Suchergebnisse - "Mercier, Isabelle"

Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity von Wang, Li, Le Mercier, Isabelle, Putra, Juan, Chen, Wenna, Liu, Jun, Schenk, Austin D, Nowak, Elizabeth C, Suriawinata, Arief A, Li, Jiannan, Noelle, Randolph J

“… V domain-containing Ig suppressor of T-cell activation (VISTA) is a negative checkpoint regulator that suppresses T cell-mediated immune responses. Previous …”
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Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators von Le Mercier, Isabelle, Lines, J. Louise, Noelle, Randolph J.

“… In the last two years, clinical trials with blocking antibodies to the negative checkpoint regulators CTLA-4 and PD-1 have rekindled the hope for cancer …”
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Defects in Emerin-Nucleoskeleton Binding Disrupt Nuclear Structure and Promote Breast Cancer Cell Motility and Metastasis von Liddane, Alexandra G, McNamara, Chelsea A, Campbell, Mallory C, Mercier, Isabelle, Holaska, James M

“… Nuclear envelope proteins play an important role in regulating nuclear size and structure in cancer. Altered expression of nuclear lamins are found in many …”
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Role of cholesterol in the development and progression of breast cancer von Llaverias, Gemma, Danilo, Christiane, Mercier, Isabelle, Daumer, Kristin, Capozza, Franco, Williams, Terence M, Sotgia, Federica, Lisanti, Michael P, Frank, Philippe G

“… Diet and obesity are important risk factors for cancer development. Many studies have suggested an important role for several dietary nutrients in the …”
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An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers von Witkiewicz, Agnieszka K, Dasgupta, Abhijit, Sotgia, Federica, Mercier, Isabelle, Pestell, Richard G, Sabel, Michael, Kleer, Celina G, Brody, Jonathan R, Lisanti, Michael P

“… Previously, we showed that caveolin-1 (Cav-1) expression is down-regulated in human breast cancer-associated fibroblasts. However, it remains unknown whether …”
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Interleukin-17 is a negative regulator of established allergic asthma von Schnyder-Candrian, Silvia, Togbe, Dieudonnée, Couillin, Isabelle, Mercier, Isabelle, Brombacher, Frank, Quesniaux, Valérie, Fossiez, Francois, Ryffel, Bernhard, Schnyder, Bruno

“… T helper (Th)17 cells producing interleukin (IL)-17 play a role in autoimmune and allergic inflammation. Here, we show that IL-23 induces IL-17 in the lung and …”
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VISTA Regulates the Development of Protective Antitumor Immunity von Le Mercier, Isabelle, Chen, Wenna, Lines, Janet L, Day, Maria, Li, Jiannan, Sergent, Petra, Noelle, Randolph J, Wang, Li

“… V-domain Ig suppressor of T-cell activation (VISTA) is a novel negative checkpoint ligand that is homologous to PD-L1 and suppresses T-cell activation. This …”
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Immunoregulatory functions of VISTA von Nowak, Elizabeth C., Lines, J. Louise, Varn, Frederick S., Deng, Jie, Sarde, Aurelien, Mabaera, Rodwell, Kuta, Anna, Le Mercier, Isabelle, Cheng, Chao, Noelle, Randolph J.

“… Summary Utilization of negative checkpoint regulators (NCRs) for cancer immunotherapy has garnered significant interest with the completion of clinical trials …”
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The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox von Martinez-Outschoorn, Ubaldo E., Whitaker-Menezes, Diana, Pavlides, Stephanos, Chiavarina, Barbara, Bonuccelli, Gloria, Trimmer, Casey, Tsirigos, Aristotelis, Migneco, Gemma, Witkiewicz, Agnieszka K., Balliet, Renee M., Mercier, Isabelle, Wang, Chengwang, Flomenberg, Neal, Howell, Anthony, Lin, Zhao, Caro, Jaime, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P

“… The role of autophagy in tumorigenesis is controversial. Both autophagy inhibitors (chloroquine) and autophagy promoters (rapamycin) block tumorigenesis by …”
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Hypoxia-Induced VISTA Promotes the Suppressive Function of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment von Deng, Jie, Li, Jiannan, Sarde, Aurelien, Lines, J Louise, Lee, Yu-Chi, Qian, David C, Pechenick, Dov A, Manivanh, Richard, Le Mercier, Isabelle, Lowrey, Christopher H, Varn, Frederick S, Cheng, Chao, Leib, David A, Noelle, Randolph J, Mabaera, Rodwell

“… Tumor hypoxia is a negative prognostic factor that is implicated in oncogenic signal activation, immune escape, and resistance to treatment. Identifying the …”
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Tumor promotion by intratumoral plasmacytoid dendritic cells is reversed by TLR7 ligand treatment von Le Mercier, Isabelle, Poujol, Dominique, Sanlaville, Amélien, Sisirak, Vanja, Gobert, Michael, Durand, Isabelle, Dubois, Bertrand, Treilleux, Isabelle, Marvel, Jacqueline, Vlach, Jaromir, Blay, Jean-Yves, Bendriss-Vermare, Nathalie, Caux, Christophe, Puisieux, Isabelle, Goutagny, Nadège

