Výsledky vyhľadávania - "Merghoub, Taha"

Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways Autor Kraehenbuehl, Lukas, Weng, Chien-Huan, Eghbali, Shabnam, Wolchok, Jedd D, Merghoub, Taha

“…The discovery and clinical implementation of immune-checkpoint inhibitors (ICIs) targeting CTLA4, PD-1 and PD-L1 has revolutionized the treatment of cancer, as…”
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Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies Autor Zappasodi, Roberta, Merghoub, Taha, Wolchok, Jedd D

“…Checkpoint blockade has formally demonstrated that reactivating anti-tumor immune responses can regress tumors. However, this only occurs in a fraction of…”
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Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine Autor Campesato, Luis Felipe, Budhu, Sadna, Tchaicha, Jeremy, Weng, Chien-Huan, Gigoux, Mathieu, Cohen, Ivan Jose, Redmond, David, Mangarin, Levi, Pourpe, Stephane, Liu, Cailian, Zappasodi, Roberta, Zamarin, Dmitriy, Cavanaugh, Jill, Castro, Alfredo C., Manfredi, Mark G., McGovern, Karen, Merghoub, Taha, Wolchok, Jedd D.

“…Tryptophan catabolism by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2 (IDO/TDO) promotes immunosuppression across different…”
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Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma Autor Snyder, Alexandra, Makarov, Vladimir, Merghoub, Taha, Yuan, Jianda, Zaretsky, Jesse M, Desrichard, Alexis, Walsh, Logan A, Postow, Michael A, Wong, Phillip, Ho, Teresa S, Hollmann, Travis J, Bruggeman, Cameron, Kannan, Kasthuri, Li, Yanyun, Elipenahli, Ceyhan, Liu, Cailian, Harbison, Christopher T, Wang, Lisu, Ribas, Antoni, Wolchok, Jedd D, Chan, Timothy A

“…In a comparison of tumors from patients with melanoma who benefitted from blockade of cytotoxic T-lymphocyte antigen 4 (CTLA-4) with tumors from patients who…”
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Rational design of anti-GITR-based combination immunotherapy Autor Zappasodi, Roberta, Sirard, Cynthia, Li, Yanyun, Budhu, Sadna, Abu-Akeel, Mohsen, Liu, Cailian, Yang, Xia, Zhong, Hong, Newman, Walter, Qi, Jingjing, Wong, Phillip, Schaer, David, Koon, Henry, Velcheti, Vamsidhar, Hellmann, Matthew D, Postow, Michael A, Callahan, Margaret K, Wolchok, Jedd D, Merghoub, Taha

“…Modulating T cell homeostatic mechanisms with checkpoint blockade can efficiently promote endogenous anti-tumor T cell responses . However, many patients still…”
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PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance Autor Verma, Vivek, Shrimali, Rajeev K, Ahmad, Shamim, Dai, Winjie, Wang, Hua, Lu, Sumin, Nandre, Rahul, Gaur, Pankaj, Lopez, Jose, Sade-Feldman, Moshe, Yizhak, Keren, Bjorgaard, Stacey L., Flaherty, Keith T., Wargo, Jennifer A., Boland, Genevieve M., Sullivan, Ryan J., Getz, Gad, Hammond, Scott A., Tan, Ming, Qi, Jingjing, Wong, Phillip, Merghoub, Taha, Wolchok, Jedd, Hacohen, Nir, Janik, John E., Mkrtichyan, Mikayel, Gupta, Seema, Khleif, Samir N.

“…Understanding resistance to antibody to programmed cell death protein 1 (PD-1; anti-PD-1) is crucial for the development of reversal strategies. In…”
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Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8 + T cells in tumors Autor Xu, Shihao, Chaudhary, Omkar, Rodríguez-Morales, Patricia, Sun, Xiaoli, Chen, Dan, Zappasodi, Roberta, Xu, Ziyan, Pinto, Antonio F M, Williams, April, Schulze, Isabell, Farsakoglu, Yagmur, Varanasi, Siva Karthik, Low, Jun Siong, Tang, Wenxi, Wang, Haiping, McDonald, Bryan, Tripple, Victoria, Downes, Michael, Evans, Ronald M, Abumrad, Nada A, Merghoub, Taha, Wolchok, Jedd D, Shokhirev, Maxim N, Ho, Ping-Chih, Witztum, Joseph L, Emu, Brinda, Cui, Guoliang, Kaech, Susan M

“…A common metabolic alteration in the tumor microenvironment (TME) is lipid accumulation, a feature associated with immune dysfunction. Here, we examined how…”
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CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors Autor Wang, Haiping, Franco, Fabien, Tsui, Yao-Chen, Xie, Xin, Trefny, Marcel P., Zappasodi, Roberta, Mohmood, Syed Raza, Fernández-García, Juan, Tsai, Chin-Hsien, Schulze, Isabell, Picard, Florence, Meylan, Etienne, Silverstein, Roy, Goldberg, Ira, Fendt, Sarah-Maria, Wolchok, Jedd D., Merghoub, Taha, Jandus, Camilla, Zippelius, Alfred, Ho, Ping-Chih

