Suchergebnisse - "McDermott, Ultan"

Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer von Gogleva, Anna, Polychronopoulos, Dimitris, Pfeifer, Matthias, Poroshin, Vladimir, Ughetto, Michaël, Martin, Matthew J., Thorpe, Hannah, Bornot, Aurelie, Smith, Paul D., Sidders, Ben, Dry, Jonathan R., Ahdesmäki, Miika, McDermott, Ultan, Papa, Eliseo, Bulusu, Krishna C.

“… Resistance to EGFR inhibitors (EGFRi) presents a major obstacle in treating non-small cell lung cancer (NSCLC). One of the most exciting new ways to find …”
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COSMIC: exploring the world's knowledge of somatic mutations in human cancer von Forbes, Simon A., Beare, David, Gunasekaran, Prasad, Leung, Kenric, Bindal, Nidhi, Boutselakis, Harry, Ding, Minjie, Bamford, Sally, Cole, Charlotte, Ward, Sari, Kok, Chai Yin, Jia, Mingming, De, Tisham, Teague, Jon W., Stratton, Michael R., McDermott, Ultan, Campbell, Peter J.

“… COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer.sanger.ac.uk) is the world's largest and most comprehensive resource for exploring the …”
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Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening von Picco, Gabriele, Chen, Elisabeth D., Alonso, Luz Garcia, Behan, Fiona M., Gonçalves, Emanuel, Bignell, Graham, Matchan, Angela, Fu, Beiyuan, Banerjee, Ruby, Anderson, Elizabeth, Butler, Adam, Benes, Cyril H., McDermott, Ultan, Dow, David, Iorio, Francesco, Stronach, Euan, Yang, Fengtang, Yusa, Kosuke, Saez-Rodriguez, Julio, Garnett, Mathew J.

“… Many gene fusions are reported in tumours and for most their role remains unknown. As fusions are used for diagnostic and prognostic purposes, and are targets …”
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Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis von Petljak, Mia, Alexandrov, Ludmil B, Brammeld, Jonathan S, Price, Stacey, Wedge, David C, Grossmann, Sebastian, Dawson, Kevin J, Ju, Young Seok, Iorio, Francesco, Tubio, Jose M C, Koh, Ching Chiek, Georgakopoulos-Soares, Ilias, Rodríguez-Martín, Bernardo, Otlu, Burçak, O'Meara, Sarah, Butler, Adam P, Menzies, Andrew, Bhosle, Shriram G, Raine, Keiran, Jones, David R, Teague, Jon W, Beal, Kathryn, Latimer, Calli, O'Neill, Laura, Zamora, Jorge, Anderson, Elizabeth, Patel, Nikita, Maddison, Mark, Ng, Bee Ling, Graham, Jennifer, Garnett, Mathew J, McDermott, Ultan, Nik-Zainal, Serena, Campbell, Peter J, Stratton, Michael R

“… Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed …”
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Personalized cancer therapy with selective kinase inhibitors: an emerging paradigm in medical oncology von McDermott, Ultan, Settleman, Jeff

“… Selective kinase inhibitors have emerged as an important class of anticancer agents, with demonstrated clinical efficacy and generally favorable toxicity …”
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Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells von Yang, Wanjuan, Soares, Jorge, Greninger, Patricia, Edelman, Elena J., Lightfoot, Howard, Forbes, Simon, Bindal, Nidhi, Beare, Dave, Smith, James A., Thompson, I. Richard, Ramaswamy, Sridhar, Futreal, P. Andrew, Haber, Daniel A., Stratton, Michael R., Benes, Cyril, McDermott, Ultan, Garnett, Mathew J.

“… Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The …”
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Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties von Menden, Michael P., Iorio, Francesco, Garnett, Mathew, McDermott, Ultan, Benes, Cyril H., Ballester, Pedro J., Saez-Rodriguez, Julio

“… Predicting the response of a specific cancer to a therapy is a major goal in modern oncology that should ultimately lead to a personalised treatment …”
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Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia von Nii, Takenobu, Prabhu, Varun V, Ruvolo, Vivian, Madhukar, Neel, Zhao, Ran, Mu, Hong, Heese, Lauren, Nishida, Yuki, Kojima, Kensuke, Garnett, Mathew J, McDermott, Ultan, Benes, Cyril H, Charter, Neil, Deacon, Sean, Elemento, Olivier, Allen, Joshua E, Oster, Wolfgang, Stogniew, Martin, Ishizawa, Jo, Andreeff, Michael

