Suchergebnisse - "Magdolen, Viktor"

CXCL9 inhibits tumour growth and drives anti-PD-L1 therapy in ovarian cancer von Seitz, Stefanie, Dreyer, Tobias F, Stange, Christoph, Steiger, Katja, Bräuer, Rosalinde, Scheutz, Leandra, Multhoff, Gabriele, Weichert, Wilko, Kiechle, Marion, Magdolen, Viktor, Bronger, Holger

“… Response to immune checkpoint blockade (ICB) in ovarian cancer remains disappointing. Several studies have identified the chemokine CXCL9 as a robust …”
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Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs) von Goettig, Peter, Magdolen, Viktor, Brandstetter, Hans

“… Including the true tissue kallikrein KLK1, kallikrein-related peptidases (KLKs) represent a family of fifteen mammalian serine proteases. While the …”
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Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1 von Kryza, Thomas, Khan, Tashbib, Lovell, Scott, Harrington, Brittney S., Yin, Julia, Porazinski, Sean, Pajic, Marina, Koistinen, Hannu, Rantala, Juha K., Dreyer, Tobias, Magdolen, Viktor, Reuning, Ute, He, Yaowu, Tate, Edward W., Hooper, John D.

“… CUB domain-containing protein 1 (CDCP1) is an oncogenic orphan transmembrane receptor and a promising target for the detection and treatment of cancer …”
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Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors von Pilgram, Oliver, Keils, Aline, Benary, Gerrit E., Müller, Janis, Merkl, Stefan, Ngaha, Sandrine, Huber, Simon, Chevillard, Florent, Harbig, Anne, Magdolen, Viktor, Heine, Andreas, Böttcher-Friebertshäuser, Eva, Steinmetzer, Torsten

“… A rational structure-based approach was employed to develop novel 3-amidinophenylalanine-derived matriptase inhibitors with improved selectivity against …”
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Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients von Gong, Weiwei, Liu, Yueyang, Seidl, Christof, Dreyer, Tobias, Drecoll, Enken, Kotzsch, Matthias, Bronger, Holger, Dorn, Julia, Magdolen, Viktor

“… Overexpression of several members of the kallikrein-related peptidase (KLK) family, including KLK4, has been reported in ovarian cancer tissue, consistent with …”
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Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer von Geng, Xiaocong, Liu, Yueyang, Diersch, Sandra, Kotzsch, Matthias, Grill, Sabine, Weichert, Wilko, Kiechle, Marion, Magdolen, Viktor, Dorn, Julia

“… KLK9, 10, 11, and 15 may represent potential cancer biomarkers for evaluating ovarian cancer prognosis. In the present study, we selected a homogeneous cohort …”
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The chemokine CX3CL1 promotes intraperitoneal tumour growth despite enhanced T-cell recruitment in ovarian cancer von Seitz, Stefanie, Dreyer, Tobias F., Stange, Christoph, Steiger, Katja, Wohlleber, Dirk, Anton, Martina, Pham, Thuý An, Sauter-Peschke, Dominique, Reuning, Ute, Multhoff, Gabriele, Weichert, Wilko, Kiechle, Marion, Magdolen, Viktor, Bronger, Holger

“… T-cell recruiting chemokines are required for a successful immune intervention in ovarian cancer, and also for the efficacy of modern anticancer agents such as …”
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Rab31-dependent regulation of transforming growth factor ß expression in breast cancer cells von Soelch, Susanne, Beaufort, Nathalie, Loessner, Daniela, Kotzsch, Matthias, Reuning, Ute, Luther, Thomas, Kirchner, Thomas, Magdolen, Viktor

“… Background The small GTP-binding protein Rab31 plays an important role in the modulation of tumor biological-relevant processes, including cell proliferation, …”
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miR‐181a overexpression predicts the poor treatment response and early‐progression of serous ovarian cancer patients von Panoutsopoulou, Konstantina, Avgeris, Margaritis, Magkou, Paraskevi, Mavridis, Konstantinos, Dreyer, Tobias, Dorn, Julia, Obermayr, Eva, Reinthaller, Alexander, Michaelidou, Kleita, Mahner, Sven, Vergote, Ignace, Loverix, Liselore, Braicu, Ioana, Sehouli, Jalid, Zeillinger, Robert, Magdolen, Viktor, Scorilas, Andreas

