Suchergebnisse - "Munk, Rachel"

Transcriptome signature of cellular senescence von Casella, Gabriel, Munk, Rachel, Kim, Kyoung Mi, Piao, Yulan, De, Supriyo, Abdelmohsen, Kotb, Gorospe, Myriam

“… Abstract Cellular senescence, an integral component of aging and cancer, arises in response to diverse triggers, including telomere attrition, macromolecular …”
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Noncoding RNAs in Alzheimer's disease von Idda, M. Laura, Munk, Rachel, Abdelmohsen, Kotb, Gorospe, Myriam

“… Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause of dementia among the elderly worldwide. Despite intense efforts to …”
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Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1 von Abdelmohsen, Kotb, Panda, Amaresh C., Munk, Rachel, Grammatikakis, Ioannis, Dudekula, Dawood B., De, Supriyo, Kim, Jiyoung, Noh, Ji Heon, Kim, Kyoung Mi, Martindale, Jennifer L., Gorospe, Myriam

“… HuR influences gene expression programs and hence cellular phenotypes by binding to hundreds of coding and noncoding linear RNAs. However, whether HuR binds to …”
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High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs von Panda, Amaresh C., De, Supriyo, Grammatikakis, Ioannis, Munk, Rachel, Yang, Xiaoling, Piao, Yulan, Dudekula, Dawood B., Abdelmohsen, Kotb, Gorospe, Myriam

“… High-throughput RNA sequencing methods coupled with specialized bioinformatic analyses have recently uncovered tens of thousands of unique circular (circ)RNAs, …”
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Emerging roles and context of circular RNAs von Panda, Amaresh C., Grammatikakis, Ioannis, Munk, Rachel, Gorospe, Myriam, Abdelmohsen, Kotb

“… Circular RNAs (circRNAs) represent a large class of noncoding RNAs (ncRNAs) that have recently emerged as regulators of gene expression. They have been shown …”
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Identification of gingerenone A as a novel senolytic compound von Moaddel, Ruin, Rossi, Martina, Rodriguez, Stephanie, Munk, Rachel, Khadeer, Mohammed, Abdelmohsen, Kotb, Gorospe, Myriam, Ferrucci, Luigi

“… Senescent cells accumulate with aging and have been shown to contribute to age-associated diseases and organ dysfunction. Eliminating senescent cells with …”
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Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations von Krasniewski, Linda K, Chakraborty, Papiya, Cui, Chang-Yi, Mazan-Mamczarz, Krystyna, Dunn, Christopher, Piao, Yulan, Fan, Jinshui, Shi, Changyou, Wallace, Tonya, Nguyen, Cuong, Rathbun, Isabelle A, Munk, Rachel, Tsitsipatis, Dimitrios, De, Supriyo, Sen, Payel, Ferrucci, Luigi, Gorospe, Myriam

“… Tissue-resident macrophages represent a group of highly responsive innate immune cells that acquire diverse functions by polarizing toward distinct …”
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DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice von Herman, Allison B., Tsitsipatis, Dimitrios, Anerillas, Carlos, Mazan-Mamczarz, Krystyna, Carr, Angelica E., Gregg, Jordan M., Wang, Mingyi, Zhang, Jing, Michel, Marc, Henry-Smith, Charnae’ A., Harris, Sophia C., Munk, Rachel, Martindale, Jennifer L., Piao, Yulan, Fan, Jinshui, Mattison, Julie A., De, Supriyo, Abdelmohsen, Kotb, Maul, Robert W., Tanaka, Toshiko, Moore, Ann Zenobia, DeMouth, Megan E., Sidoli, Simone, Ferrucci, Luigi, Liu, Yie, de Cabo, Rafael, Lakatta, Edward G., Gorospe, Myriam

“… Senescent vascular smooth muscle cells (VSMCs) accumulate in the vasculature with age and tissue damage and secrete factors that promote atherosclerotic plaque …”
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Mini marvels: superhero engagement across early childhood von Coyne, Sarah M., Ashby, Sarah, Munk, Rachel J., Holmgren, Hailey G., Shawcroft, Jane, Densley, Rebecca, Austin, Tanya, Banks, Kennedy, Van Alfen, Megan

“… Superhero engagement is common in early childhood, particularly among boys, and tends to be related to negative outcomes, such as aggression. However, most …”
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A BDNF-TrkB autocrine loop enhances senescent cell viability von Anerillas, Carlos, Herman, Allison B., Munk, Rachel, Garrido, Amanda, Lam, Kwan-Wood Gabriel, Payea, Matthew J., Rossi, Martina, Tsitsipatis, Dimitrios, Martindale, Jennifer L., Piao, Yulan, Mazan-Mamczarz, Krystyna, Fan, Jinshui, Cui, Chang-Yi, De, Supriyo, Abdelmohsen, Kotb, de Cabo, Rafael, Gorospe, Myriam

“… Cellular senescence is characterized by cell cycle arrest, resistance to apoptosis, and a senescence-associated secretory phenotype (SASP) whereby cells …”
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Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging von Occean, James R., Yang, Na, Sun, Yan, Dawkins, Marshall S., Munk, Rachel, Belair, Cedric, Dar, Showkat, Anerillas, Carlos, Wang, Lin, Shi, Changyou, Dunn, Christopher, Bernier, Michel, Price, Nathan L., Kim, Julie S., Cui, Chang-Yi, Fan, Jinshui, Bhattacharyya, Moitrayee, De, Supriyo, Maragkakis, Manolis, de Cabo, Rafael, Sidoli, Simone, Sen, Payel

“… DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of DNA methylation, is typically enriched at enhancers and gene bodies of …”
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Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis von Herman, Allison B, Anerillas, Carlos, Harris, Sophia C, Munk, Rachel, Martindale, Jennifer L, Yang, Xiaoling, Mazan-Mamczarz, Krystyna, Zhang, Yongqing, Heckenbach, Indra J, Scheibye-Knudsen, Morten, De, Supriyo, Sen, Payel, Abdelmohsen, Kotb, Gorospe, Myriam

“… Abstract A major stress response influenced by microRNAs (miRNAs) is senescence, a state of indefinite growth arrest triggered by sublethal cell damage. Here, …”
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Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest von Rossi, Martina, Anerillas, Carlos, Idda, Maria Laura, Munk, Rachel, Shin, Chang Hoon, Donega, Stefano, Tsitsipatis, Dimitrios, Herman, Allison B, Martindale, Jennifer L, Yang, Xiaoling, Piao, Yulan, Mazan-Mamczarz, Krystyna, Fan, Jinshui, Ferrucci, Luigi, Johnson, Peter F, De, Supriyo, Abdelmohsen, Kotb, Gorospe, Myriam

“… Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP) …”
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Antigen-Independent IFN-γ Production by Human Naïve CD4+ T Cells Activated by IL-12 Plus IL-18 von Munk, Rachel B., Sugiyama, Katsuki, Ghosh, Paritosh, Sasaki, Carl Y., Rezanka, Louis, Banerjee, Kasturi, Takahashi, Hidenori, Sen, Ranjan, Longo, Dan L.

“… The role of T cells in innate immunity is not well defined. In this report, we show that a subset of human peripheral blood CD4(+) T cells responds to IL-12 …”
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Author Correction: A BDNF-TrkB autocrine loop enhances senescent cell viability von Anerillas, Carlos, Herman, Allison B., Munk, Rachel, Garrido, Amanda, Lam, Kwan-Wood Gabriel, Payea, Matthew J., Rossi, Martina, Tsitsipatis, Dimitrios, Martindale, Jennifer L., Piao, Yulan, Mazan-Mamczarz, Krystyna, Fan, Jinshui, Cui, Chang-Yi, De, Supriyo, Abdelmohsen, Kotb, de Cabo, Rafael, Gorospe, Myriam

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Mitochondrial RNA in Alzheimer’s Disease Circulating Extracellular Vesicles von Kim, Kyoung Mi, Meng, Qiong, Perez de Acha, Olivia, Mustapic, Maja, Cheng, Aiwu, Eren, Erden, Kundu, Gautam, Piao, Yulan, Munk, Rachel, Wood, William H., De, Supriyo, Noh, Ji Heon, Delannoy, Michael, Cheng, Lesley, Abdelmohsen, Kotb, Kapogiannis, Dimitrios, Gorospe, Myriam

“… Alzheimer's disease (AD) is the most common type of dementia. Amyloid β (Aβ) plaques, tau-containing neurofibrillary tangles, and neuronal loss leading to …”
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Systematic identification of NF90 target RNAs by iCLIP analysis von Lodde, Valeria, Floris, Matteo, Munk, Rachel, Martindale, Jennifer L., Piredda, Davide, Napodano, Catello Mario Panu, Cucca, Francesco, Uzzau, Sergio, Abdelmohsen, Kotb, Gorospe, Myriam, Noh, Ji Heon, Idda, M. Laura

“… RNA-binding proteins (RBPs) interact with and determine the fate of many cellular RNAs directing numerous essential roles in cellular physiology. Nuclear …”
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Analysis of mitochondrial respiration and ATP synthase in frozen brain tissues von Yao, Pamela J., Munk, Rachel, Gorospe, Myriam, Kapogiannis, Dimitrios

“… Studying mitochondrial respiration capacity is essential for gaining insights into mitochondrial functions. In frozen tissue samples, however, our ability to …”
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Mechanism of Activation-Induced Downregulation of Mitofusin 2 in Human Peripheral Blood T Cells von Dasgupta, Asish, Chen, Kuang-Hueih, Munk, Rachel B, Sasaki, Carl Y, Curtis, Jessica, Longo, Dan L, Ghosh, Paritosh

“… Mitofusin 2 (Mfn2), a mitochondrial protein, was shown to have antiproliferative properties when overexpressed. In this article, we show that activation of …”
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Skeletal Muscle mRNA Splicing Variants Association With Four Different Fitness and Energetic Measures in the GESTALT Study von Donega, Stefano, Banskota, Nirad, Gupta, Esha, Gonzalez‐Freire, Marta, Moore, Ann Zenobia, Ubaida‐Mohien, Ceereena, Munk, Rachel, Zukley, Linda, Piao, Yulan, Bergeron, Chris, Bergeron, Jan, Bektas, Arsun, Zampino, Marta, Stagg, Carole, Indig, Fred, Hartnell, Lisa M., Kaileh, Mary, Fishbein, Kenneth, Spencer, Richard G., Gorospe, Myriam, De, Supriyo, Egan, Josephine M., Sen, Ranjan, Ferrucci, Luigi

“… ABSTRACT Background Physical activity is essential for maintaining muscle mitochondrial function and aerobic capacity. The molecular mechanisms underlying such …”
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