Suchergebnisse - "Nature reviews. Genetics"

Non-coding RNAs in disease: from mechanisms to therapeutics von Nemeth, Kinga, Bayraktar, Recep, Ferracin, Manuela, Calin, George A

“… Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. Since their discovery, ncRNAs have …”
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Methods and applications for single-cell and spatial multi-omics von Vandereyken, Katy, Sifrim, Alejandro, Thienpont, Bernard, Voet, Thierry

“… The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome from single cells is transforming our understanding of cell biology in …”
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Histone post-translational modifications - cause and consequence of genome function von Millán-Zambrano, Gonzalo, Burton, Adam, Bannister, Andrew J, Schneider, Robert

“… Much has been learned since the early 1960s about histone post-translational modifications (PTMs) and how they affect DNA-templated processes at the molecular …”
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The genetics of obesity: from discovery to biology von Loos, Ruth J F, Yeo, Giles S H

“… The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people's health. Polygenic (or common) obesity and rare, …”
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The biological and clinical significance of emerging SARS-CoV-2 variants von Tao, Kaiming, Tzou, Philip L, Nouhin, Janin, Gupta, Ravindra K, de Oliveira, Tulio, Kosakovsky Pond, Sergei L, Fera, Daniela, Shafer, Robert W

“… The past several months have witnessed the emergence of SARS-CoV-2 variants with novel spike protein mutations that are influencing the epidemiological and …”
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Autophagy genes in biology and disease von Yamamoto, Hayashi, Zhang, Sidi, Mizushima, Noboru

“… Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes that degrade cytoplasmic material in lysosomes. Both pathways involve …”
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The biogenesis, biology and characterization of circular RNAs von Kristensen, Lasse S, Andersen, Maria S, Stagsted, Lotte V W, Ebbesen, Karoline K, Hansen, Thomas B, Kjems, Jørgen

“… Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes with tissue-specific and cell-specific expression patterns, whose …”
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Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics von Longo, Sophia K, Guo, Margaret G, Ji, Andrew L, Khavari, Paul A

“… Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but does not capture their spatial distribution nor reveal local networks …”
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Prime editing for precise and highly versatile genome manipulation von Chen, Peter J, Liu, David R

“… Programmable gene-editing tools have transformed the life sciences and have shown potential for the treatment of genetic disease. Among the CRISPR-Cas …”
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Molecular mechanisms of transgenerational epigenetic inheritance von Fitz-James, Maximilian H, Cavalli, Giacomo

“… Increasing evidence indicates that non-DNA sequence-based epigenetic information can be inherited across several generations in organisms ranging from yeast to …”
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Engineering adeno-associated virus vectors for gene therapy von Li, Chengwen, Samulski, R Jude

“… Adeno-associated virus (AAV) vector-mediated gene delivery was recently approved for the treatment of inherited blindness and spinal muscular atrophy, and …”
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DNA sensing by the cGAS-STING pathway in health and disease von Motwani, Mona, Pesiridis, Scott, Fitzgerald, Katherine A

“… The detection of pathogens through nucleic acid sensors is a defining principle of innate immunity. RNA-sensing and DNA-sensing receptors sample subcellular …”
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Alternative splicing as a source of phenotypic diversity von Wright, Charlotte J, Smith, Christopher W. J, Jiggins, Chris D

“… A major goal of evolutionary genetics is to understand the genetic processes that give rise to phenotypic diversity in multicellular organisms. Alternative …”
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Base editing: precision chemistry on the genome and transcriptome of living cells von Rees, Holly A, Liu, David R

“… RNA-guided programmable nucleases from CRISPR systems generate precise breaks in DNA or RNA at specified positions. In cells, this activity can lead to changes …”
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Biological roles of adenine methylation in RNA von Boulias, Konstantinos, Greer, Eric Lieberman

“… N -Methyladenosine (m A) is one of the most abundant modifications of the epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances …”
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Abiotic stress responses in plants von Zhang, Huiming, Zhu, Jianhua, Gong, Zhizhong, Zhu, Jian-Kang

“… Plants cannot move, so they must endure abiotic stresses such as drought, salinity and extreme temperatures. These stressors greatly limit the distribution of …”
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microRNAs in action: biogenesis, function and regulation von Shang, Renfu, Lee, Seungjae, Senavirathne, Gayan, Lai, Eric C

“… Ever since microRNAs (miRNAs) were first recognized as an extensive gene family >20 years ago, a broad community of researchers was drawn to investigate the …”
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Best practices for single-cell analysis across modalities von Heumos, Lukas, Schaar, Anna C, Lance, Christopher, Litinetskaya, Anastasia, Drost, Felix, Zappia, Luke, Lücken, Malte D, Strobl, Daniel C, Henao, Juan, Curion, Fabiola, Schiller, Herbert B, Theis, Fabian J

“… Recent advances in single-cell technologies have enabled high-throughput molecular profiling of cells across modalities and locations. Single-cell …”
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Human organs-on-chips for disease modelling, drug development and personalized medicine von Ingber, Donald E

“… The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research …”
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Harnessing genomics to fast-track genetic improvement in aquaculture von Houston, Ross D, Bean, Tim P, Macqueen, Daniel J, Gundappa, Manu Kumar, Jin, Ye Hwa, Jenkins, Tom L, Selly, Sarah Louise C, Martin, Samuel A M, Stevens, Jamie R, Santos, Eduarda M, Davie, Andrew, Robledo, Diego

“… Aquaculture is the fastest-growing farmed food sector and will soon become the primary source of fish and shellfish for human diets. In contrast to crop and …”
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