Výsledky vyhledávání - "Molecular Targeted Therapy"

Molecular targeted therapy-related life-threatening toxicity in patients with malignancies. A systematic review of published cases Autor Assoun, Sandra, Lemiale, Virginie, Azoulay, Elie

“… The search used the Pubmed database using medical subject heading (Mesh) terms, including all FDA-approved molecular targeted therapy (TT), up to March 2019…”
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Prognosis of Japanese patients with previously untreated metastatic renal cell carcinoma in the era of molecular‐targeted therapy Autor Shinohara, Nobuo, Obara, Wataru, Tatsugami, Katsunori, Naito, Sei, Kamba, Tomomi, Takahashi, Masayuki, Murai, Sachiyo, Abe, Takashige, Oba, Koji, Naito, Seiji

“…‐targeted therapy and the clinical usefulness of the Japanese metastatic renal cancer (JMRC) prognostic classification…”
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FDG PET/CT after first molecular targeted therapy predicts survival of patients with renal cell carcinoma Autor Nakaigawa, Noboru, Kondo, Keiichi, Kaneta, Tomohiro, Tateishi, Ukihide, Minamimoto, Ryogo, Namura, Kazuhiro, Ueno, Daiki, Kobayashi, Kazuki, Kishida, Takeshi, Ikeda, Ichiro, Hasumi, Hisashi, Makiyama, Kazuhide, Hayashi, Narihiko, Osaka, Kimito, Muraoka, Kentaro, Izumi, Koji, Kawahara, Takashi, Teranishi, Jun-ichi, Miyoshi, Yasuhide, Yumura, Yasushi, Uemura, Hiroji, Inoue, Tomio, Yao, Masahiro

“…) can predict the overall survival (OS) of patients with advanced renal cell carcinoma (RCC) previously treated by molecular targeted therapies…”
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The support of human genetic evidence for approved drug indications Autor Nelson, Matthew R, Tipney, Hannah, Painter, Jeffery L, Shen, Judong, Nicoletti, Paola, Shen, Yufeng, Floratos, Aris, Sham, Pak Chung, Li, Mulin Jun, Wang, Junwen, Cardon, Lon R, Whittaker, John C, Sanseau, Philippe

“…Matthew Nelson and colleagues investigate how well genetic evidence for disease susceptibility predicts drug mechanisms. They find a correlation between gene…”
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Therapeutic targeting of acute myeloid leukemia stem cells Autor Pollyea, Daniel A, Jordan, Craig T

“…) and other forms of cancer. The nature and existence of tumor-initiating cells for leukemia and other malignancies have long been the subject of intense and rigorous study…”
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Game of thrones: immunotherapy versus molecular targeted therapy in renal cell cancer scenarios Autor Cetin, Bulent, Kosar, Alim

“…Objectives Treatment for advanced renal cell carcinoma (RCC) has become increasingly more complex over the last several years. Objective 1 is to which…”
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The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies Autor Brunner, Patrick M., Guttman-Yassky, Emma, Leung, Donald Y.M.

“…Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is driven by both terminal keratinocyte differentiation defects and strong type 2…”
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New Horizons for Precision Medicine in Biliary Tract Cancers Autor Valle, Juan W, Lamarca, Angela, Goyal, Lipika, Barriuso, Jorge, Zhu, Andrew X

“…Biliary tract cancers (BTC), including cholangiocarcinoma and gallbladder cancer, are poor-prognosis and low-incidence cancers, although the incidence of…”
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The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer Autor Ward, Jeffrey P, Gubin, Matthew M, Schreiber, Robert D

“… These antigens are derived from nonsynonymous mutations that occur during cellular transformation and, because they are foreign to the host genome, are not subject to central tolerance…”
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Tezacaftor/Ivacaftor in Subjects with Cystic Fibrosis and F508del / F508del-CFTR or F508del / G551D-CFTR Autor Donaldson, Scott H., Pilewski, Joseph M., Griese, Matthias, Cooke, Jon, Viswanathan, Lakshmi, Tullis, Elizabeth, Davies, Jane C., Lekstrom-Himes, Julie A., Wang, Linda T.

“… combination therapy in subjects with cystic fibrosis homozygous for F508del or compound heterozygous for F508del and G551D…”
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The kinome 'at large' in cancer Autor Fleuren, Emmy D. G., Zhang, Luxi, Wu, Jianmin, Daly, Roger J.

“… protein kinases that represent likely cancer drivers. However, the number of protein kinases subject to functionally relevant mutations is likely to be greater…”
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Role of RNA modifications in cancer Autor Barbieri, Isaia, Kouzarides, Tony

“…Specific chemical modifications of biological molecules are an efficient way of regulating molecular function, and a plethora of downstream signalling pathways…”
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Cancer therapy: an evolved approach Autor Willyard, Cassandra

“…Tumours are subject to the same rules of natural selection as any other living thing…”
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Persister cancer cells: Iron addiction and vulnerability to ferroptosis Autor Rodriguez, Raphaël, Schreiber, Stuart L, Conrad, Marcus

“…Ferroptosis is a unique type of non-apoptotic cell death resulting from the unrestrained occurrence of peroxidized phospholipids, which are subject to iron-mediated production of lethal oxygen radicals…”
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Prognosis of J apanese patients with previously untreated metastatic renal cell carcinoma in the era of molecular‐targeted therapy Autor Shinohara, Nobuo, Obara, Wataru, Tatsugami, Katsunori, Naito, Sei, Kamba, Tomomi, Takahashi, Masayuki, Murai, Sachiyo, Abe, Takashige, Oba, Koji, Naito, Seiji

“…‐targeted therapy and the clinical usefulness of the Japanese metastatic renal cancer ( JMRC ) prognostic classification…”
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Opioid receptors: drivers to addiction? Autor Darcq, Emmanuel, Kieffer, Brigitte Lina

“…Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder…”
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The noradrenergic pain regulation system: A potential target for pain therapy Autor Pertovaara, Antti

“…Noradrenaline, through action on α1- and α2-adrenoceptors, is involved in intrinsic control of pain. Peripheral noradrenaline that is mainly released by the…”
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Potential for HER-2/neu molecular targeted therapy for invasive bladder carcinoma: comparative study of immunohistochemistry and fluorescent in situ hybridization Autor Matsubara, Hiroyuki, Yamada, Yoshiaki, Naruse, Katsuya, Nakamura, Kogenta, Aoki, Shigeyuki, Taki, Tomohiro, Tobiume, Motoi, Zennami, Kenji, Katsuda, Remi, Honda, Nobuaki

“…Analysis of HER-2/neu expression in invasive bladder carcinoma was performed in order to evaluate the potential for molecular targeted therapy targeting HER-2…”
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Cysteine cathepsins and extracellular matrix degradation Autor Fonović, Marko, Turk, Boris

“…Cysteine cathepsins are normally found in the lysosomes where they are involved in intracellular protein turnover. Their ability to degrade the components of…”
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Trends in survival of leukemia among children, adolescents, and young adults: A population‐based study in Osaka, Japan Autor Nakata, Kayo, Okawa, Sumiyo, Fuji, Shigeo, Sato, Akira, Morishima, Toshitaka, Tada, Yuma, Inoue, Masami, Hara, Junichi, Kawa, Keisei, Miyashiro, Isao

“…‐based cancer registry data from Osaka, Japan. The study subjects comprised 2254 children (0‐14 years) and 2,905 AYAs (15‐39 years…”
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