“… Ovarian cancer (OC) remains a leading cause of gynecological cancer‐related death worldwide, characterized by poor 5‐year survival. Molecular markers could …”
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Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer von Gong, Weiwei, Liu, Yueyang, Seidl, Christof, Diamandis, Eleftherios P., Kiechle, Marion, Drecoll, Enken, Kotzsch, Matthias, Magdolen, Viktor, Dorn, Julia

“… Background In ovarian cancer, dysregulation of mRNA expression of several components of the family of the kallikrein-related peptidases (KLKs) is observed. In …”
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Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity von Guo, Shihui, Skala, Wolfgang, Magdolen, Viktor, Brandstetter, Hans, Goettig, Peter

“… Most kallikrein-related peptidases (KLKs) are N-glycosylated with N-acetylglucosamine2-mannose9 units at Asn-Xaa-Ser/Thr sequons during protein synthesis and …”
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A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity von Guo, Shihui, Skala, Wolfgang, Magdolen, Viktor, Briza, Peter, Biniossek, Martin L, Schilling, Oliver, Kellermann, Josef, Brandstetter, Hans, Goettig, Peter

“… Human kallikrein-related peptidase 2 (KLK2) is a key serine protease in semen liquefaction and prostate cancer together with KLK3/prostate-specific antigen. In …”
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Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients von Gong, Weiwei, Liu, Yueyang, Preis, Sarah, Geng, Xiaocong, Petit-Courty, Agnes, Kiechle, Marion, Muckenhuber, Alexander, Dreyer, Tobias, Dorn, Julia, Courty, Yves, Magdolen, Viktor

“… Background The serine protease KLK12 belongs to the human fifteen-member family of kallikrein-related peptidases. Differential expression accompanied by either …”
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A Pair of Prognostic Biomarkers in Triple-Negative Breast Cancer: KLK10 and KLK11 mRNA Expression von Liu, Yueyang, Gong, Weiwei, Preis, Sarah, Dorn, Julia, Kiechle, Marion, Reuning, Ute, Magdolen, Viktor, Dreyer, Tobias F.

“… Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor patient prognosis and limited therapeutic options. A lack of prognostic …”
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Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells von Grismayer, Bettina, Sölch, Susanne, Seubert, Bastian, Kirchner, Thomas, Schäfer, Sonja, Baretton, Gustavo, Schmitt, Manfred, Luther, Thomas, Krüger, Achim, Kotzsch, Matthias, Magdolen, Viktor

“… Background Rab proteins constitute a large family of monomeric GTP-binding proteins that regulate intracellular vesicle transport. Several Rab proteins, …”
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Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer von De Marchi, Tommaso, Timmermans, Mieke A., Sieuwerts, Anieta M., Smid, Marcel, Look, Maxime P., Grebenchtchikov, Nicolai, Sweep, Fred C. G. J., Smits, Jan G., Magdolen, Viktor, van Deurzen, Carolien H. M., Foekens, John A., Umar, Arzu, Martens, John W.

“… In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to …”
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Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation von Ohler, Anke, Debela, Mekdes, Wagner, Susanne, Magdolen, Viktor, Becker-Pauly, Christoph

“… The metalloproteases meprin alpha and beta are expressed in several tissues, leukocytes, and cancer cells. In skin, meprins are located in separate layers of …”
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Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences von Debela, Mekdes, Magdolen, Viktor, Schechter, Norman, Valachova, Martina, Lottspeich, Friedrich, Craik, Charles S, Choe, Youngchool, Bode, Wolfram, Goettig, Peter

“… Human tissue kallikreins (hKs) form a family of 15 closely related (chymo)trypsin-like serine proteinases. These tissue kallikreins are expressed in a wide …”
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Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin von Debela, Mekdes, Magdolen, Viktor, Skala, Wolfgang, Elsässer, Brigitta, Schneider, Eric L., Craik, Charles S., Biniossek, Martin L., Schilling, Oliver, Bode, Wolfram, Brandstetter, Hans, Goettig, Peter

“… Human KLK8/neuropsin, a kallikrein-related serine peptidase, is mostly expressed in skin and the hippocampus regions of the brain, where it regulates memory …”
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Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer von Gong, Weiwei, Liu, Yueyang, Diamandis, Eleftherios P., Kiechle, Marion, Bronger, Holger, Dorn, Julia, Dreyer, Tobias, Magdolen, Viktor

“… Background High-grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of ovarian cancer. A growing body of evidence suggests …”
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