Výsledky vyhľadávania - "Morton, Jennifer P."

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration Autor Ritschka, Birgit, Storer, Mekayla, Mas, Alba, Heinzmann, Florian, Ortells, Mari Carmen, Morton, Jennifer P, Sansom, Owen J, Zender, Lars, Keyes, William M

“…Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. However, while arrested, senescent cells secrete a variety of…”
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Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer Autor Vennin, Claire, Murphy, Kendelle J, Morton, Jennifer P, Cox, Thomas R, Pajic, Marina, Timpson, Paul

“…Pancreatic cancer is accompanied with a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression…”
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Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells Autor Lachowski, Dariusz, Cortes, Ernesto, Pink, Daniel, Chronopoulos, Antonios, Karim, Saadia A., P. Morton, Jennifer, del Río Hernández, Armando E.

“…Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive malignancy characterised by the presence of extensive desmoplasia, thought to be responsible for the…”
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Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models Autor Heinrich, Marcel A., Mostafa, Ahmed M.R.H., Morton, Jennifer P., Hawinkels, Lukas J.A.C., Prakash, Jai

“…[Display omitted] Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with an overall survival rate of less than 7–8%,…”
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Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer Autor Halbrook, Christopher J, Pontious, Corbin, Kovalenko, Ilya, Lapienyte, Laura, Dreyer, Stephan, Lee, Ho-Joon, Thurston, Galloway, Zhang, Yaqing, Lazarus, Jenny, Sajjakulnukit, Peter, Hong, Hanna S, Kremer, Daniel M, Nelson, Barbara S, Kemp, Samantha, Zhang, Li, Chang, David, Biankin, Andrew, Shi, Jiaqi, Frankel, Timothy L, Crawford, Howard C, Morton, Jennifer P, Pasca di Magliano, Marina, Lyssiotis, Costas A

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant infiltration of tumor-associated macrophages (TAMs). TAMs have been reported to drive…”
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The preclinical gap in pancreatic cancer and radiotherapy Autor Tesson, Mathias, Morton, Jennifer P.

“…Pancreatic ductal adenocarcinoma is an aggressive malignancy with limited treatment options. Chemotherapy offers little benefit and, although there is some…”
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A complex secretory program orchestrated by the inflammasome controls paracrine senescence Autor Acosta, Juan Carlos, Banito, Ana, Wuestefeld, Torsten, Georgilis, Athena, Janich, Peggy, Morton, Jennifer P., Athineos, Dimitris, Kang, Tae-Won, Lasitschka, Felix, Andrulis, Mindaugas, Pascual, Gloria, Morris, Kelly J., Khan, Sadaf, Jin, Hong, Dharmalingam, Gopuraja, Snijders, Ambrosius P., Carroll, Thomas, Capper, David, Pritchard, Catrin, Inman, Gareth J., Longerich, Thomas, Sansom, Owen J., Benitah, Salvador Aznar, Zender, Lars, Gil, Jesús

“…Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a complex pro-inflammatory response termed the…”
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CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma Autor Steele, Colin W, Karim, Saadia A, Leach, Joshua D G, Bailey, Peter, Upstill-Goddard, Rosanna, Rishi, Loveena, Foth, Mona, Bryson, Sheila, McDaid, Karen, Wilson, Zena, Eberlein, Catherine, Candido, Juliana B, Clarke, Mairi, Nixon, Colin, Connelly, John, Jamieson, Nigel, Carter, C Ross, Balkwill, Frances, Chang, David K, Evans, T R Jeffry, Strathdee, Douglas, Biankin, Andrew V, Nibbs, Robert J B, Barry, Simon T, Sansom, Owen J, Morton, Jennifer P

“…CXCR2 has been suggested to have both tumor-promoting and tumor-suppressive properties. Here we show that CXCR2 signaling is upregulated in human pancreatic…”
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CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer Autor Pereira, Brooke A, Vennin, Claire, Papanicolaou, Michael, Chambers, Cecilia R, Herrmann, David, Morton, Jennifer P, Cox, Thomas R, Timpson, Paul

“…Cancer-associated fibroblasts (CAFs) are one of the most significant components in the tumour microenvironment (TME), where they can perform several…”
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A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression Autor Auciello, Francesca R, Bulusu, Vinay, Oon, Chet, Tait-Mulder, Jacqueline, Berry, Mark, Bhattacharyya, Sohinee, Tumanov, Sergey, Allen-Petersen, Brittany L, Link, Jason, Kendsersky, Nicholas D, Vringer, Esmee, Schug, Michelle, Novo, David, Hwang, Rosa F, Evans, Ronald M, Nixon, Colin, Dorrell, Craig, Morton, Jennifer P, Norman, Jim C, Sears, Rosalie C, Kamphorst, Jurre J, Sherman, Mara H

“…Pancreatic ductal adenocarcinoma (PDAC) develops a pronounced stromal response reflecting an aberrant wound-healing process. This stromal reaction features…”
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Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade Autor Nielsen, Sebastian R., Strøbech, Jan E., Horton, Edward R., Jackstadt, Rene, Laitala, Anu, Bravo, Marina C., Maltese, Giorgia, Jensen, Adina R. D., Reuten, Raphael, Rafaeva, Maria, Karim, Saadia A., Hwang, Chang-Il, Arnes, Luis, Tuveson, David A., Sansom, Owen J., Morton, Jennifer P., Erler, Janine T.

