Výsledky vyhľadávania - "Miller, Russell A."

An energetic tale of AMPK-independent effects of metformin Autor Miller, Russell A., Birnbaum, Morris J.

“…Metformin has become a mainstay in the modest therapeutic armamentarium for the treatment of the insulin resistance of type 2 diabetes mellitus. Although…”
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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria Autor Cárdenas, César, Miller, Russell A, Smith, Ian, Bui, Thi, Molgó, Jordi, Müller, Marioly, Vais, Horia, Cheung, King-Ho, Yang, Jun, Parker, Ian, Thompson, Craig B, Birnbaum, Morris J, Hallows, Kenneth R, Foskett, J Kevin

“…Mechanisms that regulate cellular metabolism are a fundamental requirement of all cells. Most eukaryotic cells rely on aerobic mitochondrial metabolism to…”
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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin Autor Holland, William L, Miller, Russell A, Wang, Zhao V, Sun, Kai, Barth, Brian M, Bui, Hai H, Davis, Kathryn E, Bikman, Benjamin T, Halberg, Nils, Rutkowski, Joseph M, Wade, Mark R, Tenorio, Vincent M, Kuo, Ming-Shang, Brozinick, Joseph T, Zhang, Bei B, Birnbaum, Morris J, Summers, Scott A, Scherer, Philipp E

“…The protein hormone adiponectin is known to have many beneficial systemic effects, including promoting cell survival, anti-inflammation and insulin…”
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Increased circulating progranulin is not sufficient to induce cardiac dysfunction or supraventricular arrhythmia Autor McElhanon, Kevin E., Huff, Tyler C., Hirenallur-Shanthappa, Dinesh, Miller, Russell A., Christoforou, Nicolas

“…Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and the incidence of new-onset AF has been increasing over the past two decades. Several…”
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Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels Autor Roth Flach, Rachel J., Bollinger, Eliza, Reyes, Allan R., Laforest, Brigitte, Kormos, Bethany L., Liu, Shenping, Reese, Matthew R., Martinez Alsina, Luis A., Buzon, Leanne, Zhang, Yuan, Bechle, Bruce, Rosado, Amy, Sahasrabudhe, Parag V., Knafels, John, Bhattacharya, Samit K., Omoto, Kiyoyuki, Stansfield, John C., Hurley, Liam D., Song, LouJin, Luo, Lina, Breitkopf, Susanne B., Monetti, Mara, Cunio, Teresa, Tierney, Brendan, Geoly, Frank J., Delmore, Jake, Siddall, C. Parker, Xue, Liang, Yip, Ka N., Kalgutkar, Amit S., Miller, Russell A., Zhang, Bei B., Filipski, Kevin J.

“…Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the…”
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Cell-autonomous effect of cardiomyocyte branched-chain amino acid catabolism in heart failure in mice Autor Yu, Jia-yu, Cao, Nancy, Rau, Christoph D., Lee, Ro-Po, Yang, Jieping, Flach, Rachel J. Roth, Petersen, Lauren, Zhu, Cansheng, Pak, Yea-Lyn, Miller, Russell A., Liu, Yunxia, Wang, Yibin, Li, Zhaoping, Sun, Haipeng, Gao, Chen

“…Parallel to major changes in fatty acid and glucose metabolism, defect in branched-chain amino acid (BCAA) catabolism has also been recognized as a metabolic…”
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BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice Autor Bollinger, Eliza, Peloquin, Matthew, Libera, Jenna, Albuquerque, Bina, Pashos, Evanthia, Shipstone, Arun, Hadjipanayis, Angela, Sun, Zhongyuan, Xing, Gang, Clasquin, Michelle, Stansfield, John C., Tierney, Brendan, Gernhardt, Steven, Siddall, C. Parker, Greizer, Timothy, Geoly, Frank J., Vargas, Sarah R., Gao, Lily C., Williams, George, Marshall, Mackenzie, Rosado, Amy, Steppan, Claire, Filipski, Kevin J., Zhang, Bei B., Miller, Russell A., Roth Flach, Rachel J.

“…Branched chain amino acid (BCAA) catabolic defects are implicated to be causal determinates of multiple diseases. This work aimed to better understand how…”
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Metabolic Syndrome Nonalcoholic Steatohepatitis Male Mouse With Adeno‐Associated Viral Renin as a Novel Model for Heart Failure With Preserved Ejection Fraction Autor Shi, Yuji, Perez‐Bonilla, Patricia, Chen, Xian, Tam, Kelly, Marshall, Mackenzie, Morin, Jeffrey, LaViolette, Brianna, Kue, Nouaying R., Damilano, Federico, Miller, Russell A., Zhang, Bei B., Roth Flach, Rachel J., Hirenallur‐Shanthappa, Dinesh

“…Heart failure with preserved ejection fraction (HFpEF) currently accounts for more than half of patients with HF, with limited approved evidence-based…”
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AMPK activation is sufficient to increase skeletal muscle glucose uptake and glycogen synthesis but is not required for contraction-mediated increases in glucose metabolism Autor Esquejo, Ryan M., Albuquerque, Bina, Sher, Anna, Blatnik, Matthew, Wald, Kyle, Peloquin, Matthew, Delmore, Jake, Kindt, Erick, Li, Wenlin, Young, Jamey D., Cameron, Kim, Miller, Russell A.

