Suchergebnisse - "Murray, Johanne M"

The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing von Hu, Jiazhi, Sun, Lei, Shen, Fenfen, Chen, Yufei, Hua, Yu, Liu, Yang, Zhang, Mian, Hu, Yiren, Wang, Qingsong, Xu, Wei, Sun, Fei, Ji, Jianguo, Murray, Johanne M, Carr, Antony M, Kong, Daochun

“… When replication forks stall at damaged bases or upon nucleotide depletion, the intra-S phase checkpoint ensures they are stabilized and can restart. In …”
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Cryo-EM structure of the Smc5/6 holo-complex von Hallett, Stephen T, Campbell Harry, Isabella, Schellenberger, Pascale, Zhou, Lihong, Cronin, Nora B, Baxter, Jonathan, Etheridge, Thomas J, Murray, Johanne M, Oliver, Antony W

“… Abstract The Smc5/6 complex plays an essential role in the resolution of recombination intermediates formed during mitosis or meiosis, or as a result of the …”
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Recombination-restarted replication makes inverted chromosome fusions at inverted repeats von Mizuno, Ken’Ichi, Miyabe, Izumi, Schalbetter, Stephanie A., Carr, Antony M., Murray, Johanne M.

“… A new mechanism of chromosomal rearrangement is identified through the observation that broken or collapsed DNA replication forks restarted by homologous …”
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Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex von Hallett, Stephen T, Schellenberger, Pascale, Zhou, Lihong, Beuron, Fabienne, Morris, Ed, Murray, Johanne M, Oliver, Antony W

“… Abstract The multi-component Smc5/6 complex plays a critical role in the resolution of recombination intermediates formed during mitosis and meiosis, and in …”
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Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchange von Lambert, Sarah, Mizuno, Ken'ichi, Blaisonneau, Joël, Martineau, Sylvain, Chanet, Roland, Fréon, Karine, Murray, Johanne M, Carr, Antony M, Baldacci, Giuseppe

“… Template switching induced by stalled replication forks has recently been proposed to underlie complex genomic rearrangements. However, the resulting models …”
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Specialized interfaces of Smc5/6 control hinge stability and DNA association von Alt, Aaron, Dang, Hung Q., Wells, Owen S., Polo, Luis M., Smith, Matt A., McGregor, Grant A., Welte, Thomas, Lehmann, Alan R., Pearl, Laurence H., Murray, Johanne M., Oliver, Antony W.

“… The Structural Maintenance of Chromosomes (SMC) complexes: cohesin, condensin and Smc5/6 are involved in the organization of higher-order chromosome …”
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Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism von Mizuno, Ken'Ichi, Lambert, Sarah, Baldacci, Giuseppe, Murray, Johanne M, Carr, Antony M

“… Gene amplification plays important roles in the progression of cancer and contributes to acquired drug resistance during treatment. Amplification can initiate …”
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Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo von Etheridge, Thomas J, Villahermosa, Desiree, Campillo-Funollet, Eduard, Herbert, Alex David, Irmisch, Anja, Watson, Adam T, Dang, Hung Q, Osborne, Mark A, Oliver, Antony W, Carr, Antony M, Murray, Johanne M

“… The essential Smc5/6 complex is required in response to replication stress and is best known for ensuring the fidelity of homologous recombination. Using …”
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Homologous recombination repair intermediates promote efficient de novo telomere addition at DNA double-strand breaks von Davé, Anoushka, Pai, Chen-Chun, Durley, Samuel C, Hulme, Lydia, Sarkar, Sovan, Wee, Boon-Yu, Prudden, John, Tinline-Purvis, Helen, Cullen, Jason K, Walker, Carol, Watson, Adam, Carr, Antony M, Murray, Johanne M, Humphrey, Timothy C

“… Abstract The healing of broken chromosomes by de novo telomere addition, while a normal developmental process in some organisms, has the potential to cause …”
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Smc5/6 is required for repair at collapsed replication forks von Ampatzidou, Eleni, Irmisch, Anja, O'Connell, Matthew J, Murray, Johanne M

“… In eukaryotes, three pairs of structural-maintenance-of-chromosome (SMC) proteins are found in conserved multisubunit protein complexes required for …”
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DNA double-strand break repair within heterochromatic regions von Murray, Johanne M, Stiff, Tom, Jeggo, Penny A

“… DNA DSBs (double-strand breaks) represent a critical lesion for a cell, with misrepair being potentially as harmful as lack of repair. In mammalian cells, DSBs …”
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Correction: Kolesar et al. Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase. Cells 2022, 11, 165 von Kolesar, Peter, Stejskal, Karel, Potesil, David, Murray, Johanne M., Palecek, Jan J.

“… In the original publication [...] …”
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Smc5/6 maintains stalled replication forks in a recombination-competent conformation von Irmisch, Anja, Ampatzidou, Eleni, Mizuno, Ken'ichi, O'Connell, Matthew J, Murray, Johanne M

“… The Smc5/6 structural maintenance of chromosomes complex is required for efficient homologous recombination (HR). Defects in Smc5/6 result in chromosome …”
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Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase von Kolesar, Peter, Stejskal, Karel, Potesil, David, Murray, Johanne M., Palecek, Jan J.

“… Structural Maintenance of Chromosomes (SMC) complexes are important for many aspects of the chromosomal organization. Unlike cohesin and condensin, the SMC5/6 …”
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Fission yeast strains with circular chromosomes require the 9-1-1 checkpoint complex for the viability in response to the anti-cancer drug 5-fluorodeoxyuridine von Shamim, Hossain Mohammad, Minami, Yukako, Tanaka, Daiki, Ukimori, Shinobu, Murray, Johanne M., Ueno, Masaru

“… Thymidine kinase converts 5-fluorodeoxyuridine to 5-fluorodeoxyuridine monophosphate, which causes disruption of deoxynucleotide triphosphate ratios. The …”
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Novel synthetic lethality screening method identifies TIP60-dependent radiation sensitivity in the absence of BAF180 von Hopkins, Suzanna R., McGregor, Grant A., Murray, Johanne M., Downs, Jessica A., Savic, Velibor

“… In recent years, research into synthetic lethality and how it can be exploited in cancer treatments has emerged as major focus in cancer research. However, the …”
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Optimisation of the Schizosaccharomyces pombe urg1 Expression System von Watson, Adam T., Daigaku, Yasukazu, Mohebi, Saed, Etheridge, Thomas J., Chahwan, Charly, Murray, Johanne M., Carr, Antony M.

“… The ability to study protein function in vivo often relies on systems that regulate the presence and absence of the protein of interest. Two limitations for …”
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Smc5-Smc6-Dependent Removal of Cohesin from Mitotic Chromosomes von Outwin, Emily A., Irmisch, Anja, Murray, Johanne M., O'Connell, Matthew J.

“… Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley …”
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Integrating DNA damage repair with the cell cycle von Murray, Johanne M, Carr, Antony M

“… DNA is labile and constantly subject to damage. In addition to external mutagens, DNA is continuously damaged by the aqueous environment, cellular metabolites …”
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Transformation of Schizosaccharomyces pombe: Lithium Acetate/ Dimethyl Sulfoxide Procedure von Murray, Johanne M, Watson, Adam T, Carr, Antony M

“… Transformation ofSchizosaccharomyces pombewith DNA requires the conditioning of cells to promote DNA uptake followed by cell growth under conditions that …”
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