“… Imipridones constitute a novel class of antitumor agents. Here, we report that a second-generation imipridone, ONC212, possesses highly increased antitumor …”
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FANCD2 limits replication stress and genome instability in cells lacking BRCA2 von Michl, Johanna, Zimmer, Jutta, Buffa, Francesca M, McDermott, Ultan, Tarsounas, Madalena

“… Probing the synthetic lethal effect of FANCD2 deletion in BRCA2-deficient cells reveals independent roles of FANCD2 and BRCA2 in stabilizing stalled …”
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Precision oncology for acute myeloid leukemia using a knowledge bank approach von Gerstung, Moritz, Papaemmanuil, Elli, Martincorena, Inigo, Bullinger, Lars, Gaidzik, Verena I, Paschka, Peter, Heuser, Michael, Thol, Felicitas, Bolli, Niccolo, Ganly, Peter, Ganser, Arnold, McDermott, Ultan, Döhner, Konstanze, Schlenk, Richard F, Döhner, Hartmut, Campbell, Peter J

“… Peter Campbell, Hartmut Döhner and colleagues present an analysis of genetic mutations and clinical information from 1,540 patients with acute myeloid …”
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The evolutionary history of lethal metastatic prostate cancer von Gundem, Gunes, Van Loo, Peter, Kremeyer, Barbara, Alexandrov, Ludmil B., Tubio, Jose M. C., Papaemmanuil, Elli, Brewer, Daniel S., Kallio, Heini M. L., Högnäs, Gunilla, Annala, Matti, Kivinummi, Kati, Goody, Victoria, Latimer, Calli, O'Meara, Sarah, Dawson, Kevin J., Isaacs, William, Emmert-Buck, Michael R., Nykter, Matti, Foster, Christopher, Kote-Jarai, Zsofia, Easton, Douglas, Whitaker, Hayley C., Neal, David E., Cooper, Colin S., Eeles, Rosalind A., Visakorpi, Tapio, Campbell, Peter J., McDermott, Ultan, Wedge, David C., Bova, G. Steven

“… The subclonal composition of human prostate tumours and their metastases has been mapped by whole-genome sequencing, thus establishing the evolutionary trees …”
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A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components von Nilsson, Monique B, Sun, Huiying, Robichaux, Jacqulyne, Pfeifer, Matthias, McDermott, Ultan, Travers, Jon, Diao, Lixia, Xi, Yuanxin, Tong, Pan, Shen, Li, Hofstad, Mia, Kawakami, Masanori, Le, Xiuning, Liu, Xi, Fan, Youhong, Poteete, Alissa, Hu, Limei, Negrao, Marcelo V, Tran, Hai, Dmitrovsky, Ethan, Peng, David, Gibbons, Don L, Wang, Jing, Heymach, John V

“… Acquired resistance to tyrosine kinase inhibitors (TKIs) of epidermal growth factor receptor (EGFR) remains a clinical challenge. Especially challenging are …”
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A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia von Tzelepis, Konstantinos, Koike-Yusa, Hiroko, De Braekeleer, Etienne, Li, Yilong, Metzakopian, Emmanouil, Dovey, Oliver M., Mupo, Annalisa, Grinkevich, Vera, Li, Meng, Mazan, Milena, Gozdecka, Malgorzata, Ohnishi, Shuhei, Cooper, Jonathan, Patel, Miten, McKerrell, Thomas, Chen, Bin, Domingues, Ana Filipa, Gallipoli, Paolo, Teichmann, Sarah, Ponstingl, Hannes, McDermott, Ultan, Saez-Rodriguez, Julio, Huntly, Brian J.P., Iorio, Francesco, Pina, Cristina, Vassiliou, George S., Yusa, Kosuke

“… Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which mainstream treatments have not changed for decades. To identify …”
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ctDNA monitoring using patient-specific sequencing and integration of variant reads von Wan, Jonathan C M, Heider, Katrin, Gale, Davina, Murphy, Suzanne, Fisher, Eyal, Mouliere, Florent, Ruiz-Valdepenas, Andrea, Santonja, Angela, Morris, James, Chandrananda, Dineika, Marshall, Andrea, Gill, Andrew B, Chan, Pui Ying, Barker, Emily, Young, Gemma, Cooper, Wendy N, Hudecova, Irena, Marass, Francesco, Mair, Richard, Brindle, Kevin M, Stewart, Grant D, Abraham, Jean E, Caldas, Carlos, Rassl, Doris M, Rintoul, Robert C, Alifrangis, Constantine, Middleton, Mark R, Gallagher, Ferdia A, Parkinson, Christine, Durrani, Amer, McDermott, Ultan, Smith, Christopher G, Massie, Charles, Corrie, Pippa G, Rosenfeld, Nitzan

“… Circulating tumor-derived DNA (ctDNA) can be used to monitor cancer dynamics noninvasively. Detection of ctDNA can be challenging in patients with low-volume …”
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Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma von Müller, Judith, Krijgsman, Oscar, Tsoi, Jennifer, Robert, Lidia, Hugo, Willy, Song, Chunying, Kong, Xiangju, Possik, Patricia A., Cornelissen-Steijger, Paulien D. M., Foppen, Marnix H Geukes, Kemper, Kristel, Goding, Colin R., McDermott, Ultan, Blank, Christian, Haanen, John, Graeber, Thomas G., Ribas, Antoni, Lo, Roger S., Peeper, Daniel S.

“… Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway …”
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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations von Sharma, Sreenath V, Lee, Diana Y, Li, Bihua, Quinlan, Margaret P, Takahashi, Fumiyuki, Maheswaran, Shyamala, McDermott, Ultan, Azizian, Nancy, Zou, Lee, Fischbach, Michael A, Wong, Kwok-Kin, Brandstetter, Kathleyn, Wittner, Ben, Ramaswamy, Sridhar, Classon, Marie, Settleman, Jeff

“… Accumulating evidence implicates heterogeneity within cancer cell populations in the response to stressful exposures, including drug treatments. While modeling …”
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Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma von Behjati, Sam, Tarpey, Patrick S., Haase, Kerstin, Ye, Hongtao, Young, Matthew D., Alexandrov, Ludmil B., Farndon, Sarah J., Collord, Grace, Wedge, David C., Martincorena, Inigo, Cooke, Susanna L., Davies, Helen, Mifsud, William, Lidgren, Mathias, Martin, Sancha, Latimer, Calli, Maddison, Mark, Butler, Adam P., Teague, Jon W., Pillay, Nischalan, Shlien, Adam, McDermott, Ultan, Futreal, P. Andrew, Baumhoer, Daniel, Zaikova, Olga, Bjerkehagen, Bodil, Myklebost, Ola, Amary, M. Fernanda, Tirabosco, Roberto, Van Loo, Peter, Stratton, Michael R., Flanagan, Adrienne M., Campbell, Peter J.

“… Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, we present the largest sequencing study of osteosarcoma to date, …”
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A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency von Lukasiak, Sebastian, Kalinka, Alex, Gupta, Nikhil, Papadopoulos, Angelos, Saeed, Khalid, McDermott, Ultan, Hannon, Gregory James, Ross-Thriepland, Douglas, Walter, David

“… Genome-wide CRISPR sgRNA libraries have emerged as transformative tools to systematically probe gene function. While these libraries have been iterated over …”
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Targeting MYCN in neuroblastoma by BET bromodomain inhibition von Puissant, Alexandre, Frumm, Stacey M, Alexe, Gabriela, Bassil, Christopher F, Qi, Jun, Chanthery, Yvan H, Nekritz, Erin A, Zeid, Rhamy, Gustafson, William Clay, Greninger, Patricia, Garnett, Matthew J, McDermott, Ultan, Benes, Cyril H, Kung, Andrew L, Weiss, William A, Bradner, James E, Stegmaier, Kimberly

“… Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date, however, genomic biomarkers to …”
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Comprehensive Pharmacogenomic Profiling of Malignant Pleural Mesothelioma Identifies a Subgroup Sensitive to FGFR Inhibition von Quispel-Janssen, Josine M, Badhai, Jitendra, Schunselaar, Laurel, Price, Stacey, Brammeld, Jonathan, Iorio, Francesco, Kolluri, Krishna, Garnett, Matthew, Berns, Anton, Baas, Paul, McDermott, Ultan, Neefjes, Jacques, Alifrangis, Constantine

“… Despite intense research, treatment options for patients with mesothelioma are limited and offer only modest survival advantage. We screened a large panel of …”
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