Výsledky vyhledávání - "Modesti, Mauro"

A pinch of RNA spices up DNA repair Autor Modesti, Mauro

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Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling Autor Lee, Wei Ting C., Yin, Yandong, Morten, Michael J., Tonzi, Peter, Gwo, Pam Pam, Odermatt, Diana C., Modesti, Mauro, Cantor, Sharon B., Gari, Kerstin, Huang, Tony T., Rothenberg, Eli

“…Guanine-rich DNA sequences occur throughout the human genome and can transiently form G-quadruplex (G4) structures that may obstruct DNA replication, leading…”
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Sequential role of RAD51 paralog complexes in replication fork remodeling and restart Autor Berti, Matteo, Teloni, Federico, Mijic, Sofija, Ursich, Sebastian, Fuchs, Jevgenij, Palumbieri, Maria Dilia, Krietsch, Jana, Schmid, Jonas A., Garcin, Edwige B., Gon, Stéphanie, Modesti, Mauro, Altmeyer, Matthias, Lopes, Massimo

“…Homologous recombination (HR) factors were recently implicated in DNA replication fork remodeling and protection. While maintaining genome stability,…”
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STING protects breast cancer cells from intrinsic and genotoxic-induced DNA instability via a non-canonical, cell-autonomous pathway Autor Cheradame, Laura, Guerrera, Ida Chiara, Gaston, Julie, Schmitt, Alain, Jung, Vincent, Goudin, Nicolas, Pouillard, Marion, Radosevic-Robin, Nina, Modesti, Mauro, Judde, Jean-Gabriel, Cairo, Stefano, Goffin, Vincent

“…STING (Stimulator of Interferon Genes) is an endoplasmic reticulum-anchored adaptor of the innate immunity best known to trigger pro-inflammatory cytokine…”
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RADX Modulates RAD51 Activity to Control Replication Fork Protection Autor Bhat, Kamakoti P., Krishnamoorthy, Archana, Dungrawala, Huzefa, Garcin, Edwige B., Modesti, Mauro, Cortez, David

“…RAD51 promotes homologous recombination repair (HR) of double-strand breaks and acts during DNA replication to facilitate fork reversal and protect nascent DNA…”
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Distinct pathways of homologous recombination controlled by the SWS1–SWSAP1–SPIDR complex Autor Prakash, Rohit, Sandoval, Thomas, Morati, Florian, Zagelbaum, Jennifer A., Lim, Pei-Xin, White, Travis, Taylor, Brett, Wang, Raymond, Desclos, Emilie C. B., Sullivan, Meghan R., Rein, Hayley L., Bernstein, Kara A., Krawczyk, Przemek M., Gautier, Jean, Modesti, Mauro, Vanoli, Fabio, Jasin, Maria

“…Homology-directed repair (HDR), a critical DNA repair pathway in mammalian cells, is complex, leading to multiple outcomes with different impacts on genomic…”
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Human RPA activates BLM’s bidirectional DNA unwinding from a nick Autor Qin, Zhenheng, Bi, Lulu, Hou, Xi-Miao, Zhang, Siqi, Zhang, Xia, Lu, Ying, Li, Ming, Modesti, Mauro, Xi, Xu-Guang, Sun, Bo

“…BLM is a multifunctional helicase that plays critical roles in maintaining genome stability. It processes distinct DNA substrates, but not nicked DNA, during…”
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XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining Autor Nemoz, Clement, Ropars, Virginie, Frit, Philippe, Gontier, Amandine, Drevet, Pascal, Yu, Jinchao, Guerois, Raphaël, Pitois, Aurelien, Comte, Audrey, Delteil, Christine, Barboule, Nadia, Legrand, Pierre, Baconnais, Sonia, Yin, Yandong, Tadi, Satish, Barbet-Massin, Emeline, Berger, Imre, Le Cam, Eric, Modesti, Mauro, Rothenberg, Eli, Calsou, Patrick, Charbonnier, Jean Baptiste

“…The Ku70-Ku80 (Ku) heterodimer binds rapidly and tightly to the ends of DNA double-strand breaks and recruits factors of the non-homologous end-joining (NHEJ)…”
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Lig3-dependent rescue of mouse viability and DNA double-strand break repair by catalytically inactive Lig4 Autor Medina-Suárez, David, Han, Li, O’Reilly, Sandra, Liu, Jiali, Wei, Chao, Brenière, Manon, Goff, Noah J, Chen, Chen, Modesti, Mauro, Meek, Katheryn, Harrington, Bonnie, Yu, Kefei

“…Abstract Recent studies have revealed a structural role for DNA ligase 4 (Lig4) in the maintenance of a repair complex during non-homologous end joining (NHEJ)…”
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PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF Autor Tadi, Satish K., Tellier-Lebègue, Carine, Nemoz, Clément, Drevet, Pascal, Audebert, Stéphane, Roy, Sunetra, Meek, Katheryn, Charbonnier, Jean-Baptiste, Modesti, Mauro