“…Pancreatic ductal adenocarcinoma (PDAC) patients have a 5-year survival rate of only 8% largely due to late diagnosis and insufficient therapeutic options…”
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Neutrophils: Homing in on the myeloid mechanisms of metastasis Autor Leach, Joshua, Morton, Jennifer P., Sansom, Owen J.

“…•Neutrophils play important roles throughout the metastatic process.•Tumour progression and invasion are influenced by infiltrating neutrophils.•Signalling…”
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Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses Autor Blagih, Julianna, Zani, Fabio, Chakravarty, Probir, Hennequart, Marc, Pilley, Steven, Hobor, Sebastijan, Hock, Andreas K., Walton, Josephine B., Morton, Jennifer P., Gronroos, Eva, Mason, Susan, Yang, Ming, McNeish, Iain, Swanton, Charles, Blyth, Karen, Vousden, Karen H.

“…Loss of p53 function contributes to the development of many cancers. While cell-autonomous consequences of p53 mutation have been studied extensively, the role…”
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Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer Autor Raymant, Meirion, Astuti, Yuliana, Alvaro-Espinosa, Laura, Green, Daniel, Quaranta, Valeria, Bellomo, Gaia, Glenn, Mark, Chandran-Gorner, Vatshala, Palmer, Daniel H., Halloran, Christopher, Ghaneh, Paula, Henderson, Neil C., Morton, Jennifer P., Valiente, Manuel, Mielgo, Ainhoa, Schmid, Michael C.

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease for which better therapies are urgently needed. Fibroblasts and macrophages are…”
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EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas Autor Hill, William, Zaragkoulias, Andreas, Salvador-Barbero, Beatriz, Parfitt, Geraint J, Alatsatianos, Markella, Padilha, Ana, Porazinski, Sean, Woolley, Thomas E, Morton, Jennifer P, Sansom, Owen J, Hogan, Catherine

“…As we age, our tissues are repeatedly challenged by mutational insult, yet cancer occurrence is a relatively rare event. Cells carrying cancer-causing genetic…”
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Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression Autor Dozynkiewicz, Marta A, Jamieson, Nigel B, Macpherson, Iain, Grindlay, Joan, van den Berghe, Peter V E, von Thun, Anne, Morton, Jennifer P, Gourley, Charlie, Timpson, Paul, Nixon, Colin, McKay, Colin J, Carter, Ross, Strachan, David, Anderson, Kurt, Sansom, Owen J, Caswell, Patrick T, Norman, Jim C

“…Here we show that Rab25 permits the sorting of ligand-occupied, active-conformation α5β1 integrin to late endosomes/lysosomes. Photoactivation and biochemical…”
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Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma Autor Muthalagu, Nathiya, Monteverde, Tiziana, Raffo-Iraolagoitia, Ximena, Wiesheu, Robert, Whyte, Declan, Hedley, Ann, Laing, Sarah, Kruspig, Björn, Upstill-Goddard, Rosanna, Shaw, Robin, Neidler, Sarah, Rink, Curtis, Karim, Saadia A, Gyuraszova, Katarina, Nixon, Colin, Clark, William, Biankin, Andrew V, Carlin, Leo M, Coffelt, Seth B, Sansom, Owen J, Morton, Jennifer P, Murphy, Daniel J

“…MYC is implicated in the development and progression of pancreatic cancer, yet the precise level of MYC deregulation required to contribute to tumor…”
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CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype Autor Candido, Juliana B., Morton, Jennifer P., Bailey, Peter, Campbell, Andrew D., Karim, Saadia A., Jamieson, Thomas, Lapienyte, Laura, Gopinathan, Aarthi, Clark, William, McGhee, Ewan J., Wang, Jun, Escorcio-Correia, Monica, Zollinger, Raphael, Roshani, Rozita, Drew, Lisa, Rishi, Loveena, Arkell, Rebecca, Evans, T.R. Jeffry, Nixon, Colin, Jodrell, Duncan I., Wilkinson, Robert W., Biankin, Andrew V., Barry, Simon T., Balkwill, Frances R., Sansom, Owen J.

“…Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapies including single-agent immunotherapy and has a dense desmoplastic stroma, and most…”
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Increased formate overflow is a hallmark of oxidative cancer Autor Meiser, Johannes, Schuster, Anne, Pietzke, Matthias, Vande Voorde, Johan, Athineos, Dimitris, Oizel, Kristell, Burgos-Barragan, Guillermo, Wit, Niek, Dhayade, Sandeep, Morton, Jennifer P., Dornier, Emmanuel, Sumpton, David, Mackay, Gillian M., Blyth, Karen, Patel, Ketan J., Niclou, Simone P., Vazquez, Alexei

“…Formate overflow coupled to mitochondrial oxidative metabolism\ has been observed in cancer cell lines, but whether that takes place in the tumor…”
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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer Autor Morton, Jennifer P, Timpson, Paul, Karim, Saadia A, Ridgway, Rachel A, Athineos, Dimitris, Doyle, Brendan, Jamieson, Nigel B, Oien, Karin A, Lowy, Andrew M, Brunton, Valerie G, Frame, Margaret C, Evans, T R Jeffry, Sansom, Owen J

“…TP53 mutation occurs in 50-75% of human pancreatic ductal adenocarcinomas (PDAC) following an initiating activating mutation in the KRAS gene. These p53…”
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