Výsledky vyhľadávania - "Miller, Gavin J."

Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues Autor Guinan, Mieke, Benckendorff, Caecilie, Smith, Mark, Miller, Gavin J.

“…Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds,…”
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d-Glucuronate and d-Glucuronate Glycal Acceptors for the Scalable Synthesis of d-GlcN-α-1,4-d-GlcA Disaccharides and Modular Assembly of Heparan Sulfate Autor Pongener, Imlirenla, Miller, Gavin J. J.

“…Reported herein is a scalable chemical synthesis of disaccharidebuilding blocks for heparan sulfate (HS) oligosaccharide assembly.The use of…”
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Synthesis of S-Glycoside Building Blocks as Mimetics of the Repeating d-GlcN-α-1,4-d-GlcA Heparan Sulfate Disaccharide Autor O’Shea, Conor, Miller, Gavin J.

“…Heparan sulfate (HS), a sulfated linear carbohydrate that decorates the cell surface and extracellular matrix, is a key regulator of biological processes…”
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Recent advances in the chemical synthesis of sugar-nucleotides Autor Ahmadipour, Sanaz, Miller, Gavin J.

“…[Display omitted]…”
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Recent advances in the enzymatic synthesis of sugar-nucleotides using nucleotidylyltransferases and glycosyltransferases Autor Ahmadipour, Sanaz, Beswick, Laura, Miller, Gavin J.

“…Sugar-nucleotides are imperative to carbohydrate metabolism and glycoconjugate biosynthesis. Enzymatic methods to access these key materials offer a powerful…”
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Developments in the Chemical Synthesis of Heparin and Heparan Sulfate Autor Pongener, Imlirenla, O'Shea, Conor, Wootton, Hannah, Watkinson, Michael, Miller, Gavin J.

“…Heparin and heparan sulfate represent key members of the glycosaminoglycan family of carbohydrates and underpin considerable repertoires of biological…”
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An Updated Synthesis of the Diazo-Transfer Reagent Imidazole-1-sulfonyl Azide Hydrogen Sulfate Autor Potter, Garrett T, Jayson, Gordon C, Miller, Gavin J, Gardiner, John M

“…Imidazole-1-sulfonyl azide and salts thereof are valuable reagents for diazo-transfer reactions, most particularly conversion of primary amines to azides. The…”
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3,4,6-Tri-O-acetyl-1-S-acetyl-2-deoxy-2-S-phenylthio-α-d-mannopyranoside Autor Porter, Jack, Miller, Gavin J.

“…The title compound was isolated as the unexpected reaction product from a reaction attempting to access a glycosyl 1-phosphate. The product was isolated in…”
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Oxidase enzymes as sustainable oxidation catalysts Autor Wahart, Alice J. C., Staniland, Jessica, Miller, Gavin J., Cosgrove, Sebastian C.

“…Oxidation is one of the most important processes used by the chemical industry. However, many of the methods that are used pose significant sustainability and…”
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Indolo[2,3- e ]benzazocines and indolo[2,3- f ]benzazonines and their copper(II) complexes as microtubule destabilizing agents Autor Wittmann, Christopher, Dömötör, Orsolya, Kuznetcova, Irina, Spengler, Gabriella, Reynisson, Jóhannes, Holder, Lauren, Miller, Gavin J, Enyedy, Eva A, Bai, Ruoli, Hamel, Ernest, Arion, Vladimir B

“…A series of four indolo[2,3- ]benzazocines HL1-HL4 and two indolo[2,3- ]benzazonines HL5 and HL6, as well as their respective copper(II) complexes 1-6, were…”
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Chemical synthesis of C6-tetrazole ᴅ-mannose building blocks and access to a bioisostere of mannuronic acid 1-phosphate Autor Dimitriou, Eleni, Miller, Gavin J

“…Alginate is a biocompatible and industrially relevant polysaccharide that derives many of its important properties from the charged carboxylate groups within…”
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Methyl and Benzyl (Ethyl 3,4-di-O-benzyl-2-O-benzoyl-1-thio-β-d-glucopyranosyl)uronate Autor Wootton, Hannah S., Miller, Gavin J.

