Výsledky vyhľadávania - "Ndoj, Klevis"

Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition Autor Niccolai, Rachele, Göbel, Camiel, Ndoj, Klevis, Kreft, Maaike, Kuiken, Hendrik J., Lieftink, Cor, Morris, Ben, Yska, Sietse D., Hendrix, Sebastian, van den Broek, Bram, Pappalardo, Vincent, Kersten, Marie José, Beijersbergen, Roderick L., Zelcer, Noam, van Leeuwen, Fred, Jacobs, Heinz

“…•GCB-DLBCL insensitive to EZH2 inhibition become dependent on cholesterol synthesis.•This dependency relates to altered LDLR subcellular localization and LDL…”
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The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms Autor Ndoj, Klevis, Meurs, Amber, Papaioannou, Dimitra, Bjune, Katrine, Zelcer, Noam

“…Cholesterol is a vital component of cellular membranes and is an essential molecule in mammalian physiology. Yet dysregulation of hepatic cholesterol…”
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A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B–containing lipoprotein secretion Autor Meurs, Amber, Ndoj, Klevis, van den Berg, Marlene, Marinković, Goran, Tantucci, Matteo, Veenendaal, Tineke, Kuivenhoven, Jan Albert, Klumperman, Judith, Zelcer, Noam

“…Abstract Aims Apolipoprotein B (APOB)-containing very LDL (VLDL) production, secretion, and clearance by hepatocytes is a central determinant of hepatic and…”
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SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P Autor Hendrix, Sebastian, Tan, Josephine M. E., Ndoj, Klevis, Kingma, Jenina, Valiloo, Masoud, Zijlstra, Lobke F., Ottenhoff, Roelof, Seidah, Nabil G., Loregger, Anke, Kober, Daniel L., Zelcer, Noam

“…SREBP transcription factors are central regulators of lipid metabolism. Their proteolytic activation requires ER to the Golgi translocation and subsequent…”
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Intermolecular proteolytic processing of SPRING and Site-1-protease regulate SREBP signaling Autor Hendrix, Sebastian, Tan, Josephine M.E., Ndoj, Klevis, Valiloo, Masoud, Zijlstra, Lobke F., Ottenhoff, Roelof, Seidah, Nabil G., Loregger, Anke, Zelcer, Noam

“…The SREBP transcription factors are central regulators of fatty acid and cholesterol metabolism. Produced as membrane-resident precursor proteins in the ER,…”
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