Výsledky vyhľadávania - "Mammalian target of rapamycin"

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial Autor Lai, Zhi-Wei, Hanczko, Robert, Bonilla, Eduardo, Caza, Tiffany N., Clair, Brandon, Bartos, Adam, Miklossy, Gabriella, Jimah, John, Doherty, Edward, Tily, Hajra, Francis, Lisa, Garcia, Ricardo, Dawood, Maha, Yu, Jianghong, Ramos, Irene, Coman, Ioana, Faraone, Stephen V., Phillips, Paul E., Perl, Andras

“…) and mammalian target of rapamycin (mTOR) by glutathione (GSH). This randomized, double‐blind, placebo‐controlled study was undertaken to examine the safety, tolerance, and efficacy of the GSH precursor N…”
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Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension Autor Goncharov, Dmitry A, Kudryashova, Tatiana V, Ziai, Houman, Ihida-Stansbury, Kaori, DeLisser, Horace, Krymskaya, Vera P, Tuder, Rubin M, Kawut, Steven M, Goncharova, Elena A

“…). The role of the distinct mammalian target of rapamycin (mTOR) complexes mTORC1 (mTOR-Raptor) and mTORC2 (mTOR-Rictor) in PAVSMC proliferation and survival in PAH and their therapeutic relevance are unknown…”
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Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin Autor Mitani, Akihisa, Ito, Kazuhiro, Vuppusetty, Chaitanya, Barnes, Peter J., Mercado, Nicolas

“… However, the mechanism for corticosteroid resistance is still not fully elucidated. To investigate the role of mammalian target of rapamycin (mTOR…”
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Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin-like growth factor-1 in patients with acne vulgaris and their relationship with diet Autor Agamia, N.F., Abdallah, D.M., Sorour, O., Mourad, B., Younan, D.N.

“…)O1 and mammalian target of rapamycin (mTOR) interactions may be the key to understanding the links between genetic and environmental factors in acne vulgaris…”
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Chronic heat stress affects muscle hypertrophy, muscle protein synthesis and uptake of amino acid in broilers via insulin like growth factor-mammalian target of rapamycin signal pathway Autor Ma, Bingbing, He, Xiaofang, Lu, Zhuang, Zhang, Lin, Li, Jiaolong, Jiang, Yun, Zhou, Guanghong, Gao, Feng

“…Heat stress markedly impairs the growth performance of broilers, such as the reduction of breast muscle mass and yield. The aim of this study was to examine…”
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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition Autor Sun, Shi-Yong, Rosenberg, Laura M, Wang, Xuerong, Zhou, Zhongmei, Yue, Ping, Fu, Haian, Khuri, Fadlo R

“…The mammalian target of rapamycin (mTOR) has emerged as an important cancer therapeutic target…”
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Critical role of mammalian target of rapamycin for IL-10 dendritic cell induction by a flagellin A conjugate in preventing allergic sensitization Autor Schülke, Stefan, Fiedler, Anna-Helena, Junker, Ann-Christine, Flaczyk, Adam, Wolfheimer, Sonja, Wangorsch, Andrea, Heinz, Anke, Beckert, Hendrik, Nagl, Birgit, Bohle, Barbara, Vieths, Stefan, Toda, Masako, Scheurer, Stephan

“… with rFlaA:Betv1 in an experimental Bet v 1 sensitization model. Myeloid dendritic cells (mDCs) were differentiated from mouse bone marrow, and PBMCs were isolated from subjects with birch pollen allergy…”
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A New Hypothesis Describing the Pathogenesis of Oral Mucosal Injury Associated with the Mammalian Target of Rapamycin (mTOR) Inhibitors Autor Sonis, Stephen T., Villa, Alessandro

“…’ pathogenesis has been the subject of speculation, and its similar presentation to recurrent aphthous stomatitis (RAS…”
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Mammalian target of rapamycin inhibition counterbalances the inflammatory status of immune cells in patients with chronic granulomatous disease Autor Gabrion, Aurélie, Hmitou, Isabelle, Moshous, Despina, Neven, Bénédicte, Lefèvre-Utile, Alain, Diana, Jean-Sébastien, Suarez, Félipe, Picard, Capucine, Blanche, Stéphane, Fischer, Alain, Cavazzana, Marina, Touzot, Fabien

“…Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defective production of reactive oxygen species in phagocytic cells that results in…”
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A comprehensive review of everolimus clinical reports: a new mammalian target of rapamycin inhibitor Autor Gurk-Turner, Cheryle, Manitpisitkul, Wana, Cooper, Matthew

“… With these challenges in mind, this compilation of published work for the newest mammalian target of rapamycin inhibitor everolimus (Certican…”
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Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling Autor Timmerman, Kyle L, Lee, Jessica L, Dreyer, Hans C, Dhanani, Shaheen, Glynn, Erin L, Fry, Christopher S, Drummond, Micah J, Sheffield-Moore, Melinda, Rasmussen, Blake B, Volpi, Elena

