Suchergebnisse - "Nath, Neetika"

CASSIS and SMIPS: promoter-based prediction of secondary metabolite gene clusters in eukaryotic genomes von Wolf, Thomas, Shelest, Vladimir, Nath, Neetika, Shelest, Ekaterina

“… Motivation: Secondary metabolites (SM) are structurally diverse natural products of high pharmaceutical importance. Genes involved in their biosynthesis are …”
Volltext

Explainable AI Model Reveals Informative Mutational Signatures for Cancer-Type Classification von Wagner, Jonas, Oldenburg, Jan, Nath, Neetika, Simm, Stefan

“… Background/Objectives: The prediction of cancer types is primarily reliant on driver genes and their specific mutations. The advancement in novel omics …”
Volltext

Correction: Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks von Becker, Ann-Kristin, Ittermann, Till, Dörr, Markus, Felix, Stephan B., Nauck, Matthias, Teumer, Alexander, Völker, Uwe, Völzke, Henry, Kaderali, Lars, Nath, Neetika

“… [This corrects the article DOI: 10.1371/journal.pone.0271610.].[This corrects the article DOI: 10.1371/journal.pone.0271610.] …”
Volltext

Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks von Becker, Ann-Kristin, Ittermann, Till, Dörr, Markus, Felix, Stephan B., Nauck, Matthias, Teumer, Alexander, Völker, Uwe, Völzke, Henry, Kaderali, Lars, Nath, Neetika

“… Background Approaching epidemiological data with flexible machine learning algorithms is of great value for understanding disease-specific association …”
Volltext

The Natural History of Biocatalytic Mechanisms von Nath, Neetika, Mitchell, John B. O., Caetano-Anollés, Gustavo

“… Phylogenomic analysis of the occurrence and abundance of protein domains in proteomes has recently showed that the α/β architecture is probably the oldest fold …”
Volltext

Neighbourhood watch: genomic epidemiology of SARS-CoV-2 variants circulating in a German federal state, Mecklenburg-Western Pomerania, in 2020–2022 von Kohler, Christian, King, Jacqueline, Stacker, Lina, Goller, Katja V., Moritz, Juliane, Pohlmann, Anne, Nath, Neetika, Tzvetkova, Ana, Rieck, Maximilian, Paraskevopoulou, Sofia, Beslic, Denis, Hölzer, Martin, Fuchs, Stephan, Ziemann, Janine, Kaderali, Lars, Beer, Martin, Hübner, Nils-Olaf, Becker, Karsten

“… ABSTRACTGlobal and even national genome surveillance approaches do not provide the resolution necessary for rapid and accurate direct response by local public …”
Volltext

Is EC class predictable from reaction mechanism? von Nath, Neetika, Mitchell, John BO

“… Background We investigate the relationships between the EC (Enzyme Commission) class, the associated chemical reaction, and the reaction mechanism by building …”
Volltext

Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Protein Knockout Mice von Nuernberger, Vincent, Mortoga, Sharif, Metzendorf, Christoph, Burkert, Christian, Ehricke, Katrina, Knuth, Elisa, Zimmer, Jenny, Singer, Stephan, Nath, Neetika, Karim, Majedul, Yasser, Mohd, Calvisi, Diego F., Dombrowski, Frank, Ribback, Silvia

“… Objective: In the rat, the pancreatic islet transplantation model is an established method to induce hepatocellular carcinomas (HCC), due to insulin-mediated …”
Volltext

The ShGlomAssay Combines High-Throughput Drug Screening With Downstream Analyses and Reveals the Protective Role of Vitamin D3 and Calcipotriol on Podocytes von Ristov, Marie-Christin, Lange, Tim, Artelt, Nadine, Nath, Neetika, Kuss, Andreas W., Gehrig, Jochen, Lindenmeyer, Maja, Cohen, Clemens D., Gul, Sheraz, Endlich, Karlhans, Völker, Uwe, Endlich, Nicole

“… Chronic kidney disease (CKD) is a major public health burden affecting more than 500 million people worldwide. Podocytopathies are the main cause for the …”
Volltext

Enzyme informatics von Alderson, Rosanna G, De Ferrari, Luna, Mavridis, Lazaros, McDonagh, James L, Mitchell, John B O, Nath, Neetika

“… Over the last 50 years, sequencing, structural biology and bioinformatics have completely revolutionised biomolecular science, with millions of sequences and …”
Weitere Angaben

A convolutional neural network for ECG annotation as the basis for classification of cardiac rhythms von Sodmann, Philipp, Vollmer, Marcus, Nath, Neetika, Kaderali, Lars

“… Electrocardiography is the most common tool to diagnose cardiovascular diseases. Annotation, segmentation and rhythm classification of ECGs are challenging …”
Weitere Angaben

Machine Learning Based Methods and Best Practices of microRNA-Target Prediction and Validation von Nath, Neetika, Simm, Stefan

“… Within the last years, more and more noncoding RNAs (ncRNAs) became the focal point to understand cell regulatory mechanisms because one class of ncRNAs, …”
Weitere Angaben

