Suchergebnisse - "Moskwa, Patryk"

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors von Moskwa, Patryk, Buffa, Francesca M, Pan, Yunfeng, Panchakshari, Rohit, Gottipati, Ponnari, Muschel, Ruth J, Beech, John, Kulshrestha, Ritu, Abdelmohsen, Kotb, Weinstock, David M, Gorospe, Myriam, Harris, Adrian L, Helleday, Thomas, Chowdhury, Dipanjan

“… Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates with poor prognosis of breast cancer patients. Here we show that BRCA1 …”
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Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury von Acharya, Sanket S, Fendler, Wojciech, Watson, Jacqueline, Hamilton, Abigail, Pan, Yunfeng, Gaudiano, Emily, Moskwa, Patryk, Bhanja, Payel, Saha, Subhrajit, Guha, Chandan, Parmar, Kalindi, Chowdhury, Dipanjan

“… Accidental radiation exposure is a threat to human health that necessitates effective clinical planning and diagnosis. Minimally invasive biomarkers that can …”
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A Novel Host Defense System of Airways Is Defective in Cystic Fibrosis von Moskwa, Patryk, Lorentzen, Daniel, Excoffon, Katherine J. D. A, Zabner, Joseph, McCray, Paul B., Jr, Nauseef, William M, Dupuy, Corinne, Banfi, Botond

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DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis von Smolinska, Agnieszka, Singer, Kerstin, Golchert, Janine, Smyczynska, Urszula, Fendler, Wojciech, Sendler, Matthias, van den Brandt, Jens, Singer, Stephan, Homuth, Georg, Lerch, Markus M., Moskwa, Patryk

“… Pancreatic ductal adenocarcinoma (PDAC), due to its genomic heterogeneity and lack of effective treatment, despite decades of intensive research, will become …”
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Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5) von Bánfi, Botond, Tirone, Fabiana, Durussel, Isabelle, Knisz, Judit, Moskwa, Patryk, Molnár, Gergely Zoltán, Krause, Karl-Heinz, Cox, Jos A

“… NADPH oxidase 5 (NOX5) is a homologue of the gp91(phox) subunit of the phagocyte NADPH oxidase. NOX5 is expressed in lymphoid organs and testis and …”
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MiR-502 is the first reported miRNA simultaneously targeting two components of the classical non-homologous end joining (C-NHEJ) in pancreatic cell lines von Smolinska, Agnieszka, Swoboda, Julia, Fendler, Wojciech, Lerch, Markus M., Sendler, Matthias, Moskwa, Patryk

“… Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Acquired inherited and/or somatic mutations drive its development. In order to prevent …”
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Autoinhibition of p50 Rho GTPase-activating protein (GAP) is released by prenylated small GTPases von Moskwa, Patryk, Paclet, Marie-Hélène, Dagher, Marie-Claire, Ligeti, Erzsébet

“… Interaction of p50 Rho GTPase-activating protein (p50RhoGAP) with Rho family small GTPases was investigated in a yeast two-hybrid system, by radioactive GAP …”
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The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair von Xu, Ye, Sun, Yingli, Jiang, Xiaofeng, Ayrapetov, Marina K, Moskwa, Patryk, Yang, Shenghong, Weinstock, David M, Price, Brendan D

“… The complexity of chromatin architecture presents a significant barrier to the ability of the DNA repair machinery to access and repair DNA double-strand …”
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Glucocerebroside inhibits NADPH oxidase activation in cell-free system von Moskwa, Patryk, Palicz, Anita, Paclet, Marie-Hélène, Dagher, Marie-Claire, Erdős, Melinda, Maródi, László, Ligeti, Erzsébet

“… We reported earlier that monocytes and macrophages from patients with type I Gaucher disease have a decreased capacity to generate superoxide anion (O2−) on …”
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A novel host defense system of airways is defective in cystic fibrosis von Moskwa, Patryk, Lorentzen, Daniel, Excoffon, Katherine J D A, Zabner, Joseph, McCray, Jr, Paul B, Nauseef, William M, Dupuy, Corinne, Bánfi, Botond

“… The respiratory tract is constantly exposed to airborne microorganisms. Nevertheless, normal airways remain sterile without recruiting phagocytes. This innate …”
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A functional screen identifies miRs that induce radioresistance in glioblastomas von Moskwa, Patryk, Zinn, Pascal O, Choi, Young Eun, Shukla, Sachet A, Fendler, Wojciech, Chen, Clark C, Lu, Jun, Golub, Todd R, Hjelmeland, Anita, Chowdhury, Dipanjan

“… The efficacy of radiotherapy in many tumor types is limited by normal tissue toxicity and by intrinsic or acquired radioresistance. Therefore, it is essential …”
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MiR-502 regulates non-homologous end joining (NHEJ) and reduces radioresistance in human pancreatic cancer cell line von Smolinska, Agnieszka, Swoboda, Julia, Lerch, Markus M., Moskwa, Patryk

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MiR-502 is the first reported miRNA targeting simultaneously classical non-homologous end joining (NHEJ) and the cell cycle response von Smolinska, Agnieszka Anna, Swoboda, Julia, Fendler, Wojciech, Lerch, Markus M., Sendler, Matthias, Moskwa, Patryk

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Comparability of size measurements of the pancreas in magnetic resonance imaging and transabdominal ultrasound von Aghdassi, Ali A., Schauer, Birgit, Duscha, David, Ittermann, Till, Pickartz, Tilman, Budde, Christoph, Simon, Peter, Moskwa, Patryk, Kromrey, Marie L., Bülow, Robin, Völzke, Henry, Kühn, Jens, Lerch, Markus M.

“… Introduction Transabdominal ultrasound (US) and magnetic resonance imaging (MRI) are commonly used for the examination of the pancreas in clinical routine. We …”
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334 A Functional Screen Identifies miRNAs that Induce Radioresistance in Glioblastomas von Chen, Clark C., Moskwa, Patryk, Zinn, Pascal O., Hirshman, Brian R., Choi, Young Eun, Shukla, Sachet A., Fendler, Wojciech, Lu, Jun, Golub, Todd R., Hjelmeland, Anita, Chowdhury, Dipanjan

“… Abstract INTRODUCTION: The efficacy of radiotherapy in many tumor types is limited by normal tissue toxicity and by intrinsic or acquired radioresistance …”
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Development of Pancreatic Cancer: Targets for Early Detection and Treatment von Lerch, Markus M, Mayerle, Julia, Mahajan, Ujjwal, Sendler, Matthias, Weiss, F Ulrich, Aghdassi, Ali, Moskwa, Patryk, Simon, Peter

“… Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancer death worldwide and compared to other malignancies its share in cancer mortality is …”
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Chapter 19 - Repair of double-strand breaks by nonhomologous end joining; Its components and their function von Moskwa, Patryk

“… Double-strand breaks (DSBs) constitute the most dangerous DNA damage. Nonetheless, besides unwanted DSBs that continuously arise, e.g., upon ROS or ionizing …”
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Possible regulatory mechanisms of the neutrophil NADPH oxidase: The role of GTPase activating proteins and lipids von Moskwa, Patryk

“… The superoxide (O2·−) producing enzyme NADPH oxidase is composed of the membrane associated catalytic subunit cytochrome bass and the cytosolic regulators …”
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Participation of Rac GTPase activating proteins in the deactivation of the phagocytic NADPH oxidase von Moskwa, Patryk, Dagher, Marie-Claire, Paclet, Marie-Hélène, Morel, Francoise, Ligeti, Erzsébet

“… The aim of the present study was to investigate possible mechanisms that could be involved in the deactivation of the assembled, catalytically active NADPH …”
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