Výsledky vyhľadávania - "Nakane, Takanori"

New tools for automated high-resolution cryo-EM structure determination in RELION-3 Autor Zivanov, Jasenko, Nakane, Takanori, Forsberg, Björn O, Kimanius, Dari, Hagen, Wim JH, Lindahl, Erik, Scheres, Sjors HW

“…Here, we describe the third major release of RELION. CPU-based vector acceleration has been added in addition to GPU support, which provides flexibility in use…”
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New tools for automated cryo-EM single-particle analysis in RELION-4.0 Autor Kimanius, Dari, Dong, Liyi, Sharov, Grigory, Nakane, Takanori, Scheres, Sjors H W

“…We describe new tools for the processing of electron cryo-microscopy (cryo-EM) images in the fourth major release of the RELION software. In particular, we…”
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Pink beam crystallography demonstrated in SFX Autor Nakane, Takanori

“…Nass et al. [IUCrJ (2021), 8, 905-920] applied a wide bandwidth beam (pink beam) to serial femtosecond crystallography at X-ray free electron lasers. This…”
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Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION -3.1 Autor Zivanov, Jasenko, Nakane, Takanori, Scheres, Sjors H. W.

“…Methods are presented that detect three types of aberrations in single-particle cryo-EM data sets: symmetrical and antisymmetrical optical aberrations and…”
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Structures and distributions of SARS-CoV-2 spike proteins on intact virions Autor Ke, Zunlong, Oton, Joaquin, Qu, Kun, Cortese, Mirko, Zila, Vojtech, McKeane, Lesley, Nakane, Takanori, Zivanov, Jasenko, Neufeldt, Christopher J., Cerikan, Berati, Lu, John M., Peukes, Julia, Xiong, Xiaoli, Kräusslich, Hans-Georg, Scheres, Sjors H. W., Bartenschlager, Ralf, Briggs, John A. G.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions are surrounded by a lipid bilayer from which spike (S) protein trimers protrude 1 …”
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A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis Autor Zivanov, Jasenko, Nakane, Takanori, Scheres, Sjors H. W.

“…A new method to estimate the trajectories of particle motion and the amount of cumulative beam damage in electron cryo-microscopy (cryo-EM) single-particle…”
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Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION Autor Nakane, Takanori, Kimanius, Dari, Lindahl, Erik, Scheres, Sjors HW

“…Macromolecular complexes that exhibit continuous forms of structural flexibility pose a challenge for many existing tools in cryo-EM single-particle analysis…”
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Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism Autor Lee, Byung-Gil, Merkel, Fabian, Allegretti, Matteo, Hassler, Markus, Cawood, Christopher, Lecomte, Léa, O'Reilly, Francis J, Sinn, Ludwig R, Gutierrez-Escribano, Pilar, Kschonsak, Marc, Bravo, Sol, Nakane, Takanori, Rappsilber, Juri, Aragon, Luis, Beck, Martin, Löwe, Jan, Haering, Christian H

“…Complexes containing a pair of structural maintenance of chromosomes (SMC) family proteins are fundamental for the three-dimensional (3D) organization of…”
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Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc Autor Lee, Yongchan, Wiriyasermkul, Pattama, Jin, Chunhuan, Quan, Lili, Ohgaki, Ryuichi, Okuda, Suguru, Kusakizako, Tsukasa, Nishizawa, Tomohiro, Oda, Kazumasa, Ishitani, Ryuichiro, Yokoyama, Takeshi, Nakane, Takanori, Shirouzu, Mikako, Endou, Hitoshi, Nagamori, Shushi, Kanai, Yoshikatsu, Nureki, Osamu

“…The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids across the membrane and is crucial for brain drug delivery and tumor…”
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Structure and Engineering of Francisella novicida Cas9 Autor Hirano, Hisato, Gootenberg, Jonathan S, Horii, Takuro, Abudayyeh, Omar O, Kimura, Mika, Hsu, Patrick D, Nakane, Takanori, Ishitani, Ryuichiro, Hatada, Izuho, Zhang, Feng, Nishimasu, Hiroshi, Nureki, Osamu

“…The RNA-guided endonuclease Cas9 cleaves double-stranded DNA targets complementary to the guide RNA and has been applied to programmable genome editing…”
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Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone Autor Im, Dohyun, Inoue, Asuka, Fujiwara, Takaaki, Nakane, Takanori, Yamanaka, Yasuaki, Uemura, Tomoko, Mori, Chihiro, Shiimura, Yuki, Kimura, Kanako Terakado, Asada, Hidetsugu, Nomura, Norimichi, Tanaka, Tomoyuki, Yamashita, Ayumi, Nango, Eriko, Tono, Kensuke, Kadji, Francois Marie Ngako, Aoki, Junken, Iwata, So, Shimamura, Tatsuro

“…In addition to the serotonin 5-HT 2A receptor (5-HT 2A R), the dopamine D 2 receptor (D 2 R) is a key therapeutic target of antipsychotics for the treatment of…”
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Cryo-EM structures of the human volume-regulated anion channel LRRC8 Autor Kasuya, Go, Nakane, Takanori, Yokoyama, Takeshi, Jia, Yanyan, Inoue, Masato, Watanabe, Kengo, Nakamura, Ryoki, Nishizawa, Tomohiro, Kusakizako, Tsukasa, Tsutsumi, Akihisa, Yanagisawa, Haruaki, Dohmae, Naoshi, Hattori, Motoyuki, Ichijo, Hidenori, Yan, Zhiqiang, Kikkawa, Masahide, Shirouzu, Mikako, Ishitani, Ryuichiro, Nureki, Osamu

