Search Results - "Neoplasm Metastasis - pathology"

Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor by Wu, Jing-Yiing, Huang, Tsai-Wang, Hsieh, Yi-Ting, Wang, Yi-Fu, Yen, Chia-Chien, Lee, Guan-Lin, Yeh, Chang-Ching, Peng, Yi-Jen, Kuo, Ya-Yi, Wen, Hsiu-Ting, Lin, Hui-Chen, Hsiao, Cheng-Wen, Wu, Kenneth K, Kung, Hsing-Jien, Hsu, Yu-Juei, Kuo, Cheng-Chin

“… These effects are mediated by SUCNR1-triggered PI3K-hypoxia-inducible factor 1α (HIF-1α) axis. Compared with healthy subjects and tumor-free lung tissues, serum succinate…”
Get more information

The evolution of non-small cell lung cancer metastases in TRACERx by Al Bakir, Maise, Huebner, Ariana, Martínez-Ruiz, Carlos, Grigoriadis, Kristiana, Watkins, Thomas B. K., Pich, Oriol, Moore, David A., Veeriah, Selvaraju, Ward, Sophia, Laycock, Joanne, Johnson, Diana, Rowan, Andrew, Razaq, Maryam, Akther, Mita, Naceur-Lombardelli, Cristina, Prymas, Paulina, Toncheva, Antonia, Hessey, Sonya, Dietzen, Michelle, Colliver, Emma, Frankell, Alexander M., Bunkum, Abigail, Lim, Emilia L., Karasaki, Takahiro, Abbosh, Christopher, Hiley, Crispin T., Hill, Mark S., Cook, Daniel E., Wilson, Gareth A., Salgado, Roberto, Nye, Emma, Stone, Richard Kevin, Fennell, Dean A., Price, Gillian, Kerr, Keith M., Naidu, Babu, Middleton, Gary, Summers, Yvonne, Lindsay, Colin R., Blackhall, Fiona H., Cave, Judith, Blyth, Kevin G., Nair, Arjun, Ahmed, Asia, Taylor, Magali N., Procter, Alexander James, Falzon, Mary, Lawrence, David, Navani, Neal, Thakrar, Ricky M., Janes, Sam M., Papadatos-Pastos, Dionysis, Forster, Martin D., Lee, Siow Ming, Ahmad, Tanya, Quezada, Sergio A., Peggs, Karl S., Van Loo, Peter, Dive, Caroline, Hackshaw, Allan, Birkbak, Nicolai J., Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles

“…Metastatic disease is responsible for the majority of cancer-related deaths 1 . We report the longitudinal evolutionary analysis of 126 non-small cell lung…”
Get full text

Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor cell stemness and metabolism in lung cancer metastasis by Tyagi, Abhishek, Wu, Shih-Ying, Sharma, Sambad, Wu, Kerui, Zhao, Dan, Deshpande, Ravindra, Singh, Ravi, Li, Wencheng, Topaloglu, Umit, Ruiz, Jimmy, Watabe, Kounosuke

“…Smoking is associated with lung cancer and has a profound impact on tumor immunity. Nicotine, the addictive and non-carcinogenic smoke component, influences…”
Get full text

Linking the future of anticancer metal-complexes to the therapy of tumour metastases by Bergamo, Alberta, Sava, Gianni

“…Cancer chemotherapy is almost always applied to patients with one or more diagnosed metastases and is expected to impact these lesions, thus providing…”
Get more information

A vertebral skeletal stem cell lineage driving metastasis by Sun, Jun, Hu, Lingling, Bok, Seoyeon, Yallowitz, Alisha R., Cung, Michelle, McCormick, Jason, Zheng, Ling J., Debnath, Shawon, Niu, Yuzhe, Tan, Adrian Y., Lalani, Sarfaraz, Morse, Kyle W., Shinn, Daniel, Pajak, Anthony, Hammad, Mohammed, Suhardi, Vincentius Jeremy, Li, Zan, Li, Na, Wang, Lijun, Zou, Weiguo, Mittal, Vivek, Bostrom, Mathias P. G., Xu, Ren, Iyer, Sravisht, Greenblatt, Matthew B.

“…Vertebral bone is subject to a distinct set of disease processes from long bones, including a much higher rate of solid tumour metastases 1 – 4…”
Get full text

Early and multiple origins of metastatic lineages within primary tumors by Zhao, Zi-Ming, Zhao, Bixiao, Bai, Yalai, Iamarino, Atila, Gaffney, Stephen G, Schlessinger, Joseph, Lifton, Richard P, Rimm, David L, Townsend, Jeffrey P

“…Many aspects of the evolutionary process of tumorigenesis that are fundamental to cancer biology and targeted treatment have been challenging to reveal, such…”
Get more information

Proposal for an optimised definition of adverse pathology (unfavourable histology) that predicts metastatic risk in prostatic adenocarcinoma independent of grade group and pathological stage by Nguyen, Jane K, Harik, Lara R, Klein, Eric A, Li, Jianbo, Corrigan, Dillon, Liu, Shiguang, Chan, Emily, Hawley, Sarah, Auman, Heidi, Newcomb, Lisa F, Carroll, Peter R, Cooperberg, Matthew R, Filson, Christopher P, Simko, Jeff P, Nelson, Peter S, Tretiakova, Maria S, Troyer, Dean, True, Lawrence D, Vakar‐Lopez, Funda, Weight, Christopher J, Lin, Daniel W, Brooks, James D, McKenney, Jesse K

