Search Results - "Molecular Medicine"

Indole and p-cresol in feces of healthy subjects: Concentration, kinetics, and correlation with microbiome by Candeliere, Francesco, Simone, Marta, Leonardi, Alan, Rossi, Maddalena, Amaretti, Alberto, Raimondi, Stefano

“…Indole and p-cresol are precursors of the most important uremic toxins, generated from the fermentation of amino acids tryptophan and tyrosine by the…”
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Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease by Moreno-Jiménez, Elena P, Flor-García, Miguel, Terreros-Roncal, Julia, Rábano, Alberto, Cafini, Fabio, Pallas-Bazarra, Noemí, Ávila, Jesús, Llorens-Martín, María

“…The hippocampus is one of the most affected areas in Alzheimer's disease (AD) . Moreover, this structure hosts one of the most unique phenomena of the adult…”
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A machine learning approach to radiogenomics of breast cancer: a study of 922 subjects and 529 DCE-MRI features by Saha, Ashirbani, Harowicz, Michael R, Grimm, Lars J, Kim, Connie E, Ghate, Sujata V, Walsh, Ruth, Mazurowski, Maciej A

“…Recent studies showed preliminary data on associations of MRI-based imaging phenotypes of breast tumours with breast cancer molecular, genomic, and related…”
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Alterations in lipid, amino acid, and energy metabolism distinguish Crohn’s disease from ulcerative colitis and control subjects by serum metabolomic profiling by Scoville, Elizabeth A., Allaman, Margaret M., Brown, Caroline T., Motley, Amy K., Horst, Sara N., Williams, Christopher S., Koyama, Tatsuki, Zhao, Zhiguo, Adams, Dawn W., Beaulieu, Dawn B., Schwartz, David A., Wilson, Keith T., Coburn, Lori A.

“…), and non-IBD subjects. Methods Serum samples from 20 UC, 20 CD, and 20 non-IBD control subjects were obtained along with patient characteristics, including medication use and clinical disease activity…”
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First-in-Human Study on Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Escalating Doses of HEC88473, a Novel Dual GLP-1 and FGF21 Receptor Agonist in Healthy and Obese Chinese Subjects: First-in-Human Study of Single Escalating Doses of HEC88473 by Zhang, Hong, Li, Qianqian, Chen, Hong, Guo, Lingfeng, Li, Jing, Xie, Can, Yan, Jiangyu, Ding, Yanhua

“…) were evaluated in a phase I, single-ascending dose trial with healthy and obese subjects. Serum glucose, lipid, and adiponectin levels were evaluated…”
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A Phase I study of the novel immunomodulatory agent PG545 (pixatimod) in subjects with advanced solid tumours by Dredge, Keith, Brennan, Todd V, Hammond, Edward, Lickliter, Jason D, Lin, Liwen, Bampton, Darryn, Handley, Paul, Lankesheer, Fleur, Morrish, Glynn, Yang, Yiping, Brown, Michael P, Millward, Michael

“… Twenty-three subjects were enrolled across four cohorts (25, 50, 100 and 150 mg). Three dose-limiting toxicities (DLTs)-hypertension (2), epistaxis (1…”
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Integrating noninvasive molecular imaging into molecular medicine: an evolving paradigm by Massoud, Tarik F., Gambhir, Sanjiv S.

“… Integration of the two disciplines of molecular imaging and molecular medicine, combined with systems-biology approaches to understanding disease complexity, promises to provide predictive…”
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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation by Li, Jia-Yi, Englund, Elisabet, Holton, Janice L, Soulet, Denis, Hagell, Peter, Lees, Andrew J, Lashley, Tammaryn, Quinn, Niall P, Rehncrona, Stig, Björklund, Anders, Widner, Håkan, Revesz, Tamas, Lindvall, Olle, Brundin, Patrik

“…Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11–16 years) developed α-synuclein…”
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Salivary microRNAs as new molecular markers in cleft lip and palate: a new frontier in molecular medicine by Grassia, Vincenzo, Lombardi, Angela, Kawasaki, Hiromichi, Ferri, Carmela, Perillo, Letizia, Mosca, Laura, Delle Cave, Donatella, Nucci, Ludovica, Porcelli, Marina, Caraglia, Michele

“… The control group was created selecting twelve healthy subjects matched for age and sex with study group…”
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HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects by J Buzón, Maria, Massanella, Marta, Llibre, Josep M, Esteve, Anna, Dahl, Viktor, Puertas, Maria C, Gatell, Josep M, Domingo, Pere, Paredes, Roger, Sharkey, Mark, Palmer, Sarah, Stevenson, Mario, Clotet, Bonaventura, Blanco, Julià, Martinez-Picado, Javier

“…Despite highly active antiretroviral therapy, active replication persists and drives immune activation in some individuals with HIV. This activation is higher…”
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Comparison of Pharmacokinetic Similarity, Immunogenicity, and Safety of Ustekinumab and BAT2206 in Healthy Chinese Male Subjects in a Double-Blind, Randomized, Single-Dose, Parallel-Group Phase I Trial: Comparison of Pharmacokinetic Similarity, Immunogenicity, and Safety of Ustekinumab and BAT2206 by Wu, Min, Li, Xiaojiao, Yang, Deming, Wang, Meng, Zhang, Hong, Li, Cuiyun, Mai, Jiajia, Yang, Lizhi, Qi, Yunpeng, Yu, Jin-Chen, Yang, Xiaolei, Wang, Zhaohe, Gu, Cailing, Ding, Yanhua

“…Objective We aimed to evaluate the similarity of BAT2206 to its originator, ustekinumab, including pharmacokinetic profiles, immunogenicity, and safety in healthy Chinese male subjects…”
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Estimating metabolite networks subject to dietary preferences and lifestyle by Bartzis, Georgios, Peeters, Carel F. W., Uh, Hae-Won, Houwing-Duistermaat, Jeanine J., van Eeuwijk, Fred A.

