Search Results - "Mehraj, Umar"

Tumor microenvironment promotes breast cancer chemoresistance by Mehraj, Umar, Dar, Abid Hamid, Wani, Nissar A., Mir, Manzoor A.

“…Breast cancer is presently the most predominant tumor type and the second leading cause of tumor-related deaths among women. Although advancements in diagnosis…”
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Prognostic significance and targeting tumor-associated macrophages in cancer: new insights and future perspectives by Mehraj, Umar, Qayoom, Hina, Mir, Manzoor A.

“…Macrophages are phagocytic sentinel cells of the immune system that are central to both innate and adaptive immune responses and serve as the first line of…”
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The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities by Mehraj, Umar, Ganai, Rais A., Macha, Muzafar A., Hamid, Abid, Zargar, Mohammed A., Bhat, Ajaz A., Nasser, Mohd Wasim, Haris, Mohammad, Batra, Surinder K., Alshehri, Bader, Al-Baradie, Raid Saleem, Mir, Manzoor A., Wani, Nissar Ahmad

“…Background Breast cancer (BC), the second most common cause of cancer-related deaths, remains a significant threat to the health and wellness of women…”
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Expression pattern and prognostic significance of baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) in breast cancer: A comprehensive analysis by Mehraj, Umar, Aisha, Shariqa, Sofi, Shazia, Mir, Manzoor Ahmad

“…Baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, member of the inhibitor of apoptosis (IAP), is a multitasking protein and among the top 100…”
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Adapalene inhibits the growth of triple-negative breast cancer cells by S-phase arrest and potentiates the antitumor efficacy of GDC-0941 by Mehraj, Umar, Wani, Nissar Ahmad, Hamid, Abid, Alkhanani, Mustfa, Almilaibary, Abdullah, Mir, Manzoor Ahmad

“…Although advances in diagnostics and therapeutics have prolonged the survival of triple-negative breast cancer (TNBC) patients, metastasis, therapeutic…”
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Targeting Different Pathways Using Novel Combination Therapy in Triple Negative Breast Cancer by Mir, Manzoor, Khan, Hina, Mehraj, Umar, Nisar, Safura, Bhat, Basharat, Wani, Nisar

“…Triple negative breast cancer (TNBC) is one of the most aggressive subtype of breast cancer accounting for 15-20% of cases and is defined by the lack of…”
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Expression pattern and prognostic significance of CDKs in breast cancer: An integrated bioinformatic study by Mehraj, Umar, Sofi, Shazia, Alshehri, Bader, Mir, Manzoor A

“…Globally, breast cancer (BC) has become one of the most prevalent malignancies and the leading cause of tumor-related deaths among women. Dysregulation of the…”
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Nanobodies: The "Magic Bullets" in therapeutics, drug delivery and diagnostics by Mir, Manzoor A, Mehraj, Umar, Sheikh, Bashir Ahmad, Hamdani, Syed Suhail

“…Antibodies represent a well-established class of clinical diagnostics for medical applications as well as essential research and biotechnological tools…”
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Cryptolepine Targets TOP2A and Inhibits Tumor Cell Proliferation in Breast Cancer Cells - An In vitro and In silico Study by Mehraj, Umar, Qayoom, Hina, Shafi, Shazia, Farhana, Pzd, Asdaq, Syed Mohammed Basheeruddin, Mir, Manzoor Ahmad

“…DNA Topoisomerase II Alpha (TOP2A), a protein-coding gene, is central to the replication process and has been found deregulated in several malignancies,…”
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Adapalene and Doxorubicin Synergistically Promote Apoptosis of TNBC Cells by Hyperactivation of the ERK1/2 Pathway Through ROS Induction by Mehraj, Umar, Mir, Irfan Ahmad, Hussain, Mahboob ul, Alkhanani, Mustfa, Wani, Nissar Ahmad, Mir, Manzoor Ahmad

“…Doxorubicin is a commonly used chemotherapeutic agent to treat several malignancies, including aggressive tumors like triple-negative breast cancer. It has a…”
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Development of New Therapeutics to Meet the Current Challenge of Drug Resistant Tuberculosis by Sheikh, Bashir A, Bhat, Basharat A, Mehraj, Umar, Mir, Wajahat, Hamadani, Suhail, Mir, Manzoor A