“…Aims Histological grading of prostate cancer is a powerful prognostic tool, but current criteria for grade assignment are not fully optimised. Our goal was to…”
Get full text

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Peritoneal Metastases: A Systematic Review by Parikh, Manasi S, Johnson, Paul, Romanes, Jonathan Paul, Freitag, Harvey E, Spring, Mary E, Garcia-Henriquez, Norbert, Monson, John R T

“… A Medline search for English language studies published between 2004 and 2019. Medical subject headings and key terms, including…”
Get more information

Bone marrow-derived mesenchymal stem cells and the tumor microenvironment by Bergfeld, Scott A., DeClerck, Yves A.

“…Over the last decade, there has been a growing interest in the role of mesenchymal stem cells (MSC) in cancer progression. These cells have the potential to…”
Get full text

mRNA-Seq of Single Prostate Cancer Circulating Tumor Cells Reveals Recapitulation of Gene Expression and Pathways Found in Prostate Cancer by Cann, Gordon M., Gulzar, Zulfiqar G., Cooper, Samantha, Li, Robin, Luo, Shujun, Tat, Mai, Stuart, Sarah, Schroth, Gary, Srinivas, Sandhya, Ronaghi, Mostafa, Brooks, James D., Talasaz, AmirAli H.

“…Circulating tumor cells (CTC) mediate metastatic spread of many solid tumors and enumeration of CTCs is currently used as a prognostic indicator of survival in…”
Get full text

Metastasis ‘systems’ biology: how are macro-environmental signals transmitted into microenvironmental cues for disseminated tumor cells? by Grzelak, Candice Alexandra, Ghajar, Cyrus Michael

“…•DTC dormancy is maintained through tissue (particularly endothelial) homeostasis.•Chronic lifestyle exposures (e.g., alcohol) alter organ…”
Get full text

Application of a Filtration- and Isolation-by-Size Technique for the Detection of Circulating Tumor Cells in Cutaneous Melanoma by De Giorgi, Vincenzo, Pinzani, Pamela, Salvianti, Francesca, Panelos, John, Paglierani, Milena, Janowska, Agata, Grazzini, Marta, Wechsler, Janine, Orlando, Claudio, Santucci, Marco, Lotti, Torello, Pazzagli, Mario, Massi, Daniela

“… We herein investigated the presence of CTC by ISET in the peripheral blood of 140 subjects…”
Get full text

Extrapulmonary Findings and Malignancies in Participants Screened With Chest CT in the National Lung Screening Trial by Nguyen, Xuan V, Davies, Louise, Eastwood, James D, Hoang, Jenny K

“…The aim of this study was to measure the prevalence of clinically significant extrapulmonary findings on chest CT for lung cancer screening in the National…”
Get more information

Cancer stem cells: a model in the making by Marotta, Lauren L Campbell, Polyak, Kornelia

“…Cancer stem cells and their potential roles in tumor heterogeneity are currently subjects of intense investigation…”
Get full text

Obesity and triple‐negative‐breast‐cancer: Is apelin a new key target? by Gourgue, Florian, Mignion, Lionel, Van Hul, Matthias, Dehaen, Natacha, Bastien, Estelle, Payen, Valery, Leroy, Baptiste, Joudiou, Nicolas, Vertommen, Didier, Bouzin, Caroline, Delzenne, Nathalie, Gallez, Bernard, Feron, Olivier, Jordan, Bénédicte F., Cani, Patrice D.

“…Epidemiological studies have shown that obese subjects have an increased risk of developing triple…”
Get full text

Cancer theory faces doubts by Ledford, Heidi

“…A leading explanation for how disease migrates falls short on clinical evidence…”
Get full text

Cancer therapy: an evolved approach by Willyard, Cassandra

“…Tumours are subject to the same rules of natural selection as any other living thing…”
Get full text

Evaluation of the evidence on staging imaging for detection of asymptomatic distant metastases in newly diagnosed breast cancer by Brennan, M.E., Houssami, N.

“… Twenty-two studies reporting on 14,824 BC subjects (median age 53 years) undergoing staging imaging were eligible…”
Get full text

Loss of CD169 + Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma by Topf, Michael C, Harshyne, Larry, Tuluc, Madalina, Mardekian, Stacey, Vimawala, Swar, Cognetti, David M, Curry, Joseph M, Rodeck, Ulrich, Luginbuhl, Adam

“…The purpose of this study is to assess CD169 expression in metastatic and nearby tumor-free lymph nodes of patients with head and neck squamous cell carcinoma…”
Get more information

In Vivo Long-Term Monitoring of Circulating Tumor Cells Fluctuation during Medical Interventions by Juratli, Mazen A., Siegel, Eric R., Nedosekin, Dmitry A., Sarimollaoglu, Mustafa, Jamshidi-Parsian, Azemat, Cai, Chengzhong, Menyaev, Yulian A., Suen, James Y., Galanzha, Ekaterina I., Zharov, Vladimir P.

“…-bearing mouse model inoculated with MDA-MB-231-Luc2-GFP cells in the mammary gland. Two weeks after tumor inoculation, three groups of mice were the subject of the following interventions: (1…”
Get full text