Výsledky vyhledávání - "Mesenchymal Stem Cell Transplantation adverse effects"

Adipose Mesenchymal Stromal Cell‐Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose‐Escalation Trial Autor Pers, Yves-Marie, Rackwitz, Lars, Ferreira, Rosanna, Pullig, Oliver, Delfour, Christophe, Barry, Frank, Sensebe, Luc, Casteilla, Louis, Fleury, Sandrine, Bourin, Philippe, Noël, Danièle, Canovas, François, Cyteval, Catherine, Lisignoli, Gina, Schrauth, Joachim, Haddad, Daniel, Domergue, Sophie, Noeth, Ulrich, Jorgensen, Christian

“…This phase I clinical trial evaluated the safety and clinical efficacy of adipose‐derived stromal cells (ASCs) in osteoarthritis. Eighteen patients with severe…”
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Efficacy and Safety of Intravenous Mesenchymal Stem Cells for Ischemic Stroke Autor Chung, Jong-Won, Chang, Won Hyuk, Bang, Oh Young, Moon, Gyeong Joon, Kim, Suk Jae, Kim, Soo-Kyoung, Lee, Jin Soo, Sohn, Sung-Il, Kim, Yun-Hee

“…To test whether autologous modified mesenchymal stem cells (MSCs) improve recovery in patients with chronic major stroke. In this prospective, open-label,…”
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Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19 Autor Sengupta, Vikram, Sengupta, Sascha, Lazo, Angel, Woods, Peter, Nolan, Anna, Bremer, Nicholas

“…This prospective nonrandomized open-label cohort study addresses the safety and efficacy of exosomes (ExoFlo™) derived from allogeneic bone marrow mesenchymal…”
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Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines Autor Moll, Guido, Ankrum, James A., Kamhieh-Milz, Julian, Bieback, Karen, Ringdén, Olle, Volk, Hans-Dieter, Geissler, Sven, Reinke, Petra

“…Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials…”
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Clinical Efficacy and Safety of the Intra-articular Injection of Autologous Adipose-Derived Mesenchymal Stem Cells for Knee Osteoarthritis: A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial Autor Kim, Kang-Il, Lee, Myung Chul, Lee, Ju Hong, Moon, Young-Wan, Lee, Woo-Suk, Lee, Han-Jun, Hwang, Sun-Chul, In, Yong, Shon, Oog-Jin, Bae, Ki-Cheor, Song, Sang-Jun, Park, Kwan Kyu, Kim, Jun-Ho

“…Intra-articular injection of autologous culture-expanded adipose-derived mesenchymal stem cells (ADMSCs) has introduced a promising treatment option for knee…”
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Cell therapy in patients with heart failure: a comprehensive review and emerging concepts Autor Bolli, Roberto, Solankhi, Mitesh, Tang, Xiang-Liang, Kahlon, Arunpreet

“…Abstract This review summarizes the results of clinical trials of cell therapy in patients with heart failure (HF). In contrast to acute myocardial infarction…”
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Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial Autor Vega, Aurelio, Martín-Ferrero, Miguel Angel, Del Canto, Francisco, Alberca, Mercedes, García, Veronica, Munar, Anna, Orozco, Lluis, Soler, Robert, Fuertes, Juan Jose, Huguet, Marina, Sánchez, Ana, García-Sancho, Javier

“…Osteoarthritis is the most prevalent joint disease and a common cause of joint pain, functional loss, and disability. Conventional treatments demonstrate only…”
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Beneficial effects of autologous mesenchymal stem cell transplantation in active progressive multiple sclerosis Autor Petrou, Panayiota, Kassis, Ibrahim, Levin, Netta, Paul, Friedemann, Backner, Yael, Benoliel, Tal, Oertel, Frederike Cosima, Scheel, Michael, Hallimi, Michelle, Yaghmour, Nour, Hur, Tamir Ben, Ginzberg, Ariel, Levy, Yarden, Abramsky, Oded, Karussis, Dimitrios

“…In this study (trial registration: NCT02166021), we aimed to evaluate the optimal way of administration, the safety and the clinical efficacy of mesenchymal…”
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Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease Autor Dietz, Allan B, Dozois, Eric J, Fletcher, Joel G, Butler, Greg W, Radel, Darcie, Lightner, Amy L, Dave, Maneesh, Friton, Jessica, Nair, Asha, Camilleri, Emily T, Dudakovic, Amel, van Wijnen, Andre J, Faubion, William A

“…In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to…”
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Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials Autor Petrou, Panayiota, Gothelf, Yael, Argov, Zohar, Gotkine, Marc, Levy, Yossef S, Kassis, Ibrahim, Vaknin-Dembinsky, Adi, Ben-Hur, Tamir, Offen, Daniel, Abramsky, Oded, Melamed, Eldad, Karussis, Dimitrios

