Search Results - "Morgat, Clément"

Gastrin-Releasing Peptide Receptor Imaging and Therapy in the Era of Personalized Medicine by Morgat, Clément, Iagaru, Andrei, Hindié, Elif

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Re: Renu S. Eapen, James P. Buteau, Price Jackson, et al. Administering [177Lu]Lu-PSMA-617 Prior to Radical Prostatectomy in Men with High-risk Localised Prostate Cancer (LuTectomy): A Single-centre, Single-arm, Phase 1/2 Study. Eur Urol. 2024;85:217–226 by Hindié, Elif, Champion, Christophe, Morgat, Clément

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GRPR Expression in Metastatic Cancers: A Review of Potential Application of GRPR-Radioligand Therapy by Callaud, Aurélien, Duan, Heying, Hindié, Elif, Morgat, Clément, Iagaru, Andrei

“…Gastrin-Releasing Peptide Receptor (GRPR) represents a promising molecular target for radionuclide therapy (TRT) across a variety of malignancies due to its…”
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Comparison of 68Ga-PSMA-617 PET/CT and 68Ga-RM2 PET/CT in Patients with Localized Prostate Cancer Who Are Candidates for Radical Prostatectomy: A Prospective, Single-Arm, Single-Center, Phase II Study by Schollhammer, Romain, Robert, Grégoire, Asselineau, Julien, Yacoub, Mokrane, Vimont, Delphine, Balamoutoff, Nicolas, Bladou, Franck, Bénard, Antoine, Hindié, Elif, Gallerande, Henri de Clermont, Morgat, Clément

“…Considering the wide range of therapeutic options for localized prostate cancer (e.g., active surveillance, radiation-beam therapy, focal therapy, and radical…”
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N-Terminal Stabilization of Radiolabeled Neurotensin Analogues for Improved Tumor Uptake by Bodin, Sacha, Damiana, Tyrillshall S. T., Previti, Santo, Balasse, Laure, Ali, Lina, Remond, Emmanuelle, Nail, Vincent, Lamare, Frederic, Hindie, Elif, Guillet, Benjamin, Vimont, Delphine, Dalm, Simone U., Cavelier, Florine, Morgat, Clement

“…Peptide-based radiopharmaceuticals targeting neurotensin-receptor-1 (NTS1) are mainly stabilized using chemical modifications at the NT[8-13] sequence, thus…”
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Targeting neuropeptide receptors for cancer imaging and therapy: perspectives with bombesin, neurotensin, and neuropeptide-Y receptors by Morgat, Clément, Mishra, Anil Kumar, Varshney, Raunak, Allard, Michèle, Fernandez, Philippe, Hindié, Elif

“…Receptors for some regulatory peptides are highly expressed in tumors. Selective radiolabeled peptides can bind with high affinity and specificity to these…”
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Expression of Gastrin-Releasing Peptide Receptor in Breast Cancer and Its Association with Pathologic, Biologic, and Clinical Parameters: A Study of 1,432 Primary Tumors by Morgat, Clément, MacGrogan, Gaétan, Brouste, Véronique, Vélasco, Valérie, Sévenet, Nicolas, Bonnefoi, Hervé, Fernandez, Philippe, Debled, Marc, Hindié, Elif

“…A growing body of evidence suggests that gastrin-releasing peptide receptor (GRPR) might be a valuable target in breast cancer. To understand which patients…”
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Membrane and Nuclear Absorbed Doses from 177Lu and 161Tb in Tumor Clusters: Effect of Cellular Heterogeneity and Potential Benefit of Dual Targeting-A Monte Carlo Study by Larouze, Alexandre, Alcocer-Ávila, Mario, Morgat, Clément, Champion, Christophe, Hindié, Elif

“…Early use of targeted radionuclide therapy to eradicate tumor cell clusters and micrometastases might offer cure. However, there is a need to select…”
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Early use of abiraterone and radium-223 in metastatic prostate cancer by Hindié, Elif, Morgat, Clément

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Expression of neurotensin receptor-1 (NTS1) in primary breast tumors, cellular distribution, and association with clinical and biological factors by Morgat, Clément, Brouste, Véronique, Chastel, Adrien, Vélasco, Valérie, Macgrogan, Gaétan, Hindié, Elif

“…Purpose Neurotensin receptor-1 (NTS 1 ) is increasingly recognized as a potential target in diverse tumors including breast cancer, but factors associated with…”
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Silicon-Containing Neurotensin Analogues as Radiopharmaceuticals for NTS1-Positive Tumors Imaging by Fanelli, Roberto, Chastel, Adrien, Previti, Santo, Hindie, Elif, Vimont, Delphine, Zanotti-Fregonara, Paolo, Fernandez, Philippe, Garrigue, Philippe, Lamare, Frederic, Schollhammer, Romain, Balasse, Laure, Guillet, Benjamin, Remond, Emmanuelle, Morgat, Clement, Cavelier, Florine

