Suchergebnisse - "Medvinsky, Alexander"

Human haematopoietic stem cell development: from the embryo to the dish von Ivanovs, Andrejs, Rybtsov, Stanislav, Ng, Elizabeth S, Stanley, Edouard G, Elefanty, Andrew G, Medvinsky, Alexander

“… Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult haematopoietic system. Understanding how early haematopoietic …”
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Embryonic origin of the adult hematopoietic system: advances and questions von Medvinsky, Alexander, Rybtsov, Stanislav, Taoudi, Samir

“… Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood …”
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Blood flow controls bone vascular function and osteogenesis von Ramasamy, Saravana K., Kusumbe, Anjali P., Schiller, Maria, Zeuschner, Dagmar, Bixel, M. Gabriele, Milia, Carlo, Gamrekelashvili, Jaba, Limbourg, Anne, Medvinsky, Alexander, Santoro, Massimo M., Limbourg, Florian P., Adams, Ralf H.

“… While blood vessels play important roles in bone homeostasis and repair, fundamental aspects of vascular function in the skeletal system remain poorly …”
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Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta von Taoudi, Samir, Medvinsky, Alexander

“… The first definitive/adult-type hematopoietic stem cells (HSCs) in the mouse aorta-gonad-mesonephros region emerge between embryonic days 10.5 and 11.5. The …”
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Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region von Ivanovs, Andrejs, Rybtsov, Stanislav, Welch, Lindsey, Anderson, Richard A, Turner, Marc L, Medvinsky, Alexander

“… Hematopoietic stem cells (HSCs) emerge during embryogenesis and maintain hematopoiesis in the adult organism. Little is known about the embryonic development …”
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Role of host cell traversal by the malaria sporozoite during liver infection von Tavares, Joana, Formaglio, Pauline, Thiberge, Sabine, Mordelet, Elodie, Van Rooijen, Nico, Medvinsky, Alexander, Ménard, Robert, Amino, Rogerio

“… Malaria infection starts when the sporozoite stage of the Plasmodium parasite is injected into the skin by a mosquito. Sporozoites are known to traverse host …”
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Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development von Crosse, Edie I, Gordon-Keylock, Sabrina, Rybtsov, Stanislav, Binagui-Casas, Anahi, Felchle, Hannah, Nnadi, Nneka C, Kirschner, Kristina, Chandra, Tamir, Tamagno, Sara, Webb, David J, Rossi, Fiona, Anderson, Richard A, Medvinsky, Alexander

“… Hematopoietic stem cells (HSCs) first emerge in the embryonic aorta-gonad-mesonephros (AGM) region. Studies of model organisms defined intersecting signaling …”
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Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting von Jakobsson, Lars, Franco, Claudio A., Bentley, Katie, Collins, Russell T., Ponsioen, Bas, Aspalter, Irene M., Rosewell, Ian, Busse, Marta, Thurston, Gavin, Medvinsky, Alexander, Schulte-Merker, Stefan, Gerhardt, Holger

“… Notch and vascular endothelial growth factor receptor (VEGFR) coordinates endothelial cells behaviour during angiogenesis sprouting although exactly how is …”
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Cellular Origin and Functional Relevance of Collagen I Production in the Kidney von Buchtler, Simone, Grill, Alexandra, Hofmarksrichter, Stefanie, Stöckert, Petra, Schiechl-Brachner, Gabriela, Rodriguez Gomez, Manuel, Neumayer, Sophia, Schmidbauer, Kathrin, Talke, Yvonne, Klinkhammer, Barbara M, Boor, Peter, Medvinsky, Alexander, Renner, Kerstin, Castrop, Hayo, Mack, Matthias

“… Interstitial fibrosis is associated with chronic renal failure. In addition to fibroblasts, bone marrow-derived cells and tubular epithelial cells have the …”
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Direct input of monitoring data into a mechanistic ecological model as a way to identify the phytoplankton growth-rate response to temperature variations von Medvinsky, Alexander B., Nurieva, Nailya I., Adamovich, Boris V., Radchikova, Nataly P., Rusakov, Alexey V.

