Suchergebnisse - "Metspalu, Andres"

Gut metagenome associations with extensive digital health data in a volunteer-based Estonian microbiome cohort von Aasmets, Oliver, Krigul, Kertu Liis, Lüll, Kreete, Metspalu, Andres, Org, Elin

“… Microbiome research is starting to move beyond the exploratory phase towards interventional trials and therefore well-characterized cohorts will be …”
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Improved polygenic prediction by Bayesian multiple regression on summary statistics von Lloyd-Jones, Luke R., Zeng, Jian, Sidorenko, Julia, Yengo, Loïc, Moser, Gerhard, Kemper, Kathryn E., Wang, Huanwei, Zheng, Zhili, Magi, Reedik, Esko, Tõnu, Metspalu, Andres, Wray, Naomi R., Goddard, Michael E., Yang, Jian, Visscher, Peter M.

“… Accurate prediction of an individual’s phenotype from their DNA sequence is one of the great promises of genomics and precision medicine. We extend a powerful …”
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Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome von Porcu, Eleonora, Sadler, Marie C., Lepik, Kaido, Auwerx, Chiara, Wood, Andrew R., Weihs, Antoine, Sleiman, Maroun S. Bou, Ribeiro, Diogo M., Bandinelli, Stefania, Tanaka, Toshiko, Nauck, Matthias, Völker, Uwe, Delaneau, Olivier, Metspalu, Andres, Teumer, Alexander, Frayling, Timothy, Santoni, Federico A., Reymond, Alexandre, Kutalik, Zoltán

“… Comparing transcript levels between healthy and diseased individuals allows the identification of differentially expressed genes, which may be causes, …”
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Genome-wide association study identifies five risk loci for pernicious anemia von Laisk, Triin, Lepamets, Maarja, Koel, Mariann, Abner, Erik, Mägi, Reedik

“… Pernicious anemia is a rare condition characterized by vitamin B12 deficiency anemia due to lack of intrinsic factor, often caused by autoimmune gastritis …”
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Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores von Läll, Kristi, Mägi, Reedik, Morris, Andrew, Metspalu, Andres, Fischer, Krista

“… Using effect estimates from genome-wide association studies (GWAS), we identified a genetic risk score (GRS) that has the strongest association with type 2 …”
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Meta‐analysis of microRNA expression in lung cancer von Võsa, Urmo, Vooder, Tõnu, Kolde, Raivo, Vilo, Jaak, Metspalu, Andres, Annilo, Tarmo

“… The prognostic and diagnostic value of microRNA (miRNA) expression aberrations in lung cancer has been studied intensely in recent years. However, due to the …”
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Signatures of negative selection in the genetic architecture of human complex traits von Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, McRae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M., Yang, Jian

“… We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide polymorphism (SNP)-based heritability, polygenicity (proportion of …”
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Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu von Leitsalu, Liis, Haller, Toomas, Esko, Tõnu, Tammesoo, Mari-Liis, Alavere, Helene, Snieder, Harold, Perola, Markus, Ng, Pauline C, Mägi, Reedik, Milani, Lili, Fischer, Krista, Metspalu, Andres

“… The Estonian Biobank cohort is a volunteer-based sample of the Estonian resident adult population (aged ≥18 years). The current number of participants-close to …”
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The individual and global impact of copy-number variants on complex human traits von Auwerx, Chiara, Lepamets, Maarja, Sadler, Marie C, Patxot, Marion, Stojanov, Miloš, Baud, David, Mägi, Reedik, Porcu, Eleonora, Reymond, Alexandre, Kutalik, Zoltán

“… The impact of copy-number variations (CNVs) on complex human traits remains understudied. We called CNVs in 331,522 UK Biobank participants and performed …”
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The Genetic Architecture of Gene Expression in Peripheral Blood von Lloyd-Jones, Luke R, Holloway, Alexander, McRae, Allan, Yang, Jian, Small, Kerrin, Zhao, Jing, Zeng, Biao, Bakshi, Andrew, Metspalu, Andres, Dermitzakis, Manolis, Gibson, Greg, Spector, Tim, Montgomery, Grant, Esko, Tonu, Visscher, Peter M, Powell, Joseph E

“… We analyzed the mRNA levels for 36,778 transcript expression traits (probes) from 2,765 individuals to comprehensively investigate the genetic architecture and …”
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Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel von Mitt, Mario, Kals, Mart, Pärn, Kalle, Gabriel, Stacey B, Lander, Eric S, Palotie, Aarno, Ripatti, Samuli, Morris, Andrew P, Metspalu, Andres, Esko, Tõnu, Mägi, Reedik, Palta, Priit

