Suchergebnisse - "Meirelles, Osorio"

Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies von Ding, Jie, Davis-Plourde, Kendra L, Sedaghat, Sanaz, Tully, Phillip J, Wang, Wanmei, Phillips, Caroline, Pase, Matthew P, Himali, Jayandra J, Gwen Windham, B, Griswold, Michael, Gottesman, Rebecca, Mosley, Thomas H, White, Lon, Guðnason, Vilmundur, Debette, Stéphanie, Beiser, Alexa S, Seshadri, Sudha, Ikram, M Arfan, Meirelles, Osorio, Tzourio, Christophe, Launer, Lenore J

“… Dementia is a major health concern for which prevention and treatment strategies remain elusive. Lowering high blood pressure with specific antihypertensive …”
Volltext

Association of the Gut Microbiota With Cognitive Function in Midlife von Meyer, Katie, Lulla, Anju, Debroy, Kunal, Shikany, James M, Yaffe, Kristine, Meirelles, Osorio, Launer, Lenore J

“… IMPORTANCE: Animal experiments and small clinical studies support a role for the gut microbiota in cognitive functioning. Few studies have investigated gut …”
Volltext

Space and location of cerebral microbleeds, cognitive decline, and dementia in the community von Ding, Jie, Sigurðsson, Sigurður, Jónsson, Pálmi V, Eiriksdottir, Gudny, Meirelles, Osorio, Kjartansson, Olafur, Lopez, Oscar L, van Buchem, Mark A, Gudnason, Vilmundur, Launer, Lenore J

“… To assess the association of the number and anatomic location of cerebral microbleeds (CMBs), visible indicators of microvascular damage on MRI, with incident …”
Weitere Angaben

Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools von Ding, Jun, Sidore, Carlo, Butler, Thomas J., Wing, Mary Kate, Qian, Yong, Meirelles, Osorio, Busonero, Fabio, Tsoi, Lam C., Maschio, Andrea, Angius, Andrea, Kang, Hyun Min, Nagaraja, Ramaiah, Cucca, Francesco, Abecasis, Gonçalo R., Schlessinger, David

“… DNA sequencing identifies common and rare genetic variants for association studies, but studies typically focus on variants in nuclear DNA and ignore the …”
Volltext

SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors von Choy, Cecily, Chen, Joseph, Li, Jiangyuan, Gallagher, D. Travis, Lu, Jian, Wu, Daichao, Zou, Ainslee, Hemani, Humza, Baptiste, Beverly A., Wichmann, Emily, Yang, Qian, Ciffelo, Jeffrey, Yin, Rui, McKelvy, Julia, Melvin, Denise, Wallace, Tonya, Dunn, Christopher, Nguyen, Cuong, Chia, Chee W., Fan, Jinshui, Ruffolo, Jeannie, Zukley, Linda, Shi, Guixin, Amano, Tomokazu, An, Yang, Meirelles, Osorio, Wu, Wells W., Chou, Chao-Kai, Shen, Rong-Fong, Willis, Richard A., Ko, Minoru S. H., Liu, Yu-Tsueng, De, Supriyo, Pierce, Brian G., Ferrucci, Luigi, Egan, Josephine, Mariuzza, Roy, Weng, Nan-Ping

“… The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8 + T cells play a vital role. Nonetheless, the characterization of the …”
Volltext

Gut microbiome and stages of diabetes in middle-aged adults: CARDIA microbiome study von Hu, Yi-Han, Meyer, Katie, Lulla, Anju, Lewis, Cora E., Carnethon, Mercedes R., Schreiner, Pamela J., Sidney, Stephen, Shikany, James M., Meirelles, Osorio, Launer, Lenore J.

“… Background Animal and human studies suggest the gut microbiome is linked to diabetes but additional data are needed on the associations of the gut microbiome …”
Volltext

Assessment of multiphasic contrast-enhanced MR textures in differentiating small renal mass subtypes von Hoang, Uyen N., Mojdeh Mirmomen, S., Meirelles, Osorio, Yao, Jianhua, Merino, Maria, Metwalli, Adam, Marston Linehan, W., Malayeri, Ashkan A.

“… Purpose This study seeks to evaluate the use of quantitative texture parameters extracted from multiphasic contrast-enhanced magnetic resonance (MR) imaging in …”
Volltext

Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures von Allen, Chris, Büttner, Sabrina, Aragon, Anthony D, Thomas, Jason A, Meirelles, Osorio, Jaetao, Jason E, Benn, Don, Ruby, Stephanie W, Veenhuis, Marten, Madeo, Frank, Werner-Washburne, Margaret

“… Quiescence is the most common and, arguably, most poorly understood cell cycle state. This is in part because pure populations of quiescent cells are typically …”
Weitere Angaben

Proximal Femur Volumetric Bone Mineral Density and Mortality: 13 Years of Follow‐Up of the AGES‐Reykjavik Study von Marques, Elisa A, Elbejjani, Martine, Gudnason, Vilmundur, Sigurdsson, Gunnar, Lang, Thomas, Sigurdsson, Sigurdur, Aspelund, Thor, Meirelles, Osorio, Siggeirsdottir, Kristin, Launer, Lenore, Eiriksdottir, Gudny, Harris, Tamara B

“… ABSTRACT Bone mineral density (BMD) has been linked to mortality, but little is known about the independent contribution of each endosteal bone compartment and …”
Volltext

Association of Cerebral Blood Flow With Longitudinal Changes in Cerebral Microstructural Integrity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study von Bouhrara, Mustapha, Triebswetter, Curtis, Kiely, Matthew, Bilgel, Murat, Dolui, Sudipto, Erus, Guray, Meirelles, Osorio, Bryan, Nick R, Detre, John A, Launer, Lenore J

“… IMPORTANCE: Decreased cerebral tissue integrity and cerebral blood flow (CBF) are features of neurodegenerative diseases. Brain tissue maintenance is an …”
Volltext

Associations of plasma clusterin and Alzheimer’s disease-related MRI markers in adults at mid-life: The CARDIA Brain MRI sub-study von Haight, Thaddeus, Bryan, R. Nick, Meirelles, Osorio, Tracy, Russell, Fornage, Myriam, Richard, Melissa, Nasrallah, Ilya, Yaffe, Kristine, Jacobs, David R., Lewis, Cora, Schreiner, Pamela, Sidney, Stephen, Davatzikos, Christos, Launer, Lenore J.

