Výsledky vyhľadávania - "Mora, Thierry"

Physical Limit to Concentration Sensing Amid Spurious Ligands Autor Mora, Thierry

“…To adapt their behavior in changing environments, cells sense concentrations by binding external ligands to their receptors. However, incorrect ligands may…”
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Physical Limit to Concentration Sensing in a Changing Environment Autor Mora, Thierry, Nemenman, Ilya

“…Cells adapt to changing environments by sensing ligand concentrations using specific receptors. The accuracy of sensing is ultimately limited by the finite…”
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High-throughput immune repertoire analysis with IGoR Autor Marcou, Quentin, Mora, Thierry, Walczak, Aleksandra M.

“…High-throughput immune repertoire sequencing is promising to lead to new statistical diagnostic tools for medicine and biology. Successful implementations of…”
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Modeling and predicting the overlap of B- and T-cell receptor repertoires in healthy and SARS-CoV-2 infected individuals Autor Ruiz Ortega, María, Spisak, Natanael, Mora, Thierry, Walczak, Aleksandra M.

“…Adaptive immunity’s success relies on the extraordinary diversity of protein receptors on B and T cell membranes. Despite this diversity, the existence of…”
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How a well-adapted immune system is organized Autor Mayer, Andreas, Balasubramanian, Vijay, Mora, Thierry, Walczak, Aleksandra M

“…The repertoire of lymphocyte receptors in the adaptive immune system protects organisms from diverse pathogens. A well-adapted repertoire should be tuned to…”
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Antigenic waves of virus-immune coevolution Autor Marchi, Jacopo, Lässig, Michael, Walczak, Aleksandra M, Mora, Thierry

“…The evolution of many microbes and pathogens, including circulating viruses such as seasonal influenza, is driven by immune pressure from the host population…”
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Statistical mechanics for natural flocks of birds Autor Bialek, William, Cavagna, Andrea, Giardina, Irene, Mora, Thierry, Silvestri, Edmondo, Viale, Massimiliano, Walczak, Aleksandra M

“…Flocking is a typical example of emergent collective behavior, where interactions between individuals produce collective patterns on the large scale. Here we…”
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Dynamical Criticality in the Collective Activity of a Population of Retinal Neurons Autor Mora, Thierry, Deny, Stéphane, Marre, Olivier

“…Recent experimental results based on multielectrode and imaging techniques have reinvigorated the idea that large neural networks operate near a critical…”
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Genesis of the αβ T-cell receptor Autor Dupic, Thomas, Marcou, Quentin, Walczak, Aleksandra M., Mora, Thierry

“…The T-cell (TCR) repertoire relies on the diversity of receptors composed of two chains, called α and β, to recognize pathogens. Using results of high…”
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Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves Autor Adams, Rhys M, Mora, Thierry, Walczak, Aleksandra M, Kinney, Justin B

“…Despite the central role that antibodies play in the adaptive immune system and in biotechnology, much remains unknown about the quantitative relationship…”
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Single molecule microscopy reveals key physical features of repair foci in living cells Autor Miné-Hattab, Judith, Heltberg, Mathias, Villemeur, Marie, Guedj, Chloé, Mora, Thierry, Walczak, Aleksandra M, Dahan, Maxime, Taddei, Angela

“…In response to double strand breaks (DSB), repair proteins accumulate at damaged sites, forming membrane-less sub-compartments or foci. Here we explored the…”
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Fluctuating fitness shapes the clone-size distribution of immune repertoires Autor Desponds, Jonathan, Mora, Thierry, Walczak, Aleksandra M

“…The adaptive immune system relies on the diversity of receptors expressed on the surface of B- and T cells to protect the organism from a vast amount of…”
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Diversity of immune strategies explained by adaptation to pathogen statistics Autor Mayer, Andreas, Mora, Thierry, Rivoire, Olivier, Walczak, Aleksandra M

“…Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ…”
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How a well-adapting immune system remembers Autor Mayer, Andreas, Balasubramanian, Vijay, Walczak, Aleksandra M, Mora, Thierry

“…An adaptive agent predicting the future state of an environment must weigh trust in new observations against prior experiences. In this light, we propose a…”
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Neoantigen quality predicts immunoediting in survivors of pancreatic cancer Autor Łuksza, Marta, Sethna, Zachary M., Rojas, Luis A., Lihm, Jayon, Bravi, Barbara, Elhanati, Yuval, Soares, Kevin, Amisaki, Masataka, Dobrin, Anton, Hoyos, David, Guasp, Pablo, Zebboudj, Abderezak, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Odgerel, Zagaa, Leung, Joanne, Kappagantula, Rajya, Makohon-Moore, Alvin, Johns, Amber, Gill, Anthony, Gigoux, Mathieu, Wolchok, Jedd, Merghoub, Taha, Sadelain, Michel, Patterson, Erin, Monasson, Remi, Mora, Thierry, Walczak, Aleksandra M., Cocco, Simona, Iacobuzio-Donahue, Christine, Greenbaum, Benjamin D., Balachandran, Vinod P.

“…Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more immunogenic cancer cells to cause less immunogenic clones to dominate…”
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Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection Autor Minervina, Anastasia A, Komech, Ekaterina A, Titov, Aleksei, Bensouda Koraichi, Meriem, Rosati, Elisa, Mamedov, Ilgar Z, Franke, Andre, Efimov, Grigory A, Chudakov, Dmitriy M, Mora, Thierry, Walczak, Aleksandra M, Lebedev, Yuri B, Pogorelyy, Mikhail V

“…COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key role in the adaptive antiviral immune response by killing infected cells…”
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Social interactions dominate speed control in poising natural flocks near criticality Autor Bialek, William, Cavagna, Andrea, Giardina, Irene, Mora, Thierry, Pohl, Oliver, Silvestri, Edmondo, Viale, Massimiliano, Walczak, Aleksandra M

“…Flocks of birds exhibit a remarkable degree of coordination and collective response. It is not just that thousands of individuals fly, on average, in the same…”
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Thermodynamics and signatures of criticality in a network of neurons Autor Tkačik, Gašper, Mora, Thierry, Marre, Olivier, Amodei, Dario, Palmer, Stephanie E, Berry, 2nd, Michael J, Bialek, William

“…The activity of a neural network is defined by patterns of spiking and silence from the individual neurons. Because spikes are (relatively) sparse, patterns of…”
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Detecting T cell receptors involved in immune responses from single repertoire snapshots Autor Pogorelyy, Mikhail V., Minervina, Anastasia A., Shugay, Mikhail, Chudakov, Dmitriy M., Lebedev, Yuri B., Mora, Thierry, Walczak, Aleksandra M.

“…Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a vast diversity of pathogen-derived antigens. Our ability to extract…”
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Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies Autor Phillips, Angela M, Lawrence, Katherine R, Moulana, Alief, Dupic, Thomas, Chang, Jeffrey, Johnson, Milo S, Cvijovic, Ivana, Mora, Thierry, Walczak, Aleksandra M, Desai, Michael M

“…Over the past two decades, several broadly neutralizing antibodies (bnAbs) that confer protection against diverse influenza strains have been isolated…”
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