“…Depleting regulatory T cells (T reg cells) to counteract immunosuppressive features of the tumor microenvironment (TME) is an attractive strategy for cancer…”
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Immune-Active Microenvironment in Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Rationale for Immune Checkpoint Blockade Autor Jelinic, Petar, Ricca, Jacob, Van Oudenhove, Elke, Olvera, Narciso, Merghoub, Taha, Levine, Douglas A, Zamarin, Dmitriy

“…Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a highly aggressive monogenic cancer driven by SMARCA4 mutations. Here, we report responses…”
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Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma Autor Holm, Jeppe Sejerø, Funt, Samuel A., Borch, Annie, Munk, Kamilla Kjærgaard, Bjerregaard, Anne-Mette, Reading, James L., Maher, Colleen, Regazzi, Ashley, Wong, Phillip, Al-Ahmadie, Hikmat, Iyer, Gopa, Tamhane, Tripti, Bentzen, Amalie Kai, Herschend, Nana Overgaard, De Wolf, Susan, Snyder, Alexandra, Merghoub, Taha, Wolchok, Jedd D., Nielsen, Morten, Rosenberg, Jonathan E., Bajorin, Dean F., Hadrup, Sine Reker

“…CD8 + T cell reactivity towards tumor mutation-derived neoantigens is widely believed to facilitate the antitumor immunity induced by immune checkpoint…”
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ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity Autor Moral, John Alec, Leung, Joanne, Rojas, Luis A., Ruan, Jennifer, Zhao, Julia, Sethna, Zachary, Ramnarain, Anita, Gasmi, Billel, Gururajan, Murali, Redmond, David, Askan, Gokce, Bhanot, Umesh, Elyada, Ela, Park, Youngkyu, Tuveson, David A., Gönen, Mithat, Leach, Steven D., Wolchok, Jedd D., DeMatteo, Ronald P., Merghoub, Taha, Balachandran, Vinod P.

“…Group 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian tissues 1 , 2 . Although ILC2s are found in cancers of these tissues 3 ,…”
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Neutrophil phenotypes and functions in cancer: A consensus statement Autor Quail, Daniela F, Amulic, Borko, Aziz, Monowar, Barnes, Betsy J, Eruslanov, Evgeniy, Fridlender, Zvi G, Goodridge, Helen S, Granot, Zvi, Hidalgo, Andrés, Huttenlocher, Anna, Kaplan, Mariana J, Malanchi, Ilaria, Merghoub, Taha, Meylan, Etienne, Mittal, Vivek, Pittet, Mikael J, Rubio-Ponce, Andrea, Udalova, Irina A, van den Berg, Timo K, Wagner, Denisa D, Wang, Ping, Zychlinsky, Arturo, de Visser, Karin E, Egeblad, Mikala, Kubes, Paul

“…Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of…”
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Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade Autor McGranahan, Nicholas, Furness, Andrew J S, Rosenthal, Rachel, Ramskov, Sofie, Lyngaa, Rikke, Saini, Sunil Kumar, Jamal-Hanjani, Mariam, Wilson, Gareth A, Birkbak, Nicolai J, Hiley, Crispin T, Watkins, Thomas B K, Shafi, Seema, Murugaesu, Nirupa, Mitter, Richard, Akarca, Ayse U, Linares, Joseph, Marafioti, Teresa, Henry, Jake Y, Van Allen, Eliezer M, Miao, Diana, Schilling, Bastian, Schadendorf, Dirk, Garraway, Levi A, Makarov, Vladimir, Rizvi, Naiyer A, Snyder, Alexandra, Hellmann, Matthew D, Merghoub, Taha, Wolchok, Jedd D, Shukla, Sachet A, Wu, Catherine J, Peggs, Karl S, Chan, Timothy A, Hadrup, Sine R, Quezada, Sergio A, Swanton, Charles

“…As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored…”
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Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers Autor Caushi, Justina X., Zhang, Jiajia, Ji, Zhicheng, Vaghasia, Ajay, Zhang, Boyang, Hsiue, Emily Han-Chung, Mog, Brian J., Hou, Wenpin, Justesen, Sune, Blosser, Richard, Tam, Ada, Anagnostou, Valsamo, Cottrell, Tricia R., Guo, Haidan, Chan, Hok Yee, Singh, Dipika, Thapa, Sampriti, Dykema, Arbor G., Burman, Poromendro, Choudhury, Begum, Aparicio, Luis, Cheung, Laurene S., Lanis, Mara, Belcaid, Zineb, El Asmar, Margueritta, Illei, Peter B., Wang, Rulin, Meyers, Jennifer, Schuebel, Kornel, Gupta, Anuj, Skaist, Alyza, Wheelan, Sarah, Naidoo, Jarushka, Marrone, Kristen A., Brock, Malcolm, Ha, Jinny, Bush, Errol L., Park, Bernard J., Bott, Matthew, Jones, David R., Reuss, Joshua E., Velculescu, Victor E., Chaft, Jamie E., Kinzler, Kenneth W., Zhou, Shibin, Vogelstein, Bert, Taube, Janis M., Hellmann, Matthew D., Brahmer, Julie R., Merghoub, Taha, Forde, Patrick M., Yegnasubramanian, Srinivasan, Ji, Hongkai, Pardoll, Drew M., Smith, Kellie N.

