Výsledky vyhľadávania - "Nägerl, U. Valentin"

Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue Autor Tønnesen, Jan, Inavalli, V V G Krishna, Nägerl, U Valentin

“…The extracellular space (ECS) of the brain has an extremely complex spatial organization, which has defied conventional light microscopy. Consequently, despite…”
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Deciphering the functional nano‐anatomy of the tripartite synapse using stimulated emission depletion microscopy Autor Arizono, Misa, Nägerl, U. Valentin

“…A major challenge for studying neuron‐astrocyte communication lies in visualizing the tripartite synapse, which is the physical site where astrocytic processes…”
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Getting sharper: the brain under the spotlight of super-resolution microscopy Autor Arizono, Misa, Idziak, Agata, Quici, Federica, Nägerl, U. Valentin

“…Brain cells such as neurons and astrocytes exhibit an extremely elaborate morphology, and their functional specializations like synapses and glial processes…”
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Control of Ca2+ signals by astrocyte nanoscale morphology at tripartite synapses Autor Denizot, Audrey, Arizono, Misa, Nägerl, U. Valentin, Berry, Hugues, De Schutter, Erik

“…Much of the Ca2+ activity in astrocytes is spatially restricted to microdomains and occurs in fine processes that form a complex anatomical meshwork, the…”
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SpineJ: A software tool for quantitative analysis of nanoscale spine morphology Autor Levet, Florian, Tønnesen, Jan, Nägerl, U. Valentin, Sibarita, Jean-Baptiste

“…•Semi-automatic ImageJ plugin for quantitative morphometric analysis of dendritic spines.•Designed for super-resolution microscopy image data (e.g. nanoscale…”
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STED nanoscopy of actin dynamics in synapses deep inside living brain slices Autor Urban, Nicolai T, Willig, Katrin I, Hell, Stefan W, Nägerl, U Valentin

“…It is difficult to investigate the mechanisms that mediate long-term changes in synapse function because synapses are small and deeply embedded inside brain…”
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Two-photon excitation STED microscopy in two colors in acute brain slices Autor Bethge, Philipp, Chéreau, Ronan, Avignone, Elena, Marsicano, Giovanni, Nägerl, U Valentin

“…Many cellular structures and organelles are too small to be properly resolved by conventional light microscopy. This is particularly true for dendritic spines…”
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Altered morphological dynamics of activated microglia after induction of status epilepticus Autor Avignone, Elena, Lepleux, Marilyn, Angibaud, Julie, Nägerl, U. Valentin

“…Background Microglia cells are the resident macrophages of the central nervous system and are considered its first line of defense. In the normal brain, their…”
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Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo Autor Pfeiffer, Thomas, Poll, Stefanie, Bancelin, Stephane, Angibaud, Julie, Inavalli, VVG Krishna, Keppler, Kevin, Mittag, Manuel, Fuhrmann, Martin, Nägerl, U Valentin

“…Rewiring neural circuits by the formation and elimination of synapses is thought to be a key cellular mechanism of learning and memory in the mammalian brain…”
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Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices Autor Imig, Cordelia, López-Murcia, Francisco José, Maus, Lydia, García-Plaza, Inés Hojas, Mortensen, Lena Sünke, Schwark, Manuela, Schwarze, Valentin, Angibaud, Julie, Nägerl, U Valentin, Taschenberger, Holger, Brose, Nils, Cooper, Benjamin H

“…Electron microscopy can resolve synapse ultrastructure with nanometer precision, but the capture of time-resolved, activity-dependent synaptic…”
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Live-cell imaging of dendritic spines by STED microscopy Autor Nägerl, U Valentin, Willig, Katrin I, Hein, Birka, Hell, Stefan W, Bonhoeffer, Tobias

“…Time lapse fluorescence imaging has become one of the most important approaches in neurobiological research. In particular, both confocal and two-photon…”
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Dissecting tripartite synapses with STED microscopy Autor Panatier, Aude, Arizono, Misa, Nägerl, U Valentin

“…The concept of the tripartite synapse reflects the important role that astrocytic processes are thought to play in the function and regulation of neuronal…”
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Aberration correction in stimulated emission depletion microscopy to increase imaging depth in living brain tissue Autor Bancelin, Stéphane, Mercier, Luc, Murana, Emanuele, Nägerl, U. Valentin

“…Significance: Stimulated emission depletion (STED) microscopy enables nanoscale imaging of live samples, but it requires a specific spatial beam shaping that…”
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Two-color STED microscopy of living synapses using a single laser-beam pair Autor Tønnesen, Jan, Nadrigny, Fabien, Willig, Katrin I, Wedlich-Söldner, Roland, Nägerl, U Valentin

“…The advent of superresolution microscopy has opened up new research opportunities into dynamic processes at the nanoscale inside living biological specimens…”
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Impact of a tilted coverslip on two-photon and STED microscopy Autor Le Bourdellès, Guillaume, Mercier, Luc, Roos, Johannes, Bancelin, Stéphane, Nägerl, U. Valentin

“…The advent of super-resolution microscopy has opened up new avenues to unveil brain structures with unprecedented spatial resolution in the living state. Yet,…”
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Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion Autor Kawakami, Naoto, Nägerl, U Valentin, Odoardi, Francesca, Bonhoeffer, Tobias, Wekerle, Hartmut, Flügel, Alexander

“…We tracked pathogenic myelin basic protein-specific CD4+ effector T cells in early central nervous system (CNS) lesions of experimental autoimmune…”
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Two-Photon STED Microscopy for Nanoscale Imaging of Neural Morphology In Vivo Autor Ter Veer, Mirelle J T, Pfeiffer, Thomas, Nägerl, U Valentin

“…The advent of super-resolution microscopy offers to bridge the gap between electron and light microscopy. It has opened up the possibility of visualizing…”
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Nanoscale and functional heterogeneity of the hippocampal extracellular space Autor Grassi, Diego, Idziak, Agata, Lee, Antony, Calaresu, Ivo, Sibarita, Jean-Baptiste, Cognet, Laurent, Nägerl, U. Valentin, Groc, Laurent

“…The extracellular space (ECS) and its constituents play a crucial role in brain development, plasticity, circadian rhythm, and behavior, as well as brain…”
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Salivary gland macrophages and tissue-resident CD8 + T cells cooperate for homeostatic organ surveillance Autor Stolp, Bettina, Thelen, Flavian, Ficht, Xenia, Altenburger, Lukas M, Ruef, Nora, Inavalli, V V G Krishna, Germann, Philipp, Page, Nicolas, Moalli, Federica, Raimondi, Andrea, Keyser, Kirsten A, Seyed Jafari, S Morteza, Barone, Francesca, Dettmer, Matthias S, Merkler, Doron, Iannacone, Matteo, Sharpe, James, Schlapbach, Christoph, Fackler, Oliver T, Nägerl, U Valentin, Stein, Jens V

“…It is well established that tissue macrophages and tissue-resident memory CD8 T cells (T ) play important roles for pathogen sensing and rapid protection of…”
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A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP Autor Fonseca, Rosalina, Vabulas, Ramunas M, Hartl, F Ulrich, Bonhoeffer, Tobias, Nägerl, U Valentin

“…Long-lasting changes in synaptic strength are thought to play a pivotal role in activity-dependent plasticity and memory. There is ample evidence indicating…”
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