Suchergebnisse - "Montefiori, Lindsey E"

A promoter interaction map for cardiovascular disease genetics von Montefiori, Lindsey E, Sobreira, Debora R, Sakabe, Noboru J, Aneas, Ivy, Joslin, Amelia C, Hansen, Grace T, Bozek, Grazyna, Moskowitz, Ivan P, McNally, Elizabeth M, Nóbrega, Marcelo A

“… Over 500 genetic loci have been associated with risk of cardiovascular diseases (CVDs); however, most loci are located in gene-distal non-coding regions and …”
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A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci von Joslin, Amelia C., Sobreira, Débora R., Hansen, Grace T., Sakabe, Noboru J., Aneas, Ivy, Montefiori, Lindsey E., Farris, Kathryn M., Gu, Jing, Lehman, Donna M., Ober, Carole, He, Xin, Nóbrega, Marcelo A.

“… Genome-wide association studies (GWAS) have identified many disease-associated variants, yet mechanisms underlying these associations remain unclear. To …”
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Identification of atrial fibrillation associated genes and functional non-coding variants von van Ouwerkerk, Antoinette F., Bosada, Fernanda M., van Duijvenboden, Karel, Hill, Matthew C., Montefiori, Lindsey E., Scholman, Koen T., Liu, Jia, de Vries, Antoine A. F., Boukens, Bastiaan J., Ellinor, Patrick T., Goumans, Marie José T. H., Efimov, Igor R., Nobrega, Marcelo A., Barnett, Phil, Martin, James F., Christoffels, Vincent M.

“… Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of …”
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Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region von Aneas, Ivy, Decker, Donna C., Howard, Chanie L., Sobreira, Débora R., Sakabe, Noboru J., Blaine, Kelly M., Stein, Michelle M., Hrusch, Cara L., Montefiori, Lindsey E., Tena, Juan, Magnaye, Kevin M., Clay, Selene M., Gern, James E., Jackson, Daniel J., Altman, Matthew C., Naureckas, Edward T., Hogarth, Douglas K., White, Steven R., Gomez-Skarmeta, Jose Luis, Schoetler, Nathan, Ober, Carole, Sperling, Anne I., Nóbrega, Marcelo A.

“… Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the underlying mechanisms remain unclear. Here, we identify a 5 kb region …”
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Staying in the loop blocks oncogene activation von Iacobucci, Ilaria, Montefiori, Lindsey E

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Redefining the biological basis of lineage-ambiguous leukemia through genomics: BCL11B deregulation in acute leukemias of ambiguous lineage von Montefiori, Lindsey E., Mullighan, Charles G.

“… Acute leukemias of ambiguous lineage (ALAL), including mixed phenotype acute leukemia (MPAL) and related entities such as early T-cell precursor acute leukemia …”
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The genomic basis of childhood T-lineage acute lymphoblastic leukaemia von Pölönen, Petri, Di Giacomo, Danika, Seffernick, Anna Eames, Elsayed, Abdelrahman, Kimura, Shunsuke, Benini, Francesca, Montefiori, Lindsey E., Wood, Brent L., Xu, Jason, Chen, Changya, Cheng, Zhongshan, Newman, Haley, Myers, Jason, Iacobucci, Ilaria, Li, Elizabeth, Sussman, Jonathan, Hedges, Dale, Hui, Yawei, Diorio, Caroline, Uppuluri, Lahari, Frank, David, Fan, Yiping, Chang, Yunchao, Meshinchi, Soheil, Ries, Rhonda, Shraim, Rawan, Li, Alexander, Bernt, Kathrin M., Devidas, Meenakshi, Winter, Stuart S., Dunsmore, Kimberly P., Inaba, Hiroto, Carroll, William L., Ramirez, Nilsa C., Phillips, Aaron H., Kriwacki, Richard W., Yang, Jun J., Vincent, Tiffaney L., Zhao, Yaqi, Ghate, Pankaj S., Wang, Jian, Reilly, Colleen, Zhou, Xin, Sanders, Mathijs A., Takita, Junko, Kato, Motohiro, Takasugi, Nao, Chang, Bill H., Press, Richard D., Loh, Mignon, Rampersaud, Evadnie, Raetz, Elizabeth, Hunger, Stephen P., Tan, Kai, Chang, Ti-Cheng, Wu, Gang, Pounds, Stanley B., Mullighan, Charles G., Teachey, David T.