“…PD-1 blockade unleashes CD8 T cells 1 , including those specific for mutation-associated neoantigens (MANA), but factors in the tumour microenvironment can…”
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Neoadjuvant PD-1 Blockade in Resectable Lung Cancer Autor Forde, Patrick M., Chaft, Jamie E., Smith, Kellie N., Anagnostou, Valsamo, Cottrell, Tricia R., Hellmann, Matthew D., Zahurak, Marianna, Yang, Stephen C., Jones, David R., Broderick, Stephen, Battafarano, Richard J., Velez, Moises J., Rekhtman, Natasha, Olah, Zachary, Naidoo, Jarushka, Marrone, Kristen A., Verde, Franco, Guo, Haidan, Zhang, Jiajia, Caushi, Justina X., Chan, Hok Yee, Sidhom, John-William, Scharpf, Robert B., White, James, Gabrielson, Edward, Wang, Hao, Rosner, Gary L., Rusch, Valerie, Wolchok, Jedd D., Merghoub, Taha, Taube, Janis M., Velculescu, Victor E., Topalian, Suzanne L., Brahmer, Julie R., Pardoll, Drew M.

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Escape from nonsense-mediated decay associates with anti-tumor immunogenicity Autor Litchfield, Kevin, Reading, James L., Lim, Emilia L., Xu, Hang, Liu, Po, Al-Bakir, Maise, Wong, Yien Ning Sophia, Rowan, Andrew, Funt, Samuel A., Merghoub, Taha, Perkins, David, Lauss, Martin, Svane, Inge Marie, Jönsson, Göran, Herrero, Javier, Larkin, James, Quezada, Sergio A., Hellmann, Matthew D., Turajlic, Samra, Swanton, Charles

“…Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the…”
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Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy Autor Zamarin, Dmitriy, Holmgaard, Rikke B, Subudhi, Sumit K, Park, Joon Seok, Mansour, Mena, Palese, Peter, Merghoub, Taha, Wolchok, Jedd D, Allison, James P

“…Preexisting lymphocytic infiltration of tumors is associated with superior prognostic outcomes in a variety of cancers. Recent studies also suggest that…”
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Neoantigen quality predicts immunoediting in survivors of pancreatic cancer Autor Łuksza, Marta, Sethna, Zachary M., Rojas, Luis A., Lihm, Jayon, Bravi, Barbara, Elhanati, Yuval, Soares, Kevin, Amisaki, Masataka, Dobrin, Anton, Hoyos, David, Guasp, Pablo, Zebboudj, Abderezak, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Odgerel, Zagaa, Leung, Joanne, Kappagantula, Rajya, Makohon-Moore, Alvin, Johns, Amber, Gill, Anthony, Gigoux, Mathieu, Wolchok, Jedd, Merghoub, Taha, Sadelain, Michel, Patterson, Erin, Monasson, Remi, Mora, Thierry, Walczak, Aleksandra M., Cocco, Simona, Iacobuzio-Donahue, Christine, Greenbaum, Benjamin D., Balachandran, Vinod P.

“…Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more immunogenic cancer cells to cause less immunogenic clones to dominate…”
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Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses Autor Chiappinelli, Katherine B, Strissel, Pamela L, Desrichard, Alexis, Li, Huili, Henke, Christine, Akman, Benjamin, Hein, Alexander, Rote, Neal S, Cope, Leslie M, Snyder, Alexandra, Makarov, Vladimir, Budhu, Sadna, Buhu, Sadna, Slamon, Dennis J, Wolchok, Jedd D, Pardoll, Drew M, Beckmann, Matthias W, Zahnow, Cynthia A, Merghoub, Taha, Mergoub, Taha, Chan, Timothy A, Baylin, Stephen B, Strick, Reiner

“…We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in cancer through the viral defense pathway. In ovarian cancer (OC), DNMTis…”
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Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner Autor Holmgaard, Rikke B., Zamarin, Dmitriy, Li, Yanyun, Gasmi, Billel, Munn, David H., Allison, James P., Merghoub, Taha, Wolchok, Jedd D.

“…Indoleamine 2,3-dioxygenase (IDO) has been described as a major mechanism of immunosuppression in tumors, though the mechanisms of this are poorly understood…”
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