Suchergebnisse - "McLean, John A"

Ion Mobility-Mass Spectrometry: Time-Dispersive Instrumentation von May, Jody C, McLean, John A

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Untargeted Metabolomics Strategies—Challenges and Emerging Directions von Schrimpe-Rutledge, Alexandra C., Codreanu, Simona G., Sherrod, Stacy D., McLean, John A.

“… Metabolites are building blocks of cellular function. These species are involved in enzyme-catalyzed chemical reactions and are essential for cellular …”
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Correlating Resolving Power, Resolution, and Collision Cross Section: Unifying Cross-Platform Assessment of Separation Efficiency in Ion Mobility Spectrometry von Dodds, James N, May, Jody C, McLean, John A

“… Here we examine the relationship among resolving power (R ), resolution (R ), and collision cross section (CCS) for compounds analyzed in previous ion mobility …”
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Ion mobility conformational lipid atlas for high confidence lipidomics von Leaptrot, Katrina L., May, Jody C., Dodds, James N., McLean, John A.

“… Lipids are highly structurally diverse molecules involved in a wide variety of biological processes. Here, we use high precision ion mobility-mass spectrometry …”
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Evaluation of Collision Cross Section Calibrants for Structural Analysis of Lipids by Traveling Wave Ion Mobility-Mass Spectrometry von Hines, Kelly M, May, Jody C, McLean, John A, Xu, Libin

“… Collision cross section (CCS) measurement of lipids using traveling wave ion mobility-mass spectrometry (TWIM-MS) is of high interest to the lipidomics field …”
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Predicting Ion Mobility Collision Cross-Sections Using a Deep Neural Network: DeepCCS von Plante, Pier-Luc, Francovic-Fontaine, Élina, May, Jody C, McLean, John A, Baker, Erin S, Laviolette, François, Marchand, Mario, Corbeil, Jacques

“… Untargeted metabolomic measurements using mass spectrometry are a powerful tool for uncovering new small molecules with environmental and biological …”
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An Interlaboratory Evaluation of Drift Tube Ion Mobility-Mass Spectrometry Collision Cross Section Measurements von Stow, Sarah M, Causon, Tim J, Zheng, Xueyun, Kurulugama, Ruwan T, Mairinger, Teresa, May, Jody C, Rennie, Emma E, Baker, Erin S, Smith, Richard D, McLean, John A, Hann, Stephan, Fjeldsted, John C

“… Collision cross section (CCS) measurements resulting from ion mobility-mass spectrometry (IM-MS) experiments provide a promising orthogonal dimension of …”
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Integrating ion mobility into comprehensive multidimensional metabolomics workflows: critical considerations von May, Jody C., McLean, John A.

“… Background Ion mobility (IM) separation capabilities are now widely available to researchers through several commercial vendors and are now being adopted into …”
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Mapping Microbial Response Metabolomes for Induced Natural Product Discovery von Derewacz, Dagmara K, Covington, Brett C, McLean, John A, Bachmann, Brian O

“… Intergeneric microbial interactions may originate a significant fraction of secondary metabolic gene regulation in nature. Herein, we expose a genomically …”
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MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1 von Popay, Tessa M, Wang, Jing, Adams, Clare M, Howard, Gregory Caleb, Codreanu, Simona G, Sherrod, Stacy D, McLean, John A, Thomas, Lance R, Lorey, Shelly L, Machida, Yuichi J, Weissmiller, April M, Eischen, Christine M, Liu, Qi, Tansey, William P

“… The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer …”
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Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit von Brown, Jacquelyn A., Codreanu, Simona G., Shi, Mingjian, Sherrod, Stacy D., Markov, Dmitry A., Neely, M. Diana, Britt, Clayton M., Hoilett, Orlando S., Reiserer, Ronald S., Samson, Philip C., McCawley, Lisa J., Webb, Donna J., Bowman, Aaron B., McLean, John A., Wikswo, John P.

“… Background Understanding blood-brain barrier responses to inflammatory stimulation (such as lipopolysaccharide mimicking a systemic infection or a cytokine …”
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Multidimensional Separations of Intact Phase II Steroid Metabolites Utilizing LC-Ion Mobility-HRMS von Davis, Jr, Don E, Leaptrot, Katrina L, Koomen, David C, May, Jody C, Cavalcanti, Gustavo de A, Padilha, Monica C, Pereira, Henrique M G, McLean, John A

“… The detection and unambiguous identification of anabolic-androgenic steroid metabolites are essential in clinical, forensic, and antidoping analyses. Recently, …”
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Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice von Norris, Adriana C., Yazlovitskaya, Eugenia M., Zhu, Lin, Rose, Bailey S., May, Jody C., Gibson-Corley, Katherine N., McLean, John A., Stafford, John M., Graham, Todd R.

“… Genetic association studies have linked ATP10A and closely related type IV P-type ATPases (P4-ATPases) to insulin resistance and vascular complications, such …”
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Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli von Wiebe, Michelle A., Brannon, John R., Steiner, Bradley D., Bamidele, Adebisi, Schrimpe-Rutledge, Alexandra C., Codreanu, Simona G., Sherrod, Stacy D., McLean, John A., Hadjifrangiskou, Maria

“… The observation that l- serine uptake occurs as E. coli cultures grow is well established, yet the benefit E. coli garners from this uptake remains unclear …”
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Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption von Allwardt, Vanessa, Ainscough, Alexander J., Viswanathan, Priyalakshmi, Sherrod, Stacy D., McLean, John A., Haddrick, Malcolm, Pensabene, Virginia

“… Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery …”
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Improving the discovery of secondary metabolite natural products using ion mobility–mass spectrometry von Schrimpe-Rutledge, Alexandra C, Sherrod, Stacy D, McLean, John A

“… [Display omitted] •IM techniques separate ions in the gas-phase based on size, shape, and charge.•Deviations from mobility-mass trend lines can be prioritized …”
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A human milk oligosaccharide prevents intestinal inflammation in adulthood via modulating gut microbial metabolism von Schalich, Kasey M., Buendia, Matthew A., Kaur, Harpreet, Choksi, Yash A., Washington, M. Kay, Codreanu, Gabriela S., Sherrod, Stacy D., McLean, John A., Peek, Jr, Richard M., Acra, Sari A., Townsend, Steven D., Yan, Fang

“… At present, neither basic research nor clinical studies have revealed the exact biological functions or mechanisms of action of individual oligosaccharides …”
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Broadscale resolving power performance of a high precision uniform field ion mobility-mass spectrometer von May, Jody C, Dodds, James N, Kurulugama, Ruwan T, Stafford, George C, Fjeldsted, John C, McLean, John A

“… An extensive study of two current ion mobility resolving power theories ("conditional" and "semi-empirical") was undertaken using a recently developed drift …”
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Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism von Derewacz, Dagmara K, Goodwin, Cody R, McNees, C Ruth, McLean, John A, Bachmann, Brian O

“… Bacteria develop resistance to many classes of antibiotics vertically, by engendering mutations in genes encoding transcriptional and translational apparatus …”
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Profiling and imaging of tissues by imaging ion mobility-mass spectrometry von McLean, John A., Ridenour, Whitney B., Caprioli, Richard M.

“… Molecular profiling and imaging mass spectrometry (IMS) of tissues can often result in complex spectra that are difficult to interpret without additional …”
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