Suchergebnisse - "Misztak, Paulina"

Epigenetic marks and their relationship with BDNF in the brain of suicide victims von Misztak, Paulina, Pańczyszyn-Trzewik, Patrycja, Nowak, Gabriel, Sowa-Kućma, Magdalena

“… Background Suicide is a common phenomenon affecting people of all ages. There is a strong relationship between suicidal ideation and depressive disorders …”
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DNA Methylation in Depression and Depressive-Like Phenotype: Biomarker or Target of Pharmacological Intervention? von Paoli, Caterina, Misztak, Paulina, Mazzini, Giulia, Musazzi, Laura

“… Major depressive disorder (MDD) is a debilitating psychiatric disorder, the third leading global cause of disability. Regarding aetiopathogenetic mechanisms …”
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Sex and Circadian Rhythm Dependent Behavioral Effects of Chronic Stress in Mice and Modulation of Clock Genes in the Prefrontal Cortex von Mingardi, Jessica, Giovenzana, Mattia, Nicosia, Noemi, Misztak, Paulina, Ieraci, Alessandro, Musazzi, Laura

“… Behavioral stress is a recognized triggering factor for systemic diseases, including psychiatric disorders. The stress response is subjected to circadian …”
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Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase von Misztak, Paulina, Sowa-Kućma, Magdalena, Pańczyszyn-Trzewik, Patrycja, Szewczyk, Bernadeta, Nowak, Gabriel

“… Chronic stress is the key factor contributing to the development of depressive symptoms. Chronic restraint stress (CRS) is well validated and is one of the …”
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Repeated Sulforaphane Treatment Reverses Depressive-like Behavior and Exerts Antioxidant Effects in the Olfactory Bulbectomy Model in Mice von Pańczyszyn-Trzewik, Patrycja, Stachowicz, Katarzyna, Misztak, Paulina, Nowak, Gabriel, Sowa-Kućma, Magdalena

“… Growing evidence suggests that activators of nuclear factor erythroid-derived 2-like 2 (Nrf2), such as sulforaphane, may represent promising novel …”
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The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims von Młyniec, Katarzyna, Doboszewska, Urszula, Szewczyk, Bernadeta, Sowa-Kućma, Magdalena, Misztak, Paulina, Piekoszewski, Wojciech, Trela, Franciszek, Ostachowicz, Beata, Nowak, Gabriel

“… Zinc is one of the most important trace elements in our body. Patients suffering from depression show lower serum zinc levels compared to healthy controls …”
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Combined hyperforin and lanicemine treatment instead of ketamine or imipramine restores behavioral deficits induced by chronic restraint stress and dietary zinc restriction in mice von Pochwat, Bartłomiej, Misztak, Paulina, Masternak, Julia, Bączyńska, Ewa, Bijata, Krystian, Roszkowska, Matylda, Bijata, Monika, Włodarczyk, Jakub, Szafarz, Małgorzata, Wyska, Elżbieta, Muszyńska, Bożena, Krakowska, Agata, Opoka, Włodzimierz, Nowak, Gabriel, Szewczyk, Bernadeta

“… Clinical and preclinical studies show evidence that chronic stress or nutritional deficits in dietary zinc (Zn) intake may be risk factors for developing major …”
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Olfactory bulbectomy-induced changes in phospholipids and protein profiles in the hippocampus and prefrontal cortex of rats. A preliminary study using a FTIR spectroscopy von Depciuch, Joanna, Sowa-Kućma, Magdalena, Misztak, Paulina, Szewczyk, Bernadeta, Nowak, Gabriel, Pankiewicz, Piotr, Parlińska-Wojtan, Magdalena

“… Dysfunctions in neuronal proteins can lead to development of depression. Lipids determine the localization and function of proteins in the cell membrane and …”
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Alterations of Bio-elements, Oxidative, and Inflammatory Status in the Zinc Deficiency Model in Rats von Doboszewska, Urszula, Szewczyk, Bernadeta, Sowa-Kućma, Magdalena, Noworyta-Sokołowska, Karolina, Misztak, Paulina, Gołębiowska, Joanna, Młyniec, Katarzyna, Ostachowicz, Beata, Krośniak, Mirosław, Wojtanowska-Krośniak, Agnieszka, Gołembiowska, Krystyna, Lankosz, Marek, Piekoszewski, Wojciech, Nowak, Gabriel

“… Our previous study showed that dietary zinc restriction induces depression-like behavior with concomitant up-regulation of the N -methyl- d -aspartate receptor …”
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Stress-induced alterations in 5-HT1A receptor transcriptional modulators NUDR and Freud-1 von Szewczyk, Bernadeta, Kotarska, Katarzyna, Daigle, Mireille, Misztak, Paulina, Sowa-Kucma, Magdalena, Rafalo, Anna, Curzytek, Katarzyna, Kubera, Marta, Basta-Kaim, Agnieszka, Nowak, Gabriel, Albert, Paul R

