Výsledky vyhľadávania - "Mammalian genome"

Radiation, inflammation and the immune response in cancer Autor McKelvey, Kelly J., Hudson, Amanda L., Back, Michael, Eade, Tom, Diakos, Connie I.

“…Radiation is an important component of cancer treatment with more than half of all patients receive radiotherapy during their cancer experience. While the…”
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Host genetic control of gut microbiome composition Autor Bubier, Jason A., Chesler, Elissa J., Weinstock, George M.

“…The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in…”
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Metagenomics: a path to understanding the gut microbiome Autor Yen, Sandi, Johnson, Jethro S.

“…The gut microbiome is a major determinant of host health, yet it is only in the last 2 decades that the advent of next-generation sequencing has enabled it to…”
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Significance of lncRNA abundance to function Autor Grammatikakis, Ioannis, Lal, Ashish

“…Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse cellular processes. Although the vast majority of lncRNAs are expressed at lower levels…”
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The alliance of genome resources: transforming comparative genomics Autor Bult, Carol J., Sternberg, Paul W.

“…Comparing genomic and biological characteristics across multiple species is essential to using model systems to investigate the molecular and cellular…”
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microbiome: stress, health and disease Autor Moloney, Rachel D, Desbonnet, Lieve, Clarke, Gerard, Dinan, Timothy G, Cryan, John F

“…Bacterial colonisation of the gut plays a major role in postnatal development and maturation of key systems that have the capacity to influence central nervous…”
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The gut microbiome of laboratory mice: considerations and best practices for translational research Autor Ericsson, Aaron C., Franklin, Craig L.

“…Just as the gut microbiota (GM) is now recognized as an integral mediator of environmental influences on human physiology, susceptibility to disease, and…”
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The diversity outbred mouse population Autor Churchill, Gary A., Gatti, Daniel M., Munger, Steven C., Svenson, Karen L.

“…The Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains…”
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Humanized mouse models of immunological diseases and precision medicine Autor Shultz, Leonard D., Keck, James, Burzenski, Lisa, Jangalwe, Sonal, Vaidya, Shantashri, Greiner, Dale L., Brehm, Michael A.

“…With the increase in knowledge resulting from the sequencing of the human genome, the genetic basis for the underlying differences in individuals, their…”
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CRISPR-Cas orthologues and variants: optimizing the repertoire, specificity and delivery of genome engineering tools Autor Cebrian-Serrano, Alberto, Davies, Benjamin

“…Robust and cost-effective genome editing in a diverse array of cells and model organisms is now possible thanks to the discovery of the RNA-guided…”
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Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations Autor Kaspar, Daniela, Hastreiter, Sieglinde, Irmler, Martin, Hrabé de Angelis, Martin, Beckers, Johannes

“…Nutritional constraints including not only caloric restriction or protein deficiency, but also energy-dense diets affect metabolic health and frequently lead…”
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Treating Rett syndrome: from mouse models to human therapies Autor Vashi, Neeti, Justice, Monica J.

“…Rare diseases are very difficult to study mechanistically and to develop therapies for because of the scarcity of patients. Here, the rare neuro-metabolic…”
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The birth of piRNAs: how mammalian piRNAs are produced, originated, and evolved Autor Sun, Yu H., Lee, Brent, Li, Xin Zhiguo

“…PIWI-interacting RNAs (piRNAs), small noncoding RNAs 24–35 nucleotides long, are essential for animal fertility. They play critical roles in a range of…”
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Mouse Genome Informatics (MGI): latest news from MGD and GXD Autor Ringwald, Martin, Richardson, Joel E., Baldarelli, Richard M., Blake, Judith A., Kadin, James A., Smith, Cynthia, Bult, Carol J.

“…The Mouse Genome Informatics (MGI) database system combines multiple expertly curated community data resources into a shared knowledge management ecosystem…”
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Humanized mouse models of immunological diseases and precision medicine Autor Shultz, Leonard D., Keck, James, Burzenski, Lisa, Jangalwe, Sonal, Vaidya, Shantashri, Greiner, Dale L., Brehm, Michael A.