“… Plasmacytoid dendritic cells (pDC) are key regulators of antiviral immunity. In previous studies, we reported that pDC-infiltrating human primary breast tumors …”
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Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide von Quann, Kevin, Gonzales, Donna M., Mercier, Isabelle, Wang, Chenguang, Sotgia, Federica, Pestell, Richard G., Lisanti, Michael P., Jasmin, Jean-François

“… Caveolin-1 (Cav-1) is a critical regulator of tumor progression in a variety of cancers where it has been shown to act as either a tumor suppressor or tumor …”
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Caveolin-1 deficiency increases cerebral ischemic injury von Jasmin, Jean-François, Malhotra, Samit, Singh Dhallu, Manjeet, Mercier, Isabelle, Rosenbaum, Daniel M, Lisanti, Michael P

“… Caveolins (Cav), the principal structural proteins of the caveolar domains, have been implicated in the pathogenesis of ischemic injury. Indeed, changes in …”
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Rational design of a SOCS1-edited tumor-infiltrating lymphocyte therapy using CRISPR/Cas9 screens von Schlabach, Michael R., Lin, Sharon, Collester, Zachary R., Wrocklage, Christopher, Shenker, Sol, Calnan, Conor, Xu, Tianlei, Gannon, Hugh S., Williams, Leila J., Thompson, Frank, Dunbar, Paul R., LaMothe, Robert A., Garrett, Tracy E., Colletti, Nicholas, Hohmann, Anja F., Tubo, Noah J., Bullock, Caroline P., Le Mercier, Isabelle, Sofjan, Katri, Merkin, Jason J., Keegan, Sean, Kryukov, Gregory V., Dugopolski, Caroline, Stegmeier, Frank, Wong, Karrie, Sharp, Fiona A., Cadzow, Louise, Benson, Micah J.

“… Cell therapies such as tumor-infiltrating lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with …”
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Tryptophan hydroxylase-1 regulates immune tolerance and inflammation von Nowak, Elizabeth C, de Vries, Victor C, Wasiuk, Anna, Ahonen, Cory, Bennett, Kathryn A, Le Mercier, Isabelle, Ha, Dae-Gon, Noelle, Randolph J

“… Nutrient deprivation based on the loss of essential amino acids by catabolic enzymes in the microenvironment is a critical means to control inflammatory …”
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A randomized crossover study to compare efavirenz and etravirine treatment von Nguyen, Alain, Calmy, Alexandra, Delhumeau, Cécile, Mercier, Isabelle K, Cavassini, Matthias, Fayet-Mello, Aurélie, Elzi, Luigia, Genné, Daniel, Rauch, Andri, Bernasconi, Enos, Hirschel, Bernard

“… Efavirenz (EFV) causes neuropsychiatric side-effects and an unfavourable blood lipid profile. We investigated the effect of replacing EFV with etravirine (ETR) …”
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Caveolin-1 regulates the anti-atherogenic properties of macrophages von Pavlides, Stephanos, Gutierrez-Pajares, Jorge L, Katiyar, Sanjay, Jasmin, Jean-François, Mercier, Isabelle, Walters, Rhonda, Pavlides, Christos, Pestell, Richard G, Lisanti, Michael P, Frank, Philippe G

“… Atherosclerosis is a complex disease initiated by the vascular accumulation of lipoproteins in the sub-endothelial space, followed by the infiltration of …”
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Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers von Sotgia, Federica, Rui, Hallgeir, Bonuccelli, Gloria, Mercier, Isabelle, Pestell, Richard G, Lisanti, Michael P

“… Estrogen exposure is considered a significant risk factor for breast cancer development. Estrogen receptor (ER) alpha is expressed at low levels in normal …”
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A New VISTA on combination therapy for negative checkpoint regulator blockade von Deng, Jie, Le Mercier, Isabelle, Kuta, Anna, Noelle, Randolph J.

“… Negative checkpoint regulators function to restrain T cell responses to maintain tolerance and limit immunopathology. However, in the setting of malignancy, …”
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Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy von Witkiewicz, Agnieszka K., Casimiro, Mathew C., Dasgupta, Abhijit, Mercier, Isabelle, Wang, Chenguang, Bonuccelli, Gloria, Jasmin, Jean-François, Frank, Philippe G., Pestell, Richard G., Kleer, Celina G., Sotgia, Federica, Lisanti, Michael P.

“… Here, we discuss recent evidence that an absence of stromal Cav-1 expression in human breast cancers is a powerful single independent predictor of early …”
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