Výsledky vyhľadávania - "Merle, Candice"

Acquisition of cancer stem cell capacities after spontaneous cell fusion Autor Merle, Candice, Lagarde, Pauline, Lartigue, Lydia, Chibon, Frédéric

“…Background Cancer stem/Initiating cell (CS/IC) hypothesis argues that CS/ICs are responsible of tumour initiation, drug resistance, metastasis or disease…”
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Cell–cell fusion of mesenchymal cells with distinct differentiations triggers genomic and transcriptomic remodelling toward tumour aggressiveness Autor Delespaul, Lucile, Gélabert, Caroline, Lesluyes, Tom, Le Guellec, Sophie, Pérot, Gaëlle, Leroy, Laura, Baud, Jessica, Merle, Candice, Lartigue, Lydia, Chibon, Frédéric

“…Cell–cell fusion is a physiological process that is hijacked during oncogenesis and promotes tumour evolution. The main known impact of cell fusion is to…”
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Contractile fibroblasts form a transient niche for the branching mammary epithelium Autor Sumbal, Jakub, Journot, Robin P., Attri, Kriti, Danek, Veronika, Merle, Candice, Faraldo, Marisa M., Sumbalova Koledova, Zuzana, Fre, Silvia

“…Fibroblasts are stromal cells found in connective tissue that are critical for organ development, tissue homeostasis and pathology. Single-cell transcriptomic…”
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Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme Autor Jacquemin, Guillaume, Wurmser, Annabelle, Huyghe, Mathilde, Sun, Wenjie, Homayed, Zeinab, Merle, Candice, Perkins, Meghan, Qasrawi, Fairouz, Richon, Sophie, Dingli, Florent, Arras, Guillaume, Loew, Damarys, Vignjevic, Danijela, Pannequin, Julie, Fre, Silvia

“…Tumours are complex ecosystems composed of different types of cells that communicate and influence each other. While the critical role of stromal cells in…”
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Cell fusion enhances energy metabolism of mesenchymal tumor hybrid cells to sustain their proliferation and invasion Autor Brito, Ariadna, Merle, Candice, Lagarde, Pauline, Faustin, Benjamin, Devin, Anne, Lartigue, Lydia, Chibon, Frederic

“…Background Cell-to-cell fusion is emerging as a key element of the metastatic process in various cancer types. We recently showed that hybrids made from the…”
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Genome remodeling upon mesenchymal tumor cell fusion contributes to tumor progression and metastatic spread Autor Lartigue, Lydia, Merle, Candice, Lagarde, Pauline, Delespaul, Lucile, Lesluyes, Tom, Le Guellec, Sophie, Pérot, Gaelle, Leroy, Laura, Coindre, Jean-Michel, Chibon, Frédéric

“…Cell fusion in tumor progression mostly refers to the merging of a cancer cell with a cell that has migration and immune escape capabilities such as…”
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DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age Autor Urbanus, Jos, Cosgrove, Jason, Beltman, Joost B., Elhanati, Yuval, Moral, Rafael A., Conrad, Cecile, van Heijst, Jeroen W., Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P., Guyonnet, Léa, Frisén, Jonas, Fre, Silvia, Walczak, Aleksandra M., Mora, Thierry, Jacobs, Heinz, Schumacher, Ton N., Perié, Leïla

“…Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce…”
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Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence Autor Andrique, Caroline, Morardet, Laetitia, Linares, Laetitia K., Cissé, Madi Y., Merle, Candice, Chibon, Frédéric, Provot, Sylvain, Haÿ, Eric, Ea, Hang-Korng, Cohen-Solal, Martine, Modrowski, Dominique

“…Sarcomas are still unsolved therapeutic challenges. Cancer stem cells are believed to contribute to sarcoma development, but lack of specific markers prevents…”
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Recording Lineage History with Cellular Barcodes in the Mammary Epithelium and in Breast Cancer Autor Merle, Candice, Fre, Silvia

“…Lineage tracing methods have extensively advanced our understanding of physiological cell behaviour in vivo and in situ and have vastly contributed to decipher…”
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Transcriptional landscapes underlying Notch-induced lineage conversion and plasticity of mammary basal cells Autor Merle, Candice, Rodrigues, Calvin, Pourkhalili Langeroudi, Atefeh, Journot, Robin, Rost, Fabian, Dang, Yiteng, Rulands, Steffen, Fre, Silvia

“…The mammary epithelium derives from multipotent mammary stem cells (MaSCs) that engage into differentiation during embryonic development. However, adult MaSCs…”
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Cell fusion enhances energy metabolism of mesenchymal tumor hybrid cells to sustain their proliferation and invasion Autor Brito, Ariadna, Merle, Candice, Lagarde, Pauline, Faustin, Benjamin, Devin, Anne, Lartigue, Lydia, Chibon, Frederic

