Výsledky vyhledávání - "MicroRNAs"

Exosome microRNA signatures in patients with complex regional pain syndrome undergoing plasma exchange Autor Ramanathan, Sujay, Douglas, Sabrina R., Alexander, Guillermo M., Shenoda, Botros B., Barrett, James E., Aradillas, Enrique, Sacan, Ahmet, Ajit, Seena K.

“…Background Therapeutic plasma exchange (PE) or plasmapheresis is an extracorporeal procedure employed to treat immunological disorders. Exosomes, nanosized…”
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MicroRNA Autor Lu, Thomas X., Rothenberg, Marc E.

“…MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are…”
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Can Circulating MicroRNAs, Cytokines, and Adipokines Help to Differentiate Psoriatic Arthritis from Erosive Osteoarthritis of the Hand? A Case–Control Study Autor Fioravanti, Antonella, Cheleschi, Sara, Cavalier, Etienne, Reginster, Jean-Yves, Alokail, Majed, Ladang, Aurélie, Tenti, Sara, Bedogni, Giorgio

“…The differential diagnosis of erosive osteoarthritis of the hand (EHOA) and psoriatic arthritis (PsA) is challenging, especially considering the absence of…”
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Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer Autor Liu, Mingyang, Zhang, Yuqing, Yang, Jingxuan, Zhan, Hanxiang, Zhou, Zhijun, Jiang, Yuanyuan, Shi, Xiuhui, Fan, Xiao, Zhang, Junxia, Luo, Wenyi, Fung, Kar-Ming A, Xu, Chao, Bronze, Michael S, Houchen, Courtney W, Li, Min

“…Pancreatic cancer is characterized by extensive metastasis. Epithelial-mesenchymal transition (EMT) plasticity plays a critical role in tumor progression and…”
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An overview of microRNAs: Biology, functions, therapeutics, and analysis methods Autor Saliminejad, Kioomars, Khorram Khorshid, Hamid Reza, Soleymani Fard, Shahrzad, Ghaffari, Seyed Hamidollah

“…MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of…”
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MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs Autor Gabisonia, Khatia, Prosdocimo, Giulia, Aquaro, Giovanni Donato, Carlucci, Lucia, Zentilin, Lorena, Secco, Ilaria, Ali, Hashim, Braga, Luca, Gorgodze, Nikoloz, Bernini, Fabio, Burchielli, Silvia, Collesi, Chiara, Zandonà, Lorenzo, Sinagra, Gianfranco, Piacenti, Marcello, Zacchigna, Serena, Bussani, Rossana, Recchia, Fabio A., Giacca, Mauro

“…Prompt coronary catheterization and revascularization have markedly improved the outcomes of myocardial infarction, but have also resulted in a growing number…”
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Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors Autor Beg, Muhammad S., Brenner, Andrew J., Sachdev, Jasgit, Borad, Mitesh, Kang, Yoon-Koo, Stoudemire, Jay, Smith, Susan, Bader, Andreas G., Kim, Sinil, Hong, David S.

“…Summary Purpose Naturally occurring tumor suppressor microRNA-34a (miR-34a) downregulates the expression of >30 oncogenes across multiple oncogenic pathways,…”
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MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes Autor Veitch, Shawn, Njock, Makon-Sébastien, Chandy, Mark, Siraj, M. Ahsan, Chi, Lijun, Mak, HaoQi, Yu, Kai, Rathnakumar, Kumaragurubaran, Perez-Romero, Carmina Anjelica, Chen, Zhiqi, Alibhai, Faisal J., Gustafson, Dakota, Raju, Sneha, Wu, Ruilin, Zarrin Khat, Dorrin, Wang, Yaxu, Caballero, Amalia, Meagher, Patrick, Lau, Edward, Pepic, Lejla, Cheng, Henry S., Galant, Natalie J., Howe, Kathryn L., Li, Ren-Ke, Connelly, Kim A., Husain, Mansoor, Delgado-Olguin, Paul, Fish, Jason E.