“…Preclinical studies have shown that neurotrophic growth factors (NTFs) extend the survival of motor neurons in amyotrophic lateral sclerosis (ALS) and that the…”
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Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial Autor Mautner, Ken, Gottschalk, Michael, Boden, Scott D., Akard, Alison, Bae, Won C., Black, Lora, Boggess, Blake, Chatterjee, Paramita, Chung, Christine B., Easley, Kirk A., Gibson, Greg, Hackel, Josh, Jensen, Katie, Kippner, Linda, Kurtenbach, Chad, Kurtzberg, Joanne, Mason, R. Amadeus, Noonan, Benjamin, Roy, Krishnendu, Valentine, Verle, Yeago, Carolyn, Drissi, Hicham

“…Various types of cellular injection have become a popular and costly treatment option for patients with knee osteoarthritis despite a paucity of literature…”
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Use of mesenchymal stem cells for therapy of cardiac disease Autor Karantalis, Vasileios, Hare, Joshua M

“…Despite substantial clinical advances over the past 65 years, cardiovascular disease remains the leading cause of death in America. The past 15 years has…”
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Route of Delivery Modulates the Efficacy of Mesenchymal Stem Cell Therapy for Myocardial Infarction: A Meta-Analysis of Preclinical Studies and Clinical Trials Autor Kanelidis, Anthony J, Premer, Courtney, Lopez, Juan, Balkan, Wayne, Hare, Joshua M

“…Accumulating data support a therapeutic role for mesenchymal stem cell (MSC) therapy; however, there is no consensus on the optimal route of delivery. We…”
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Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease Autor Molendijk, Ilse, Bonsing, Bert A, Roelofs, Helene, Peeters, Koen C M J, Wasser, Martin N J M, Dijkstra, Gerard, van der Woude, C Janneke, Duijvestein, Marjolijn, Veenendaal, Roeland A, Zwaginga, Jaap-Jan, Verspaget, Hein W, Fibbe, Willem E, van der Meulen-de Jong, Andrea E, Hommes, Daniel W

“…Patients with perianal fistulizing Crohn's disease have a poor prognosis because these lesions do not heal well. We evaluated the effects of local…”
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Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial Autor Jo, Chris Hyunchul, Lee, Young Gil, Shin, Won Hyoung, Kim, Hyang, Chai, Jee Won, Jeong, Eui Cheol, Kim, Ji Eun, Shim, Hackjoon, Shin, Ji Sun, Shin, Il Seob, Ra, Jeong Chan, Oh, Sohee, Yoon, Kang Sup

“…Mesenchymal stem cells (MSCs) are known to have a potential for articular cartilage regeneration. However, most studies focused on focal cartilage defect…”
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Intra‐Articular Injection of Autologous Adipose Tissue‐Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo‐Controlled Clinical Trial Autor Lee, Woo‐Suk, Kim, Hwan Jin, Kim, Kang‐Il, Kim, Gi Beom, Jin, Wook

“…Mesenchymal stem cells (MSCs) have been the focus of an emerging treatment for osteoarthritis. However, few studies reported about outcomes of an…”
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Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products Autor Moll, Guido, Ankrum, James A, Olson, Scott D, Nolta, Jan A

“…Abstract The number of mesenchymal stromal/stem cell (MSC) therapeutics and types of clinical applications have greatly diversified during the past decade,…”
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Umbilical cord mesenchymal stem cells for COVID‐19 acute respiratory distress syndrome: A double‐blind, phase 1/2a, randomized controlled trial Autor Lanzoni, Giacomo, Linetsky, Elina, Correa, Diego, Messinger Cayetano, Shari, Alvarez, Roger A., Kouroupis, Dimitrios, Alvarez Gil, Ana, Poggioli, Raffaella, Ruiz, Phillip, Marttos, Antonio C., Hirani, Khemraj, Bell, Crystal A., Kusack, Halina, Rafkin, Lisa, Baidal, David, Pastewski, Andrew, Gawri, Kunal, Leñero, Clarissa, Mantero, Alejandro M. A., Metalonis, Sarah W., Wang, Xiaojing, Roque, Luis, Masters, Burlett, Kenyon, Norma S., Ginzburg, Enrique, Xu, Xiumin, Tan, Jianming, Caplan, Arnold I., Glassberg, Marilyn K., Alejandro, Rodolfo, Ricordi, Camillo

“…Acute respiratory distress syndrome (ARDS) in COVID‐19 is associated with high mortality. Mesenchymal stem cells are known to exert immunomodulatory and…”
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MiR-17-92 enriched exosomes derived from multipotent mesenchymal stromal cells enhance axon-myelin remodeling and motor electrophysiological recovery after stroke Autor Xin, Hongqi, Liu, Zhongwu, Buller, Benjamin, Li, Yanfeng, Golembieski, William, Gan, Xinling, Wang, Fengjie, Lu, Mei, Ali, Meser M, Zhang, Zheng G, Chopp, Michael

“…MiR-17-92 cluster enriched exosomes derived from multipotent mesenchymal stromal cells (MSCs) increase functional recovery after stroke. Here, we investigate…”
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