Search Results - "Moody, M Anthony"
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Influenza and Antibody-Dependent Cellular Cytotoxicity
ISSN: 1664-3224, 1664-3224Published: Switzerland Frontiers Media S.A 25.06.2019Published in Frontiers in immunology (25.06.2019)“…Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and pandemic rises in illness and death. An error prone replication…”
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A rhesus macaque model of Asian-lineage Zika virus infection
ISSN: 2041-1723, 2041-1723Published: London Nature Publishing Group UK 28.06.2016Published in Nature communications (28.06.2016)“…Infection with Asian-lineage Zika virus (ZIKV) has been associated with Guillain–Barré syndrome and fetal abnormalities, but the underlying mechanisms remain…”
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3
In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies
ISSN: 1097-4172, 1097-4172Published: United States 05.08.2021Published in Cell (05.08.2021)“…SARS-CoV-2-neutralizing antibodies (NAbs) protect against COVID-19. A concern regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement…”
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4
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses
ISSN: 1540-9538, 1540-9538Published: United States 04.06.2018Published in The Journal of experimental medicine (04.06.2018)“…T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and…”
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5
Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody
ISSN: 1091-6490, 1091-6490Published: United States 02.01.2018Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2018)“…Circulating influenza viruses evade neutralization in their human hosts by acquiring escape mutations at epitopes of prevalent antibodies. A goal for…”
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Viral receptor-binding site antibodies with diverse germline origins
ISSN: 1097-4172Published: United States 21.05.2015Published in Cell (21.05.2015)“…Vaccines for rapidly evolving pathogens will confer lasting immunity if they elicit antibodies recognizing conserved epitopes, such as a receptor-binding site…”
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Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors
ISSN: 1098-5514, 1098-5514Published: United States 01.10.2011Published in Journal of virology (01.10.2011)“…V2/V3 conformational epitope antibodies that broadly neutralize HIV-1 (PG9 and PG16) have been recently described. Since an elicitation of previously known…”
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8
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies
ISSN: 1097-4172, 1097-4172Published: United States 27.05.2021Published in Cell (27.05.2021)“…Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied the evolution of glycan-reactive B cells of rhesus macaques and humans…”
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9
Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG
ISSN: 1091-6490, 1091-6490Published: United States 28.05.2013Published in Proceedings of the National Academy of Sciences - PNAS (28.05.2013)“…Analysis of correlates of risk of infection in the RV144 HIV-1 vaccine efficacy trial demonstrated that plasma IgG against the HIV-1 envelope (Env) variable…”
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10
Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth
ISSN: 1529-2908, 1529-2916, 1529-2916Published: New York Nature Publishing Group US 01.02.2020Published in Nature immunology (01.02.2020)“…A goal of HIV vaccine development is to elicit antibodies with neutralizing breadth. Broadly neutralizing antibodies (bNAbs) to HIV often have unusual…”
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11
Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin
ISSN: 1091-6490, 1091-6490Published: United States 23.08.2011Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2011)“…Seasonal antigenic drift of circulating influenza virus leads to a requirement for frequent changes in vaccine composition, because exposure or vaccination…”
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12
Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge
ISSN: 2041-1723, 2041-1723Published: London Nature Publishing Group UK 08.06.2017Published in Nature communications (08.06.2017)“…The RV144 Thai trial HIV-1 vaccine of recombinant poxvirus (ALVAC) and recombinant HIV-1 gp120 subtype B/subtype E (B/E) proteins demonstrated 31% vaccine…”
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Treponema pallidum genetic diversity and its implications for targeted vaccine development: A cross-sectional study of early syphilis cases in Southwestern Colombia
ISSN: 1932-6203, 1932-6203Published: United States Public Library of Science 19.07.2024Published in PloS one (19.07.2024)“…Venereal syphilis, caused by the spirochete Treponema pallidum subsp. pallidum (TPA), is surging worldwide, underscoring the need for a vaccine with global…”
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Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies
ISSN: 1097-4172, 1097-4172Published: United States 31.07.2014Published in Cell (31.07.2014)“…Development of strategies for induction of HIV-1 broadly neutralizing antibodies (bnAbs) by vaccines is a priority. Determining the steps of bnAb induction in…”
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Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies
ISSN: 1946-6242, 1946-6242Published: United States 15.03.2017Published in Science translational medicine (15.03.2017)“…A preventive HIV-1 vaccine should induce HIV-1-specific broadly neutralizing antibodies (bnAbs). However, bnAbs generally require high levels of somatic…”
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A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection
ISSN: 1098-5514, 1098-5514Published: United States 01.06.2012Published in Journal of virology (01.06.2012)“…Variants near the HLA-DP gene show the strongest genome-wide association with chronic hepatitis B virus (HBV) infection and HBV recovery/persistence in Asians…”
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Innovations in HIV-1 Vaccine Design
ISSN: 0149-2918, 1879-114X, 1879-114XPublished: United States Elsevier Inc 01.03.2020Published in Clinical therapeutics (01.03.2020)“…The field of HIV-1 vaccinology has evolved during the last 30 years from the first viral vector HIV gene insert constructs to vaccination regimens using a…”
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18
Transient inhibition of lysosomal functions potentiates nucleic acid vaccines
ISSN: 1091-6490, 1091-6490Published: United States 31.10.2023Published in Proceedings of the National Academy of Sciences - PNAS (31.10.2023)“…Nucleic acid vaccines have shown promising results in the clinic against infectious diseases and cancers. To robustly improve the vaccine efficacy and safety,…”
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Influence of HLA-C expression level on HIV control
ISSN: 1095-9203, 1095-9203Published: United States 05.04.2013Published in Science (American Association for the Advancement of Science) (05.04.2013)“…A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also…”
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Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2
ISSN: 1097-4180, 1097-4180Published: United States 24.01.2013Published in Immunity (Cambridge, Mass.) (24.01.2013)“…The RV144 HIV-1 trial of the canary pox vector (ALVAC-HIV) plus the gp120 AIDSVAX B/E vaccine demonstrated an estimated efficacy of 31%, which correlated…”
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