“…Maintenance of cell volume against osmotic change is crucial for proper cell functions. Leucine-rich repeat-containing 8 proteins are anion-selective channels…”
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Structural basis for xenobiotic extrusion by eukaryotic MATE transporter Autor Miyauchi, Hirotake, Moriyama, Satomi, Kusakizako, Tsukasa, Kumazaki, Kaoru, Nakane, Takanori, Yamashita, Keitaro, Hirata, Kunio, Dohmae, Naoshi, Nishizawa, Tomohiro, Ito, Koichi, Miyaji, Takaaki, Moriyama, Yoshinori, Ishitani, Ryuichiro, Nureki, Osamu

“…Mulitidrug and toxic compound extrusion (MATE) family transporters export xenobiotics to maintain cellular homeostasis. The human MATE transporters mediate the…”
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Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide Autor Morita, Junko, Kato, Kazuki, Nakane, Takanori, Kondo, Yuki, Fukuda, Hiroo, Nishimasu, Hiroshi, Ishitani, Ryuichiro, Nureki, Osamu

“…In plants, leucine-rich repeat receptor-like kinases (LRR-RKs) perceive ligands, including peptides and small molecules, to regulate various physiological…”
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Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance Autor Kabe, Yasuaki, Nakane, Takanori, Koike, Ikko, Yamamoto, Tatsuya, Sugiura, Yuki, Harada, Erisa, Sugase, Kenji, Shimamura, Tatsuro, Ohmura, Mitsuyo, Muraoka, Kazumi, Yamamoto, Ayumi, Uchida, Takeshi, Iwata, So, Yamaguchi, Yuki, Krayukhina, Elena, Noda, Masanori, Handa, Hiroshi, Ishimori, Koichiro, Uchiyama, Susumu, Kobayashi, Takuya, Suematsu, Makoto

“…Progesterone-receptor membrane component 1 (PGRMC1/Sigma-2 receptor) is a haem-containing protein that interacts with epidermal growth factor receptor (EGFR)…”
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Data processing pipeline for serial femtosecond crystallography at SACLA Autor Nakane, Takanori, Joti, Yasumasa, Tono, Kensuke, Yabashi, Makina, Nango, Eriko, Iwata, So, Ishitani, Ryuichiro, Nureki, Osamu

“…A data processing pipeline for serial femtosecond crystallography at SACLA was developed, based on Cheetah [Barty et al. (2014). J. Appl. Cryst.47, 1118–1131]…”
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Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel Autor Kasuya, Go, Yamaura, Toshiaki, Ma, Xiao-Bo, Nakamura, Ryoki, Takemoto, Mizuki, Nagumo, Hiromitsu, Tanaka, Eiichi, Dohmae, Naoshi, Nakane, Takanori, Yu, Ye, Ishitani, Ryuichiro, Matsuzaki, Osamu, Hattori, Motoyuki, Nureki, Osamu

“…P2X receptors are non-selective cation channels gated by extracellular ATP, and the P2X7 receptor subtype plays a crucial role in the immune and nervous…”
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Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface Autor Toyoda, Yosuke, Morimoto, Kazushi, Suno, Ryoji, Horita, Shoichiro, Yamashita, Keitaro, Hirata, Kunio, Sekiguchi, Yusuke, Yasuda, Satoshi, Shiroishi, Mitsunori, Shimizu, Tomoko, Urushibata, Yuji, Kajiwara, Yuta, Inazumi, Tomoaki, Hotta, Yunhon, Asada, Hidetsugu, Nakane, Takanori, Shiimura, Yuki, Nakagita, Tomoya, Tsuge, Kyoshiro, Yoshida, Suguru, Kuribara, Tomoko, Hosoya, Takamitsu, Sugimoto, Yukihiko, Nomura, Norimichi, Sato, Miwa, Hirokawa, Takatsugu, Kinoshita, Masahiro, Murata, Takeshi, Takayama, Kiyoshi, Yamamoto, Masaki, Narumiya, Shuh, Iwata, So, Kobayashi, Takuya

“…Prostaglandin E receptor EP4, a G-protein-coupled receptor, is involved in disorders such as cancer and autoimmune disease. Here, we report the crystal…”
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High‐viscosity sample‐injection device for serial femtosecond crystallography at atmospheric pressure Autor Shimazu, Yoshiaki, Tono, Kensuke, Tanaka, Tomoyuki, Yamanaka, Yasuaki, Nakane, Takanori, Mori, Chihiro, Terakado Kimura, Kanako, Fujiwara, Takaaki, Sugahara, Michihiro, Tanaka, Rie, Doak, R. Bruce, Shimamura, Tatsuro, Iwata, So, Nango, Eriko, Yabashi, Makina

“…A sample‐injection device has been developed at SPring‐8 Angstrom Compact Free‐Electron Laser (SACLA) for serial femtosecond crystallography (SFX) at…”
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NMR-Based Rational Drug Design of G:G Mismatch DNA Binding Ligand Trapping Transient Complex via Disruption of a Key Allosteric Interaction Autor Sakurabayashi, Shuhei, Furuita, Kyoko, Yamada, Takeshi, Sugiura, Noriaki, Nomura, Makoto, Nakane, Takanori, Kawamoto, Akihiro, Kurisu, Genji, Miyanoiri, Yohei, Fujiwara, Toshimichi, Nakatani, Kazuhiko, Kojima, Chojiro

“…Small molecules that bind to mismatched DNA have been applied in various fields, including nanotechnology, bioimaging, and therapeutics. However, the intrinsic…”
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