“… Clinical and epidemiological studies of older persons have implicated clusterin in Alzheimer's disease (AD) pathogenesis. In the context of identifying early …”
Volltext

Genetics of serum BDNF: Meta-analysis of the Val66Met and genome-wide association study von Terracciano, Antonio, Piras, Maria Grazia, Lobina, Monia, Mulas, Antonella, Meirelles, Osorio, Sutin, Angelina R., Chan, Wayne, Sanna, Serena, Uda, Manuela, Crisponi, Laura, Schlessinger, David

“… Abstract Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic …”
Volltext

The proteomics of quiescent and nonquiescent cell differentiation in yeast stationary-phase cultures von Davidson, George S, Joe, Ray M, Roy, Sushmita, Meirelles, Osorio, Allen, Chris P, Wilson, Melissa R, Tapia, Phillip H, Manzanilla, Elaine E, Dodson, Anne E, Chakraborty, Swagata, Carter, Mark, Young, Susan, Edwards, Bruce, Sklar, Larry, Werner-Washburne, Margaret

“… As yeast cultures enter stationary phase in rich, glucose-based medium, differentiation of two major subpopulations of cells, termed quiescent and …”
Weitere Angaben

Characterization of differentiated quiescent and nonquiescent cells in yeast stationary-phase cultures von Aragon, Anthony D, Rodriguez, Angelina L, Meirelles, Osorio, Roy, Sushmita, Davidson, George S, Tapia, Phillip H, Allen, Chris, Joe, Ray, Benn, Don, Werner-Washburne, Margaret

“… Cells in glucose-limited Saccharomyces cerevisiae cultures differentiate into quiescent (Q) and nonquiescent (NQ) fractions before entering stationary phase …”
Weitere Angaben

White matter microstructure, white matter lesions, and hypertension: An examination of early surrogate markers of vascular-related brain change in midlife von Haight, Thaddeus, Nick Bryan, R., Erus, Guray, Hsieh, Meng-Kang, Davatzikos, Christos, Nasrallah, Ilya, D'Esposito, Mark, Jacobs, David R., Lewis, Cora, Schreiner, Pamela, Sidney, Stephen, Meirelles, Osorio, Launer, Lenore J.

“… We examined imaging surrogates of white matter microstructural abnormalities which may precede white matter lesions (WML) and represent a relevant marker of …”
Volltext

Hospital-treated prevalent infections, the plasma proteome and incident dementia among UK older adults von Beydoun, May A., Beydoun, Hind A., Noren Hooten, Nicole, Meirelles, Osorio, Li, Zhiguang, El-Hajj, Ziad W., Weiss, Jordan, Maino Vieytes, Christian A., Launer, Lenore J., Evans, Michele K., Zonderman, Alan B.

“… The plasma proteome can mediate the association of hospital-treated infections with dementia incidence. We screened up to 37,269 UK Biobank participants aged …”
Volltext

Genetic and biomarker modulation of arterial stiffness change in the SardiNIA population cohort von Asefa, Nigus G., Meirelles, Osorio, Lakatta, Edward, Fiorillo, Edoardo, Scuteri, Angelo, Cucca, Francesco, Marongiu, Michele, Delitala, Alessandro, Schlessinger, David, Launer, Lenore J.

“… Arterial stiffness (AS), quantified by pulse wave velocity (PWV), arises due to impaired arterial elastic tissue and smooth muscle dysfunction. We aimed to …”
Volltext

Sedentary behavior, brain-derived neurotrophic factor and brain structure in midlife: A longitudinal brain MRI sub-study of the coronary artery risk development in young adults study von Zhang, Xuan, Meirelles, Osorio D., Li, Zhiguang, Yaffe, Kristine, Bryan, R. Nick, Qiu, Chengxuan, Launer, Lenore J.

“… Brain-derived neurotrophic factor levels are higher in those who are physically active and lower in people with cognitive dysfunction. This study investigated …”
Volltext

N-Terminal pro-Brain Natriuretic Peptide and Associations With Brain Magnetic Resonance Imaging (MRI) Features in Middle Age: The CARDIA Brain MRI Study von Ferguson, Ian T., Elbejjani, Martine, Sabayan, Behnam, Jacobs, David R., Meirelles, Osorio, Sanchez, Otto A., Tracy, Russell, Bryan, Nick, Launer, Lenore J.

“… As part of research on the heart-brain axis, we investigated the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with brain structure and …”
Volltext

SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits von Meirelles, Osorio D, Ding, Jun, Tanaka, Toshiko, Sanna, Serena, Yang, Hsih-Te, Dudekula, Dawood B, Cucca, Francesco, Ferrucci, Luigi, Abecasis, Goncalo, Schlessinger, David

“… Measurement error and biological variability generate distortions in quantitative phenotypic data. In longitudinal studies with repeated measurements, the …”
Volltext