“…Methyl and benzyl (ethyl 3,4-di-O-benzyl-2-O-benzoyl-1-thio-β-D-glucopyranosyl)uronate were synthesised from a protected thioglycoside in three steps. A…”
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Polyvalent Mannuronic Acid-Coated Gold Nanoparticles for Probing Multivalent Lectin–Glycan Interaction and Blocking Virus Infection Autor Basaran, Rahman, Budhadev, Darshita, Dimitriou, Eleni, Wootton, Hannah S., Miller, Gavin J., Kempf, Amy, Nehlmeier, Inga, Pöhlmann, Stefan, Guo, Yuan, Zhou, Dejian

“…Multivalent lectin–glycan interactions (MLGIs) are vital for viral infection, cell-cell communication and regulation of immune responses. Their structural and…”
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Prospects for anti-Candida therapy through targeting the cell wall: A mini-review Autor Ahmadipour, Sanaz, Field, Robert A., Miller, Gavin J.

“…The impact of fungal infections on humans is a serious public health issue that has received much less attention than bacterial infection and treatment,…”
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Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug Autor Porter, Jack, Noble, Amanda R., Signoret, Nathalie, Fascione, Martin A., Miller, Gavin J.

“…Nucleoside analogues are established treatments for cancer and viral infection. Gemcitabine is a commonly employed nucleoside analogue displaying anticancer…”
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Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease β Secretase, BACE1 Autor Mycroft-West, Courtney J., Devlin, Anthony J., Cooper, Lynsay C., Guimond, Scott E., Procter, Patricia, Guerrini, Marco, Miller, Gavin J., Fernig, David G., Yates, Edwin A., Lima, Marcelo A., Skidmore, Mark A.

“…Only palliative therapeutic options exist for the treatment of Alzheimer’s Disease; no new successful drug candidates have been developed in over 15 years. The…”
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Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice Autor Pryde, David C., Jones, Lyn H., Gervais, David P., Stead, David R., Blakemore, David C., Selby, Matthew D., Brown, Alan D., Coe, Jotham W., Badland, Matthew, Beal, David M., Glen, Rebecca, Wharton, Yvonne, Miller, Gavin J., White, Phil, Zhang, Ningli, Benoit, Michelle, Robertson, Karen, Merson, James R., Davis, Heather L., McCluskie, Michael J.

“…Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies (Ab) which reduce nicotine entering the brain, and hence the…”
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Fluorinating the Sugar and the Nucleotide: Exploring Fluorination Within GDP-Mannose Probes Using Chemoenzymatic Synthesis Autor Dolan, Jonathan P., Evans, Sean T., Benckendorff, Caecilie M. M., Sari, Suat, Ní Cheallaigh, Aisling, Miller, Gavin J.

“…Fluorinated glycans offer a prime opportunity to study the intricacies of their associated binding events with proteins, invoke resistance toward enzymatic…”
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Inhibition of BACE1, the β-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus Autor Mycroft-West, Courtney, Devlin, Anthony, Cooper, Lynsay, Procter, Patricia, Miller, Gavin, Fernig, David, Guerrini, Marco, Guimond, Scott, Lima, Marcelo, Yates, Edwin, Skidmore, Mark

“…The pharmaceutical and anticoagulant agent heparin, a member of the glycosaminoglycan family of carbohydrates, has previously been identified as a potent…”
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Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase Autor Ahmadipour, Sanaz, Wahart, Alice J C, Dolan, Jonathan P, Beswick, Laura, Hawes, Chris S, Field, Robert A, Miller, Gavin J

“…Sufferers of cystic fibrosis are at significant risk of contracting chronic bacterial lung infections. The dominant pathogen in these cases is mucoid…”
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