Výsledky vyhledávání - "Molecular cell"

Ferroptosis at the intersection of lipid metabolism and cellular signaling Autor Liang, Deguang, Minikes, Alexander M, Jiang, Xuejun

“…Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated to play an important role in multiple diseases including cancer,…”
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Redox metabolism: ROS as specific molecular regulators of cell signaling and function Autor Lennicke, Claudia, Cochemé, Helena M

“…Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes are indispensable for organismal physiology and life itself. The term…”
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A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells Autor Hoffmann, Markus, Kleine-Weber, Hannah, Pöhlmann, Stefan

“…The pandemic coronavirus SARS-CoV-2 threatens public health worldwide. The viral spike protein mediates SARS-CoV-2 entry into host cells and harbors a S1/S2…”
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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells Autor Xiong, Jia, He, Jia, Zhu, Jun, Pan, Jiongli, Liao, Weijie, Ye, Hongying, Wang, Haofei, Song, Yinjing, Du, Yue, Cui, Bijun, Xue, Maoguang, Zheng, Wanling, Kong, Xiangxing, Jiang, Kai, Ding, Kefeng, Lai, Lihua, Wang, Qingqing

“…Tumor-infiltrating myeloid cells (TIMs) are crucial cell populations involved in tumor immune escape, and their functions are regulated by multiple epigenetic…”
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Integrated lncRNA function upon genomic and epigenomic regulation Autor Herman, Allison B, Tsitsipatis, Dimitrios, Gorospe, Myriam

“…Although some long noncoding (lnc)RNAs are known since the 1950s, the past 25 years have uncovered myriad lncRNAs with diverse sequences, structures, and…”
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A conceptual framework for understanding phase separation and addressing open questions and challenges Autor Mittag, Tanja, Pappu, Rohit V

“…Macromolecular phase separation is being recognized for its potential importance and relevance as a driver of spatial organization within cells. Here, we…”
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Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy Autor Bader, Jackie E, Voss, Kelsey, Rathmell, Jeffrey C

“…The growing field of immune metabolism has revealed promising indications for metabolic targets to modulate anti-cancer immunity. Combination therapies…”
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Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers Autor Shi, Hailing, Wei, Jiangbo, He, Chuan

“…Cellular RNAs are naturally decorated with a variety of chemical modifications. The structural diversity of the modified nucleosides provides regulatory…”
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The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death Autor Ai, Youwei, Meng, Yutong, Yan, Bo, Zhou, Qinyi, Wang, Xiaodong

“…Apoptosis, the first regulated form of cell death discovered in mammalian cells, is executed by caspase-3/7, which are dormant in living cells but become…”
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Role of Mitochondria in Ferroptosis Autor Gao, Minghui, Yi, Junmei, Zhu, Jiajun, Minikes, Alexander M, Monian, Prashant, Thompson, Craig B, Jiang, Xuejun

“…Ferroptosis is a regulated necrosis process driven by iron-dependent lipid peroxidation. Although ferroptosis and cellular metabolism interplay with one…”
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Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1 Autor Yan, Bo, Ai, Youwei, Sun, Qi, Ma, Yan, Cao, Yang, Wang, Jiawen, Zhang, Zhiyuan, Wang, Xiaodong

“…Ferroptosis is a form of necrotic cell death caused by iron-dependent peroxidation of polyunsaturated phospholipids on cell membranes and is actively…”
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Mechanisms Controlling PD-L1 Expression in Cancer Autor Cha, Jong-Ho, Chan, Li-Chuan, Li, Chia-Wei, Hsu, Jennifer L, Hung, Mien-Chie

“…The engagement of programmed cell death protein 1 (PD-1; encoded by the PDCD1 gene) receptor expressed on activated T cells and its ligand, programmed…”
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RNA m6A methylation across the transcriptome Autor Sendinc, Erdem, Shi, Yang

“…Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In…”
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The Biogenesis, Functions, and Challenges of Circular RNAs Autor Li, Xiang, Yang, Li, Chen, Ling-Ling

“…Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing of exons of thousands of genes in eukaryotes. circRNAs are generally…”
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Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death Autor Cobine, Paul A, Brady, Donita C

“…Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme…”
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How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms Autor Corley, Meredith, Burns, Margaret C, Yeo, Gene W

“…RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with transcripts in all manner of RNA-driven processes. The structures…”
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Life of RISC: Formation, action, and degradation of RNA-induced silencing complex Autor Iwakawa, Hiro-Oki, Tomari, Yukihide

“…Small RNAs regulate a wide variety of biological processes by repressing the expression of target genes at the transcriptional and post-transcriptional levels…”
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Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity Autor Yoon, Haejin, Shaw, Jillian L, Haigis, Marcia C, Greka, Anna

“…Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular membranes, and regulate energy metabolism. Questions…”
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Reshaping endoplasmic reticulum quality control through the unfolded protein response Autor Wiseman, R Luke, Mesgarzadeh, Jaleh S, Hendershot, Linda M

“…Endoplasmic reticulum quality control (ERQC) pathways comprising chaperones, folding enzymes, and degradation factors ensure the fidelity of ER protein folding…”
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The CRISPR-Cas toolbox and gene editing technologies Autor Liu, Guanwen, Lin, Qiupeng, Jin, Shuai, Gao, Caixia

“…The emergence of CRISPR-Cas systems has accelerated the development of gene editing technologies, which are widely used in the life sciences. To improve the…”
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