“… T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour 1 that has eluded comprehensive genomic characterization, which is partly due to the high …”
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Gene therapy for pathologic gene expression von Montefiori, Lindsey E, Nobrega, Marcelo A

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Venetoclax plus gilteritinib is effective in preclinical models of FLT3-mutant BCL11B-a lineage-ambiguous leukemia von Montefiori, Lindsey E, Iacobucci, Ilaria, Gao, Qingsong, Moore, Jamila, Wright, William C, Wei, Huimei, Baviskar, Pradyumna, Sona, Surbhi, Jin, Hongjian, Budhraja, Amit, Lott, Josi, Tatarata, Qi Zhang, Cheng, Zhongshan, Khan, Tanya, Backhaus Wagner, Emily A, Johnson, Melissa, Mehr, Cyrus M, Freeman, Burgess, Janke, Laura, Haferlach, Torsten, Geeleher, Paul, Mead, Paul E, Konopleva, Marina, Opferman, Joseph T, Mullighan, Charles G

“… Aberrant activation of BCL11B (BCL11B-a) defines a subtype of lineage-ambiguous leukemias with T-lymphoid and myeloid features, co-occurring activating FLT3 …”
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Repurposing the Whole Expression Transcriptome Assay for the Genetic Diagnosis of T-Cell Acute Lymphoblastic Leukemia and Lymphoma von Bardelli, Valentina, Arniani, Silvia, Pierini, Valentina, Nardelli, Carlotta, Matteucci, Caterina, Lema Fernandez, Anair Graciela, Crocioni, Maria, Cerrano, Marco, Salutari, Prassede, Papayanidis, Cristina, Trappolini, Silvia, Giglio, Fabio, Mastaglio, Sara, Zappasodi, Patrizia, Pasciolla, Crescenza, Defina, Marzia, Piccini, Matteo, Lanzarone, Giuseppe, Di Giacomo, Danika, Sica, Simona, Montefiori, Lindsey E, Mullighan, Charles G, Mecucci, Cristina, La Starza, Roberta

“… Unlike other cases of acute leukemia, the diagnosis of T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) is uniquely based on morphology and flow …”
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Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia von Montefiori, Lindsey E, Bendig, Sonja, Gu, Zhaohui, Chen, Xiaolong, Pölönen, Petri, Ma, Xiaotu, Murison, Alex, Zeng, Andy, Garcia-Prat, Laura, Dickerson, Kirsten, Iacobucci, Ilaria, Abdelhamed, Sherif, Hiltenbrand, Ryan, Mead, Paul E, Mehr, Cyrus M, Xu, Beisi, Cheng, Zhongshan, Chang, Ti-Cheng, Westover, Tamara, Ma, Jing, Stengel, Anna, Kimura, Shunsuke, Qu, Chunxu, Valentine, Marcus B, Rashkovan, Marissa, Luger, Selina, Litzow, Mark R, Rowe, Jacob M, den Boer, Monique L, Wang, Victoria, Yin, Jun, Kornblau, Steven M, Hunger, Stephen P, Loh, Mignon L, Pui, Ching-Hon, Yang, Wenjian, Crews, Kristine R, Roberts, Kathryn G, Yang, Jun J, Relling, Mary V, Evans, William E, Stock, Wendy, Paietta, Elisabeth M, Ferrando, Adolfo A, Zhang, Jinghui, Kern, Wolfgang, Haferlach, Torsten, Wu, Gang, Dick, John E, Klco, Jeffery M, Haferlach, Claudia, Mullighan, Charles G

“… Lineage-ambiguous leukemias are high-risk malignancies of poorly understood genetic basis. Here, we describe a distinct subgroup of acute leukemia with …”
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Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development von Boogerd, Cornelis J, Zhu, Xiaoming, Aneas, Ivy, Sakabe, Noboru J, Zhang, Lunfeng, Sobreira, Debora R, Montefiori, Lindsey E, Bogomolovas, Julius, Joslin, Amelia C, Zhou, Bin, Chen, Ju, Nobrega, Marcelo, Evans, Sylvia M