Macrophages Are Polarized toward an Inflammatory Phenotype by their Aged Microenvironment in the Human Skin von Gather, Leonie, Nath, Neetika, Falckenhayn, Cassandra, Oterino-Sogo, Sergio, Bosch, Thomas, Wenck, Horst, Winnefeld, Marc, Grönniger, Elke, Simm, Stefan, Siracusa, Annette

“… Aging of the skin is accompanied by cellular as well as tissue environmental changes, ultimately reducing the ability of the tissue to regenerate and …”
Weitere Angaben

Stimulation of soluble guanylyl cyclase (sGC) by riociguat attenuates heart failure and pathological cardiac remodelling von Rüdebusch, Julia, Benkner, Alexander, Nath, Neetika, Fleuch, Lina, Kaderali, Lars, Grube, Karina, Klingel, Karin, Eckstein, Gertrud, Meitinger, Thomas, Fielitz, Jens, Felix, Stephan B.

“… Background and Purpose Heart failure is associated with an impaired NO–soluble guanylyl cyclase (sGC)–cGMP pathway and its augmentation is thought to be …”
Volltext

Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE-/-mice von Gast, Martina, Rauch, Bernhard H, Nakagawa, Shinichi, Haghikia, Arash, Jasina, Andrzej, Haas, Jan, Nath, Neetika, Jensen, Lars, Stroux, Andrea, Böhm, Andreas, Friebel, Julian, Rauch, Ursula, Skurk, Carsten, Blankenberg, Stefan, Zeller, Tanja, Prasanth, Kannanganattu V, Meder, Benjamin, Kuss, Andreas, Landmesser, Ulf, Poller, Wolfgang

“… The immune system is considered a key driver of atherosclerosis, and beyond proteins and microRNAs (miRs), long non-coding RNAs (lncRNAs) are implicated in …”
Weitere Angaben

Riociguat attenuates the changes in left ventricular proteome and microRNA profile after experimental aortic stenosis in mice von Benkner, Alexander, Rüdebusch, Julia, Nath, Neetika, Hammer, Elke, Grube, Karina, Gross, Stefan, Dhople, Vishnu M., Eckstein, Gertrud, Meitinger, Thomas, Kaderali, Lars, Völker, Uwe, Fielitz, Jens, Felix, Stephan B.

“… Background and Purpose Development and progression of heart failure involve endothelial and myocardial dysfunction as well as a dysregulation of the …”
Volltext

Quantifying Soil Microbiome Abundance by Metatranscriptomics and Complementary Molecular Techniques—Cross‐Validation and Perspectives von Dahl, Mathilde Borg, Brachmann, Stella, Söllinger, Andrea, Schnell, Marina, Ahlers, Laureen, Wutkowska, Magdalena, Hoff, Katharina J., Nath, Neetika, Groß, Verena, Wang, Haitao, Weil, Micha, Piecha, Marc, Schaffer, Marc, Jensen, Corinna, Kuss, Andreas W., Gall, Christoph, Wimmer, Erika, Pribasnig, Thomas, Tveit, Alexander Tøsdal, Sigurdsson, Bjarni D., Schleper, Christa, Richter, Andreas, Urich, Tim

“… ABSTRACT Linking meta‐omics and biogeochemistry approaches in soils has remained challenging. This study evaluates the use of an internal RNA extraction …”
Volltext

Uniting Cheminformatics and Chemical Theory To Predict the Intrinsic Aqueous Solubility of Crystalline Druglike Molecules von McDonagh, James L, Nath, Neetika, De Ferrari, Luna, van Mourik, Tanja, Mitchell, John B. O

“… We present four models of solution free-energy prediction for druglike molecules utilizing cheminformatics descriptors and theoretically calculated …”
Volltext

Genome-Wide DNA Alterations in X-Irradiated Human Gingiva Fibroblasts von Nath, Neetika, Hagenau, Lisa, Weiss, Stefan, Tzvetkova, Ana, Jensen, Lars R., Kaderali, Lars, Port, Matthias, Scherthan, Harry, Kuss, Andreas W.

“… While ionizing radiation (IR) is a powerful tool in medical diagnostics, nuclear medicine, and radiology, it also is a serious threat to the integrity of …”
Volltext

Evaluation of crowdsourced mortality prediction models as a framework for assessing artificial intelligence in medicine von Bergquist, Timothy, Schaffter, Thomas, Yan, Yao, Yu, Thomas, Prosser, Justin, Gao, Jifan, Chen, Guanhua, Charzewski, Łukasz, Nawalany, Zofia, Brugere, Ivan, Retkute, Renata, Prusokas, Alidivinas, Prusokas, Augustinas, Choi, Yonghwa, Lee, Sanghoon, Choe, Junseok, Lee, Inggeol, Kim, Sunkyu, Kang, Jaewoo, Mooney, Sean D, Guinney, Justin

“… Applications of machine learning in healthcare are of high interest and have the potential to improve patient care. Yet, the real-world accuracy of these …”
Weitere Angaben