Suchergebnisse - "MacDonald, Thomas M"

Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial von Williams, Bryan, MacDonald, Thomas M, Morant, Steve, Webb, David J, Sever, Peter, McInnes, Gordon, Ford, Ian, Cruickshank, J Kennedy, Caulfield, Mark J, Salsbury, Jackie, Mackenzie, Isla, Padmanabhan, Sandosh, Brown, Morris J

“… Optimal drug treatment for patients with resistant hypertension is undefined. We aimed to test the hypotheses that resistant hypertension is most often caused …”
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Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy von Flynn, Robert W, Bonellie, Sandra R, Jung, Roland T, MacDonald, Thomas M, Morris, Andrew D, Leese, Graham P

“… For patients on T(4) replacement, the dose is guided by serum TSH concentrations, but some patients request higher doses due to adverse symptoms. The aim of …”
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Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies von Williams, Bryan, MacDonald, Thomas M, Morant, Steve V, Webb, David J, Sever, Peter, McInnes, Gordon T, Ford, Ian, Cruickshank, J Kennedy, Caulfield, Mark J, Padmanabhan, Sandosh, Mackenzie, Isla S, Salsbury, Jackie, Brown, Morris J

“… In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did …”
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Pioglitazone and bladder cancer: a propensity score matched cohort study von Wei, Li, MacDonald, Thomas M., Mackenzie, Isla S.

“… WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Pioglitazone is mainly used in combination with diet and exercise and other anti‐diabetic medications to treat type …”
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Spironolactone use and risk of incident cancers: a retrospective, matched cohort study von Mackenzie, Isla S., Morant, Steven V., Wei, Li, Thompson, Alastair M., MacDonald, Thomas M.

“… Aims Spironolactone is widely used to treat heart failure, hypertension and liver disease with increased usage in recent years. Spironolactone has endocrine …”
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The Digital Platform and Its Emerging Role in Decentralized Clinical Trials von Copland, Rachel R, Hanke, Sten, Rogers, Amy, Mpaltadoros, Lampros, Lazarou, Ioulietta, Zeltsi, Alexandra, Nikolopoulos, Spiros, MacDonald, Thomas M, Mackenzie, Isla S

“… Decentralized clinical trials (DCTs) are becoming increasingly popular. Digital clinical trial platforms are software environments where users complete …”
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Factors influencing participation and long-term commitment to self-monitoring of blood pressure in a large remote clinical trial: The treatment in morning versus evening (TIME) study von Vickneson, Keeran, Rogers, Amy, Anbarasan, Thineskrishna, Rorie, David A, MacDonald, Thomas M, Mackenzie, Isla S

“… This study investigates factors associated with active participation, and long-term commitment, to home blood pressure monitoring (HBPM) in the TIME study, a …”
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Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial von Brown, Morris J, McInnes, Gordon T, Papst, Cheraz Cherif, Zhang, Jack, MacDonald, Thomas M

“… Short-term studies have suggested that the use of initial combination therapy for the control of blood pressure improves early effectiveness. We tested whether …”
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Adverse events and overall health and well-being after COVID-19 vaccination: interim results from the VAC4COVID cohort safety study von Rogers, Amy, Rooke, Evelien, Morant, Steve, Guthrie, Greg, Doney, Alex, Duncan, Andrew, Mackenzie, Isla, Barr, Rebecca, Pigazzani, Filippo, Zutis, Krists, MacDonald, Thomas M

“… ObjectivesTo describe the incidence of adverse events (AEs), reactogenicity symptoms, menstrual changes and overall self-rated improvement in health and …”
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Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial von Brown, Morris J, Williams, Bryan, Morant, Steve V, Webb, David J, Caulfield, Mark J, Cruickshank, J Kennedy, Ford, Ian, McInnes, Gordon, Sever, Peter, Salsbury, Jackie, Mackenzie, Isla S, Padmanabhan, Sandosh, MacDonald, Thomas M

“… Potassium depletion by thiazide diuretics is associated with a rise in blood glucose. We assessed whether addition or substitution of a potassium-sparing …”
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A secondary qualitative analysis of stakeholder views about participant recruitment, retention, and adherence in decentralised clinical trials (DCTs) von Coyle, Joanne, Rogers, Amy, Copland, Rachel, De Paoli, Giorgia, MacDonald, Thomas M., Mackenzie, Isla S.