“…Background Type 2 diabetes (T2D) is associated with coronary microvascular dysfunction, which is thought to contribute to compromised diastolic function,…”
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Regulatory Mechanism of MicroRNA Expression in Cancer Autor Ali Syeda, Zainab, Langden, Siu Semar Saratu’, Munkhzul, Choijamts, Lee, Mihye, Song, Su Jung

“…Altered gene expression is the primary molecular mechanism responsible for the pathological processes of human diseases, including cancer. MicroRNAs (miRNAs)…”
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MicroRNAs: history, biogenesis, and their evolving role in animal development and disease Autor Bhaskaran, M, Mohan, M

“…The discovery of microRNAs (miRNAs) in 1993 followed by developments and discoveries in small RNA biology have redefined the biological landscape by…”
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MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions Autor Catalanotto, Caterina, Cogoni, Carlo, Zardo, Giuseppe

“…The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a sequence specific manner has had a massive impact on biology. Recent…”
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Circulating microRNAs in Medicine Autor Pozniak, Tetiana, Shcharbin, Dzmitry, Bryszewska, Maria

“…Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, are promising sensitive biomarkers for various diseases…”
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Investigating the biology of microRNA links to ALDH1A1 reveals candidates for preclinical testing in acute myeloid leukemia Autor Vlahopoulos, Spiros A, Varisli, Lokman, Zoumpourlis, Panagiotis, Spandidos, Demetrios A, Zoumpourlis, Vassilis

“…Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a member of the aldehyde dehydrogenase gene subfamily that encode enzymes with the ability to oxidize…”
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Metazoan MicroRNAs Autor Bartel, David P

“…MicroRNAs (miRNAs) are ∼22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals,…”
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Adipose-derived circulating miRNAs regulate gene expression in other tissues Autor Thomou, Thomas, Mori, Marcelo A., Dreyfuss, Jonathan M., Konishi, Masahiro, Sakaguchi, Masaji, Wolfrum, Christian, Rao, Tata Nageswara, Winnay, Jonathon N., Garcia-Martin, Ruben, Grinspoon, Steven K., Gorden, Phillip, Kahn, C. Ronald

“…Adipose tissue is a major site of energy storage and has a role in the regulation of metabolism through the release of adipokines. Here we show that mice with…”
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Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver Autor Hsu, Shu-hao, Wang, Bo, Kota, Janaiah, Yu, Jianhua, Costinean, Stefan, Kutay, Huban, Yu, Lianbo, Bai, Shoumei, La Perle, Krista, Chivukula, Raghu R., Mao, Hsiaoyin, Wei, Min, Clark, K. Reed, Mendell, Jerry R., Caligiuri, Michael A., Jacob, Samson T., Mendell, Joshua T., Ghoshal, Kalpana

“…miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism and promotes hepatitis C virus (HCV) replication. Reduced miR-122…”
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microRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases Autor Basak, Indranil, Patil, Ketan S, Alves, Guido, Larsen, Jan Petter, Møller, Simon Geir

“…The last decade has experienced the emergence of microRNAs as a key molecular tool for the diagnosis and prognosis of human diseases. Although the focus has…”
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Nanoscale delivery systems for microRNAs in cancer therapy Autor Boca, Sanda, Gulei, Diana, Zimta, Alina-Andreea, Onaciu, Anca, Magdo, Lorand, Tigu, Adrian Bogdan, Ionescu, Calin, Irimie, Alexandru, Buiga, Rares, Berindan-Neagoe, Ioana

“…Concomitant with advances in research regarding the role of miRNAs in sustaining carcinogenesis, major concerns about their delivery options for anticancer…”
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Programming inactive RNA-binding small molecules into bioactive degraders Autor Tong, Yuquan, Lee, Yeongju, Liu, Xiaohui, Childs-Disney, Jessica L., Suresh, Blessy M., Benhamou, Raphael I., Yang, Chunying, Li, Weimin, Costales, Matthew G., Haniff, Hafeez S., Sievers, Sonja, Abegg, Daniel, Wegner, Tristan, Paulisch, Tiffany O., Lekah, Elizabeth, Grefe, Maison, Crynen, Gogce, Van Meter, Montina, Wang, Tenghui, Gibaut, Quentin M. R., Cleveland, John L., Adibekian, Alexander, Glorius, Frank, Waldmann, Herbert, Disney, Matthew D.

“…Target occupancy is often insufficient to elicit biological activity, particularly for RNA, compounded by the longstanding challenges surrounding the molecular…”
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Puccinia striiformis f. sp. tritici microRNA-like RNA 1 (Pst-milR1), an important pathogenicity factor of Pst, impairs wheat resistance to Pst by suppressing the wheat pathogenesis-related 2 gene Autor Wang, Bing, Sun, Yanfei, Song, Na, Zhao, Mengxin, Liu, Rui, Feng, Hao, Wang, Xiaojie, Kang, Zhensheng

“…Small RNAs (sRNAs), an important type of pathogenicity factor, contribute to impairing host immune responses. However, little is known about sRNAs in Puccinia…”
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