“…Tuberculosis (TB) is a prominent infective disease and a major reason of mortality/ morbidity globally. Mycobacterium tuberculosis causes a long-lasting latent…”
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Topical retinoid drug Adapalene: A new frontier in cancer treatment by sofi, Shazia, Jan, Nusrat, Mehraj, Umar, Ahmad Mir, Manzoor

“…[Display omitted] •Cancer is a predominant cause of mortality and a significant scientific concern worldwide. It is a significant global health issue…”
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Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors by Sofi, Shazia, Mehraj, Umar, Qayoom, Hina, Aisha, Shariqa, Almilaibary, Abdullah, Alkhanani, Mustfa, Mir, Manzoor Ahmad

“…Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in uncontrolled cell proliferation and eventual tumor formation…”
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Cyclin-dependent kinases in breast cancer: expression pattern and therapeutic implications by Sofi, Shazia, Mehraj, Umar, Qayoom, Hina, Aisha, Shariqa, Asdaq, Syed Mohammad Basheeruddin, Almilaibary, Abdullah, Mir, Manzoor A.

“…Presently, breast cancer (BC) is one of the most common malignancies diagnosed and the leading cause of tumor-related deaths among women worldwide. Cell cycle…”
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Clinicopathological Significance and Expression Pattern of Bcl2 in Breast Cancer: A Comprehensive in silico and in vitro Study by sofi, Shazia, Mehraj, Umar, Jan, Nusrat, Almilaibary, Abdullah, Ahmad, Irshad, Ahmad, Fuzail, Ahmad Mir, Manzoor

“…[Display omitted] •This study reflects the pivotal role and prognostic consequence of Bcl2 in BC pathogenesis.•Bcl2 was selected as a potent target for this…”
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Chemokines in triple-negative breast cancer heterogeneity: New challenges for clinical implications by Mehraj, Umar, Mushtaq, Umar, Mir, Manzoor A., Saleem, Afnan, Macha, Muzafar A., Lone, Mohammad Nadeem, Hamid, Abid, Zargar, Mohammed A., Ahmad, Syed Mudasir, Wani, Nissar Ahmad

“…Tumor heterogeneity is a hallmark of cancer and one of the primary causes of resistance to therapies. Triple-negative breast cancer (TNBC), which accounts for…”
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Chloroquine sensitises hypoxic colorectal cancer cells to ROS-mediated cell death via structural disruption of pyruvate dehydrogenase kinase 1 by Mir, Irfan Ahmad, Mir, Hilal Ahmad, Mehraj, Umar, Bhat, Mohd Younus, Mir, Manzoor Ahmad, Dar, Tanveer Ali, Hussain, Mahboob-Ul

“…Chloroquine (CQ), an autophagy antagonist, has been recently explored as a repurposable medicine for cancer; however the exact mechanism of its action is still…”
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Expression Pattern and Prognostic Significance of Chemokines in Breast cancer: An Integrated Bioinformatics Analysis by Mehraj, Umar, Alshehri, Bader, Khan, Azmat Ali, Bhat, Ajaz A., Bagga, Puneet, Wani, Nissar Ahmad, Mir, Manzoor Ahmad

“…Breast cancer (BC), one of the most prevalent malignancies, is the second major cause of mortality from cancer among women worldwide. Even though substantial…”
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Expression patterns and therapeutic implications of CDK4 across multiple carcinomas: a molecular docking and MD simulation study by Qayoom, Hina, Mehraj, Umar, Sofi, Shazia, Aisha, Shariqa, Almilaibary, Abdullah, Alkhanani, Mustfa, Mir, Manzoor Ahmad

“…The CDKs are known to play a critical role in cell cycle regulation process. Among the different groups of CDKs, CDK4 overexpression/hyperactivation is found…”
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Synthesis and Biological Evaluation of Novel Uracil Derivatives as Thymidylate Synthase Inhibitors by Lone, Mohammad Nadeem, Gul, Shazia, Mehraj, Umar, Sofi, Shazia, Dar, Abid Hamid, Ganie, Shabir Ahmad, Wani, Nissar Ahmad, Mir, Manzoor Ahmad, Zargar, Mohammed A.

“…Cell division is driven by nucleic acid metabolism, and thymidylate synthase (TYMS) catalyzes a rate-limiting step in nucleotide synthesis. As a result,…”
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