Výsledky vyhľadávania - "Metformin/analysis"

Investigating the root cause of N-nitrosodimethylamine formation in metformin pharmaceutical products Autor Nasr, Nasr Eldin Hussein, Metwaly, Metwaly Gamel, Ahmed, Eman Osama, Fares, Ahmed Roshdy, ElMeshad, Aliaa Nabil

Získať plný text

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK Autor Wang, Yu, An, Hongying, Liu, Ting, Qin, Caolitao, Sesaki, Hiromi, Guo, Shaodong, Radovick, Sally, Hussain, Mehboob, Maheshwari, Akhil, Wondisford, Fredric E., O’Rourke, Brian, He, Ling

“…Impaired mitochondrial respiratory activity contributes to the development of insulin resistance in type 2 diabetes. Metformin, a first-line antidiabetic drug,…”
Získať plný text

Metformin environmental exposure: A systematic review Autor Ambrosio-Albuquerque, Eliane Papa, Cusioli, Luis Fernando, Bergamasco, Rosângela, Sinópolis Gigliolli, Adriana Aparecida, Lupepsa, Luara, Paupitz, Brennda Ribeiro, Barbieri, Pablo Américo, Borin-Carvalho, Luciana Andreia, de Brito Portela-Castro, Ana Luiza

“…This review discussed the occurrence, ecological impacts, and effects of metformin, a drug used for type 2 diabetes among other diseases. It is one of the most…”
Získať plný text

Quantitative target and systematic non-target analysis of polar organic micro-pollutants along the river Rhine using high-resolution mass-spectrometry – Identification of unknown sources and compounds Autor Ruff, Matthias, Mueller, Miriam S., Loos, Martin, Singer, Heinz P.

“…In this study, the contamination by polar organic pollutants was investigated along the Rhine River, an important source of drinking water for 22 million…”
Získať plný text

Occurrence, toxic effects and removal of metformin in the aquatic environments in the world: Recent trends and perspectives Autor Elizalde-Velázquez, Gustavo Axel, Gómez-Oliván, Leobardo Manuel

“…[Display omitted] •MET antidiabetic drug review was conducted.•The annual consumption of MET worldwide is in tons.•The occurrence of MET in the world ranges…”
Získať plný text

Surface molecularly imprinted polymer on magnetic multi-walled carbon nanotubes for selective recognition and preconcentration of metformin in biological fluids prior to its sensitive chemiluminescence determination: Central composite design optimization Autor Toudeshki, Reza Mohammadi, Dadfarnia, Shayessteh, Haji Shabani, Ali Mohammad

“…Novel molecularly imprinted polymer (MIP) for metformin was synthesized on the surface of magnetic multi-walled carbon nanotubes (MMWCNTs) as the support…”
Získať plný text

Quantitative determination of potential genotoxic impurities in metformin hydrochloride and empagliflozin tablets through ultra-performance liquid chromatographymass spectrometry Autor Xiao, Tingyu, Hu, Xin, Chen, Yucheng, Lin, Huaqing

“…An increasing number of drug research institutions consider genotoxic impurity research a core task in drug research and development. Peroxides in drugs may…”
Získať plný text

Formation and occurrence of transformation products of metformin in wastewater and surface water Autor Tisler, Selina, Zwiener, Christian

“…The aim of this work was to investigate the occurrence and fate of the antidiabetic metformin (MF) and its transformation products (TPs) in wastewater and…”
Získať plný text

A global perspective on the use, occurrence, fate and effects of anti-diabetic drug metformin in natural and engineered ecosystems Autor Briones, Rowena M., Sarmah, Ajit K., Padhye, Lokesh P.

“…Metformin is the most commonly used anti-diabetic drug in the world. When consumed, this unmetabolised pharmaceutical compound is excreted by the body and…”
Získať plný text

Spectrophotometric Determination of Metformin in Different Pharmaceutical Combinations With Glipizide or Sitagliptin in Presence of Toxic Impurities of Metformin Autor Abdallah, Fatma F, Magdy, Fatma, Abdelaleem, Eglal A, Emam, Aml A

“…The presented quadruple divisor spectrophotometric method was able to resolve and analyze a complex quintuple drug matrix with severe overlapped spectra…”
Zistit podrobnosti o prístupe

Development and validation of simple spectrophotometric and chemometric methods for simultaneous determination of empagliflozin and metformin: Applied to recently approved pharmaceutical formulation Autor Ayoub, Bassam M.