“…Introduction The metabolome is an intermediate between DNA variation and clinical phenotypes. Metabolomics have been widely used in biomedical studies for…”
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Pathogenic STX3 variants affecting the retinal and intestinal transcripts cause an early-onset severe retinal dystrophy in microvillus inclusion disease subjects by Janecke, Andreas R., Liu, Xiaoqin, Adam, Rüdiger, Punuru, Sumanth, Viestenz, Arne, Strauß, Valeria, Laass, Martin, Sanchez, Elizabeth, Adachi, Roberto, Schatz, Martha P., Saboo, Ujwala S., Mittal, Naveen, Rohrschneider, Klaus, Escher, Johanna, Ganesh, Anuradha, Al Zuhaibi, Sana, Al Murshedi, Fathiya, AlSaleem, Badr, Alfadhel, Majid, Al Sinani, Siham, Alkuraya, Fowzan S., Huber, Lukas A., Müller, Thomas, Heidelberger, Ruth, Janz, Roger

“…Biallelic STX3 variants were previously reported in five individuals with the severe congenital enteropathy, microvillus inclusion disease (MVID). Here, we…”
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Lifestyle, body mass index, diabetes, and the risk of pancreatic cancer in a nationwide population-based cohort study with 7.4 million Korean subjects by Park, Byung Kyu, Seo, Jeong Hun, Chung, Jae Bock, Choi, Jung Kyu

“… We investigated the risk factors for pancreatic cancer. Using the Korean National Health Insurance database, subjects who participated in the health examination program between 2005 and 2006 were identified and followed up until 2017…”
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A genome-wide association study identifies a novel East Asian–specific locus for dementia with Lewy bodies in Japanese subjects by Mitsumori, Risa, Asanomi, Yuya, Morizono, Takashi, Shigemizu, Daichi, Niida, Shumpei, Ozaki, Kouichi

“… Methods We conducted a genome-wide association study (GWAS) in Japanese subjects (211 DLB cases and 6113 controls…”
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Correction to: Exploring the missing heritability in subjects with hearing loss, enlarged vestibular aqueducts, and a single or no pathogenic SLC26A4 variant by Smits, Jeroen J., de Bruijn, Suzanne E., Lanting, Cornelis P., Oostrik, Jaap, O’Gorman, Luke, Mantere, Tuomo, Cremers, Frans P. M., Roosing, Susanne, Yntema, Helger G., de Vrieze, Erik, Derks, Ronny, Hoischen, Alexander, Pegge, Sjoert A. H., Neveling, Kornelia, Pennings, Ronald J. E., Kremer, Hannie

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Gestational Dating by Urine Metabolic Profile at High Resolution Weekly Sampling Timepoints: Discovery and Validation by Sylvester, Karl G., Hao, Shiying, Li, Zhen, Han, Zhi, Tian, Lu, Ladella, Subhashini, Wong, Ronald J., Shaw, Gary M., Stevenson, David K., Cohen, Harvey J., Whitin, John C., McElhinney, Doff B., Ling, Xuefeng B.

“…: Two independent, normal pregnancy cohorts with high-density weekly urine sampling (discovery: 478 samples from 19 subjects at California…”
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Early detection of colorectal neoplasia: application of a blood-based serological protein test on subjects undergoing population-based screening by Kleif, Jakob, Jørgensen, Lars Nannestad, Hendel, Jakob W, Madsen, Mogens R, Vilandt, Jesper, Brandsborg, Søren, Andersen, Lars Maagaard, Khalid, Ali, Ingeholm, Peter, Ferm, Linnea, Davis, Gerard J, Gawel, Susan H, Martens, Frans, Andersen, Berit, Rasmussen, Morten, Christensen, Ib Jarle, Nielsen, Hans Jørgen

“…Blood-based biomarkers used for colorectal cancer screening need to be developed and validated in appropriate screening populations. We aimed to develop a…”
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Safety of Intravitreal Gene Therapy for Treatment of Subjects with Leber Hereditary Optic Neuropathy due to Mutations in the Mitochondrial ND4 Gene: The REVEAL Study by Vignal-Clermont, Catherine, Girmens, Jean-François, Audo, Isabelle, Said, Saddek Mohand, Errera, Marie-Hélène, Plaine, Lise, O’Shaughnessy, Denis, Taiel, Magali, Sahel, José-Alain

“… LHON remains a disease with a high unmet medical need. Objective This is a report of an open-label, single-center, dose-escalation study that evaluated the safety and tolerability of lenadogene nolparvovec in 15 subjects with LHON for up to…”
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A study of 9 common breath VOCs in 504 healthy subjects using PTR-TOF-MS by Jia, Zhunan, Ong, Wei Qiang, Zhang, Fuchang, Du, Fang, Thavasi, Velmurugan, Thirumalai, Venkatesan

“…Introduction This study employs Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) to analyze exhaled breath profiles of 504 healthy adults, focusing on nine…”
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