Výsledky vyhľadávania - "Macrophages - pathology"

Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects Autor Gordon, Elizabeth M., Yao, Xianglan, Xu, Haitao, Karkowsky, William, Kaler, Maryann, Kalchiem-Dekel, Or, Barochia, Amisha V., Gao, Meixia, Keeran, Karen J., Jeffries, Kenneth R., Levine, Stewart J.

“…) macrophages from asthmatic subjects and identify how APOE regulates IL-1β secretion. Macrophages were isolated from asthmatic BALF and derived from THP-1…”
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Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation Autor Spencer, Michael, Yao-Borengasser, Aiwei, Unal, Resat, Rasouli, Neda, Gurley, Catherine M, Zhu, Beibei, Peterson, Charlotte A, Kern, Philip A

“… for markers of inflammation and fibrosis, and macrophages from obese and lean subjects were counted and characterized immunohistochemically…”
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Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis Autor Tabas, Ira, Bornfeldt, Karin E

“…Macrophage immunometabolism, the changes in intracellular metabolic pathways that alter the function of these highly plastic cells, has been the subject of intense interest in the past few years…”
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Hypertension is associated with the reduction in epidermal small fibres independently of sural nerve inflammation in type 2 diabetic subjects Autor Wang, Zhenchao, Kushibiki, Hanae, Tarusawa, Takefusa, Osonoi, Sho, Ogasawara, Saori, Miura, Chinatsu, Sasaki, Takanori, Ryuzaki, Masaki, Yagihashi, Soroku, Mizukami, Hiroki

“…Diabetic polyneuropathy (DPN) is a multifactorial disease associated not only with hyperglycaemia but also with circulatory disturbances such as hypertension…”
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Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor Autor Wu, Jing-Yiing, Huang, Tsai-Wang, Hsieh, Yi-Ting, Wang, Yi-Fu, Yen, Chia-Chien, Lee, Guan-Lin, Yeh, Chang-Ching, Peng, Yi-Jen, Kuo, Ya-Yi, Wen, Hsiu-Ting, Lin, Hui-Chen, Hsiao, Cheng-Wen, Wu, Kenneth K, Kung, Hsing-Jien, Hsu, Yu-Juei, Kuo, Cheng-Chin

“… These effects are mediated by SUCNR1-triggered PI3K-hypoxia-inducible factor 1α (HIF-1α) axis. Compared with healthy subjects and tumor-free lung tissues, serum succinate…”
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Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis Autor Edgar, Laurienne, Akbar, Naveed, Braithwaite, Adam T, Krausgruber, Thomas, Gallart-Ayala, Héctor, Bailey, Jade, Corbin, Alastair L, Khoyratty, Tariq E, Chai, Joshua T, Alkhalil, Mohammad, Rendeiro, André F, Ziberna, Klemen, Arya, Ritu, Cahill, Thomas J, Bock, Christoph, Laurencikiene, Jurga, Crabtree, Mark J, Lemieux, Madeleine E, Riksen, Niels P, Netea, Mihai G, Wheelock, Craig E, Channon, Keith M, Rydén, Mikael, Udalova, Irina A, Carnicer, Ricardo, Choudhury, Robin P

“…) compared with control subjects (n=16…”
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Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subjects With Insulin Resistance Autor Spencer, Michael, Finlin, Brian S., Unal, Resat, Zhu, Beibei, Morris, Andrew J., Shipp, Lindsey R., Lee, Jonah, Walton, R. Grace, Adu, Akosua, Erfani, Rod, Campbell, Marilyn, McGehee, Robert E., Peterson, Charlotte A., Kern, Philip A.

“… of ω-3 fatty acids on adipocytes and macrophages in vitro. Insulin-resistant, nondiabetic subjects were treated with Omega-3-Acid Ethyl Esters (4 g/day…”
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Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation Autor Pan, Yong, Hui, Xiaoyan, Hoo, Ruby Lai Chong, Ye, Dewei, Chan, Cyrus Yuk Cheung, Feng, Tianshi, Wang, Yu, Lam, Karen Siu Ling, Xu, Aimin

“…Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-associated metabolic complications. However, the molecular links…”
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Macrophage and Fibroblast Interactions in Biomaterial‐Mediated Fibrosis Autor Witherel, Claire E., Abebayehu, Daniel, Barker, Thomas H., Spiller, Kara L.

“…‐inflammatory drugs, hydrophobic coatings, etc.), many materials are still subject to a foreign body response, resulting in encapsulation of dense, scar…”
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Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss Autor Cancello, Raffaella, Henegar, Corneliu, Viguerie, Nathalie, Taleb, Soraya, Poitou, Christine, Rouault, Christine, Coupaye, Muriel, Pelloux, Veronique, Hugol, Danielle, Bouillot, Jean-Luc, Bouloumié, Anne, Barbatelli, Giorgio, Cinti, Saverio, Svensson, Per-Arne, Barsh, Gregory S., Zucker, Jean-Daniel, Basdevant, Arnaud, Langin, Dominique, Clément, Karine

“…Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss Raffaella Cancello 1 , Corneliu…”
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Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages Autor Belchamber, Kylie B R, Singh, Richa, Batista, Craig M, Whyte, Moira K, Dockrell, David H, Kilty, Iain, Robinson, Matthew J, Wedzicha, Jadwiga A, Barnes, Peter J, Donnelly, Louise E

