Search Results - "NECROSIS"

Transmembrane tumor necrosis factor alpha attenuates pressure-overload cardiac hypertrophy via tumor necrosis factor receptor 2 by Miao, Kun, Zhou, Ling, Ba, Hongping, Li, Chenxi, Gu, Haiyan, Yin, Bingjiao, Wang, Jing, Yang, Xiang-ping, Li, Zhuoya, Wang, Dao Wen

“…Tumor necrosis factor-alpha (TNF-α) plays an important pathogenic role in cardiac hypertrophy and heart failure (HF); however, anti-TNF is paradoxically…”
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Efficacy of EUS-Guided Necrosectomies in Patients with Walled-Off Pancreatic Necrosis by Khomiak, Igor, Rotar, O., Tereshkevych, I., Khomiak, A., Hrama, O.

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CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis by Moquin, David M., McQuade, Thomas, Chan, Francis Ka-Ming

“…Necroptosis/programmed necrosis is initiated by a macro-molecular protein complex termed the necrosome. Receptor interacting protein kinase 1 (RIPK1/RIP1) and…”
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Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD by Bamias, Giorgos, Menghini, Paola, Pizarro, Theresa T, Cominelli, Fabio

“…TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are members of the TNF and TNFR superfamilies, respectively, with…”
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TNF signaling drives myeloid-derived suppressor cell accumulation by Zhao, Xueqiang, Rong, Lijie, Zhao, Xiaopu, Li, Xiao, Liu, Xiaoman, Deng, Jingjing, Wu, Hao, Xu, Xia, Erben, Ulrike, Wu, Peihua, Syrbe, Uta, Sieper, Joachim, Qin, Zhihai

“…TNF, an inflammatory cytokine that is enriched in the tumor microenvironment, promotes tumor growth and subverts innate immune responses to cancer cells. We…”
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Structural principles of tumor necrosis factor superfamily signaling by Vanamee, Éva S, Faustman, Denise L

“…The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in cell proliferation, survival, and death. Stimulating or inhibiting…”
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Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer by O’Connell, James, Porter, John, Kroeplien, Boris, Norman, Tim, Rapecki, Stephen, Davis, Rachel, McMillan, David, Arakaki, Tracy, Burgin, Alex, Fox III, David, Ceska, Tom, Lecomte, Fabien, Maloney, Alison, Vugler, Alex, Carrington, Bruce, Cossins, Benjamin P, Bourne, Tim, Lawson, Alastair

“…Tumour necrosis factor (TNF) is a cytokine belonging to a family of trimeric proteins; it has been shown to be a key mediator in autoimmune diseases such as…”
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Reply to the Letter to the Editor of Dr. Pauwels et al by Shmidt, Eugenia, Dulai, Parambir S

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Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2 by Okubo, Yoshiaki, Mera, Toshiyuki, Wang, Limei, Faustman, Denise L.

“…T-regulatory cells (T regs ) are a rare lymphocyte subtype that shows promise for treating infectious disease, allergy, graft-versus-host disease, autoimmunity…”
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Molecular mechanisms and complications of TNF blockade in heart failure: targeting signalling and genetic determinants of therapeutic response by Javed, Qamar

“…Tumour necrosis factor-alpha (TNF) plays a pivotal role in the inflammatory cascade associated with both cardiovascular pathology and autoimmune conditions…”
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TRAF2 multitasking in TNF receptor-induced signaling to NF-κB, MAP kinases and cell death by Borghi, Alice, Verstrepen, Lynn, Beyaert, Rudi

“…[Display omitted] Tumor Necrosis Factor (TNF) is a potent inflammatory cytokine that exerts its functions through the activation of two distinct receptors,…”
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Cell Death in the Kidney by Priante, Giovanna, Gianesello, Lisa, Ceol, Monica, Del Prete, Dorella, Anglani, Franca

“…Apoptotic cell death is usually a response to the cell’s microenvironment. In the kidney, apoptosis contributes to parenchymal cell loss in the course of acute…”
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TNF and ROS Crosstalk in Inflammation by Blaser, Heiko, Dostert, Catherine, Mak, Tak W., Brenner, Dirk

“…Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell…”
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Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway by Lacerda, Lydia, Somers, Sarin, Opie, Lionel H, Lecour, Sandrine

“…Ischaemic postconditioning (IPostC) is a powerful protective phenomenon that activates prosurvival intrinsic signalling cascades to limit reperfusion injury…”
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ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC by Dziedzic, Slawomir A., Su, Zhenyi, Jean Barrett, Vica, Najafov, Ayaz, Mookhtiar, Adnan K., Amin, Palak, Pan, Heling, Sun, Li, Zhu, Hong, Ma, Averil, Abbott, Derek W., Yuan, Junying

“…Ubiquitylation of the TNFR1 signalling complex (TNF-RSC) controls the activation of RIPK1, a kinase critically involved in mediating multiple TNFα-activated…”
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In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution by Renz, Peter F., Ghoshdastider, Umesh, Baghai Sain, Simona, Valdivia-Francia, Fabiola, Khandekar, Ameya, Ormiston, Mark, Bernasconi, Martino, Duré, Clara, Kretz, Jonas A., Lee, Minkyoung, Hyams, Katie, Forny, Merima, Pohly, Marcel, Ficht, Xenia, Ellis, Stephanie J., Moor, Andreas E., Sendoel, Ataman

“…The tumour evolution model posits that malignant transformation is preceded by randomly distributed driver mutations in cancer genes, which cause clonal…”
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Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases by Croft, Michael, Siegel, Richard M.

“…Key Points TNF inhibitors are among the most effective protein-based drugs for reducing inflammation associated with several rheumatic diseases In addition to…”
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Many stimuli pull the necrotic trigger, an overview by Vanlangenakker, N, Vanden Berghe, T, Vandenabeele, P

“…The lab of Jürg Tschopp was the first to report on the crucial role of receptor-interacting protein kinase 1 (RIPK1) in caspase-independent cell death. Because…”
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Towards understanding the role of nanomedicine in targeting TNFR2 in rheumatoid arthritis by Lambuk, Fatmawati, Nordin, Nor Asyikin, Mussa, Ali, Lambuk, Lidawani, Ahmad, Suhana, Hassan, Rosline, Kadir, Ramlah, Mohamud, Rohimah, Yahya, Nurul Khaiza

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovium and progressive joint destruction which significantly…”
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TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer by Walczak, Henning

“…Tumor necrosis factor (TNF) is crucial for innate immunity, but deregulated TNF signaling also plays an eminent role in the pathogenesis of many chronic…”
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