Suchergebnisse - "Meyer zu Schwabedissen, Henriette E"

OATP1B3-1B7, a novel organic anion transporting polypeptide, is modulated by FXR ligands and transports bile acids von Malagnino, Vanessa, Hussner, Janine, Issa, Ali, Midzic, Angela, Meyer Zu Schwabedissen, Henriette E

“… Organic anion transporting polypeptide (OATP) 1B3-1B7 (LST-3TM12) is a member of the OATP1B [solute carrier organic anion transporter ( ) ] family. This …”
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Expression and Function of Organic Anion Transporting Polypeptides in the Human Brain: Physiological and Pharmacological Implications von Schäfer, Anima M., Meyer zu Schwabedissen, Henriette E., Grube, Markus

“… The central nervous system (CNS) is an important pharmacological target, but it is very effectively protected by the blood–brain barrier (BBB), thereby …”
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Uptake Transporters of the SLC21, SLC22A, and SLC15A Families in Anticancer Therapy—Modulators of Cellular Entry or Pharmacokinetics? von Brecht, Karin, Schäfer, Anima Magdalena, Meyer zu Schwabedissen, Henriette E.

“… Solute carrier transporters comprise a large family of uptake transporters involved in the transmembrane transport of a wide array of endogenous substrates …”
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Increased coproporphyrin serum levels in healthy volunteers treated with the cholesterol uptake inhibitor ezetimibe von Kinzi, Jonny, Grube, Markus, Seibert, Isabell, Siegmund, Werner, Meyer zu Schwabedissen, Henriette E.

“… Ezetimibe undergoes glucuronidation that results in the active metabolite ezetimibe phenoxy‐glucuronide (ezetimibe‐glucuronide). This phase‐II metabolite was …”
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Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta von Taggi, Valerio, Riera Romo, Mario, Piquette-Miller, Micheline, Meyer zu Schwabedissen, Henriette E., Neuhoff, Sibylle

“… Drug transporters play an important role in the maintenance of chemical balance and homeostasis in different tissues. In addition to their physiological …”
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The influence of OATP2B1 and atorvastatin on coproporphyrin isomers in rats von Kinzi, Jonny, Grube, Markus, Hussner, Janine, Seibert, Isabell, Hamburger, Matthias, Meyer zu Schwabedissen, Henriette E.

“… Coproporphyrin I (CPI) and III (CPIII) are discussed as biomarkers for organic anion transporting polypeptides (OATPs). We report on CPI and CPIII levels in …”
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OATP2B1 – The underrated member of the organic anion transporting polypeptide family of drug transporters? von Kinzi, Jonny, Grube, Markus, Meyer zu Schwabedissen, Henriette E.

“… [Display omitted] The organic anion transporting polypeptide 2B1 (OATP2B1) was one of the first cloned members of the SLCO family. However, its physiological …”
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Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide von Witzigmann, Dominik, Uhl, Philipp, Sieber, Sandro, Kaufman, Christina, Einfalt, Tomaz, Schöneweis, Katrin, Grossen, Philip, Buck, Jonas, Ni, Yi, Schenk, Susanne H, Hussner, Janine, Meyer zu Schwabedissen, Henriette E, Québatte, Gabriela, Mier, Walter, Urban, Stephan, Huwyler, Jörg

“… Active targeting and specific drug delivery to parenchymal liver cells is a promising strategy to treat various liver disorders. Here, we modified synthetic …”
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A face‐to‐face comparison of the BBB cell models hCMEC/D3 and hBMEC for their applicability to adenoviral expression of transporters von Taggi, Valerio, Schäfer, Anima M., Dolce, Asaél, Meyer zu Schwabedissen, Henriette E.

“… The blood–brain barrier (BBB) is a structure mainly formed by brain capillary endothelial cells (BCEC) whose role is to regulate the exchange of compounds …”
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Impact and Enablers of Pharmacogenetic-Informed Treatment Decisions—A Longitudinal Mixed-Methods Study Exploring the Patient Perspective von Bollinger, Anna, Semedo Fortes, Melissa, Meyer zu Schwabedissen, Henriette E., Hersberger, Kurt E., Stäuble, Céline K., Allemann, Samuel S.

“… Pharmacogenetic (PGx) testing is a promising approach for optimizing drug therapies. However, there is limited knowledge regarding its real-world utilization …”
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Pharmacogenetic-Guided Antidepressant Selection as an Opportunity for Interprofessional Collaboration: A Case Report von Stäuble, Céline K., Lampert, Markus L., Mikoteit, Thorsten, Hatzinger, Martin, Hersberger, Kurt E., Meyer zu Schwabedissen, Henriette E.