“…Several independent studies have demonstrated the overexpression of NTS1 in various malignancies, which make this receptor of interest for imaging and therapy…”
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Modular One-Pot Strategy for the Synthesis of Heterobivalent Tracers by Bailly, Thibaud, Bodin, Sacha, Goncalves, Victor, Denat, Franck, Morgat, Clement, Prignon, Aurelie, Valverde, Ibai E.

“…Bivalent ligands, i.e., molecules having two ligands covalently connected by a linker, have been gathering attention since the first description of their…”
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Development of Radiopharmaceuticals for NPY Receptor-5 (Y5) Nuclear Imaging in Tumors by Synthesis of Specific Agonists and Investigation of Their Binding Mode by Bodin, Sacha, Peuker, Lisa C, Jestin, Emmanuelle, Alves, Isabel D, Velasco, Valérie, Ait-Arsa, Imade, Schollhammer, Romain, Lamare, Frédéric, Vimont, Delphine, MacGrogan, Gaétan, Hindié, Elif, Beck-Sickinger, Annette G, Morgat, Clément

“…The neuropeptide-Y (NPY) family acts through four G protein-coupled receptor subtypes in humans, namely, Y , Y , Y , and Y . A growing body of evidence suggest…”
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A Vision for Gastrin-Releasing Peptide Receptor Targeting for Imaging and Therapy: Perspective from Academia and Industry by Morgat, Clément, Duan, Heying, Dalm, Simone, Hindié, Elif, Günther, Thomas, Krause, Bernd J, Kramer, Vasko, Cavelier, Florine, Stephens, Andrew W, Moran, Stephen, Lamb, Laura, Iagaru, Andrei

“…The gastrin-releasing peptide receptor (GRPR) is overexpressed in various cancers, including prostate cancer, breast cancer, small cell and non-small cell lung…”
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Palladium-103 (103Pd/103mRh), a promising Auger-electron emitter for targeted radionuclide therapy of disseminated tumor cells - absorbed doses in single cells and clusters, with comparison to 177Lu and 161Tb by Hindié, Elif, Larouze, Alexandre, Alcocer-Ávila, Mario, Morgat, Clément, Champion, Christophe

“…Early use of targeted radionuclide therapy (TRT) to eradicate disseminated tumor cells (DTCs) might offer cure. Selection of appropriate radionuclides is…”
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Rational design of NT-PSMA heterobivalent probes for prostate cancer theranostics by Previti, Santo, Bodin, Sacha, Rémond, Emmanuelle, Vimont, Delphine, Hindié, Elif, Morgat, Clément, Cavelier, Florine

“…Targeting the prostate-specific membrane antigen (PSMA) with radiopharmaceuticals for imaging and/or therapy has demonstrated significant advancement in the…”
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Comparative analysis of positron emitters for theranostic applications based on small bioconjugates highlighting 43Sc, 61Cu and 45Ti by Hindié, Elif, Köster, Ulli, Champion, Christophe, Zanotti-Fregonara, Paolo, Morgat, Clément

“…Background Targeted radionuclide therapy with 177 Lu-labelled small conjugates is expanding rapidly, and its success is linked to appropriate patient…”
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Design and Synthesis of 68Ga‐Labeled Peptide‐Based Heterodimers for Dual Targeting of NTS1 and GRPR by Bodin, Sacha, Previti, Santo, Jestin, Emmanuelle, Rémond, Emmanuelle, Vimont, Delphine, Lamare, Frédéric, Ait‐Arsa, Imade, Hindié, Elif, Cavelier, Florine, Morgat, Clément

“…Tumor heterogeneity remains one of the main obstacles for cancer diagnosis and treatment. The simultaneous targeting of several cancer biomarkers is an…”
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Targeted radioactive therapy for prostate cancer by Hindié, Elif, Morgat, Clément, Alcocer-Ávila, Mario E, Champion, Christophe

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Radiation protection considerations with [89Zr]Zr-girentuximab PET and surgery by Chowdhury, Adnan, Morgat, Clément, Bailly, Clement, Sunderland, John, Graves, Stephen A., Scott, Andrew M., Baker, Sean, Holman, Beverley F.

“…Background 89 Zr is emerging as a popular positron-emitting radionuclide for imaging; however, its 909 keV gamma emission presents shielding challenges, and…”
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