Suchergebnisse - "Macaulay, Valentine"

Therapeutic Targeting of the IGF Axis von Osher, Eliot, Macaulay, Valentine M.

“… The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to …”
Volltext

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation von Pfister, Sophia X, Markkanen, Enni, Jiang, Yanyan, Sarkar, Sovan, Woodcock, Mick, Orlando, Giulia, Mavrommati, Ioanna, Pai, Chen-Chun, Zalmas, Lykourgos-Panagiotis, Drobnitzky, Neele, Dianov, Grigory L, Verrill, Clare, Macaulay, Valentine M, Ying, Songmin, La Thangue, Nicholas B, D'Angiolella, Vincenzo, Ryan, Anderson J, Humphrey, Timothy C

“… Histone H3K36 trimethylation (H3K36me3) is frequently lost in multiple cancer types, identifying it as an important therapeutic target. Here we identify a …”
Weitere Angaben

Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies von Simpson, Aaron, Petnga, Wilfride, Macaulay, Valentine M., Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas

“… Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted …”
Volltext

Can we unlock the potential of IGF-1R inhibition in cancer therapy? von King, Helen, Aleksic, Tamara, Haluska, Paul, Macaulay, Valentine M.

“… •Low bioactivity protects from development of cancer.•However IGF inhibitor monotherapy is largely inactive in unselected cancer patients.•Some patients …”
Volltext

Bad to the Bone: The Role of the Insulin-Like Growth Factor Axis in Osseous Metastasis von Rieunier, Guillaume, Wu, Xiaoning, Macaulay, Valentine M, Lee, Adrian V, Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas

“… Bone metastases are a frequent complication of cancer that are associated with considerable morbidity. Current treatments may temporarily palliate the symptoms …”
Weitere Angaben

GeneFEAST: the pivotal, gene-centric step in functional enrichment analysis interpretation von Taylor, Avigail, Macaulay, Valentine M, Miossec, Matthieu J, Maurya, Anand K, Buffa, Francesca M

“… GeneFEAST, implemented in Python, is a gene-centric functional enrichment analysis summarization and visualization tool that can be applied to large functional …”
Volltext

Obesity: a perfect storm for carcinogenesis von Harris, Benjamin H. L., Macaulay, Valentine M., Harris, David A., Klenerman, Paul, Karpe, Fredrik, Lord, Simon R., Harris, Adrian L., Buffa, Francesca M.

“… Obesity-related cancers account for 40% of the cancer cases observed in the USA and obesity is overtaking smoking as the most widespread modifiable risk factor …”
Volltext

RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition von Earwaker, Philip, Anderson, Caroline, Willenbrock, Frances, Harris, Adrian L., Protheroe, Andrew S., Macaulay, Valentine M.

“… The outlook for patients with advanced renal cell cancer (RCC) has been improved by targeted agents including inhibitors of the PI3 kinase (PI3K)-AKT-mTOR …”
Volltext

The type 1 insulin-like growth factor receptor pathway von Chitnis, Meenali M, Yuen, John S P, Protheroe, Andrew S, Pollak, Michael, Macaulay, Valentine M

“… Research conducted over the past two decades has shown the importance of the type 1 insulin-like growth factor receptor (IGF1R) in tumorigenesis, metastasis, …”
Weitere Angaben

Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells von Aleksic, Tamara, Chitnis, Meenali M, Perestenko, Olga V, Gao, Shan, Thomas, Peter H, Turner, Gareth D, Protheroe, Andrew S, Howarth, Mark, Macaulay, Valentine M

“… The type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein composed of two extracellular alpha subunits and two beta subunits with …”
Weitere Angaben

IGF-1 regulates cancer cell immune evasion in prostate cancer von Nandakumar, Ashwin M., Barberis, Alessandro, Kim, Jinseon, Lang, Cameron R., Mills, Jack V., Rieunier, Guillaume, Doultsinos, Dimitrios, Taylor, Avigail, Jainarayanan, Ashwin, Phyu, Su M., Campo, Leticia, Easton, Alistair, Parkes, Eileen E., James, Timothy, Hamdy, Freddie C., Verrill, Clare, Mills, Ian G., Macaulay, Valentine M.

“… Insulin-like growth factor-1 (IGF-1) is associated with prostate cancer (PCa) development and lethality and exhibits immunosuppressive properties in other …”
Volltext

Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma von Simpson, Aaron D., Soo, Ying Wei Jenetta, Rieunier, Guillaume, Aleksic, Tamara, Ansorge, Olaf, Jones, Chris, Macaulay, Valentine M.