“…New univariate spectrophotometric method and multivariate chemometric approach were developed and compared for simultaneous determination of empagliflozin and…”
Získať plný text

N-Nitrosodimethylamine Contamination in the Metformin Finished Products Autor Zmysłowski, Adam, Książek, Iza, Szterk, Arkadiusz

“…A GC–MS/MS method with EI ionization was developed and validated to detect and quantify N-nitrosodimethylamine (NDMA) and seven other nitrosamines in 105…”
Získať plný text

International Regulatory Collaboration on the Analysis of Nitrosamines in Metformin-Containing Medicines Autor Keire, David A., Bream, Robert, Wollein, Uwe, Schmaler-Ripcke, Jeannette, Burchardt, Annette, Conti, Massimiliano, Zmysłowski, Adam, Keizers, Peter, Morin, Justin, Poh, Jalene, George, Mark, Wierer, Michael

“…Recalls of some batches of metformin have occurred due to the detection of N -nitrosodimethylamine (NDMA) in amounts above the acceptable intake (AI) of 96 ng…”
Získať plný text

High-performance liquid chromatography method for simultaneous determination of the degradation products of metformin hydrochloride and vildagliptin Autor Demirović, Amra, Uzunović, Alija, Veledar-Hamalukić, Anisa

“…With the growing production of tablets containing two or more active pharmaceutical ingredients, analytical methods must align with this patient-friendly…”
Získať plný text

Community-level responses and environmental fate of metformin in freshwater mesocosms Autor Blandford, Nicholas C., Palace, Vince, Rodríguez-Gil, José Luis, Timlick, Lauren, Stanley, Madeline, Frank, Richard A., Campbell, Sheena, Rudy, Martina, Marshall, Stephanie, Wynia, Abby, Clark, Thomas, Cunningham, Jessie, Alaee, Mehran, Parrott, Joanne, Kidd, Karen A., Stevack, Kathleen, Sabourin, Lyne, Renaud, Justin B., Sumarah, Mark W., Nielsen, Kristin, McMaster, Mark E., Ussery, Erin

“…The type 2 diabetes drug metformin is among the most frequently prescribed, dispensed, and consumed pharmaceuticals worldwide; and its heavy use and poor…”
Získať plný text

Spatial analysis of metformin use compared with nicotine and caffeine consumption through wastewater-based epidemiology in China Autor Shao, Xue-Ting, Cong, Zi-Xiang, Liu, Si-Yu, Wang, Zhuang, Zheng, Xiao-Yu, Wang, De-Gao

“…Monitoring the consumption of pharmaceuticals and licit drugs is important for assessing the needs of public health owing to the impact on individuals as well…”
Získať plný text

Occurrence and fate of the antidiabetic drug metformin and its metabolite guanylurea in the environment and during drinking water treatment Autor Scheurer, Marco, Michel, Amandine, Brauch, Heinz-Jürgen, Ruck, Wolfgang, Sacher, Frank

“…Metformin, an antidiabetic drug with one of the highest consumption rates of all pharmaceuticals worldwide, is biologically degraded to guanylurea in…”
Získať plný text

Prediction of concentration levels of metformin and other high consumption pharmaceuticals in wastewater and regional surface water based on sales data Autor Oosterhuis, Mathijs, Sacher, Frank, ter Laak, Thomas L.

“…Local consumption data of pharmaceuticals were used to study the emission to wastewater and surface waters in two small Dutch water catchments. For nine high…”
Získať plný text

Occurrence of the antidiabetic drug Metformin and its ultimate transformation product Guanylurea in several compartments of the aquatic cycle Autor Trautwein, Christoph, Berset, Jean-Daniel, Wolschke, Hendrik, Kümmerer, Klaus

“…In 2030, the World Health Organization estimates that more than 350million people will be diagnosed with diabetes. Consequently, Metformin – the biguanide drug…”
Získať plný text

Biodegradation of metformin and guanylurea by aerobic cultures enriched from sludge Autor Briones, Rowena M., Zhuang, Wei-Qin, Sarmah, Ajit K.

“…Sewage sludge from a municipal wastewater treatment facility employing activated sludge process was pre-incubated with varying substrates and mixtures of…”
Získať plný text