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mammalian gene function resource: the international knockout mouse consortium Autor Bradley, Allan, Anastassiadis, Konstantinos, Ayadi, Abdelkader, Battey, James F, Bell, Cindy, Birling, Marie-Christine, Bottomley, Joanna, Brown, Steve D, Bürger, Antje, Bult, Carol J, Bushell, Wendy, Collins, Francis S, Desaintes, Christian, Doe, Brendan, Economides, Aris, Eppig, Janan T, Finnell, Richard H, Fletcher, Colin, Fray, Martin, Frendewey, David, Friedel, Roland H, Grosveld, Frank G, Hansen, Jens, Hérault, Yann, Hicks, Geoffrey, Hörlein, Andreas, Houghton, Richard, Hrabé de Angelis, Martin, Huylebroeck, Danny, Iyer, Vivek, de Jong, Pieter J, Kadin, James A, Kaloff, Cornelia, Kennedy, Karen, Koutsourakis, Manousos, Kent Lloyd, K. C, Marschall, Susan, Mason, Jeremy, McKerlie, Colin, McLeod, Michael P, von Melchner, Harald, Moore, Mark, Mujica, Alejandro O, Nagy, Andras, Nefedov, Mikhail, Nutter, Lauryl M, Pavlovic, Guillaume, Peterson, Jane L, Pollock, Jonathan, Ramirez-Solis, Ramiro, Rancourt, Derrick E, Raspa, Marcello, Remacle, Jacques E, Ringwald, Martin, Rosen, Barry, Rosenthal, Nadia, Rossant, Janet, Ruiz Noppinger, Patricia, Ryder, Ed, Schick, Joel Zupicich, Schnütgen, Frank, Schofield, Paul, Seisenberger, Claudia, Selloum, Mohammed, Simpson, Elizabeth M, Skarnes, William C, Smedley, Damian, Stanford, William L, Francis Stewart, A, Stone, Kevin, Swan, Kate, Tadepally, Hamsa, Teboul, Lydia, Tocchini-Valentini, Glauco P, Valenzuela, David, West, Anthony P, Yamamura, Ken-ichi, Yoshinaga, Yuko, Wurst, Wolfgang

“…In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the…”
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Comprehensive selection signature analyses in dairy cattle exploiting purebred and crossbred genomic data Autor Nayak, Sonali Sonejita, Panigrahi, Manjit, Rajawat, Divya, Ghildiyal, Kanika, Sharma, Anurodh, Parida, Subhashree, Bhushan, Bharat, Mishra, B. P., Dutt, Triveni

“…The main objective of the current research was to locate, annotate, and highlight specific areas of the bovine genome that are undergoing intense positive…”
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The Ontology of Biological Attributes (OBA)—computational traits for the life sciences Autor Stefancsik, Ray, Balhoff, James P., Balk, Meghan A., Ball, Robyn L., Bello, Susan M., Caron, Anita R., Chesler, Elissa J., de Souza, Vinicius, Gehrke, Sarah, Haendel, Melissa, Harris, Laura W., Harris, Nomi L., Ibrahim, Arwa, Koehler, Sebastian, Matentzoglu, Nicolas, McMurry, Julie A., Mungall, Christopher J., Munoz-Torres, Monica C., Putman, Tim, Robinson, Peter, Smedley, Damian, Sollis, Elliot, Thessen, Anne E., Vasilevsky, Nicole, Walton, David O., Osumi-Sutherland, David

“…Existing phenotype ontologies were originally developed to represent phenotypes that manifest as a character state in relation to a wild-type or other…”
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Exploring the mediating role of potential therapeutic genes in the pathogenesis of hypopituitarism through the metabolites from a genomic perspective Autor Sun, Yesheng, Zhang, Ying, Luan, Tengfei, Li, Ruichun, Cai, Dongpeng, Zhang, Wei

“…Hypopituitarism is a severe endocrine disorder characterized by a partial or complete hormone deficiency in the anterior or posterior pituitary gland. Current…”
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Insights from homozygous signatures of cervus nippon revealed genetic architecture for components of fitness Autor Goli, Rangasai Chandra, Mahar, Karan, Manohar, Peela Sai, Chishi, Kiyevi G, Prabhu, Immanual Gilwax, Choudhary, Sonu, Rathi, Pallavi, Chinnareddyvari, Chandana Sree, Haritha, Pala, Metta, Muralidhar, Shetkar, Mahantesh, Kumar, Amit, N D, Chethan Patil, Vidyasagar, Sukhija, Nidhi, Kanaka, K. K.

“…This study investigates the genomic landscape of Sika deer populations, emphasizing the detection and characterization of runs of homozygosity (ROH) and their…”
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