptor showed impaired melanoma growth. Tumor …”
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Comparison of protein expression between human livers and the hepatic cell lines HepG2, Hep3B, and Huh7 using SWATH and MRM-HR proteomics: Focusing on drug-metabolizing enzymes von Shi, Jian, Wang, Xinwen, Lyu, Lingyun, Jiang, Hui, Zhu, Hao-Jie

“… However, the validity of this model is still a subject of debate because the expressions of various proteins in the cell lines, including drug-metabolizing enzymes (DMEs …”
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Glyco-genes change expression in cancer through aberrant methylation von Vojta, Aleksandar, Samaržija, Ivana, Bočkor, Luka, Zoldoš, Vlatka

“… Most eukaryotic proteins are modified by covalent addition of glycan molecules that considerably influence their function. Aberrant glycosylation is profoundly …”
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Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters von Karaköse, Melia, Kocabaş, Muhammet, Can, Mustafa, Karakurt, Feridun, Kulaksızoğlu, Mustafa, Esen, Hacı Hasan

“… ) and endocan in adrenal cortical tumors and the factors associated with them. The study included 6 subjects with adrenocortical adenoma (ACA …”
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International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels von Huang, Fen, Wong, Xiuming, Jan, Lily Y

“… The role this channel plays in physiological systems remains to be established and is currently a subject of intense investigation …”
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Circulating tumour-derived microvesicles in plasma of gastric cancer patients von Baran, Jaroslaw, Baj-Krzyworzeka, Monika, Weglarczyk, Kazimierz, Szatanek, Rafal, Zembala, Maria, Barbasz, Jakub, Czupryna, Antoni, Szczepanik, Antoni, Zembala, Marek

“… Cell membrane microfragments called microvesicles (MV) originating from different cells are circulating in the blood of healthy subjects and their elevated numbers are found in different diseases, including cancer …”
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MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein von Kuo, Po-Lin, Liao, Szi-Hui, Hung, Jen-Yu, Huang, Ming-Shyan, Hsu, Ya-Ling

“… Bone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are increasingly …”
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Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotyping von Haferlach, C, Dicker, F, Schnittger, S, Kern, W, Haferlach, T

“… ). A total of 500 of 506 (98.8%) cases were successfully stimulated for metaphase generation and are subject to this study …”
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Inflammation alters the expression pattern of drug transporters during Caco‐2 cell stimulation and azoxymethane‐induced colon tumorigenesis von El‐Daly, Sherien M., Gouhar, Shaimaa A., Abdelrahman, Sahar S.

“… Drug transporters play a pivotal role in modulating drug disposition and are subject to alterations under inflammatory conditions …”
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Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia von Yang, Ming-Yu, Lin, Pai-Mei, Yang, Chao-Hui, Hu, Ming-Luen, Chen, I-Ya, Lin, Sheng-Fung, Hsu, Cheng-Ming

“… diagnosed with cytogenetically abnormal-acute myeloid leukemia (CA-AML) and 85 healthy subjects …”
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Sulfasalazine disposition in a subject with 376C>T (nonsense mutation) and 421C>A variants in the ABCG2 gene von Gotanda, Keisuke, Tokumoto, Tomoko, Hirota, Takeshi, Fukae, Masato, Ieiri, Ichiro

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The thyroid hormone-αvβ3 integrin axis in ovarian cancer: regulation of gene transcription and MAPK-dependent proliferation von Shinderman-Maman, E, Cohen, K, Weingarten, C, Nabriski, D, Twito, O, Baraf, L, Hercbergs, A, Davis, P J, Werner, H, Ellis, M, Ashur-Fabian, O

“… Ovarian carcinoma is the fifth common cause of cancer death in women, despite advanced therapeutic approaches. αvβ3 integrin, a plasma membrane receptor, binds …”
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All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia von Shen, Zhi-Xiang, Shi, Zhan-Zhong, Fang, Jing, Gu, Bai-Wei, Li, Jun-Min, Zhu, Yong-Mei, Shi, Jing-Yi, Zheng, Pei-Zheng, Yan, Hua, Liu, Yuan-Fang, Chen, Yu, Shen, Yang, Wu, Wen, Tang, Wei, Waxman, Samuel, De Thé, Hugues, Wang, Zhen-Yi, Chen, Sai-Juan, Chen, Zhu

“… In this study, 61 newly diagnosed APL subjects were randomized into three treatment groups, namely by ATRA, As(2)O(3 …”
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A parsimonious 3-gene signature predicts clinical outcomes in an acute myeloid leukemia multicohort study von Wagner, Sarah, Vadakekolathu, Jayakumar, Tasian, Sarah K., Altmann, Heidi, Bornhäuser, Martin, Pockley, A. Graham, Ball, Graham R., Rutella, Sergio

“… Acute myeloid leukemia (AML) is a genetically heterogeneous hematological malignancy with variable responses to chemotherapy. Although recurring cytogenetic …”
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Tacrine derivatives stimulate human glioma SF295 cell death and alter important proteins related to disease development: An old drug for new targets von Costa Nunes, Fernanda, Silva, Letícia Barros, Winter, Evelyn, Silva, Adny Henrique, de Melo, Leônidas João, Rode, Michele, Martins, Marcos Antônio Pinto, Zanatta, Nilo, Feitosa, Sarah Coelho, Bonacorso, Hélio Gauze, Creczynski-Pasa, Tânia Beatriz

“… Glioblastoma is the most common and aggressive glioma, characterized by brain invasion capability. Being very resistant to the current therapies, since even …”
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Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma von Barr, Paul M, Miller, Thomas P, Friedberg, Jonathan W, Peterson, Derick R, Baran, Andrea M, Herr, Megan, Spier, Catherine M, Cui, Haiyan, Roe, Denise J, Persky, Daniel O, Casulo, Carla, Littleton, Jamie, Schwartz, Mark, Puvvada, Soham, Landowski, Terry H, Rimsza, Lisa M, Dorr, Robert T, Fisher, Richard I, Bernstein, Steven H, Briehl, Margaret M

“… Lymphoma cells are subject to higher levels of oxidative stress compared with their normal counterparts and may be vulnerable to manipulations of the cellular redox balance …”
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Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution von Van den Eynden, Jimmy, Basu, Swaraj, Larsson, Erik

“… While such genes should in theory be subject to strong purifying (negative) selection against damaging somatic mutations, these patterns have been elusive and purifying selection remains inadequately explored in cancer …”
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