“… The effect of stress on the mRNA and protein level of the 5-HT1A receptor and two of its key transcriptional modulators, NUDR and Freud-1, was examined in the …”
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Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders von Nicosia, Noemi, Giovenzana, Mattia, Misztak, Paulina, Mingardi, Jessica, Musazzi, Laura

“… Glutamate is the main excitatory neurotransmitter in the brain wherein it controls cognitive functional domains and mood. Indeed, brain areas involved in …”
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Changes in neurotrophic signaling pathways in brain areas of the chronic mild stress rat model of depression as a signature of ketamine fast antidepressant response/non-response von Derosa, Sara, Misztak, Paulina, Mingardi, Jessica, Mazzini, Giulia, Müller, Heidi Kaastrup, Musazzi, Laura

“… Major Depressive Disorder (MDD) is a highly debilitating disorder characterized by a persistent feeling of sadness and anhedonia. Traditional antidepressants …”
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Histone deacetylases (HDACs) as therapeutic target for depressive disorders von Misztak, Paulina, Pańczyszyn-Trzewik, Patrycja, Sowa-Kućma, Magdalena

“… •The most current state of knowledge on the importance of histone deacetylases (HDACs) in depression.•Role of HDACs in the pathophysiology of depression.•Role …”
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MULTIOMIC PROFILING OF RAPID ANTIDEPRESSANT MECHANISMS IN A RAT MODEL OF DEPRESSION von Musazzi, Laura, Mingardi, Jessica, Misztak, Paulina, Magri, Chiara, Martini, Paolo, Barbon, Alessandro

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Changes in working memory induced by lipopolysaccharide administration in mice are associated with metabotropic glutamate receptors 5 and contrast with changes induced by cyclooxygenase-2: Involvement of postsynaptic density protein 95 and down syndrome cell adhesion molecule von Stachowicz, Katarzyna, Pańczyszyn-Trzewik, Patrycja, Sowa-Kućma, Magdalena, Misztak, Paulina

“… The strength and quality of the signal propagated by the glutamate synapse (Glu) depend, among other things, on the structure of the postsynaptic part and the …”
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Time-dependent dual mode of action of COX-2 inhibition on mouse serum corticosterone levels von Pańczyszyn-Trzewik, Patrycja, Sowa-Kućma, Magdalena, Misztak, Paulina, Tabecka-Lonczynska, Anna, Stachowicz, Katarzyna

“… •Short-term COX-2 inhibition increased corticosterone levels,•Long-term COX-2 inhibition lowered corticosterone levels,•Corticosterone levels are regulated …”
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Are there differences in lipid peroxidation and immune biomarkers between major depression and bipolar disorder: Effects of melancholia, atypical depression, severity of illness, episode number, suicidal ideation and prior suicide attempts von Sowa-Kućma, Magdalena, Styczeń, Krzysztof, Siwek, Marcin, Misztak, Paulina, Nowak, Rafał J., Dudek, Dominika, Rybakowski, Janusz K., Nowak, Gabriel, Maes, Michael

“… There is evidence that major depression (MDD) and bipolar disorder (BD) are accompanied by activated immune & oxidative (I&O) pathways. To compare I&O …”
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Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway von Pochwat, Bartlomiej, Sowa-Kucma, Magdalena, Kotarska, Katarzyna, Misztak, Paulina, Nowak, Gabriel, Szewczyk, Bernadeta

“… Rationale Numerous studies suggest agents that act on glutamatergic transmission as potential antidepressants. Preclinical and clinical evidence suggests that …”
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Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2 von Stachowicz, Katarzyna, Sowa-Kućma, Magdalena, Pańczyszyn-Trzewik, Patrycja, Misztak, Paulina, Marciniak, Marcin, Bobula, Bartosz, Tokarski, Krzysztof

“… •Concurrent MTEP and NS398 reduced mGluR7 in WT mice hippocampus.•Concomitant MTEP and NS398 impaired the memory in mGluR7 KO mouse.•Simultaneous MTEP and …”
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Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression von Tse, Wing Sze, Pochwat, Bartłomiej, Szewczyk, Bernadeta, Misztak, Paulina, Bobula, Bartosz, Tokarski, Krzysztof, Worch, Remigiusz, Czarnota-Bojarska, Marta, Lipton, Stuart A., Zaręba-Kozioł, Monika, Bijata, Monika, Wlodarczyk, Jakub

“… In the search for new options for the pharmacological treatment of major depressive disorder, compounds with a rapid onset of action and high efficacy but …”
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