“… with COPD.Monocyte-derived macrophages (MDMs) were generated from non-smoker, smoker and COPD subjects, differentiated in either granulocyte macrophage-colony stimulating factor (G-Mφ…”
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Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system Autor Rawji, Khalil S., Young, Adam M.H., Ghosh, Tanay, Michaels, Nathan J., Mirzaei, Reza, Kappen, Janson, Kolehmainen, Kathleen L., Alaeiilkhchi, Nima, Lozinski, Brian, Mishra, Manoj K., Pu, Annie, Tang, Weiwen, Zein, Salma, Kaushik, Deepak K., Keough, Michael B., Plemel, Jason R., Calvert, Fiona, Knights, Andrew J., Gaffney, Daniel J., Tetzlaff, Wolfram, Franklin, Robin J. M., Yong, V. Wee

“…; however, its efficiency declines with increasing age. Both intrinsic changes in the oligodendrocyte progenitor cell population and extrinsic factors in the lesion microenvironment of older subjects contribute to this decline…”
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Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy Autor Göös, Helka, Fogarty, Christopher L., Sahu, Biswajyoti, Plagnol, Vincent, Rajamäki, Kristiina, Nurmi, Katariina, Liu, Xiaonan, Einarsdottir, Elisabet, Jouppila, Annukka, Pettersson, Tom, Vihinen, Helena, Krjutskov, Kaarel, Saavalainen, Päivi, Järvinen, Asko, Muurinen, Mari, Greco, Dario, Scala, Giovanni, Curtis, James, Nordström, Dan, Flaumenhaft, Robert, Vaarala, Outi, Kovanen, Panu E., Keskitalo, Salla, Ranki, Annamari, Kere, Juha, Lehto, Markku, Notarangelo, Luigi D., Nejentsev, Sergey, Eklund, Kari K., Varjosalo, Markku, Taipale, Jussi, Seppänen, Mikko R.J.

“…CCAAT enhancer–binding protein epsilon (C/EBPε) is a transcription factor involved in late myeloid lineage differentiation and cellular function. The only…”
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Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes Autor Bae, Jung Hwan, Jo, Seung, Kim, Seong Jin, Lee, Jong Min, Jeong, Ji Hun, Kang, Jeong Suk, Cho, Nam-Jun, Kim, Sang Soo, Lee, Eun Young, Moon, Jong-Seok

“… The mtDNA levels were elevated in the plasma from patients with type 2 diabetes compared to healthy subjects…”
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Macrophage-Like Cell Density Is Increased in Proliferative Diabetic Retinopathy Characterized by Optical Coherence Tomography Angiography Autor Ong, Janice X., Nesper, Peter L., Fawzi, Amani A., Wang, Jacob M., Lavine, Jeremy A.

“…) using optical coherence tomography angiography (OCTA). The study included 72 eyes of 72 subjects…”
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Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance Autor Li, Pingping, Liu, Shuainan, Lu, Min, Bandyopadhyay, Gautum, Oh, Dayoung, Imamura, Takeshi, Johnson, Andrew M F, Sears, Dorothy, Shen, Zhufang, Cui, Bing, Kong, Lijuan, Hou, Shaocong, Liang, Xiao, Iovino, Salvatore, Watkins, Steven M, Ying, Wei, Osborn, Olivia, Wollam, Joshua, Brenner, Martin, Olefsky, Jerrold M

“…), a lectin mainly secreted by macrophages, is elevated in both obese subjects and mice. Administration of Gal3 to mice causes insulin resistance and glucose intolerance…”
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Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer Autor Singhal, Sunil, Stadanlick, Jason, Annunziata, Michael J, Rao, Abhishek S, Bhojnagarwala, Pratik S, O'Brien, Shaun, Moon, Edmund K, Cantu, Edward, Danet-Desnoyers, Gwenn, Ra, Hyun-Jeong, Litzky, Leslie, Akimova, Tatiana, Beier, Ulf H, Hancock, Wayne W, Albelda, Steven M, Eruslanov, Evgeniy B

“…Data from mouse tumor models suggest that tumor-associated monocyte/macrophage lineage cells (MMLCs) dampen antitumor immune responses. However, given the…”
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EP300-mediated H3K18la regulation of METTL3 promotes macrophage ferroptosis and atherosclerosis through the m6A modification of SLC7A11 Autor Chen, Jingquan, Liu, Zongrong, Yue, Zhujun, Tan, Qiang, Yin, Hongshun, Wang, Haifei, Chen, Zhilong, Zhu, Yanbing, Zheng, Jianghua

“…Macrophages, as the primary immune cell population in atherosclerosis (AS), exhibit complex pathogenic mechanisms that are not fully elucidated. This study…”
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Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury Autor Griffin, Allison D, Turtzo, L Christine, Parikh, Gunjan Y, Tolpygo, Alexander, Lodato, Zachary, Moses, Anita D, Nair, Govind, Perl, Daniel P, Edwards, Nancy A, Dardzinski, Bernard J, Armstrong, Regina C, Ray-Chaudhury, Abhik, Mitra, Partha P, Latour, Lawrence L

“…Traumatic microbleeds are small foci of hypointensity seen on T2*-weighted MRI in patients following head trauma that have previously been considered a marker…”
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M2 macrophages and regulatory T cells in lethal prostate cancer Autor Erlandsson, Ann, Carlsson, Jessica, Lundholm, Marie, Fält, Anna, Andersson, Sven‐Olof, Andrén, Ove, Davidsson, Sabina

“… Methods This nested case‐control study included subjects from a cohort of men diagnosed with PCa as an incidental finding during transurethral resection of the prostate…”
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