Suchergebnisse - "Mice, Inbred BALB C"

Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice von Pereira, Ethel R, Kedrin, Dmitriy, Seano, Giorgio, Gautier, Olivia, Meijer, Eelco F J, Jones, Dennis, Chin, Shan-Min, Kitahara, Shuji, Bouta, Echoe M, Chang, Jonathan, Beech, Elizabeth, Jeong, Han-Sin, Carroll, Michael C, Taghian, Alphonse G, Padera, Timothy P

“… Whether cancer cells in lymph nodes can seed distant metastases has been a subject of considerable debate …”
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A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor von Yu, Jinlei, Luo, Yang, Zhu, Zhenlai, Zhou, Yufeng, Sun, Licheng, Gao, Jixin, Sun, Jinlv, Wang, Gang, Yao, Xu, Li, Wei

“… Previous studies have revealed significant alterations in the skin microbiota of patients with atopic dermatitis (AD) not only in diversity and composition but …”
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The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients von Premkumar, Lakshmanane, Segovia-Chumbez, Bruno, Jadi, Ramesh, Martinez, David R, Raut, Rajendra, Markmann, Alena, Cornaby, Caleb, Bartelt, Luther, Weiss, Susan, Park, Yara, Edwards, Caitlin E, Weimer, Eric, Scherer, Erin M, Rouphael, Nadine, Edupuganti, Srilatha, Weiskopf, Daniela, Tse, Longping V, Hou, Yixuan J, Margolis, David, Sette, Alessandro, Collins, Matthew H, Schmitz, John, Baric, Ralph S, de Silva, Aravinda M

“… The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in late 2019 is responsible for a pandemic of severe respiratory illness …”
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IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells von Galand, Claire, Leyva-Castillo, Juan Manuel, Yoon, Juhan, Han, Alex, Lee, Margaret S., McKenzie, Andrew N.J., Stassen, Michael, Oyoshi, Michiko K., Finkelman, Fred D., Geha, Raif S.

“… Cutaneous exposure to food allergens predisposes to food allergy, which is commonly associated with atopic dermatitis (AD). Levels of the epithelial cytokine …”
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Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population von Levine, Morgan E, Suarez, Jorge A, Brandhorst, Sebastian, Balasubramanian, Priya, Cheng, Chia-Wei, Madia, Federica, Fontana, Luigi, Mirisola, Mario G, Guevara-Aguirre, Jaime, Wan, Junxiang, Passarino, Giuseppe, Kennedy, Brian K, Wei, Min, Cohen, Pinchas, Crimmins, Eileen M, Longo, Valter D

“… Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 …”
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An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint von Ramanan, Deepshika, Sefik, Esen, Galván-Peña, Silvia, Wu, Meng, Yang, Liang, Yang, Zhen, Kostic, Aleksandar, Golovkina, Tatyana V, Kasper, Dennis L, Mathis, Diane, Benoist, Christophe

“… perturbations, then further transferred by females for multiple generations. RORγ Treg proportions negatively correlated with IgA production and coating of gut commensals, traits also subject to maternal transmission, in an immunoglobulin …”
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Bio-orthogonal Metabolic Fluorine Labeling Enables Deep-Tissue Visualization of Tumor Cells In Vivo by 19 F Magnetic Resonance Imaging von Chen, Dongxia, Lin, Yaying, Li, Ao, Luo, Xiangjie, Yang, Chaoyong, Gao, Jinhao, Lin, Hongyu

“… The high resolution, deep penetration, and negligible biological background of F magnetic resonance imaging (MRI) makes it a potential means for imaging …”
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Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis von Llabani, Evijola, Hicklin, Robert W., Lee, Hyang Yeon, Motika, Stephen E., Crawford, Lisa A., Weerapana, Eranthie, Hergenrother, Paul J.

“… Herein, we subject the diterpene natural product pleuromutilin to reaction sequences focused on creating ring system diversity in few synthetic steps …”
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Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation von Yang, Zhaogang, Xie, Jing, Zhu, Jing, Kang, Chen, Chiang, Chiling, Wang, Xinmei, Wang, Xiaobing, Kuang, Tairong, Chen, Feng, Chen, Zhou, Zhang, Aili, Yu, Bo, Lee, Robert J., Teng, Lesheng, Lee, L. James

“… Exosome-based drug delivery is currently a subject of intensive research. Here, we report a novel strategy to produce nanoscale exosome-mimics (EMs …”
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Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia von Wang, Jun, Xu, Yanhui, Chen, Zhanghua, Liang, Jiankun, Lin, Zefeng, Liang, Huiying, Xu, Yiping, Wu, Qi, Guo, Xuanjie, Nie, Junli, Lu, Bingtai, Huang, Bing, Xian, Huifang, Wang, Xiaohui, Wu, Qiang, Zeng, Jixiao, Chai, Chengwei, Zhang, Meixue, Lin, Yuzhen, Zhang, Li, Zhao, Shanmeizi, Tong, Yanlu, Zeng, Liang, Gu, Xiaoqiong, Chen, Zhuang-Gui, Yi, Shuhong, Zhang, Tong, Delfouneso, David, Zhang, Yan, Nutt, Stephen L, Lew, Andrew M, Lu, Liwei, Bai, Fan, Xia, Huimin, Wen, Zhe, Zhang, Yuxia

“…  cells to levels comparable to those of control subjects. In summary, our comprehensive immune profiling in infants with BA had educed that B-cell-modifying …”
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The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae von Leduc, Isabelle, Connolly, Kristie L., Begum, Afrin, Underwood, Knashka, Darnell, Stephen, Shafer, William M., Balthazar, Jacqueline T., Macintyre, Andrew N., Sempowski, Gregory D., Duncan, Joseph A., Little, Marguerite B., Rahman, Nazia, Garges, Eric C., Jerse, Ann E.