“… We present an approach (knowledge-and-data-driven, KDD, modeling) that allows us to get closer to understanding the processes that affect the dynamics of …”
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Feedforward Control of Plant Nitrate Transporter NRT1.1 Biphasic Adaptive Activity von Rashid, Mubasher, Bera, Soumen, Banerjee, Malay, Medvinsky, Alexander B, Sun, Gui-Quan, Li, Bai-Lian, Sljoka, Adnan, Chakraborty, Amit

“… Defective nitrate signaling in plants causes disorder in nitrogen metabolism, and it negatively affects nitrate transport systems, which toggle between high- …”
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Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region von Rybtsov, Stanislav, Sobiesiak, Malgorzata, Taoudi, Samir, Souilhol, Céline, Senserrich, Jordi, Liakhovitskaia, Anna, Ivanovs, Andrejs, Frampton, Jon, Zhao, Suling, Medvinsky, Alexander

“… The aorta-gonad-mesonephros region plays an important role in hematopoietic stem cell (HSC) development during mouse embryogenesis. The vascular endothelial …”
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Tracing the Origin of the HSC Hierarchy Reveals an SCF-Dependent, IL-3-Independent CD43− Embryonic Precursor von Rybtsov, Stanislav, Batsivari, Antoniana, Bilotkach, Kateryna, Paruzina, Daria, Senserrich, Jordi, Nerushev, Oleg, Medvinsky, Alexander

“… Definitive hematopoietic stem cells (HSCs) develop in the aorta gonad mesonephros (AGM) region in a stepwise manner. Type I pre-HSCs express CD41 but lack CD45 …”
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Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells von Souilhol, Céline, Gonneau, Christèle, Lendinez, Javier G., Batsivari, Antoniana, Rybtsov, Stanislav, Wilson, Heather, Morgado-Palacin, Lucia, Hills, David, Taoudi, Samir, Antonchuk, Jennifer, Zhao, Suling, Medvinsky, Alexander

“… During embryonic development, adult haematopoietic stem cells (HSCs) emerge preferentially in the ventral domain of the aorta in the aorta–gonad–mesonephros …”
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Phase synchronization of chlorophyll and total phosphorus oscillations as an indicator of the transformation of a lake ecosystem von Rusakov, Alexey V., Adamovich, Boris V., Nurieva, Nailya I., Kovalevskaya, Raisa Z., Mikheyeva, Tamara M., Radchikova, Nataly P., Zhukava, Hanna A., Veres, Yulia K., Zhukova, Tatyana V., Medvinsky, Alexander B.

“… The ecosystem of the Naroch Lakes (Belarus) includes three water bodies, Lake Batorino, Lake Myastro and Lake Naroch. These lakes have a common catchment area …”
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Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis von Fitch, Simon R, Kimber, Gillian M, Wilson, Nicola K, Parker, Aimée, Mirshekar-Syahkal, Bahar, Göttgens, Berthold, Medvinsky, Alexander, Dzierzak, Elaine, Ottersbach, Katrin

“… The first adult-repopulating hematopoietic stem cells (HSCs) emerge in the aorta-gonads-mesonephros (AGM) region of the embryo. We have recently identified the …”
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Developing HSCs become Notch independent by the end of maturation in the AGM region von Souilhol, Céline, Lendinez, Javier G, Rybtsov, Stanislav, Murphy, Fiona, Wilson, Heather, Hills, David, Batsivari, Antoniana, Binagui-Casas, Anahí, McGarvey, Alison C, MacDonald, H Robson, Kageyama, Ryoichiro, Siebel, Christian, Zhao, Suling, Medvinsky, Alexander

“… The first definitive hematopoietic stem cells (dHSCs) in the mouse emerge in the dorsal aorta of the embryonic day (E) 10.5 to 11 aorta-gonad-mesonephros (AGM) …”
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1009 – SPATIALLY POLARISED MOLECULAR SIGNALLING UNDERLIES DEVELOPMENT OF HAEMATOPOIETIC STEM CELLS IN THE MAMMALIAN EMBRYO von Medvinsky, Alexander

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Understanding Hematopoietic Stem Cell Development through Functional Correlation of Their Proliferative Status with the Intra-aortic Cluster Architecture von Batsivari, Antoniana, Rybtsov, Stanislav, Souilhol, Celine, Binagui-Casas, Anahi, Hills, David, Zhao, Suling, Travers, Paul, Medvinsky, Alexander

“… During development, hematopoietic stem cells (HSCs) emerge in the aorta-gonad-mesonephros (AGM) region through a process of multi-step maturation and …”
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Allosteric regulation of glutamate dehydrogenase deamination activity von Bera, Soumen, Rashid, Mubasher, Medvinsky, Alexander B., Sun, Gui-Quan, Li, Bai-Lian, Acquisti, Claudia, Sljoka, Adnan, Chakraborty, Amit

“… Glutamate dehydrogenase (GDH) is a key enzyme interlinking carbon and nitrogen metabolism. Recent discoveries of the GDH specific role in breast cancer, …”
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