“… Mutations in the transcription factor TBX20 are associated with congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development and …”
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Asthma-associated variants induce IL33 differential expression through a novel regulatory region von Aneas, Ivy, Decker, Donna C, Howard, Chanie L, Sobreira, Débora R, Sakabe, Noboru J, Blaine, Kelly M, Stein, Michelle M, Hrusch, Cara L, Montefiori, Lindsey E, Tena, Juan, Magnaye, Kevin M, Clay, Selene M, Gern, James E, Jackson, Daniel J, Altman, Matthew C, Naureckas, Edward T, Hogarth, Douglas K, White, Steven R, Gomez-Skarmeta, Jose Luis, Schoetler, Nathan, Ober, Carole, Sperling, Anne I, Nobrega, Marcelo A

“… ABSTRACT Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the underlying mechanisms remain unclear. Here, we identify a 5 …”
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ALL-144: Oncogenic Deregulation of BCL11B in Lineage Ambiguous Leukemia von Montefiori, Lindsey E., Bendig, Sonja, Gu, Zhaohui, Chen, Xiaolong, Polonen, Petri, Ma, Xiaotu, Murison, Alex, Zeng, Andy, Garcia-Prat, Laura, Dickerson, Kirsten, Iacobucci, Ilaria, Abdelhamed, Sherif, Hiltenbrand, Ryan, Mead, Paul E., Mehr, Cyrus M., Xu, Beisi, Cheng, Zhongshan, Chang, Ti-Cheng, Westover, Tamara, Ma, Jing, Stengel, Anna, Kimura, Shunsuke, Qu, Chunxu, Valentine, Marcus B., Rashkovan, Marissa, Luger, Selina, Litzow, Mark R., Rowe, Jacob M., den Boer, Monique L., Wang, Victoria, Yin, Jun, Kornblau, Steven M., Hunger, Stephen P., Loh, Mignon L., Pui, Ching-Hon, Yang, Wenjian, Crews, Kristine R., Roberts, Kathryn G., Yang, Jun J., Relling, Mary V., Evans, William E., Stock, Wendy, Paietta, Elisabeth M., Ferrando, Adolfo A., Zhang, Jinghui, Kern, Wolfgang, Haferlach, Torsten, Wu, Gang, Dick, John E., Klco, Jeffery M., Haferlach, Claudia, Mullighan, Charles G.

“… Acute leukemias of ambiguous lineage (ALAL) pose significant diagnostic and therapeutic challenges due to lack of clarity surrounding their cellular origins …”
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Poster: ALL-144: Oncogenic Deregulation of BCL11B in Lineage Ambiguous Leukemia von Montefiori, Lindsey E., Bendig, Sonja, Gu, Zhaohui, Chen, Xiaolong, Polonen, Petri, Ma, Xiaotu, Murison, Alex, Zeng, Andy, Garcia-Prat, Laura, Dickerson, Kirsten, Iacobucci, Ilaria, Abdelhamed, Sherif, Hiltenbrand, Ryan, Mead, Paul E., Mehr, Cyrus M., Xu, Beisi, Cheng, Zhongshan, Chang, Ti-Cheng, Westover, Tamara, Ma, Jing, Stengel, Anna, Kimura, Shunsuke, Qu, Chunxu, Valentine, Marcus B., Rashkovan, Marissa, Luger, Selina, Litzow, Mark R., Rowe, Jacob M., den Boer, Monique L., Wang, Victoria, Yin, Jun, Kornblau, Steven M., Hunger, Stephen P., Loh, Mignon L., Pui, Ching-Hon, Yang, Wenjian, Crews, Kristine R., Roberts, Kathryn G., Yang, Jun J., Relling, Mary V., Evans, William E., Stock, Wendy, Paietta, Elisabeth M., Ferrando, Adolfo A., Zhang, Jinghui, Kern, Wolfgang, Haferlach, Torsten, Wu, Gang, Dick, John E., Klco, Jeffery M., Haferlach, Claudia, Mullighan, Charles G.

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A promoter interaction map for cardiovascular disease genetics von Montefiori, Lindsey E, Sobreira, Debora R, Sakabe, Noboru J, Aneas, Ivy, Joslin, Amelia C, Hansen, Grace T, Bozek, Grazyna, Moskowitz, Ivan P, Mcnally, Elizabeth M, Nobrega, Marcelo A

“… Over 500 genetic loci have been associated with risk of cardiovascular diseases (CVDs), however most loci are located in gene-distal non-coding regions and …”
Volltext