“…In mammalian cells, classical non-homologous end joining (c-NHEJ) is critical for DNA double-strand break repair induced by ionizing radiation and during V(D)J…”
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Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells Autor Garcin, Edwige B., Gon, Stéphanie, Sullivan, Meghan R., Brunette, Gregory J., Cian, Anne De, Concordet, Jean-Paul, Giovannangeli, Carine, Dirks, Wilhelm G., Eberth, Sonja, Bernstein, Kara A., Prakash, Rohit, Jasin, Maria, Modesti, Mauro

“…Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi…”
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Unraveling the structure of DNA during overstretching by using multicolor, single-molecule fluorescence imaging Autor van Mameren, Joost, Gross, Peter, Farge, Geraldine, Hooijman, Pleuni, Modesti, Mauro, Falkenberg, Maria, Wuite, Gijs J L, Peterman, Erwin J G

“…Single-molecule manipulation studies have revealed that double-stranded DNA undergoes a structural transition when subjected to tension. At forces that depend…”
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Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors Autor Santofimia-Castaño, Patricia, Fraunhoffer, Nicolas, Liu, Xi, Bessone, Ivan Fernandez, di Magliano, Marina Pasca, Audebert, Stephane, Camoin, Luc, Estaras, Matias, Brenière, Manon, Modesti, Mauro, Lomberk, Gwen, Urrutia, Raul, Soubeyran, Philippe, Neira, Jose Luis, Iovanna, Juan

“…We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid–liquid phase separation (LLPS). NUPR1-driven…”
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Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining Autor Normanno, Davide, Négrel, Aurélie, de Melo, Abinadabe J, Betzi, Stéphane, Meek, Katheryn, Modesti, Mauro

“…XRCC4 and DNA Ligase 4 (LIG4) form a tight complex that provides DNA ligase activity for classical non-homologous end joining (the predominant DNA…”
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Rab6 regulates transport and targeting of exocytotic carriers Autor Grigoriev, Ilya, Splinter, Daniël, Keijzer, Nanda, Wulf, Phebe S, Demmers, Jeroen, Ohtsuka, Toshihisa, Modesti, Mauro, Maly, Ivan V, Grosveld, Frank, Hoogenraad, Casper C, Akhmanova, Anna

“…Constitutive exocytosis delivers newly synthesized proteins, lipids, and other molecules from the Golgi apparatus to the cell surface. This process is mediated…”
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A noncatalytic function of the ligation complex during nonhomologous end joining Autor Cottarel, Jessica, Frit, Philippe, Bombarde, Oriane, Salles, Bernard, Négrel, Aurélie, Bernard, Stéphanie, Jeggo, Penny A, Lieber, Michael R, Modesti, Mauro, Calsou, Patrick

“…Nonhomologous end joining is the primary deoxyribonucleic acid (DNA) double-strand break repair pathway in multicellular eukaryotes. To initiate repair, Ku…”
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Reconstitution of anaphase DNA bridge recognition and disjunction Autor Sarlós, Kata, Biebricher, Andreas S, Bizard, Anna H, Bakx, Julia A M, Ferreté-Bonastre, Anna G, Modesti, Mauro, Paramasivam, Manikandan, Yao, Qi, Peterman, Erwin J G, Wuite, Gijs J L, Hickson, Ian D

“…Faithful chromosome segregation requires that the sister chromatids be disjoined completely. Defective disjunction can lead to the persistence of histone-free…”
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Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution Autor Candelli, Andrea, Holthausen, Jan Thomas, Depken, Martin, Brouwer, Ineke, Franker, Mariëlla A M, Marchetti, Margherita, Heller, Iddo, Bernard, Stéphanie, Garcin, Edwige B, Modesti, Mauro, Wyman, Claire, Wuite, Gijs J L, Peterman, Erwin J G

“…During recombinational repair of double-stranded DNA breaks, RAD51 recombinase assembles as a nucleoprotein filament around single-stranded DNA to form a…”
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The SMC-like RecN protein is at the crossroads of several genotoxic stress responses in Escherichia coli Autor Camus, Adrien, Espinosa, Elena, Zapater Baras, Pénélope, Singh, Parul, Quenech’Du, Nicole, Vickridge, Elise, Modesti, Mauro, Barre, François Xavier, Espéli, Olivier

“…DNA damage repair (DDR) is an essential process for living organisms and contributes to genome maintenance and evolution. DDR involves different pathways…”
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Probing Physical Properties of a DNA-Protein Complex Using Nanofluidic Channels Autor Frykholm, Karolin, Alizadehheidari, Mohammadreza, Fritzsche, Joachim, Wigenius, Jens, Modesti, Mauro, Persson, Fredrik, Westerlund, Fredrik

“…A method to investigate physical properties of a DNA‐protein complex in solution is demonstrated. By using tapered nanochannels and lipid passivation the…”
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