“…The AMP-activated protein kinase (AMPK) is a cellular sensor of energetics and when activated in skeletal muscle during contraction can impart changes in…”
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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP Autor Miller, Russell A., Chu, Qingwei, Xie, Jianxin, Foretz, Marc, Viollet, Benoit, Birnbaum, Morris J.

“…Biguanides such as metformin, which is the most widely prescribed drug for type-2 diabetes, are shown to antagonize the actions of glucagon by decreasing the…”
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Glucagon: acute actions on hepatic metabolism Autor Miller, Russell A., Birnbaum, Morris J.

“…Type 2 diabetes mellitus is the result of impaired systemic control of glucose homeostasis, in part through the dysregulation of the hormone glucagon. Glucagon…”
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Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration Autor Sun, Zheng, Miller, Russell A, Patel, Rajesh T, Chen, Jie, Dhir, Ravindra, Wang, Hong, Zhang, Dongyan, Graham, Mark J, Unterman, Terry G, Shulman, Gerald I, Sztalryd, Carole, Bennett, Michael J, Ahima, Rexford S, Birnbaum, Morris J, Lazar, Mitchell A

“…It is believed that lipid accumulation in the liver, or fatty liver disease, contributes to insulin resistance in this organ and, thus, poorly controlled…”
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Targeting hepatic glutaminase activity to ameliorate hyperglycemia Autor Miller, Russell A, Shi, Yuji, Lu, Wenyun, Pirman, David A, Jatkar, Aditi, Blatnik, Matthew, Wu, Hong, Cárdenas, César, Wan, Min, Foskett, J Kevin, Park, Junyoung O, Zhang, Yiyi, Holland, William L, Rabinowitz, Joshua D, Birnbaum, Morris J

“…In mice, elevated glucagon during type 2 diabetes promotes more hepatic glutamine flux and greater gluconeogenesis, while reducing glutamine metabolism in the…”
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Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling Autor Miller, Russell A., Chu, Qingwei, Le Lay, John, Scherer, Philipp E., Ahima, Rexford S., Kaestner, Klaus H., Foretz, Marc, Viollet, Benoit, Birnbaum, Morris J.

“…The adipocyte-derived hormone adiponectin signals from the fat storage depot to regulate metabolism in peripheral tissues. Inversely correlated with body fat…”
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Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy Autor Salatto, Christopher T, Miller, Russell A, Cameron, Kimberly O, Cokorinos, Emily, Reyes, Allan, Ward, Jessica, Calabrese, Matthew F, Kurumbail, Ravi G, Rajamohan, Francis, Kalgutkar, Amit S, Tess, David A, Shavnya, Andre, Genung, Nathan E, Edmonds, David J, Jatkar, Aditi, Maciejewski, Benjamin S, Amaro, Marina, Gandhok, Harmeet, Monetti, Mara, Cialdea, Katherine, Bollinger, Eliza, Kreeger, John M, Coskran, Timothy M, Opsahl, Alan C, Boucher, Germaine G, Birnbaum, Morris J, DaSilva-Jardine, Paul, Rolph, Tim

“…Diabetic nephropathy remains an area of high unmet medical need, with current therapies that slow down, but do not prevent, the progression of disease. A…”
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Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models Autor Esquejo, Ryan M., Salatto, Christopher T., Delmore, Jake, Albuquerque, Bina, Reyes, Allan, Shi, Yuji, Moccia, Rob, Cokorinos, Emily, Peloquin, Matthew, Monetti, Mara, Barricklow, Jason, Bollinger, Eliza, Smith, Brennan K., Day, Emily A., Nguyen, Chuong, Geoghegan, Kieran F., Kreeger, John M., Opsahl, Alan, Ward, Jessica, Kalgutkar, Amit S., Tess, David, Butler, Lynne, Shirai, Norimitsu, Osborne, Timothy F., Steinberg, Gregory R., Birnbaum, Morris J., Cameron, Kimberly O., Miller, Russell A.

“…Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid…”
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What We Teach When We Teach German Constitutional Law: An Introduction to the Collection Memorializing Donald P. Kommers Autor Miller, Russell A.

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Making Open Access Viable Economically Autor Hyde, Andrew, Miller, Russell A., Towfigh, Emanuel V.

“…The Editors-in-Chief have decided that we will provide our much-cherished readers with an editorial every so often as a way of sharing insights from the…”
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Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia Autor Miller, Russell A., Shi, Yuji, Lu, Wenyun, Pirman, David A., Jatkar, Aditi, Blatnik, Matthew, Wu, Hong, Cárdenas, César, Wan, Min, Foskett, J. Kevin, Park, Junyoung O., Zhang, Yiyi, Holland, William L., Rabinowitz, Joshua D., Birnbaum, Morris J.

“…In the version of this article initially published, the “[13C2]α-ketoglutarate” label on Fig. 1g is incorrect. It should be “[13C5]α-ketoglutarate”…”
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Ligand-regulated peptide aptamers Autor Miller, Russell A

“…The peptide aptamer approach employs high-throughput selection to identify members of a randomized peptide library displayed from a scaffold protein by virtue…”
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