“… High-grade glioma (HGG) is highly resistant to therapy, prompting us to investigate the contribution of insulin-like growth factor receptor (IGF-1R), linked …”
Volltext

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status von Bardella, Chiara, El-Bahrawy, Mona, Frizzell, Norma, Adam, Julie, Ternette, Nicola, Hatipoglu, Emine, Howarth, Kimberley, O'Flaherty, Linda, Roberts, Ian, Turner, Gareth, Taylor, Jennifer, Giaslakiotis, Konstantinos, Macaulay, Valentine M, Harris, Adrian L, Chandra, Ashish, Lehtonen, Heli J, Launonen, Virpi, Aaltonen, Lauri A, Pugh, Christopher W, Mihai, Radu, Trudgian, David, Kessler, Benedikt, Baynes, John W, Ratcliffe, Peter J, Tomlinson, Ian P, Pollard, Patrick J

“… Germline mutations in the FH gene encoding the Krebs cycle enzyme fumarate hydratase predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC) …”
Volltext

A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer von Macaulay, Valentine M, Lord, Simon, Hussain, Syed, Maroto, José Pablo, Jones, Robert Hugh, Climent, Miguel Ángel, Cook, Natalie, Lin, Chia-Chi, Wang, Shian-Shiang, Bianchini, Diletta, Bailey, Mark, Schlieker, Laura, Bogenrieder, Thomas, de Bono, Johann

“… This multicentre, open-label, Phase Ib/II trial evaluated the insulin-like growth factor (IGF) 1/2 neutralising antibody xentuzumab plus enzalutamide in …”
Volltext

Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage von Aleksic, Tamara, Gray, Nicki, Wu, Xiaoning, Rieunier, Guillaume, Osher, Eliot, Mills, Jack, Verrill, Clare, Bryant, Richard J, Han, Cheng, Hutchinson, Kathryn, Lambert, Adam G, Kumar, Rajeev, Hamdy, Freddie C, Weyer-Czernilofsky, Ulrike, Sanderson, Michael P, Bogenrieder, Thomas, Taylor, Stephen, Macaulay, Valentine M

“… Internalization of ligand-activated type I IGF receptor (IGF1R) is followed by recycling to the plasma membrane, degradation or nuclear translocation. Nuclear …”
Weitere Angaben

IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer von Aleksic, Tamara, Verrill, Clare, Bryant, Richard J, Han, Cheng, Worrall, Andrew Ross, Brureau, Laurent, Larré, Stephane, Higgins, Geoff S, Fazal, Fahad, Sabbagh, Ahmad, Haider, Syed, Buffa, Francesca M, Cole, David, Macaulay, Valentine M

“… Background: Activated type 1 insulin-like growth factor receptors (IGF-1Rs) undergo internalisation and nuclear translocation, promoting cell survival. We …”
Volltext

Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors von Macaulay, Valentine M, Middleton, Mark R, Eckhardt, S Gail, Rudin, Charles M, Juergens, Rosalyn A, Gedrich, Richard, Gogov, Sven, McCarthy, Sean, Poondru, Srinivasu, Stephens, Andrew W, Gadgeel, Shirish M

“… Cross-talk between type I IGF receptor (IGF1R), insulin receptor (INSR), and epidermal growth factor receptor (EGFR) mediates resistance to individual receptor …”
Weitere Angaben

Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma von Gupta, Avinash, Towers, Christopher, Willenbrock, Frances, Brant, Roz, Hodgson, Darren Richard, Sharpe, Alan, Smith, Paul, Cutts, Anthony, Schuh, Anna, Asher, Ruth, Myers, Kevin, Love, Sharon, Collins, Linda, Wise, Adelyn, Middleton, Mark Roy, Macaulay, Valentine Moya

“… Background Aiming to improve treatment options for BRAF wild-type melanoma, we previously conducted the DOC-MEK study of docetaxel with MEK inhibitor (MEKi) …”
Volltext

CHK1 inhibition exacerbates replication stress induced by IGF blockade von Wu, Xiaoning, Seraia, Elena, Hatch, Stephanie B., Wan, Xiao, Ebner, Daniel V., Aroldi, Francesca, Jiang, Yanyan, Ryan, Anderson J., Bogenrieder, Thomas, Weyer-Czernilofsky, Ulrike, Rieunier, Guillaume, Macaulay, Valentine M.

“… We recently reported that genetic or pharmacological inhibition of insulin-like growth factor receptor (IGF-1R) slows DNA replication and induces replication …”
Volltext

Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction von Rieunier, Guillaume, Wu, Xiaoning, Harris, Letitia E, Mills, Jack V, Nandakumar, Ashwin, Colling, Laura, Seraia, Elena, Hatch, Stephanie B, Ebner, Daniel V, Folkes, Lisa K, Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas, Ryan, Anderson J, Macaulay, Valentine M

“… Inhibition of IGF receptor (IGF1R) delays repair of radiation-induced DNA double-strand breaks (DSB), prompting us to investigate whether IGF1R influences …”
Weitere Angaben