“… isotope tracers, and phosphorylation of proteins associated with insulin (Akt) and amino acid-induced mammalian target of rapamycin (mTOR) complex 1 (mTORC1) signaling…”
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Evaluation of Serum Pyruvate Kinase M2 and Key Glycolytic Signatures and Its Correlation with Phosphatidylinositol-3-kinase/Akt/Mammalian Target of Rapamycin Pathway in Women with Breast Carcinoma Autor Monteiro, Flama, Shetty, Vijith Vittal, Shetty, Shilpa S., Acharya, Ranjitha, Suhasini, P. C., Nalilu, Suchetha Kumari

“…Abstract Background: A desired target for cancer therapy is a cancer-specific metabolism which is associated with innate or acquired therapeutic resistance,…”
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Complications of mammalian target of rapamycin inhibitor anticancer treatment among patients with tuberous sclerosis complex are common and occasionally life-threatening Autor Trelinska, Joanna, Dachowska, Iwona, Kotulska, Katarzyna, Fendler, Wojciech, Jozwiak, Sergiusz, Mlynarski, Wojciech

“…The aim of this study was to evaluate the most common adverse events (AEs) linked to everolimus therapy, a mammalian target of rapamycin (mTOR…”
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A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3‐kinase/v‐akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma Autor Korkolopoulou, Penelope, Levidou, Georgia, Trigka, Eleni‐Andriana, Prekete, Niki, Karlou, Maria, Thymara, Irene, Sakellariou, Stratigoula, Fragkou, Paraskevi, Isaiadis, Dimitrios, Pavlopoulos, Petros, Patsouris, Efstratios, Saetta, Angelica A.

“…What's known on the subject? and What does the study add? A few published studies investigating single or various PI3K/AKT/mTOR signalling components have produced inconsistent results…”
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Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling Autor Fujita, Satoshi, Rasmussen, Blake B., Cadenas, Jerson G., Drummond, Micah J., Glynn, Erin L., Sattler, Fred R., Volpi, Elena

“…Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling Satoshi Fujita 1 2 , Blake B…”
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Activation of mammalian target of rapamycin pathway confers adverse outcome in nonsmall cell lung carcinoma Autor Liu, Dan, Huang, Yi, Chen, Bojiang, Zeng, Jing, Guo, Na, Zhang, Shangfu, Liu, Lunxu, Xu, Hong, Mo, Xianming, Li, Weimin

“…BACKGROUND: Dysregulation of the mammalian target of rapamycin (mTOR) pathway has been shown to contribute to tumorigenesis…”
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Hypoxia‐inducible factor and mammalian target of rapamycin pathway markers in urothelial carcinoma of the bladder: possible therapeutic implications Autor Tickoo, Satish K., Milowsky, Matthew I., Dhar, Nitin, Dudas, Maria E., Gallagher, David J., Al‐Ahmadie, Hikmat, Gopalan, Anuradha, Fine, Samson W., Ishill, Nicole, Bajorin, Dean F., Reuter, Victor E.

“…What’s known on the subject? and What does the study add? The hypoxia‐inducible factor (HIF) and mammalian target of rapamycin…”
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Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia Autor Favier, François B, Costes, Frédéric, Defour, Aurélia, Bonnefoy, Régis, Lefai, Etienne, Baugé, Stéphane, Peinnequin, André, Benoit, Henri, Freyssenet, Damien

“…Although it is well established that chronic hypoxia leads to an inexorable loss of skeletal muscle mass in healthy subjects, the underlying molecular mechanisms involved in this process are currently unknown…”
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Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells Autor Bianchi, Nicoletta, Finotti, Alessia, Ferracin, Manuela, Lampronti, Ilaria, Zuccato, Cristina, Breveglieri, Giulia, Brognara, Eleonora, Fabbri, Enrica, Borgatti, Monica, Negrini, Massimo, Gambari, Roberto

“… In the first part of this study microarray analysis was performed both in mithramycin-induced K562 cells and erythroid precursors from healthy subjects or β…”
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A phase I study of the mammalian target of rapamycin inhibitor sirolimus and MEC chemotherapy in relapsed and refractory acute myelogenous leukemia Autor Perl, Alexander E, Kasner, Margaret T, Tsai, Donald E, Vogl, Dan T, Loren, Alison W, Schuster, Stephen J, Porter, David L, Stadtmauer, Edward A, Goldstein, Steven C, Frey, Noelle V, Nasta, Sunita D, Hexner, Elizabeth O, Dierov, Jamil K, Swider, Cezary R, Bagg, Adam, Gewirtz, Alan M, Carroll, Martin, Luger, Selina M

“…Inhibiting mammalian target of rapamycin (mTOR) signaling in acute myelogenous leukemia (AML…”
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