“…Background: Cell-to-cell fusion is emerging as a key element of the metastatic process in various cancer types. We recently showed that hybrids made from the…”
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Fusion-mediated chromosomal instability promotes aneuploidy patterns that resemble human tumors Autor Delespaul, Lucile, Merle, Candice, Lesluyes, Tom, Lagarde, Pauline, Le Guellec, Sophie, Pérot, Gaëlle, Baud, Jessica, Carlotti, Martina, Danet, Coralie, Fèvre, Murielle, Rousseau, Benoit, Durrieu, Stéphanie, Teichmann, Martin, Coindre, Jean-Michel, Lartigue, Lydia, Chibon, Frédéric

“…Oncogenesis is considered to result from chromosomal instability, in addition to oncogene and tumor-suppressor alterations. Intermediate to aneuploidy and…”
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Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with DMD Deletion Autor Merle, Candice, Thébault, Noémie, LeGuellec, Sophie, Baud, Jessica, Pérot, Gaëlle, Lesluyes, Tom, Delespaul, Lucile, Lartigue, Lydia, Chibon, Frédéric

“…Whole-genome doubling is the second most frequent genomic event, after TP53 alterations, in advanced solid tumors and is associated with poor prognosis…”
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Distinct Cellular Origins and Differentiation Process Account for Distinct Oncogenic and Clinical Behaviors of Leiomyosarcomas Autor Darbo, Elodie, Pérot, Gaëlle, Darmusey, Lucie, Le Guellec, Sophie, Leroy, Laura, Gaston, Laëtitia, Desplat, Nelly, Thébault, Noémie, Merle, Candice, Rochaix, Philippe, Valentin, Thibaud, Ferron, Gwenaël, Chevreau, Christine, Bui, Binh, Stoeckle, Eberhard, Ranchere-Vince, Dominique, Méeus, Pierre, Terrier, Philippe, Piperno-Neumann, Sophie, Collin, Françoise, De Pinieux, Gonzague, Duffaud, Florence, Coindre, Jean-Michel, Blay, Jean-Yves, Chibon, Frédéric

“…In leiomyosarcoma (LMS), a very aggressive disease, a relatively transcriptionally uniform subgroup of well-differentiated tumors has been described and is…”
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Transcriptional landscapes underlying Notch-induced lineage conversion and plasticity of mammary basal cells Autor Merle, Candice, Rodrigues, Calvin, Langeroudi, Atefeh Pourkhalili, Journot, Robin, Rost, Fabian, Dang, Yiteng, Rulands, Steffen, Fre, Silvia

“…The mammary epithelium derives from multipotent mammary stem cells (MaSCs) that progressively restrict their potency and engage into lineage commitment during…”
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Distinct cellular origins and differentiation process account for distinct oncogenic and clinical behaviors of leiomyosarcomas Autor Darbo, Elodie, Pérot, Gaëlle, Darmusey, Lucie, Sophie Le Guellec, Leroy, Laura, Gaston, Laëtitia, Desplat, Nelly, Thébault, Noémie, Merle, Candice, Rochaix, Philippe, Valentin, Thibaud, Ferron, Gwenaël, Chevreau, Christine, Bui, Binh, Stoeckle, Eberhard, Ranchere-Vince, Dominique, Méeus, Pierre, Terrier, Philippe, Piperno-Neumann, Sophie, Collin, Françoise, De Pinieux, Gonzague, Duffaud, Florence, Jean-Michel Coindre, Blay, Jean-Yves, Chibon, Frédéric

“…In leiomyosarcoma (LMS), a very aggressive disease, a relatively transcriptionally uniform subgroup of well differentiated tumors has been described and is…”
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Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme Autor Jacquemin, Guillaume, Wurmser, Annabelle, Huyghe, Mathilde, Sun, Wenjie, Homayed, Zeinab, Merle, Candice, Qasrawi, Fairouz, Perkins, Meghan, Richon, Sophie, Dingli, Florent, Arras, Guillaume, Loew, Damarys, Vignjevic, Danijela, Pannequin, Julie, Fre, Silvia

“…Tumours are complex ecosystems composed of different types of cells that communicate and influence each other. While the critical role of stromal cells in…”
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DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age Autor Urbanus, Jos, Cosgrove, Jason, Beltman, Joost, Elhanati, Yuval, De Andrade Moral, Rafael, Conrad, Cecile, Jeroen Van Heijst, Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P, Frisen, Jonas, Fre, Silvia, Walczak, Aleksandra, Mora, Thierry, Jacobs, Heinz, Shumacher, Ton, Perie, Leila

“…Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce…”
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