“… Genetic imputation is a cost-efficient way to improve the power and resolution of genome-wide association (GWA) studies. Current publicly accessible imputation …”
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Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants von Leitsalu, Liis, Palover, Marili, Sikka, Timo Tõnis, Reigo, Anu, Kals, Mart, Pärn, Kalle, Nikopensius, Tiit, Esko, Tõnu, Metspalu, Andres, Padrik, Peeter, Tõnisson, Neeme

“… Genotype-first approach allows to systematically identify carriers of pathogenic variants in BRCA1/2 genes conferring a high risk of familial breast and …”
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An epigenome-wide association study of metabolic syndrome and its components von Nuotio, Marja-Liisa, Pervjakova, Natalia, Joensuu, Anni, Karhunen, Ville, Hiekkalinna, Tero, Milani, Lili, Kettunen, Johannes, Järvelin, Marjo-Riitta, Jousilahti, Pekka, Metspalu, Andres, Salomaa, Veikko, Kristiansson, Kati, Perola, Markus

“… The role of metabolic syndrome (MetS) as a preceding metabolic state for type 2 diabetes and cardiovascular disease is widely recognised. To accumulate …”
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Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons von Fischer, Krista, Kettunen, Johannes, Würtz, Peter, Haller, Toomas, Havulinna, Aki S., Kangas, Antti J., Soininen, Pasi, Esko, Tõnu, Tammesoo, Mari-Liis, Mägi, Reedik, Smit, Steven, Palotie, Aarno, Ripatti, Samuli, Salomaa, Veikko, Ala-Korpela, Mika, Perola, Markus, Metspalu, Andres

“… Early identification of ambulatory persons at high short-term risk of death could benefit targeted prevention. To identify biomarkers for all-cause mortality …”
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Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells von Kasela, Silva, Kisand, Kai, Tserel, Liina, Kaleviste, Epp, Remm, Anu, Fischer, Krista, Esko, Tõnu, Westra, Harm-Jan, Fairfax, Benjamin P., Makino, Seiko, Knight, Julian C., Franke, Lude, Metspalu, Andres, Peterson, Pärt, Milani, Lili

“… Inappropriate activation or inadequate regulation of CD4+ and CD8+ T cells may contribute to the initiation and progression of multiple autoimmune and …”
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Manhattan Harvester and Cropper: a system for GWAS peak detection von Haller, Toomas, Tasa, Tõnis, Metspalu, Andres

“… Background Selection of interesting regions from genome wide association studies (GWAS) is typically performed by eyeballing of Manhattan Plots. This is no …”
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The effect of X-linked dosage compensation on complex trait variation von Sidorenko, Julia, Kassam, Irfahan, Kemper, Kathryn E., Zeng, Jian, Lloyd-Jones, Luke R., Montgomery, Grant W., Gibson, Greg, Metspalu, Andres, Esko, Tonu, Yang, Jian, McRae, Allan F., Visscher, Peter M.

“… Quantitative genetics theory predicts that X-chromosome dosage compensation (DC) will have a detectable effect on the amount of genetic and therefore …”
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Editorial: Can population health be personalized? Estonia and Finland as examples von Kääriäinen, Helena, Metspalu, Andres, Perola, Markus

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Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse von Pujol-Gualdo, Natàlia, Läll, Kristi, Lepamets, Maarja, Rossi, Henna-Riikka, Arffman, Riikka K., Piltonen, Terhi T., Mägi, Reedik, Laisk, Triin

“… Pelvic organ prolapse is a common gynecological condition with limited understanding of its genetic background. In this work, we perform a genome-wide …”
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Genotype–covariate interaction effects and the heritability of adult body mass index von Robinson, Matthew R, English, Geoffrey, Moser, Gerhard, Lloyd-Jones, Luke R, Triplett, Marcus A, Zhu, Zhihong, Nolte, Ilja M, van Vliet-Ostaptchouk, Jana V, Snieder, Harold, Esko, Tonu, Milani, Lili, Mägi, Reedik, Metspalu, Andres, Magnusson, Patrik K E, Pedersen, Nancy L, Ingelsson, Erik, Johannesson, Magnus, Yang, Jian, Cesarini, David, Visscher, Peter M

“… Matthew Robinson, Peter Visscher and colleagues use phenotypic data on 172,000 sibling pairs and phenotypic and SNP data on 150,832 unrelated individuals to …”
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