“… Background Decentralised clinical trials (DCTs) are clinical trials where all or most trial activities occur in or near participants’ homes instead of …”
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Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double‐Blind Randomized Controlled Trial von MacDonald, Thomas M., Williams, Bryan, Webb, David J., Morant, Steve, Caulfield, Mark, Cruickshank, J. Kennedy, Ford, Ian, Sever, Peter, Mackenzie, Isla S., Padmanabhan, Sandosh, McCann, Gerald P., Salsbury, Jackie, McInnes, Gordon, Brown, Morris J.

“… Background Guidelines for hypertension vary in their preference for initial combination therapy or initial monotherapy, stratified by patient profile; …”
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Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease: the ALL-HEART RCT and economic evaluation von Mackenzie, Isla S, Hawkey, Christopher J, Ford, Ian, Greenlaw, Nicola, Pigazzani, Filippo, Rogers, Amy, Struthers, Allan D, Begg, Alan G, Wei, Li, Avery, Anthony J, Taggar, Jaspal S, Walker, Andrew, Duce, Suzanne L, Barr, Rebecca J, Dumbleton, Jennifer S, Rooke, Evelien D, Townend, Jonathan N, Ritchie, Lewis D, MacDonald, Thomas M

“… Allopurinol is a xanthine oxidase inhibitor that lowers serum uric acid and is used to prevent acute gout flares in patients with gout. Observational and small …”
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Acid‐suppression medications and bacterial gastroenteritis: a population‐based cohort study von Wei, Li, Ratnayake, Lasantha, Phillips, Gabby, McGuigan, Chris C., Morant, Steve V., Flynn, Robert W., Mackenzie, Isla S., MacDonald, Thomas M.

“… Aims To investigate whether acid‐suppression medicines (ASMs) increase the risk of bacterial gastroenteritis. Methods A population‐based, propensity‐score …”
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Impact of allopurinol use on urate concentration and cardiovascular outcome von Wei, Li, Mackenzie, Isla S., Chen, Yang, Struthers, Allan D., MacDonald, Thomas M.

“… WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Guidelines recommend that the therapeutic goal of urate‐lowering therapy (ULT) is to achieve a urate concentration …”
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Effectiveness of statins on total cholesterol and cardiovascular disease and all-cause mortality in osteoarthritis and rheumatoid arthritis von Sheng, Xia, Murphy, Michael J, Macdonald, Thomas M, Wei, Li

“… There is increasing prevalence of hypercholesterolemia among patients with osteoarthritis (OA) and rheumatoid arthritis (RA). We examined the effectiveness of …”
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Factors influencing home blood pressure monitor ownership in a large clinical trial von Anbarasan, Thineskrishna, Rogers, Amy, Rorie, David A, Grieve, J W Kerr, Flynn, Robert W V, MacDonald, Thomas M, Mackenzie, Isla S

“… Home blood pressure monitor (HBPM) ownership prevalence and the factors that influence it are unclear. This study aimed to investigate factors associated with …”
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The effect of changes to GOLD severity stage on long term morbidity and mortality in COPD von Flynn, Robert W. V., MacDonald, Thomas M., Chalmers, James D., Schembri, Stuart

“… Background The Global Initiative for Chronic Obstructive Lung Disease (GOLD) severity stage classifies Chronic Obstructive Pulmonary Disease (COPD) into groups …”
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Adverse cardiovascular effects of acute salt loading in young normotensive individuals von Tzemos, Nikolaos, Lim, Pitt O, Wong, Suzanne, Struthers, Allan D, MacDonald, Thomas M

“… We sought to explore the effects of salt loading in young normotensives on vascular endothelial function, echocardiographic left ventricular diastolic …”
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The effect of statins on muscle symptoms in primary care: the StatinWISE series of 200 N-of-1 RCTs von Herrett, Emily, Williamson, Elizabeth, Brack, Kieran, Perkins, Alexander, Thayne, Andrew, Shakur-Still, Haleema, Roberts, Ian, Prowse, Danielle, Beaumont, Danielle, Jamal, Zahra, Goldacre, Ben, van Staa, Tjeerd, MacDonald, Thomas M, Armitage, Jane, Moore, Michael, Hoffman, Maurice, Smeeth, Liam

“… Uncertainty persists about whether or not statins cause symptomatic muscle adverse effects (e.g. pain, stiffness and weakness) in the absence of severe …”
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