“… There is a pressing need for a gonorrhea vaccine due to the high disease burden associated with gonococcal infections globally and the rapid evolution of …”
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Ruminococcus gnavus ameliorates atopic dermatitis by enhancing Treg cell and metabolites in BALB/c mice von Ahn, Jae‐Rin, Lee, Seung‐Hwa, Kim, Byunghyun, Nam, Myung Hee, Ahn, Yoon Kyung, Park, Yoon Mee, Jeong, Seon‐Mi, Park, Min Jee, Song, Kun Baek, Lee, So‐Yeon, Hong, Soo‐Jong, Eigenmann, Philippe

“…  gnavus in infants with atopic dermatitis (AD) compared with that in healthy subjects. However, the underlying mechanisms remain unclear …”
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Eosinophil extracellular traps activate type 2 innate lymphoid cells through stimulating airway epithelium in severe asthma von Choi, Youngwoo, Kim, Young‐Min, Lee, Hee‐Ra, Mun, Jiyeong, Sim, Soyoon, Lee, Dong‐Hyun, Pham, Duy Le, Kim, Seung‐Hyun, Shin, Yoo Seob, Lee, Seung‐Woo, Park, Hae‐Sim

“… ), and healthy control subjects (HC, n = 8). To confirm the effect of EETs, airway hyperresponsiveness (AHR …”
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Immunization of cats to induce neutralizing antibodies against Fel d 1, the major feline allergen in human subjects von Thoms, Franziska, Jennings, Gary T., Maudrich, Melanie, Vogel, Monique, Haas, Stefanie, Zeltins, Andris, Hofmann-Lehmann, Regina, Riond, Barbara, Grossmann, Jonas, Hunziker, Peter, Fettelschoss-Gabriel, Antonia, Senti, Gabriela, Kündig, Thomas M., Bachmann, Martin F.

“… Cat allergy in human subjects is usually caused by the major cat allergen Fel d 1 and is found in approximately 10 …”
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Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects von Kublin, James G, Mikolajczak, Sebastian A, Sack, Brandon K, Fishbaugher, Matt E, Seilie, Annette, Shelton, Lisa, VonGoedert, Tracie, Firat, Melike, Magee, Sara, Fritzen, Emma, Betz, Will, Kain, Heather S, Dankwa, Dorender A, Steel, Ryan W J, Vaughan, Ashley M, Noah Sather, D, Murphy, Sean C, Kappe, Stefan H I

“… Pf GAP3KO sporozoites were delivered to 10 volunteers using infected mosquito bites with a single exposure consisting of 150 to 200 bites per subject …”
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Cell-Membrane-Localizing, Two-Photon Probe for Ratiometric Imaging of γ-Glutamyl Transpeptidase in Cancerous Cells and Tissues von Reo, Ye Jin, Dai, Mingchong, Yang, Yun Jae, Ahn, Kyo Han

“… The detection of the enzyme activity is an important subject, leading to about 40 activatable fluorescent probes so far …”
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The effect of astaxanthin on inflammation in hyperosmolarity of experimental dry eye model in vitro and in vivo von Li, Hui, Li, Jiangfeng, Hou, Chenting, Li, Jinjian, Peng, Hui, Wang, Qing

“… ) in in vitro and in vivo experiments, respectively. Experimental subjects were first pretreated with AST, and then the effect of the compound was assessed with clinical evaluation …”
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IL-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity in asthma von Bick, Fabian, Brenis Gómez, Claudia M., Lammens, Inés, Van Moorleghem, Justine, De Wolf, Caroline, Dupont, Sam, Dumoutier, Laure, Smith, Neal P., Villani, Alexandra-Chloé, Browaeys, Robin, Alladina, Jehan, Haring, Alexis M., Medoff, Benjamin D., Cho, Josalyn L., Bigirimana, René, Vieira, Joao, Hammad, Hamida, Blanchetot, Christophe, Schuijs, Martijn J., Lambrecht, Bart N.

“… In a translational approach using segmental allergen challenge, we recently described elevated IL-9 levels in human subjects with allergic asthma compared with nonasthmatic controls …”
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Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis von Noti, Mario, Wojno, Elia D Tait, Kim, Brian S, Siracusa, Mark C, Giacomin, Paul R, Nair, Meera G, Benitez, Alain J, Ruymann, Kathryn R, Muir, Amanda B, Hill, David A, Chikwava, Kudakwashe R, Moghaddam, Amin E, Sattentau, Quentin J, Alex, Aneesh, Zhou, Chao, Yearley, Jennifer H, Menard-Katcher, Paul, Kubo, Masato, Obata-Ninomiya, Kazushige, Karasuyama, Hajime, Comeau, Michael R, Brown-Whitehorn, Terri, de Waal Malefyt, Rene, Sleiman, Patrick M, Hakonarson, Hakon, Cianferoni, Antonella, Falk, Gary W, Wang, Mei-Lun, Spergel, Jonathan M, Artis, David

“… Eosinophilic esophagitis (EoE) is characterized by esophageal eosinophilia, but the underlying mechanisms promoting eosinophil accumulation remain unclear …”
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Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor von Matsunaga, Naoya, Ogino, Takashi, Hara, Yukinori, Tanaka, Takahiro, Koyanagi, Satoru, Ohdo, Shigehiro

“… Although malignant phenotypes of triple-negative breast cancer (TNBC) are subject to circadian alterations, the role of cancer stem cells (CSC …”
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