“… In the herein reported case of a 42-year-old woman diagnosed with anxiety and depression, a long history of antidepressant ineffectiveness and adverse drug …”
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Influence of Slco2b1‐knockout and SLCO2B1‐humanization on coproporphyrin I and III levels in rats von Kinzi, Jonny, Hussner, Janine, Schäfer, Anima M., Treyer, Andrea, Seibert, Isabell, Tillmann, Annika, Mueller, Vanessa, Gherardi, Clarisse, Vonwyl, Celina, Hamburger, Matthias, Meyer zu Schwabedissen, Henriette E.

“… Background and Purpose Coproporphyrin (CP) I and III are byproducts of haem synthesis currently investigated as biomarkers for drug–drug interactions involving …”
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Drug transporter - enzyme crossroads: Does OATP2B1 shape Cyp3a-driven midazolam metabolism in rats? von Paloumpis, Nikolaos, Rysz, Marta, Bianchi, Noemi, Seibert, Isabell, Kinzi, Jonny, Schäfer, Anima M., Brecht, Karin, Ricklin, Daniel, Meyer zu Schwabedissen, Henriette E.

“… OATP2B1, encoded by SLCO2B1, is an uptake transporter in liver. Humanized SLCO2B1+/+ rats showed increased hepatic Cyp3a1 expression compared to rSlco2b1−/− …”
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Unravelling the Antiproliferative Activity of 1,2,5-oxadiazole Derivatives von EHRSAM, DANIEL, PORTA, FABIOLA, MORI, MATTEO, SCHWABEDISSEN, HENRIETTE E. MEYER ZU, DALLA VIA, LISA, GARCIA-ARGAEZ, AÌDA NELLY, BASILE, LIVIA, MENEGHETTI, FIORELLA, VILLA, STEFANIA, GELAIN, ARIANNA

“… To develop several new derivatives aimed to complete the studies concerning the antiproliferative profile of the oxadiazole derivative MD77. The substitution …”
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Gentamicin Population Pharmacokinetics in Pediatric Patients—A Prospective Study with Data Analysis Using the saemix Package in R von Paioni, Paolo, Jäggi, Vera F., Tilen, Romy, Seiler, Michelle, Baumann, Philipp, Bräm, Dominic S., Jetzer, Carole, Haid, Robin T. U., Goetschi, Aljoscha N., Goers, Roland, Müller, Daniel, Coman Schmid, Diana, Meyer zu Schwabedissen, Henriette E., Rinn, Bernd, Berger, Christoph, Krämer, Stefanie D.

“… The aminoglycoside gentamicin is used for the empirical treatment of pediatric infections. It has a narrow therapeutic window. In this prospective study at …”
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Establishment and Validation of Competitive Counterflow as a Method To Detect Substrates of the Organic Anion Transporting Polypeptide 2B1 von Schäfer, Anima M, Bock, Thomas, Meyer Zu Schwabedissen, Henriette E

“… The organic anion transporting polypeptide (OATP) 2B1 is ubiquitously expressed and known to facilitate cellular entry. It is widely accepted that transport …”
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Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9 von Ehrsam, Daniel, Sieber, Sandro, Oufir, Mouhssin, Porta, Fabiola, Hamburger, Matthias, Huwyler, Joerg, Schwabedissen, Henriette E. Meyer Zu

“… The concept of triggered drug release offers a possibility to overcome the toxic side effects of chemotherapeutics in cancer treatment by reducing systemic …”
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The scaffold protein PDZK1 modulates expression and function of the organic anion transporting polypeptide 2B1 von Ferreira, Celio, Hagen, Paul, Stern, Melanie, Hussner, Janine, Zimmermann, Uwe, Grube, Markus, Meyer zu Schwabedissen, Henriette E.

“… The protein family of Organic Anion Transporting Polypeptides (OATPs) summarizes various transporters known to facilitate cellular uptake of xenobiotics. One …”
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Thyroid Hormones Are Transport Substrates and Transcriptional Regulators of Organic Anion Transporting Polypeptide 2B1 von Meyer Zu Schwabedissen, Henriette E, Ferreira, Celio, Schaefer, Anima M, Oufir, Mouhssin, Seibert, Isabell, Hamburger, Matthias, Tirona, Rommel G

“… Levothyroxine replacement therapy forms the cornerstone of hypothyroidism management. Variability in levothyroxine oral absorption may contribute to the …”
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The effect of itraconazole, a strong CYP3A4 inhibitor, on the pharmacokinetics of the first‐in‐class ACKR3/CXCR7 antagonist, ACT‐1004‐1239 von Huynh, Christine, Dingemanse, Jasper, Meyer zu Schwabedissen, Henriette E., Fonseca, Marlene, Sidharta, Patricia N.

“… Cytochrome P450 (CYP) 3A4 is an enzyme involved in the metabolism of many drugs that are currently on the market and is therefore a key player in drug–drug …”
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